Frank Abimbola Ogundolie

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• Doctor of Philosophy
• Researcher at Baze University

Background Apoptosis-signaling kinase 1 is a MAPKKK (mitogen-activated protein kinase) overexpressed in various types of human cancer including colorectal cancer. It mediates inflammation and apoptosis and promotes cell proliferation through the transcription of cyclin D1. 5-Fluorouracil remains one of the primary recommended drugs to manage colore...

Inflammatory markers has been implicated during NSAID-induced gastric ulcer as it enhances leukocyte adhesion which also contribute to lipid peroxidation and decrease in antioxidants. Cucumis melo seeds (L. Indorous) is well known to contain some active component with strong anti-inflammatory potentials. Therefore, this study aimed to investigate t...

One of the world's ravaging toxins that affect both human health and animals is the mycotoxins. Mycotoxins are generally referred to as the secondary metabolites of fungi. These metabolites are commonly found in cereals, other agricultural produce and in animal feeds. The exposure of the farm produce to these classes of toxins has resulted in major...

Flooding is a global natural disaster that occurs when water rises over normal levels and damages infrastructure, buildings, and land. Lately, a substantial rise has occurred in the frequency and severity of floods in Nigeria due to urbanization, population growth and climate change. This study aims to identify areas in the Osun River Basin (ORB) i...

Despite Caffeine being known essentially for its psychoactive properties, an attempt was made in this study to investigate its potential antimalarial activity considering that it's an alkaloid and that the malaria parasite is a purine auxotroph. In the baseline experiment, caffeine was administered at three doses (5, 10 and 20 mg/kg) once daily in...

Seeds endophytes play crucial roles in enhancing plants’ health and productivity by conferring protection, improving fitness and resilience, and enhancing nutrient uptake. These endophytes are also used for environmental management and production of bioactive compounds for various biomedical applications. In recent years, endophytes are of interest...

River flooding is a major natural disaster that has caused enormous damage to our environment, infrastructure and human life. River flooding has led to flooding in river basins which has disrupted human activities and fatalities. This study is a review of river basin flooding, the impact of machine learning techniques in flood prediction in river b...

The hexane fraction of Psorospermum aurantiacum Engl., Hypericaceae, was found to prevent photo aging in skin cells lines. Therefore, this research aimed to evaluate the anti-skin aging potentials of compounds isolated from the most bioactive fraction using in silico and in vitro models. Compounds were isolated by column chromatography, and their s...

We investigated changes in the quality of palm oil, shea butter and their blend as affected by repeated usage in deep frying of cheese were investigated. Palm oil, shea butter and their blend (1:1 w/w) were used in repeated deep frying of cheese at 150 o C for 15 minutes, repeated eight times, repeated for six (6) consecutive days Changes in oil qu...

In this review, we describe recent developments and strategies involved in the utilization of solid supports for the management of wastewater by means of biological treatments. The origin of wastewater determines whether it is considered natural or industrial waste, and the source(s) singly or collectively contribute to increase water pollution. Po...

The abnormality is the state of health that can be attached to various things. This abnormality could be caused by exposure to infectious diseases, reoccurring underlying health conditions, metabolic disorders, comorbidities, and genetic mutations. There are many factors attached to the general well-being of the human body, some of which include im...

The hexane fraction of Psorospermum aurantiacum (PA) was found to prevent photoaging in skin cells lines. Therefore, this research aimed to evaluate the anti-skin aging potentials of compounds isolated from this bioactive fraction using in- silico and in- vitro models. Compounds were isolated by column chromatography and their structures were deter...

Despite Caffeine being known essentially for its psychoactive properties, an attempt was made in this study to investigate its potential antimalarial activity considering that it’s an alkaloid and that the malaria parasite is a purine auxotroph. In the baseline experiment, caffeine was administered at three doses (5, 10 and 20 mg/kg) once daily in...

The uncontrolled use of chemicals, urban wastes, nuclear resources, mining, petrochemicals and disposal of sewage sludge only a few anthropogenic activities that have contributed to the rapid industrialization and severe heavy metal contamination of soils and waterways. Both inorganic and organic pollutants, such as heavy metals, pesticides, petrol...

Nanomaterials have been recognized as one of the leading biotechnological materials that have several applications in nanotechnology as they provide exceptional size-dependent features that make these materials possess several practical applications in numerous endeavors of human activity, including water purification. Moreover, it has been observe...

Chitosan nanoparticle is today fast becoming an important natural biopolymer that is obtained from the deacetylation process of chitin. Chitin is nature's most abundant biopolymer derived from the exoskeleton crustaceans, the cell wall of fungi scales of reptiles among others. The use of this natural biopolymer is now on the rise across various ind...

The rise in economic losses due to various forms of meat contaminations in the previous decades opened up meat processing industries to the use of chemicals and petroleum-based packaging materials, various end to end processing of meat and its by products. Today, due to health concerns associated with these methods, there is gradual increase in the...

The enhanced antibiotic resistance amid microorganisms has prompted many researchers to investigate the wastewater treatment plants, highlighted as the main source of heavy metal resistance genes (HMRGs) in the environment. Therefore, the applications of molecular techniques have been identified as a sustainable biotechnological tool that could pro...

The success of any drug depends on the biocompatibility, biodegradability of its carrier, and the bioavailability of the active ingredients at the target site of action. Appropriate formulations of the delivery methods using nanotube platforms now make these drugs more effective than the conventional form. Methods of deliveries of drugs in the syst...

Graphene-based nanomaterials (GBN) comprise two-dimensional (2D) nanomaterials isolated from graphite. These nanomaterials contain monoatomic layers of sp2 hybridized carbon atoms formed in honeycomb lattice. They are largely carbon atoms based, which are organized in the form of a honeycomb lattice. Derivatives of GBN, mainly include plain graphen...

The quest to develop more effective and cost-efficient environmental monitoring methods has efficiently improved with high sensitivity, rapidness, and selectivity, over the traditional low detecting and analytical methods such as capillary electrophoresis, potentiometric biosensor Quartz Crystal Microbalance (QCM), chromatographic techniques, Scann...

Food safety has become a global concern due to its impact on the health of the human population, and so efficient methods of monitoring food safety have led to several conventional and non-conventional methods. Biosensors, which are a non-conventional method of monitoring food analysis, are required for several food industry applications due to the...

In the food sector, ensuring the safety of packaged food products reaching the consumers or end-users have over the years been a major concern in the industry. Several outbreaks have been reported over the years caused by foodborne pathogens or the consumption of expired products. The use of nanobiomaterials for food packaging which can monitor the...

Food safety today is a major concern for both food processing industries and consumers in general. One of the challenges facing this industry is timely and cost-effective methods or technologies for easy identification of contaminated packaged foods. Over the years, constant efforts have been increasingly utilized to ensure better and improved pack...