Fredrik Strand

Fredrik Strand
Karolinska Institutet | KI · Department of Oncology-Pathology

MSc MD PhD

About

44
Publications
7,175
Reads
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1,015
Citations
Citations since 2017
39 Research Items
834 Citations
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Introduction
I am an MD PhD Radiologist at Karolinska University Hospital active in the breast imaging field. My main research is focused on improving breast cancer screening and assessing neoadjuvant therapy response. Methodologically, I am exploring the application of deep learning image analysis both to mammograms and to MRI examinations.
Additional affiliations
July 2018 - present
University of California, San Francisco
Position
  • PostDoc Position
Description
  • Visiting post doc
May 2014 - June 2018
Karolinska Institutet
Position
  • PhD Student

Publications

Publications (44)
Article
Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC vs. SDC among screened women with breast cancer. The primary s...
Article
Full-text available
Computer-aided detection systems based on deep learning have shown good performance in breast cancer detection. However, high-density breasts show poorer detection performance since dense tissues can mask or even simulate masses. Therefore, the sensitivity of mammography for breast cancer detection can be reduced by more than 20% in dense breasts....
Preprint
Full-text available
Artificial intelligence (AI) cancer detectors are showing promising results and may soon be used for clinical breast cancer screening in radiology departments. Validation of such programs in different settings is mandatory. This is a retrospective study after the application of a commercial AI cancer detector program to a cancer-enriched mammograph...
Preprint
Computer-aided detection systems based on deep learning have shown good performance in breast cancer detection. However, high-density breasts show poorer detection performance since dense tissues can mask or even simulate masses. Therefore, the sensitivity of mammography for breast cancer detection can be reduced by more than 20% in dense breasts....
Preprint
Vision transformers have demonstrated the potential to outperform CNNs in a variety of vision tasks. But the computational and memory requirements of these models prohibit their use in many applications, especially those that depend on high-resolution images, such as medical image classification. Efforts to train ViTs more efficiently are overly co...
Article
Full-text available
Screening programs must balance the benefit of early detection with the cost of overscreening. Here, we introduce a novel reinforcement learning-based framework for personalized screening, Tempo, and demonstrate its efficacy in the context of breast cancer. We trained our risk-based screening policies on a large screening mammography dataset from M...
Preprint
Full-text available
Interval and large invasive breast cancers, which are associated with worse prognosis than other cancers, are usually detected at a late stage due to false negative assessments of screening mammograms. The missed screening-time detection is commonly caused by the tumor being obscured by its surrounding breast tissues, a phenomenon called masking. T...
Article
Full-text available
PURPOSE Accurate risk assessment is essential for the success of population screening programs in breast cancer. Models with high sensitivity and specificity would enable programs to target more elaborate screening efforts to high-risk populations, while minimizing overtreatment for the rest. Artificial intelligence (AI)-based risk models have demo...
Article
Full-text available
Background Kidney disease and renal failure are associated with hospital deaths in patients with COVID − 19. We aimed to test if contrast enhancement affects short-term renal function in hospitalized COVID − 19 patients. Methods Plasma creatinine (P-creatinine) was measured on the day of computed tomography (CT) and 24 h, 48 h, and 4–10 days after...
Article
Background Suppression of background parenchymal enhancement (BPE) is commonly observed after neoadjuvant -chemotherapy (NAC) at contrast-enhanced breast MRI. It was hypothesized that nonsuppressed BPE may be associated with -inferior response to NAC. Purpose To investigate the relationship between lack of BPE suppression and pathologic response. M...
Article
Full-text available
Purpose: Severe COVID-19 is associated with inflammation, thromboembolic disease, and high mortality. We studied factors associated with fatal outcomes in consecutive COVID-19 patients examined by computed tomography pulmonary angiogram (CTPA). Methods: This retrospective, single-center cohort analysis included 130 PCR-positive patients hospitalize...
Preprint
Full-text available
Background Kidney disease and renal failure are associated with hospital deaths in patients with Covid-19. We aimed to test if contrast enhancement (CE) affects short-term renal function in hospitalized Covid-19 patients. Methods Plasma creatinine (P-creatinine) was measured on the day of computed tomography (CT) and 24 h, 48 h, and 4–10 days after...
Article
