Franklin Garcia-Godoy

• DDS, MS, PhD, PhD
• Professor at University of Tennessee Health Science Center

Pharmacy malpractice poses serious risks to patient safety and exposes healthcare providers to significant legal liability. This study examines the critical strategies for preventing pharmacy malpractice through a comprehensive analysis of preventative strategies, legal frameworks, and best practices. It represents the first investigation into the...

Background: Orthodontics and orthognathic surgery present challenges such as extended treatment durations, patient discomfort, and complications like root resorption. Recent advancements in tissue engineering and nanotechnology offer promising solutions by improving bone regeneration, periodontal repair, and biomaterial integration. Objectives: Thi...

Clinical case report of a Class II División II maloclussion treated in two phases with Carriere Motion Appliance and fixed appliances .

Introduction: There are no published studies on the facial changes that the Motion Appliance can produce in

This review synthesizes the findings from 252 studies to explore the relationship between the oral pathogens associated with periodontitis, dental caries, and systemic diseases. Individuals with oral diseases, such as periodontitis, are between 1.7 and 7.5 times (average 3.3 times) more likely to develop systemic diseases or suffer adverse pregnanc...

Polymers have become essential in advancing bone tissue engineering, providing adaptable bone healing and regeneration solutions. Their biocompatibility and biodegradability make them ideal candidates for creating scaffolds that mimic the body’s natural extracellular matrix (ECM). However, significant challenges remain, including degradation by-pro...

Purpose: To explore the latest trends in research on whitening toothpaste and to present the issues and future perspectives of these studies. Methods: An initial PubMed search was performed, followed by a meticulous manual review. A total of 543 papers were initially retrieved, and 54 final research papers were selected and analyzed through a manua...

The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity and insufficient biological signaling. This review examines nanoparticles (NPs) in tissue engineering (TE) to address these challenges, evaluating polymers, metals, ceramics, and com...

Effective management of head and neck cancer (HNC) poses a significant challenge in the field of oncology, due to its intricate pathophysiology and limited treatment options. The most common HNC malignancy is head and neck squamous cell carcinoma (HNSCC). HNSCC treatment includes a combination of surgery, radiation, and chemotherapy. While HNSCC is...

Purpose: To evaluate the impact of coffee attributes on tooth discoloration, emphasizing the importance of potential factors such as serving temperature, bean variety, and chlorogenic acid (CGA) content. Methods: Coffee preparation involved the extraction of espresso from four types of roasted beans (Vietnam Robusta, Uganda Robusta, Ethiopia Yirga...

Purpose: The purpose of this study was to investigate the microleakage of atraumatic glass ionomer restorations with and without silver diammine fluoride (SDF) application. Restorations with SDF are termed silver-modified atraumatic restorations (SMART). Methods: Sixty carious extracted permanent teeth were randomly allocated to two SMART groups an...

PURPOSE The study aims to investigate the influence of the ferrule effect and types of posts on the stress distribution in three morphological types of the maxillary central incisor. MATERIALS AND METHODS Nine models were created for 3 maxillary central incisor morphology types: “Fat” type - crown 12.5 mm, root 13 mm, and buccolingual cervical dia...

Objectives This study aimed to investigate the elemental analysis and microhardness of a bioactive material (Activa) and marginal tooth structure after storage in different media. Materials and Methods Fifteen teeth received cervical restorations with occlusal enamel and gingival dentin margins using the tested material bonded with a universal adh...

Objectives To provide a 3‐year follow‐up of previously treated patients to assess and compare the periodontal responses and clinical performance of proximal subgingival open sandwich restorations. Materials and Methods Ninety‐five adults participated in the study, with a combined total of 120 compound Class II cavities. These cavities had gingival...

Aerosols produced by dental handpieces represent a permanent risk of disease transmission in the dental environment. The current study evaluated the effects of natural ventilation (open windows) on Streptococcus mutans airborne contamination by dental handpieces in simulated clinical conditions. A dental phantom was placed on a dental chair at a st...

The evolution of medical knowledge about oral microbiota has increased awareness of its important role for the entire human body health. A wide range of microbial species colonizing the oral cavity interact both with each other and with their host through complex pathways. Usually, these interactions lead to a harmonious coexistence (i.e. eubiosis)...

This study aimed to evaluate the periodontal responses of subgingival proximal margins elevated using different restorative materials. One hundred and twenty proximal cavities with dentin/cementum gingival margins were elevated using one of four materials and completed with the same overlaying resin composite, namely resin-modified glass ionomer, g...

