Frank Daniel Scherag

Frank Daniel Scherag
University of Freiburg | Albert-Ludwigs-Universität Freiburg · Department of Microsystems Engineering (IMTEK)

Dr.-Ing., Dipl.-Biol.

About

23
Publications
1,119
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
65
Citations

Publications

Publications (23)
Patent
Full-text available
The present invention relates to the field of microplate assay-based analytical and diagnostic applications, in particular immunoaffinity assays, ELISA or ELISpot assays. More specifically, the present invention relates to functionalized hydrogel coatings of assay plates. The present invention provides a novel method of manufacturing a surface-bond...
Article
Full-text available
This work describes a novel technique for the deposition of surface‐attached hydrogels, which is based on a combination of spray coating and CH‐insertion cross‐linking (CHic) to create a protein repellent surface. To this, hydrogel precursor polymers are spray coated onto the surface to be modified, dried, and photo cross‐linked in the solid state....
Article
In this study, we present the generation of novel, multifunctional polymer networks through a combination of C,H-insertion cross-linking (CHic) and click chemistry. To this, copolymers consisting of hydrophilic N,N-dimethylacrylamide as matrix component and repeat units containing azide moieties, as well as benzophenone or anthraquinone groups, are...
Patent
Full-text available
Embodiments of the present invention provide a tube which Filter has a region that tapers in the direction of an end of the tube; an opening at the end of the tube for receiving a sample material; and a microfluidic structure which is arranged inside the tube in the tapering region thereof and which is connected to the opening, wherein the microflu...
Patent
Full-text available
Device for the in-vivo and/or in-vitro enrichment of target structures in a sample liquid, including at least one functional portion, which is provided with receptors for enriching the target structures. In order to improve the enrichment of the target structures in the sample liquid, it is provided according to the invention that the functional po...
Chapter
In our project we aim to develop living, adaptive and energy-autonomous material systems that show dynamic, life-like and non-equilibrium (energy) features. Our demonstrators represent a first step towards future implementation of novel technologies into industrial products and everyday life applications. In this study, we present bioinspired demon...
Article
Objectives: Ureteral stenting is a widely used method for noninvasive urinary drainage in ureteral obstruction. However, biofilm development due to transient bacteriuria can cause severe complications such as incrustation with subsequent obstruction as well as recurrent urinary tract infection. Apart from local ailment such as dysuria, this increa...
Article
In bioanalytical applications, many coating strategies have been established for so-called “blocking” of the surfaces. However, most of the procedures developed so far require additional processing steps for surface blocking and small variations in the blocking efficiency result in increased background noise, which lowers the overall sensitivity of...
Article
Medical wires inserted into the blood stream of patients offer an attractive perspective to capture rare cells such as circulating tumor cells in vivo. A major challenge in such systems is to achieve an efficient interaction of the desired cells with the sensing surface and avoid those cells that simply flow by the wire without any contact while fl...
Book
Inhaltlicher Schwerpunkt dieses Bandes ist die Anreicherung, Detektion und Analyse von seltenen Zellen aus einem laminaren Strömungsfeld mithilfe von drahtförmigen, rezep-tormodifizierten Oberflächen. Als bedeutendes Beispiel für seltene Zellen werden im Blut zirkulierende Tumorzellen betrachtet. Eine Identifizierung dieser Tumorzellen ist von sig-...
Patent
Full-text available
Ausführungsbeispiele der vorliegenden Erfindung schaffen eine Röhre mit einem zu einem Ende der Röhre hin verjüngenden Bereich; einer Öffnung an dem Ende der Röhre zum Aufnehmen eines Probenmaterials; und einer mikrofluidischen Struktur, die innerhalb der Röhre in dem verjüngenden Bereich der Röhre angeordnet ist und die mit der Öffnung verbunden i...
Article
The detection of circulating tumor cells (CTCs) in the blood of cancer patients is a challenging task. CTCs are, especially at the early stages of cancer development, extremely rare cells hidden in a vast background of regular blood cells. We describe a new strategy for the isolation of CTCs from whole blood. The key component is a medical wire coa...
Article
A novel type of anaerobic bacteria was previously isolated from profundal lake sediment by direct dilution of the sediment in mineral agar medium containing glucose and a background lawn of Methanospirillum hungatei as a syntrophic partner. The isolated bacteria grouped with aerobic Bacillus spp. according to their 16S rRNA gene sequence, and the m...
Article
Full-text available
The implementation of PCR reactions in the presence of metallic surfaces is interesting for the generation of novel bioanalytical devices, because metals exhibit high mechanical stability, good thermal conductivity, and flexibility during deformation. However, metallic substrates are usually non-compatible with enzymatic reactions such as PCR due t...
Conference Paper
Full-text available
We present a device platform for point-of-care testing of whole blood samples. It enables the determination of the viral load of blood on a processor-controlled device platform. For the analysis process two disposable cartridges carrying the fluidic and a media module are placed together in one device platform. In order to verify the operational ca...

Network

Cited By

Projects

Project (1)