Improved breast cancer risk models enable targeted screening strategies that achieve earlier detection and less screening harm than existing guidelines. To bring deep learning risk models to clinical practice, we need to further refine their accuracy, validate them across diverse populations, and demonstrate their potential to improve clinical work...
Preprint
Full-text available
Segmentation of COVID-19 lesions from chest CT scans is of great importance for better diagnosing the disease and investigating its extent. However, manual segmentation can be very time consuming and subjective, given the lesions' large variation in shape, size and position. On the other hand, we still lack large manually segmented datasets that co...
Article
Full-text available
Dynamic contrast-enhanced (DCE) MRI provides both morphological and functional information regarding breast tumor response to neoadjuvant chemotherapy (NAC). The purpose of this retrospective study is to test if prediction models combining multiple MRI features outperform models with single features. Four features were quantitatively calculated in...
Preprint
Full-text available
Screening programs must balance the benefits of early detection against the costs of over screening. Achieving this goal relies on two complementary technologies: (1) the ability to assess patient risk, (2) the ability to develop personalized screening programs given that risk. While methodologies for assessing patient risk have significantly impro...
Chapter
The ability to accurately estimate risk of developing breast cancer would be invaluable for clinical decision-making. One promising new approach is to integrate image-based risk models based on deep neural networks. However, one must take care when using such models, as selection of training data influences the patterns the network will learn to id...
Article
Background Mammography screening reduces breast cancer mortality, but a proportion of breast cancers are missed and are detected at later stages or develop during between-screening intervals. Purpose To develop a risk model based on negative mammograms that identifies women likely to be diagnosed with breast cancer before or at the next screening e...
Article
Full-text available
Background We examined the potential change in cancer detection when using an artificial intelligence (AI) cancer-detection software to triage certain screening examinations into a no radiologist work stream, and then after regular radiologist assessment of the remainder, triage certain screening examinations into an enhanced assessment work stream...
Article
Full-text available
Importance A computer algorithm that performs at or above the level of radiologists in mammography screening assessment could improve the effectiveness of breast cancer screening. Objective To perform an external evaluation of 3 commercially available artificial intelligence (AI) computer-aided detection algorithms as independent mammography reade...
Article
Background There is great interest in developing artificial intelligence (AI)-based computer-aided detection (CAD) systems for use in screening mammography. Comparative performance benchmarks from true screening cohorts are needed. Purpose To determine the range of human first-reader performance measures within a population-based screening cohort o...
Article
Objective Women with advanced HER2− breast cancer have limited treatment options. Breast MRI functional tumor volume (FTV) is used to predict pathologic complete response (pCR) to improve treatment efficacy. In addition to FTV, background parenchymal enhancement (BPE) may predict response and was explored for HER2− patients in the I-SPY-2 TRIAL. Me...
Preprint
Full-text available
Evidence suggests that networks trained on large datasets generalize well not solely because of the numerous training examples, but also class diversity which encourages learning of enriched features. This raises the question of whether this remains true when data is scarce - is there an advantage to learning with additional labels in low-data regi...
Preprint
Full-text available
The ability to accurately estimate risk of developing breast cancer would be invaluable for clinical decision-making. One promising new approach is to integrate image-based risk models based on deep neural networks. However, one must take care when using such models, as selection of training data influences the patterns the network will learn to id...
Article
Full-text available
Breast parenchymal enhancement (BPE) has shown association with breast cancer risk and response to neoadjuvant treatment. However, BPE quantification is challenging, and there is no standardized segmentation method for measurement. We investigated the use of a fully automated breast fibroglandular tissue segmentation method to calculate BPE from dy...
Article
Full-text available
Background Background parenchymal enhancement (BPE) of normal tissue at breast magnetic resonance imaging is suggested to be an independent risk factor for breast cancer. Its association with established risk factors for breast cancer is not fully investigated. Purpose To study the association between BPE and risk factors for breast cancer in a he...
Article
Full-text available