Purpose: To evaluate and compare the effects of different scaling and polishing techniques on the surface roughness of four different restorative materials. Methods: 72 specimens were prepared, molded to a size of 8.0 by 2.0 mm, and cured according to the manufacturers' instructions. The specimens were stored at 37°C for 24 hours and then thermo...

Objectives: This work aimed to evaluate if doxycycline-doped polymeric nanoparticles possessed any anti-inflammatory effect and promote osteogenic/cementogenic differentiation of stem cells from human periodontal ligament (PDLSCs). Methods: The polymeric nanoparticles (NPs) were produced by a polymerization/precipitation process and doped with d...

Background: To determine the safety of Botox and its potential effect on alleviating radiation therapy (RT)-induced sialadenitis in head and neck cancer patients. Methods: Twenty patients with stage III/IV head and neck cancer were randomized to receive Botox or saline injections into both submandibular glands (SMG). There were three visits: one...

Purpose: To evaluate the potential secondary caries reduction of bulk-fill resin composite restorations treated with different fluoride (F)-based agents prior to restoration placement. Methods: 25 upper extracted molars received Class V cavities on both buccal and lingual surfaces with an enamel margin and root surface margin. The teeth were ran...

Purpose: To evaluate the effects of toothpaste tablets on the gloss and surface roughness of resin-based composite materials and determine the relationship between gloss and roughness. Methods: Rectangular jigs were designed and printed. Wells (2 mm deep x 7 mm diameter) were filled with Filtek Supreme Ultra A2B, light-cured and polished. A smal...

This in-silico investigation evaluated the mechanical impact of Morse tape implant-abutment interface and retention system (with and without screw) and restorative materials (composite block and monolithic zirconia) by means of a three-dimensional finite element analysis (3D-FEA). Four 3D models were designed for the lower first molar. A dental imp...

Purpose: To compare the amount of abrasion of four whitening toothpastes, two conventional toothpastes, and seven experimental toothpastes with varying concentrations of hydrogen peroxide. Methods: Bovine dentin specimens were treated with the four whitening toothpastes (containing three different concentrations of hydrogen peroxide: 0.75%, 1.50...

Secondary caries is responsible for 60 percent of all replacement restorations in the typical dental practice. Risk factors for secondary caries are similar to those for primary caries development. Unfortunately, it is not possible to accurately predict which patients are at risk for restoration failure. During the past several decades, fluoride-re...

The aim of this study is to compare the marginal seal and tensile bond strength (TBS) of prostheses fixed to enamel-dentin using different adhesive systems. Resin-composite inlays directly fabricated from Class V cavities of extracted human molars/premolars and mini-dumbbell-shaped specimens of bonded enamel-dentin were prepared for microleakage an...

Purpose This study gathered perceptions from four stakeholder groups in the Dominican Republic (DR) regarding acquiring professional dental competencies and clinical skills. Methods Researcher-created surveys covering core dental competencies and clinical skills were distributed to stakeholder groups associated with nine different DR dental progra...

This study compared the periodontopathic bacterial adhesion to four restorative materials used for deep margin elevation at 2, 24, and 48‐h after incubation. Discs were produced from four restorative materials: resin modified glass ionomer, glass hybrid, flowable bulk fill resin composite, and bioactive ionic resin. Root dentin was used as control....

Purpose: To test the efficacy of nitrogen doped-TiO₂ (N-TiO₂) nanoparticles (NPs) on teeth whitening under visible light irradiation. Methods: N-TiOV₂ NPs were prepared by the sol-gel method, using TiN as a precursor. Their light absorbance and crystal structures were characterized. Photocatalytic reactions were tested using methylene blue (MB)...

Purpose: To test the feasibility of nitrogen-doped TiO₂ nanoparticles in the killing of Streptococcus mutans (S. mutans) for short term treatment. Methods: For the study, S. mutans were treated with the combinations of N-TiO₂, visible light, and without/with 0.5% H₂O₂ inclusion. Visible light was irradiated for 3 minutes one time. Results: Met...

The purpose of this study was to compare the envelope flap and triangular flap for impacted lower third molar (M3) extraction and their effects on the periodontal health of adjacent second molars (M2). A population of 60 patients undergoing M3 extraction with the envelope flap (Group A) or triangular flap (Group B) was analyzed, comparing probing p...

