Frédérique Morizot

CERIES CHANEL · skin reseach department

Skin aging is an ineluctable process leading to the progressive loss of tissue integrity and is characterized by various outcomes such as wrinkling and sagging. Researchers have identified impacting environmental factors (sun exposure, smoking, etc.) and several molecular mechanisms leading to skin aging. We have previously performed genome-wide as...

Biologic rhythms of cells and organisms are well documented and have been extensively studied at the physiologic and molecular levels. For the skin, many circadian changes have been investigated but few systematic studies comparing skin at different body sites have been reported. In this study we investigated facial and forearm skin circadian rhyth...

Extracellular vesicles (EVs) and their miRNA cargo are intercellular communicators transmitting their pleiotropic messages between different cell types, tissues, and body fluids. Recently, they have been reported to contribute to skin homeostasis and were identified as members of the senescence-associated secretory phenotype of human dermal fibrobl...

Background Cosmetics are commonly attributed with increasing skin evenness, yet little published data characterizes the effect, either perceptually or physically. We therefore investigated whether makeup increases skin evenness using a perceptual measurement and two physical measurements of color and luminance homogeneity. Materials and Methods Tw...

Recent studies show that health perception from faces by humans is a good predictor of good health and healthy behaviors. We aimed to automatize human health perception by training a Convolutional Neural Network on a related task (age estimation) combined with a Ridge Regression to rate faces. Indeed, contrary to health ratings, large datasets with...

Hormonal contraception is known to cause subtle but widespread behavioral changes. Here, we investigated whether changes in cosmetic habits are associated with use of the hormonal contraceptive pill. We photographed a sample of women (N = 36) who self-reported whether or not they use the contraceptive pill, as well as their cosmetic habits. A separ...

Loss of functionality during aging of cells and organisms is caused and accompanied by altered cell-to-cell communication and signalling. One factor thereby is the chronic accumulation of senescent cells and the concomitant senescence-associated secretory phenotype (SASP) that contributes to microenvironment remodelling and a pro-inflammatory statu...

Background Sagging eyelid is considered as an outward of skin ageing and may cause medical issues. However, little is known about the factors involved in sagging eyelid. Objective To determine genetic risk factors for sagging eyelid. Methods The study was conducted in a cohort of 502 unrelated Caucasian women living in the Paris region. All inclu...

There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life-and healthspan of mice. Senescent cells negatively affect their surrounding tissue by losing their cell specific functionality and by secreting a pro-tumorigenic and pro-inflammatory mixtu...

Numerous studies report that women, including female athletes, use makeup to give themselves an image that is compatible with the social norms of femininity. Using a psychosocial approach, our studies aimed to deepen our knowledge of the relation between makeup and femininity in a French population. In study 1, using a free word association task, p...

Background: Validated tools are essential to evaluate facial skin aging for both dermatological and cosmetic investigations. While many visual aging scales have been developed, few have been validated and none in terms of degree of distinguishability (DD). We developed and validated a series of visual scales using a novel digital interface for sco...

A healthy appearance is linked to important behavioural outcomes. Here we investigated whether positive facial affect is a cue for perceived health. In study one, two groups of participants rated the perceived health or perceived happiness of a large set of faces with neutral expressions. Perceived happiness predicted perceived health, as did anthr...

Age is a fundamental social dimension and a youthful appearance is of importance for many individuals, perhaps because it is a relevant predictor of aspects of health, facial attractiveness and general well-being. We recently showed that facial contrast—the color and luminance difference between facial features and the surrounding skin—is age-relat...

Solar lentigines are a common feature of sun-induced skin ageing. Little is known, however, about the genetic factors contributing to their development. In this genome-wide association study, we aimed to identify genetic loci associated with solar lentigines on the face in 502 middle-aged French women. Nine SNPs, gathered in two independent blocks...

Looking healthy is a desirable trait, and facial skin color is a predictor of perceived health. However, skin conditions that cause dissatisfaction with appearance are specific to particular facial areas. We investigated whether color variation in facial skin is related to perceived health. Study 1 defined three areas based on color differences bet...

How healthy someone appears has important social consequences. Yet the visual cues that determine perceived health remain poorly understood. Here we report evidence that facial contrast-the luminance and color contrast between internal facial features and the surrounding skin- is a cue for the perception of health from the face. Facial contrast was...

Background: Knowledge of skin biology and its alterations in different populations is very important for the development of appropriate skin care strategies. Objectives: To evaluate and compare morphological, structural and biophysical properties of photoaged skin in French and Brazilian populations using biophysical and skin imaging techniques....

Background: In this work, we propose an innovative approach based on a rotary tribometer coupled with laser velocimetry for measuring the elastic wave propagation on the skin. Methods: The method is based on a dynamic contact with the control of the normal force (Fn ), the contact length and speed. During the test a quantification of the frictio...

Aspects of facial contrast decrease with age in Caucasian women, and Caucasian female faces with higher contrast look younger (Porcheron et al, 2013). Here we investigated faces and raters of other racial groups to see whether the link between facial contrast and age is universal. Using sets of carefully controlled full face color photographs of 18...