IMPORTANCE Mammography screening currently relies on subjective human interpretation. Artificial intelligence (AI) advances could be used to increase mammography screening accuracy by reducing missed cancers and false positives. OBJECTIVE To evaluate whether AI can overcome human mammography interpretation limitations with a rigorous, unbiased eval...
Article
Full-text available
Importance Mammography screening currently relies on subjective human interpretation. Artificial intelligence (AI) advances could be used to increase mammography screening accuracy by reducing missed cancers and false positives. Objective To evaluate whether AI can overcome human mammography interpretation limitations with a rigorous, unbiased eva...
Conference Paper
BACKGROUND: Background parenchymal enhancement (BPE) describes the natural phenomenon observed on breast MRI in which normal breast tissue demonstrates signal enhancement from uptake of intravenous contrast. BPE may provide independent and additive value for prediction of pathologic complete response (pCR) using MRI measured functional tumor volume...
Article
Background Most risk prediction models for breast cancer are based on questionnaires and mammographic density assessments. By training a deep neural network, further information in the mammographic images can be considered. Purpose To develop a risk score that is associated with future breast cancer and compare it with density-based models. Materia...
Article
Full-text available
For AI researchers, access to a large and well-curated dataset is crucial. Working in the field of breast radiology, our aim was to develop a high-quality platform that can be used for evaluation of networks aiming to predict breast cancer risk, estimate mammographic sensitivity, and detect tumors. Our dataset, Cohort of Screen-Aged Women (CSAW), i...
Article
Full-text available
Background: If screening participants do not trust computerized decision-making, screening participation may be affected by the introduction of such methods. Purpose: To survey breast cancer screening participants' attitudes towards potential future uses of computerization. Material and methods: A survey was constructed. Women in a breast canc...
Article
Full-text available
Background Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis. Methods We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotland Breast Cancer Register, Swe...
Article
Purpose: Women with radiographically dense or texturally complex breasts are at increased risk for interval cancer, defined as cancers diagnosed after a normal screening examination. The purpose of this study was to create masking measures and apply them to identify interval risk in a population of women who experienced either screen-detected or i...
Article
Full-text available
Background: High mammographic density is associated with breast cancer and with delayed detection. We have examined whether localized density, at the site of the subsequent cancer, is independently associated with being diagnosed with a large-sized or interval breast cancer. Methods: Within a prospective cohort of 63,130 women, we examined 891 w...
Article
Full-text available
Background: Breast cancer prognosis is strongly associated with tumor size at diagnosis. We aimed to identify factors associated with diagnosis of large (> 2 cm) compared to small tumors, and to examine implications for long-term prognosis. Methods: We examined 2012 women with invasive breast cancer, of whom 1466 had screen-detected and 546 inte...
Article
urpose: To test the hypothesis that prior non-adherence to mammography screening could predict subsequent non-adherence to breast cancer treatment. Specifically, we hypothesized that as compared with adherers, screening non-adherers may be more likely to have delayed surgery, discontinue their adjuvant hormone therapy, and consequently have worse b...
Article
Full-text available
Background Interval breast cancers are often diagnosed at a more advanced stage than screen-detected cancers. Our aim was to identify features in screening mammograms of the normal breast that would differentiate between future interval cancers and screen-detected cancers, and to understand how each feature affects tumor detectability. Methods From...
Article
Full-text available
Behavioural findings indicate that the core executive functions of inhibition and working memory are closely linked, and neuroimaging studies indicate overlap between their neural correlates. There has not, however, been a comprehensive study, including several inhibition tasks and several working memory tasks, performed by the same subjects. In th...
Article
Phonological working memory (PWM) tasks consist of a sequence of stimulus-encoding, maintenance and response. Few previous functional magnetic resonance imaging (fMRI) studies of PWM have employed event-related designs that make it possible to analyze the activations associated with each phase of such a task. The exploration of the cortical activat...

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Projects

Projects (2)
Project
To develop imaging biomarkers for prediction of treatment response and disease free survival in breast cancer patients
Project
My past and present research around some topics in medical imaging.