Purpose: To evaluate and compare the effect of pressure during curing on resin composite bond strength to dentin using a self-etch bonding protocol. Methods: 20 human teeth were cut to the mid-coronal dentin and received a standardized smear layer. The prepared teeth were randomly assigned to the following two groups (n= 10/group): (1) without p...

Purpose: To compare the autofluorescence (AF) spectra of resin products with teeth to determine if this type of non-invasive testing is feasible for differentiating resin products from teeth during resin repair. Methods: For the study, 11 methacrylate-based resin products were chosen. A 405 nm laser was used to induce AF, and a spectrophotometer...

Purpose: The purpose of this study was to evaluate the surface roughness of three different brands of prefabricated pediatric zirconia crowns (ZRCs) following simulated toothbrushing with a variety of dentifrices. Methods: Ninety-six total maxillary right central incisor prefabricated pediatric ZRCs (n equals 32 ZRCs/brand) were obtained from the m...

Objectives: This study aimed to evaluate the effect of aging on the marginal quality of glass hybrid (GH) material used to elevate dentin gingival margins, and to analyze the consistency of the results obtained by 3 in vitro methods. Materials and methods: Ten teeth received compound class II cavities with subgingival margins. The dentin gingiva...

Purpose: To test the applicability of autofluorescence (AF) spectrum and image in the detection and identification of oral pathogens. Methods: Oral pathogens (Candida albicans, Porphyromonas gingivalis, Streptococcus mutans) and teeth were used. To induce AF, the 405 nm laser was used as a light source, and AF was obtained and observed using a s...

Purpose: To investigate and compare the effects of the two widely used regenerative endodontics medicaments: Triple antibiotic paste (ciprofloxacine-metronidazole-clindamycin) and calcium hydroxide on the microhardness and degradation of human root dentin. Methods: Following ethical approval and subject consent to use teeth in this research stud...

Background: There is still debate about the most appropriate restorative material category to relocate the proximal deep cervical margins, thus, this study aimed to compare the marginal and internal adaptation of four base materials used for deep margin elevation, and to evaluate each base material/overlying composite interface. Material and meth...

Paracrine factors secreted in the conditioned media of periodontal ligament derived stem cells (PDLSCs) have been shown to downregulate inflammatory effects of IL-1β on chondrocytes wherein milk fat globule-epidermal growth factor 8 (MFG-E8) is one of the PDLSCs highly secretory proteins. Therefore, the objective of this study was to investigate th...

Purpose: To evaluate the laboratory long-term effect of various whitening dentifrices on the surface roughness of two brands of resin composite (TPH ST, Filtek Bulk Fill One) using a mechanical toothbrushing simulation. Methods: Thirty-two samples each of Filtek and TPH were fabricated in ring molds 10 x 1 mm. Samples were randomly grouped (n=8;...

Research has been conducted into the advantages of the systemic administration of an- tibiotics. The aim of this systematic review and meta-analysis was to assess the efficacy of systemic antibiotic administration in the treatment of peri-implantitis in terms of bleeding on probing (BoP) and probing pocket depth (PPD). Literature searches were perf...

To examine the effect of mold enclosure and chisel design on macro shear fatigue bond strengths of dental adhesive systems. The fatigue bond strength testing was conducted with two commercially available dental adhesive systems, (1) OptiBond eXTRa and (2) Scotchbond Universal, for bonding a resin composite (Filtek Supreme Ultra) to both enamel and...

Aim To evaluate and compare the effects of both manual and ultrasonic scaling on surface roughness of four different base materials, used for elevating dentin/cementum gingival margins of proximal cavities. Methods and Materials Eighty human upper molars with compound Class II mesial cavities, with gingival margins 1 mm below the cemento–enamel ju...

The present investigation evaluated the effect of the combination of different dental filling materials in Class I cavities under occlusal loading using three-dimensional finite elements analysis (FEA). Six computer-generated and restored models of a lower molar were created in the CAD software and compared according to the biomechanical response d...

Purpose: To determine the efficacy of an oral spray and oral rinses to inhibit oral cariogenic dual species biofilm formation on hydroxyapatite (HA) discs. Methods: The Streptococcus mutans (NCTC 10449, ATCC), Lactobacilli casei (NCIB 8820, ATCC) dual species biofilm formation and inhibition on HA disc was tested using five antimicrobial product...

