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Fredrik von Kieseritzky

Fredrik von Kieseritzky
Arubedo AB, Stockholm, Sweden

Associate Professor

About

22
Publications
3,726
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299
Citations
Introduction
For the most part, I'm doing CNS drug discovery, from organic synthesis to clinical trials. I dabble in organic electronics too.

Publications

Publications (22)
Preprint
Psilocybin is a psychedelic substance approaching clinical use. The drug has long-lasting effects after single or multiple administrations and enhances structural plasticity in the brain. Little is known if the plasticity inducing effects of psilocybin could be timed to other treatments and promote a larger effect. We investigated the effect of psi...
Article
A correct determination of the ionization potential (IP) and electron affinity (EA) as wells as the energy gap is essential to properly characterize a series of key phenomena related to...
Article
Full-text available
Study design: A qualitative study with an emergent design using semi-structured interviews in focus groups. Objectives: To explore the expectations, experiences and desires among individuals who are prescribed drugs for spinal cord injury (SCI) neuropathic pain (NP). Setting: SCI rehabilitation centre. Methods: Eighteen informants with SCI a...
Article
Full-text available
Small-molecules (SM) have attracted a great deal of attention in the field of solar energy conversion due to their unique properties compared to polymers, such as well-defined molecular weight and lack of regio-isomeric impurities. Furthermore, these materials can be synthesized in a variety of configurational architectures, representing an opportu...
Article
Full-text available
In organic photovoltaic (OPV) devices, one way to increase light harvesting is to combine materials with complementary absorptions. However, the physical properties behind this process, such as Förster Resonance Energy Transfer (FRET), remain elusive. In this paper, a mixture of the metalloporphyrin Zn(5BrTTP ) and the donor-acceptor copolymer PSiF...
Patent
Full-text available
The invention relates to a one-pot reaction for the preparation of a compound of Formula (I). The compound of Formula (I) may be further transformed into picropodophyllin and derivatives thereof.
Article
Full-text available
A cost-efficient and facile synthesis of (S)-4-vinyldihydrofuran-2(3H)-one ((S)-1), better known as (S)-Taniguchi lactone, is described. Racemic Taniguchi lactone rac-1 was ring-opened with (S)-1-benzylmethylamine providing a diastereomeric mixture of hydroxyl-amides. The desired diastereomer (S,S)-2 was isolated by crystallization and subjected to...
Article
Full-text available
Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer's disease. Synthetic methods, crystal structures, and structure−activity relationships for target activity, permeability, and hERG activity are reported and discussed. Compound (S)-1m was one of the most promising compounds in this report, with high...
Article
Full-text available
Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer's disease. Synthetic methods, crystal structures, and structure-activity relationships for target activity, permeability, and hERG activity are reported and discussed. Compound (S)-1m was one of the most promising compounds in this report, with high...
Article
Full-text available
The evaluation of a series of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and the discovery of a clinical candidate drug for Alzheimer's disease, (S)-32 (AZD3839), are described. The improvement in permeability properties by the introduction of fluorine adjacent to the amidine moiety, resulting in in viv...
Article
Full-text available
By stepwise and regioselective installation of functional groups, we have synthesized and characterized two pyridines, 3-fluoro-5-iodo-2-(methylthio)-6-(trimethylsilyl)isonicotinonitrile and 3-fluoro-5-iodo-2-methoxy-6-(trimethylsilyl)isonicotinonitrile, substituted with five different elements, not including hydrogen, using known and newly develop...
Article
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Thin films of aligned supramolecular architectures built from newly synthesized thiophene-substituted porphyrins have been processed from solution on surfaces.
Article
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Ordered films of polycyclic aromatic hydrocarbons (PAHs) and porphyrins with functional (e.g. thiophene) side-groups are good candidates for (opto-)electronic applications where fast charge separation and transport are required. Such highly ordered thin films of PAHs, including discotic hexa-peri-hexabenzocoronene (HBC) and C132–C16,4, as well as b...
Article
Full-text available
3,4-Dimethoxythiophene (2) was synthesized in one-step from readily available bulk chemicals via a ring closure reaction, and was then trans-etherified with ethylene glycol to give 3,4-ethylenedioxythiophene (3) (EDOT).
Thesis
Full-text available
This thesis deals with synthesis and characterization of new oligothiophenes and derivatives thereof, for use in semiconductor applications. One series of regiodefined oligothiophenes up to the octamer was prepared and evaluated. Photoluminescence quantum efficiencies in solution were 22-31 %, but dropped to 2-5 % in the solid state. One oligothiop...
Article
Full-text available
The use of non-polar, small polymers as matrices for the analysis of low molecular weight compounds in polymer-assisted laser desorption/ionization mass spectrometry (PALDI-MS) is demonstrated. The matrices evaluated were either based on an oligothiophene or a benzodioxin backbone. Metallocenes, polycyclic hydrocarbons, a fluorosurfactant, and a su...
Article
Full-text available
We have developed a new synthetic protocol for the unsymmetrically alkylated and halogenated terthiophenes 5 and 10. To demonstrate their usefulness as building blocks for well-defined oligothiophenes, we synthesized a series of seven new sexi-, septi- and octithiophenes. Terthiophene 5 could be dimerized to the didecylsexithiophene In6 and terthio...
Article
The title compound dl-biTOT (1, dl-2,2′,3,3′-tetrahydro2,2′-bithieno[3,2-b][1,4]oxathiine) was prepared in a five-step synthesis using cheap and readily available starting materials, with an overall yield of 50%. Compound 1 is believed to display interesting and unique properties as a building block in oligomer and polymer applications in the rapid...

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