Facial contrast-the luminance and color contrast between internal facial features and the surrounding skin-is a cue for several aspects of face perception, including face detection, sex classification, age estimation, and judgments of attractiveness. It is also increased by makeup. Here we report evidence that facial contrast is also a cue for the...

Introduction L’objectif de cette étude est d’étudier l’évolution des signes de vieillissement du visage à 11 ans d’écart et leur association avec l’âge perçu. Patientes et méthodes Trois cent trente femmes ayant participé à une étude sur le vieillissement cutané réalisée en 2002 alors qu’elles étaient âgées de 44 à 70 ans ont participé à cette étu...

Objectives: Ageing leads to characteristic changes in the appearance of facial skin. Among these changes, we can distinguish the skin topographic cues (skin sagging and wrinkles), the dark spots and the dark circles around the eyes. Although skin changes are similar in Caucasian and Chinese faces, the age of occurrence and the severity of age-rela...

The structuring of the dermis with a network of collagen and elastic fibres gives a three-dimensional structure to the skin network with directions perpendicular and parallel to the skin surface. This three-dimensional morphology prints on the surface of the stratum corneum a three dimensional network of lines which express the mechanical tension o...

A genome-wide association study (GWAS) was conducted on 502 French middle-aged Caucasian women to identify genetic factors that may affect skin aging severity. A high-throughput Illumina Human Omni1-Quad beadchip was used. After single-nucleotide polymorphism (SNP) quality controls, 795,063 SNPs remained for analysis purposes. Possible stratificati...

The majority of the studies conducted on sleep deprivation has been dedicated to the consequences on the psychomotor performances. However, the impact of a debt of sleep on the skin has never been studied to date. Fourteen Caucasian females subjects (30-40 years) were included in this study that consisted in 3 sessions: baseline session (2 days), c...

Dehydration of the stratum corneum leads to sensations and symptoms of 'dry skin' such as skin tightness and itchiness. As these complaints are frequently experienced by airline travellers, the aim of this study was to investigate the changes in skin surface hydration during long distance flights. The study was performed on four healthy Caucasian,...

Current classifications of healthy skin are based on a limited number of characteristics such as oiliness or susceptibility to sun exposure. The aim of this study, carried out on 259 Caucasian women aged between 20 and 50, was to establish a classification of healthy facial skin irrespective of age, based on visual and tactile characteristics, usin...

This research aims at assessing the influence of baseline skin colour on the ability of reflectance spectrophotometry to detect cutaneous erythema induced by a low concentration of methyl nicotinate (2.5 mM) (first objective), and to detect tanning induced by ultraviolet rays (UVA+UVB) at infra-erythemal doses (second objective). Two independent st...

Background/aims: Understanding structural and functional differences between facial areas is necessary for the formulation of cosmetics and dermatological preparations well tailored to the skin's biophysical characteristics. The objective of the present study was to compare biophysical parameters on malar and frontal facial areas of healthy women c...

This study aimed to examine the frequency of self-assessed facial skin sensitivity and its different patterns, and the relationship with gender and sun sensitivity in a general adult population. A standardized 11-item questionnaire investigating reactions experienced during the past year was developed. The questions explored different patterns of s...

Ethnic differences in skin properties has attracted great interest in the past, but apart from the visible differences in pigmentation, their assessment has frequently yielded indefinite or conflicting results. Whereas it is self-evident that skin aging affects all human beings regardless of their ethnic background, it is commonly assumed that diff...

Hormonal replacement therapy (HRT) has been shown in the past to influence well being as well as several somatic features in menopausal women. The aim of this analysis was to study the effect of HRT on various biophysical properties of the skin of menopausal women. Two sub-samples were built to test the effect (1) of 'short-term' HRT in recently me...

To assess the relative contribution of intrinsic aging vs lifestyle factors to facial skin age. Prospective analysis of a cohort. Skin research institute. A cohort of 361 white women (age range, 18-80 years) with apparently healthy skin. Visual and tactile assessment of facial skin features. Twenty-four skin characteristics were used to build a ski...

The aim of this analysis was to study the possible effect of hormonal replacement therapy on some biophysical properties of the skin of menopausal women. A study was carried out on 106 menopausal, phototype I to IV women with clinically healthy skin. During the medical evaluation, the menopausal status, duration of the menopause, and, possible use...

The sun reactive skin type classification is based on sunburn susceptibility, tanning ability and phenotypic information. As subjects rarely match all features of a given skin type, the attribution to a class is partially subjective. The aims of the study, were to analyse the contribution of each characteristic to the classification made by the exp...

Biologic rhythms of cells and organisms are well documented and have been extensively studied at the physiologic and molecular levels. For the skin, many circadian changes have been investigated but few systematic studies comparing skin at different body sites have been reported. In this study we investigated facial and forearm skin circadian rhyth...

Background/aims: The aim of this study was to compare the biophysical properties of different facial zones. Methods: We investigated transepidermal water loss (TEWL), skin temperature and sebum casual level (CL) on 90 adjacent test sites distributed on the forehead, cheeks and chin of five women. Results: All three parameters showed a symmetrical d...