Purpose: To quantify the biological contamination of a dental operatory environment using a biological tracer. Methods: A Streptococcus mutans suspension was infused into the mouth of a phantom, and an operator performed standardized dental procedures using an air turbine, a contra-angle handpiece, or an ultrasonic scaler either with windows ope...

This review aimed to characterize the effect of direct restorative material types and adhesive protocols on marginal adaptation and the bond strength of the interface between the material and the proximal dentin/cementum. An electronic search of 3 databases (the National Library of Medicine [MEDLINE/PubMed], Scopus, and ScienceDirect) was conducted...

Purpose: To analyze the biological effects of four base materials used for elevation of proximal subgingival margins on gingival epithelial cells. Methods: Twenty-eight specimens for each of the four base materials (total 112 specimens) were used: resin-modified glass ionomer (RMGI), glass hybrid (HV-GIC), flowable bulk fill resin composite (Bul...

This is a narrative review of the literature assessing the potential effectiveness of doping dentin polymeric adhesives with zinc compounds in order to improve bonding efficacy, remineralization and protection against degradation. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI and Web of Science. Throug...

To compare full and partial coverage crowns made with different CAD/CAM leucite reinforced ceramic blocks on fracture resistance and fractographic analysis. Full coverage and partial coverage crowns with finish line at 2 mm and 4 mm above the gingiva for molars made with IPS Empress CAD and Rosetta BM. After fatigue process, the fracture test and f...

Purpose To investigate the effect of a cervical cavity extending 1 mm apical to the cemento–enamel junction (CEJ) on fracture resistance and failure mode of maxillary central incisors that have been treated endodontically, present with complete and incomplete ferrules, and are restored with and without a fiber post. Methods and Materials 50 intact...

Objectives: The case report describes a minimally invasive, multidisciplinary approach to a single discolored anterior tooth, with internal bleaching using traditional Japanese paper (Washi), a gingivoplasty with a three-dimensional (3D) printed surgical guide, and ultrathin feldspathic porcelain veneers. Clinical consideration: The patient's prim...

Objective: Minimally invasive techniques that use silver compounds and glass ionomer cement are suggested for caries management due to their effectiveness, simplicity, and low cost. The aim of this review is to examine the evidence supporting the use of silver compounds and glass ionomer cement in dentistry. Study design: Literature was searched...

Purpose: To evaluate color and gloss changes of three different resin composites after staining and whitening. Methods: 57 disc-shaped composite samples were made for each of three resin composite materials [Activa BioActive Restorative (Activa), Filtek Supreme (Filtek), and TPH Spectra (TPH)], producing 19 samples per composite (n=19). Each gro...

Purpose: To examine the effects of an ion-releasing filler-containing gel on the remineralization of dentin using optical coherence tomography (OCT). Methods: Dentin slabs of bovine teeth were sliced and shaped into a rectangular form. Specimens were treated with undersaturated 0.1 M lactic acid buffer solution (pH 4.75) for 10 minutes and then...

To evaluate the flexural and bonding properties, marginal adaptation, and polymerization shrinkage in flowable composite restorations and their relationships, four new generation flowable composites, one conventional, and one bulk-fill flowable composite were used in this study. Flexural properties of the composites and shear bond strength to ename...

Due to the essential role of dentists in stopping the COVID-19 pandemic, the purpose of this review is to help dentists to detect any weaknesses in their disinfection and cross-contamination prevention protocols, and to triage dental treatments to meet the needs of patients during the pandemic. We used PRISMA to identify peer-reviewed publications...

Purpose: To evaluate the influence of light irradiation on the clinical efficiency of an in-office whitening agent. Methods: The in-office whitening agent (Opalescence Boost 35%) was used in this study. Two whitening regimens were evaluated on maxillary anterior teeth: (1) with light irradiation; and (2) without light irradiation. The ΔE*, chang...

The aim of this study was to evaluate the effect of 2% chlorhexidine digluconate (CHX) on microtensile bond strength (µTBS) between an adhesive system and under 3 dentin conditions. For that, this study evaluated the adhesive interface at initial, after 6 months and 1 year of storage. Forty-eight human third molars were prepared and randomly divide...

Abstract Objective: The purpose of this study was to evaluate the effectiveness of five different polishing systems on a computer-aided design and computer-aided manufacturing (CAD/CAM) polymer-infiltrated ceramic-network restoration with nanoscale assessment using atomic force microscopy (AFM) and visual assessment performed by dental school seni...

