Franziska Labrenz

Franziska Labrenz
Ruhr-Universität Bochum | RUB · Abteilung für Medizinische Psychologie und Soziologie

Dr.

About

30
Publications
9,668
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
346
Citations
Additional affiliations
April 2020 - present
Ruhr-Universität Bochum
Position
  • PostDoc Position
January 2018 - present
University Hospital Essen
Position
  • PostDoc Position
September 2013 - present
University Hospital Essen
Position
  • PostDoc Position
Education
January 2010 - November 2013
Ruhr-Universität Bochum
Field of study
  • Psychology
October 2007 - September 2009
University of Duisburg-Essen
Field of study
  • Applied Cognition and Media Science
October 2004 - September 2007
University of Duisburg-Essen
Field of study
  • Applied Communication and Media Science

Publications

Publications (30)
Article
Systemic inflammation impairs mood and cognitive functions, and seems to be involved in the pathophysiology of psychiatric disorders. Functional magnetic resonance imaging (fMRI) studies revealed altered task-related blood-oxygen-level-dependent (BOLD) responses during experimental endotoxemia, but little is known about effects of systemic inflamma...
Article
Full-text available
As a fundamental learning process, fear conditioning promotes the formation of associations between predictive cues and biologically significant signals. In its application to pain, conditioning may provide important insight into mechanisms underlying pain-related fear, although knowledge especially in interoceptive pain paradigms remains scarce. F...
Article
Conditioned pain-related fear may contribute to hyperalgesia and central sensitization, but this has not been tested for interoceptive, visceral pain. The underlying ability to accurately predict pain is based on predictive cue properties and may alter the sensory processing and cognitive-emotional modulation of pain thus exacerbating the subjectiv...
Chapter
Despite its clinical relevance and the potential to extend insights into the processing and modulation of pain derived from investigations of placebo phenomena, the nocebo effect has received comparably little attention over the past decades. Research from experimental and clinical studies is only beginning to unravel the behavioral, functional, an...
Article
Full-text available
Avoidance behaviors are shaped by associative learning processes in response to fear of impending threats, particularly physical harm. As part of a defensive repertoire, avoidance is highly adaptive in case of acute danger, serving a potent protective function. However, persistent or excessive fear and maladaptive avoidance are considered key facto...
Article
Associative learning and memory mechanisms drive interoceptive signaling along the gut-brain axis, thus shaping affective-emotional reactions and behavior. Specifically, learning to predict potentially harmful, visceral pain is assumed to succeed within very few trials. However, the temporal dynamics of cerebellar and cerebral fMRI signal changes u...
Article
Full-text available
Structural brain alterations in chronic pain conditions remain incompletely understood, especially in chronic visceral pain. Patients with chronic-inflammatory or functional bowel disorders experience recurring abdominal pain in concert with other gastrointestinal symptoms, such as altered bowel habits, which are often exacerbated by stress. Despit...
Article
Full-text available
Several diffusion tensor imaging studies reveal that white matter (WM) lesions are common in children suffering from benign cerebellar tumours who are treated with surgery only. The clinical implications of WM alterations that occur as a direct consequence of cerebellar disease have not been thoroughly studied. Here, we analysed structural and diff...
Article
Full-text available
The role of pain-related fear learning and memory processes, conceptually embedded within the fear-avoidance model of chronic pain, is increasingly recognized. The unique biological salience of interoceptive, visceral pain with its cognitive, emotional, and motivational facets fosters associative learning. Conditioned fear is in principle adaptive...
Article
Full-text available
Although the broad role of fear and hypervigilance in conditions of the gut-brain axis like irritable bowel syndrome is supported by converging evidence, the underlying mechanisms remain incompletely understood. Even in healthy individuals, it remains unclear how pain-related fear may contribute to pain-related attentional biases for acute visceral...
Article
Full-text available
Visceroception is a complex phenomenon comprising the sensation, interpretation, and integration of sensations along the gut-brain axis, including pain or defecatory urgency. Stress is considered a crucial risk factor for the development and maintenance of disorders of gut-brain signaling, which are characterized by altered visceroception. Although...
Article
Background Visceral hypersensitivity plays a key role in the pathophysiology of chronic visceral pain like irritable bowel syndrome (IBS), which is significantly more prevalent in women. Possible sex differences in visceral sensitivity remain poorly studied. We assessed sex differences in visceral sensitivity and their association with subclinical...
Article
It has been argued that reported negative effects of social networking site use on well-being and depression might be due to the vast opportunities for unflattering social comparison on Facebook. Social media websites offer Likes, a numeric representation of social acceptance, as a form of “online social currency,” which can be seen as a secondary...
Article
Full-text available
There is evidence to support a role of the cerebellum in emotional learning processes, which are demonstrably altered in patients with chronic pain. We tested if cerebellar activation is altered during visceral pain-related fear conditioning and extinction in irritable bowel syndrome (IBS). Cerebellar blood oxygenation level-dependent (BOLD) data f...
Article
Background: Studies investigating mechanisms underlying nocebo responses in pain have mainly focused on negative expectations induced by verbal suggestions. Herein, we addressed neural and behavioral correlates of nocebo responses induced by classical conditioning in a visceral pain model. Methods: In two independent studies, a total of 40 healt...
Conference Paper
Die Beteiligung spezifischer Großhirnareale an assoziativen Lern- und Gedächtnisprozessen bei chronischen Schmerzen ist durch eine Vielzahl experimenteller Studien gut belegt. Jedoch gibt es erste Hinweise, dass das Kleinhirn ebenfalls kognitiv-emotionale Lernvorgänge vermittelt. Insbesondere funktionelle chronische Schmerzen wie beim Reizdarmsyndr...
Conference Paper
Hyperalgesie ist ein Schlüsselkonzept in der Pathophysiologie chronischer Schmerzen. Es wird angenommen, dass klassisch-konditionierte, Schmerz-assoziierte Furcht zur Entstehung einer Hyperalgesie unter Beteiligung zentralnervöser Sensibilisierung beiträgt. Jedoch beruhen bisherige Ergebnisse auf somatischen Schmerzmodellen und gelten somit nicht u...
Conference Paper
While functional MRI studies revealed altered task-related BOLD responses during experimental endotoxemia, little is known how systemic inflammation affects resting state activity of the brain. In this randomized, placebo-controlled study, healthy men received either low-dose (0.4 ng/kg) lipopolysaccharide (LPS) (N = 20) or saline (N = 25). Resting...
Conference Paper
Tier- und humanexperimentelle Studien zeigen, dass das Kleinhirn an der klassischen Furchtkonditionierung beteiligt ist. Furchtkonditionierung ist für die Pathophysiologie chronischer Schmerzsyndrome relevant, da diese häufig mit Angsterkrankungen überlappen. Vor dem Hintergrund der deutlich höheren Prävalenz chronischer Schmerzsyndrome bei Frauen...
Conference Paper
Die klassische Konditionierung beruht auf dem Erlernen einer prädiktiven Assoziation zwischen einem neutralen Stimulus (CS) und einem biologisch signifikantem Signal (US). So ist das Erlernen von Assoziationen zwischen Umwelt- und viszeralen Schmerzsignalen ein bedeutender, aber bislang kaum verstandener Konditionierungsprozess, der aber im Kontext...
Article
Full-text available
Recent studies implicate a common response monitoring system, being active during erroneous and correct responses. Converging evidence from time-frequency decompositions of the response-related ERP revealed that evoked theta activity at fronto-central electrode positions differentiates correct from erroneous responses in simple tasks, but also in m...
Article
Full-text available
Attentional mechanisms are a crucial prerequisite to organize behavior. Most situations may be characterized by a 'competition' between salient, but irrelevant stimuli and less salient, relevant stimuli. In such situations top-down and bottom-up mechanisms interact with each other. In the present fMRI study, we examined how interindividual differen...

