Frederico Barbosa

• Master of Science
• Technical University of Lisbon

The high and growing number of trauma or disease-related non-union fractures in an aging population has increased the clinical demand for tissue-engineered bone. Bone tissue is considered a conductive and piezoelectric material as a result of being mainly composed by collagen and hydroxyapatite [1]. Thus, electroactive materials (both electroconduc...

In this work, electroconductive 3D scaffolds of poly(capro-ε-lactone) – poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PCL-PEDOT:PSS) suitable for bone TE applications and ES were developed. The effects of an alkaline treatment (NaOH) of PCL scaffolds and the performance of two different crosslinkers at anchoring PEDOT:PSS to PCL constru...

The growing number of non-union fractures in an aging population has increased the clinical demand for tissue-engineered bone. Electrical stimulation (ES) has been described as a promising strategy for bone regeneration treatments in several clinical studies. However the underlying mechanism by which ES augments bone formation is still poorly under...

The current procedures being applied in the clinical setting to address osteoporosis-related delayed union and nonunion bone fractures have been found to present mostly suboptimal outcomes. As a result, bone tissue engineering (BTE) solutions involving the development of implantable biomimetic scaffolds to replace damaged bone and support its regen...

Bone defects can result from different incidents such as acute trauma, infection or tumor resection. While in most instances bone healing can be achieved given the tissue's innate ability of self-repair, for critical-sized defects spontaneous regeneration is less likely to occur, therefore requiring surgical intervention. Current clinical procedure...

Bone defect repair remains a critical challenge in current orthopedic clinical practice, as the available therapeutic strategies only offer suboptimal outcomes. Therefore, bone tissue engineering (BTE) approaches, involving the development of biomimetic implantable scaffolds combined with osteoprogenitor cells and native-like physical stimuli, are...

IMPACT STATEMENT In this study entitled “Hydroxyapatite-filled osteoinductive and piezoelectric nanofibers for bone tissue engineering”, we describe the development of novel hydroxyapatite (HAp)-filled osteoinductive piezoelectric poly(vinylidene fluoride-cotetrafluoroethylene) (PVDF-TrFE) electrospun nanofibers as a potential strategy for supporti...

The design of biomaterials using different cues can greatly influence cell homeostasis and biological response. Some examples of such cues include topography, surface hydrophilicity, electroconductivity and the immobilization/encapsulation of bioactive molecules. Electrical stimulation is an important biophysical cue that affects MSCs osteogenic di...

There is a need for the development of materials suitable for neural regeneration applications, including nerve conduits, sensors, and scaffolds for tissue engineering. In this work, we propose the development of an electroconductive blend of Poly(acrylonitrile) (PAN) with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) suitabl...

There is a need for reliable whole organ models of the spinal cord. The design of such models requires the use of appropriate (stem) cells, polymeric materials and biophysical stimuli. Electrical stimulation (ES) is a promising biophysical stimuli for tissue engineering strategies. The phenotype of the stimulated cells (e.g., neurons, astrocytes, o...

Supplementary Information file containing extra data.

This study describes, for the first time, the successful incorporation of poly(ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) in Poly(acrylonitrile) (PAN) fibers. While electroconductive PEDOT:PSS is extremely challenging to electrospun into fibers. Therefore, PAN, a polymer easy to electrospun, was chosen as a carrier due to its bioco...

INTRODUCTION:The development of an adequate therapy for non-union bone fractures remains largely elusive, with currentclinical strategies only achieving suboptimal outcomes. Bone tissue engineering (BTE) strategies focusing on the fabrication ofscaffolds to replace damaged tissue and support the regeneration process have been gaining interest. Whil...

There is a need for reliable whole organ models of the spinal cord. The design of such models requires the use of appropriate (stem) cells, polymeric materials and biophysical stimuli. Electrical stimulation (ES) is a promising biophysical stimuli for tissue engineering strategies. The phenotype of the stimulated cells (e.g., neurons, astrocytes, o...

INTRODUCTION: Bone tissue engineering remains a core area of research in regenerative medicine. Bone tissue is a terminally differentiated tissue rich in collagen and hydroxyapatite, and its regenerative potential is limited. Bioprinting allows the production of 3D porous scaffolds capable of osteointegration and regeneration. The application of el...

Articular cartilage is a highly specialized tissue found in diarthrodial joints, which is crucial for healthy articular motion. Despite its importance, articular cartilage has limited regenerative capacities, and the degeneration of this tissue is a leading cause of disability worldwide, with hundreds of millions of people affected. As current trea...

The construction of an artificial vertebrae requires the development of biomimetic artificial tissue microenvironments, capable of supporting the complex cell interactions of native tissues. The three-dimensional structure and chemistry of polymeric materials can impact how effectively cell differentiation occurs. Moreover, the presence of bioactiv...

There is a need for reliable whole organ models of the spinal cord. The design of such models requires the use of appropriate (stem) cells, polymeric materials and biophysical stimuli. Electrical stimulation (ES) is a promising biophysical stimuli for tissue engineering strategies. The phenotype of the stimulated cells (e.g., neurons, astrocytes, o...

Invited Presentation - Webinar

Osteochondral tissue (OCT) related diseases, particularly osteoarthritis, number among the most prevalent in the adult population worldwide. However, no satisfactory clinical treatments have been developed to date to resolve this unmet medical issue. Osteochondral tissue engineering (OCTE) strategies involving the fabrication of OCT-mimicking scaff...