Purpose: To evaluate the effect of different substrate stiffness [sound dentin (SD), resin composite core (RC) or metal core (MC)] on the stress distribution of a zirconia posterior three-unit fixed partial denture (FPD). Methods: The abutment teeth (first molar and first premolar) were modeled, containing 1.5 mm of axial reduction, and convergi...

Background: There is a paucity of literature on the state of oral health in the minority populations of Utah. The purpose of this study was to analyze the oral health needs of individuals in Health Professional Shortage Areas (HPSA) regions in Utah, many of whom belong to minority groups. Methods: The study was conducted through the use of a retros...

The purpose of this study was to evaluate the bonding and wear properties of self‐adhesive flowable restorative materials. Five self‐adhesive flowable restorative materials were used. The study parameters were: (i) shear bond strengths; (ii) microleakage; (iii) occlusal wear; and (iv) qualitative evaluation of the bonding interface. The range of sh...

Purpose: To evaluate and compare the effect on micro-tensile bond strength (µTBS) of a double layer application of three universal adhesives applied in self-etch mode to proximal dentin/cementum gingival margins of class II direct composite restorations, immediately and after 12 months water storage. Methods: 66 molars with compound class II cav...

The wear of dentures carries with it the possibility of an inflammatory response by the denture-bearing tissues. Lack of or improper hygiene has been shown to contribute to denture stomatitis (DS). Although essential, denture hygiene is often overlooked by patients or performed improperly. As professional caregivers dentists must instruct patients...

Osteoarthritis (OA) is the most common type of arthritis, afflicting millions of people in the world. Elevation of inflammatory mediators and enzymatic matrix destruction is often associated with OA. Therefore, the objective of this study was to investigate the effects of conditioned medium from periodontal ligament derived stem cells (PDLSCs) on i...

Background Light-emitting diode (LED) and quartz-tungsten-halogen (QTH) curing lights are used commonly in clinics. The aim of this study was to assess the effect of these lights on the proliferation of human gingival epithelial cells. Methods Smulow-Glickman (S-G) cells were exposed to a VALO LED (Ultradent) or an XL3000 QTH (3M ESPE) light at 1...

BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is of considerable concern among clinicians and researchers, with no clear pathology mechanism, preventive, or treatment protocols. AIM: This study aimed to assess the effects of geranylgeraniol (GGOH) on the toxicity induced by clinical doses of zoledronic acid (ZOL) on gingival epith...

Purpose: Since pediatric zirconia crowns (ZRCs) are prefabricated, they may be sterilized following try-in for re-use. Possible changes in color stability, gloss, and translucency were evaluated for four brands of prefabricated zirconia crowns following autoclave and cold sterilization. Methods: Sixteen maxillary right central incisor prefabricated...

Aim To obtain a consensus on the domains of cariology for undergraduates in dental schools in the Caribbean. Materials and Methods Dental school deans from the Dominican Republic (DR) and Puerto Rico (PR) were invited to participate. Afterwards, 24 cariology faculty members from the dental schools in the DR received a 40‐hour workshop on the curre...

Statement of problem Different designs of posterior minimally invasive fixed partial dentures (MIFPDs) still require additional tooth preparation for guide planes, occlusal rest seats, and grooves and/or slots to increase retention and resistance forms. Whether a design with less tooth reduction can be successful is unclear. Purpose This in vitro...

Purpose: To evaluate the ability of a pencil-type transducer connected to a pulser-receiver to measure remaining dentin thickness (RDT). Methods: A total of 24 freshly extracted bovine incisors were used to prepare dentin disks with certain thicknesses (0.5, 1.0, 1.5 and 2.0 mm). The thicknesses of the specimens were measured with an ultrasonic...

Introduction: The thickness threshold for detecting endodontic biomaterials depends on many factors, such as the nature of the radiopacifier and the particle size. Aim: The aim of this study was to determine the effect of thickness on radiodensity of various endodontic biomaterials; and evaluate the impact of radiopacifier particle size on radioden...

Purpose: To investigate whether the addition of sodium-DNA (Na-DNA) to chlorhexidine (CHX)-containing mouthwash influenced morphology and viability of a reconstituted human oral epithelium (ROE), and protects ROE against oxidative stress. Methods: Multi-layered 0.5 cm² ROE specimens were positioned inside a continuous flow bioreactor and grown a...