Network

Cited By

Projects

Projects (3)
Project
Peripheral inflammatory processes as they occur as a result of viral or bacterial infections are associated with the release of pro-inflammatory cytokines. These cytokines regulate the peripheral inflammatory response but also reach the central nervous system through vagal, spinal and humoral signaling pathways. Within the brain, diverse changes in psychological processes and behaviors are induced as a result of peripheral inflammation. This so-called “sickness syndrome” involves physiological and psychological symptoms and changes, such as an increase in body temperature, reduction in appetite (anorexia), increased pain sensitivity (hyperalgesia) and depressed mood. While these behavioral changes are an adaptive response to inflammation aimed at facilitating recuperation and regeneration in acute illness, during chronic inflammation, these symptoms may also contribute to abnormal health behaviors and conditions such as chronic pain and depression. In order to elucidate the mechanisms and clinical implications of sickness behavior resulting from peripheral inflammation, we experimentally study the peripheral and central effects of inflammation in the context of pain and mood disturbances. Moreover, we analyze the sensitivity of peripheral immune cells to neuroendocrine mediators of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in patients with chronic inflammatory bowel disease and healthy controls. Together, with this line of research we hope to contribute to a better understanding of afferent immune-to-brain communication and the role of neuroendocrine and immune mediators in the pathophysiology of chronic pain and mood disturbances.
Project
Virtually all types of chronic pain conditions are more prevalent in women when compared to men. Therefore, differences between men and women in the response to pain are highly relevant to improve our understanding of the etiology and pathophysiology of chronic pain conditions and may lead to more personalized treatments. However, the mechanisms underlying sex differences are yet incompletely understood in the context of acute and chronic abdominal pain. Therefore, one focus in all our pain experimental pain studies is to compare healthy women and men with regard to biological and psychosocial differences in pain behavior and its underlying neural mechanisms.
Project
Learned associations between environmental contexts or cues that predict the occurrence of pain constitute important conditioning processes, which remain incompletely understood. At the same time, cues or conditions that signal safety from pain may be just as relevant, an area of research that is just beginning to unfold. Together, learning and “unlearning” about predictive signals for pain and safety, respectively, are likely very relevant for the pathophysiology and treatment of conditions associated with chronic pain. In this line of research we are combining our research interest in chronic visceral pain with a new focus on conditioning and extinction research. To do so, we implement conditioning paradigms to study pain-related fear and safety learning and its subsequent extinction by applying visual signals paired with painful visceral stimuli in healthy participants and patients with chronic abdominal pain. By means of functional magnetic resonance imaging (fMRI) we use these paradigms to analyze the brain mechanisms underlying the learning and extinction of visceral pain-associated fear. In order to address the putative specificity of these conditioning processes to the nature of the painful signal, we are now striving to compare different painful signals from visceral when compared to somatic pain modalities in healthy volunteers and patients with chronic abdominal pain.