Franklin David Nash

Center for Scientific Analysis of Policy, LLC · Administration

Considerable attention is being paid to acute concussive injury (Traumatic Brain Injury, TBI) and to the long-term consequence of repeated head trauma (Chronic Traumatic Encephalopathy, CTE). Although related, they are separate and unique entities. With TBI, the search is for means of rapid diagnosis and classification. In the case of CTE, the scie...

NOTE: This paper is written in more of an academic style, rather than the semi-academic style commonly associated with white papers. This is because the authors believe that it is more important to forgo the delays (and the prestige) of academic publishing in favor of more rapidly sharing these results with the broader voting public.

The relations between renin release and renal hemodynamics, renal sodium load, and sodium and water balance were studied during hyponatremia, hypernatremia, mercurial natriuresis, norepinephrine infusion, and reduction in renal perfusion pressure. Significant reciprocal relations were found between renin secretory activity and the renal arterial pl...

Dynamic renal arterial flow pattern, arterial compliance, and pre-glomerular conductance were predicted from the measured canine renal arterial pressure pulse pattern using on-line analog computer simulation of renal arterial parameters. The flow was accurately predicted not only under steady-state conditions but also in the presence of marked fluc...

Effects on sodium reabsorption and oxygen consumption of the renal arterial injection of three metabolic inhibitors were studied by unilateral clearance techniques in anesthetized dogs. In control studies, 21.5 ± 2.3 mEq sodium were reabsorbed per millimole oxygen consumed within a range of sodium reabsorption of from 2 to 9 mEq/min. A total dose o...

Summary We administered an organic mercurial diuretic compound, an organic mercurial non-diuretic compound and an inhibitor of carbonic anhydrase to anesthetized dogs. Using conventional clearance methods, we measured renal plasma flow, filtration rate, sodium reabsorption and oxygen consumption. The mercurial diuretic compound blocked a fraction o...