Frank H Comhaire

Frank H Comhaire
Ghent University | UGhent · Endocrinology

prof. em. dr. med. dr. sci.

About

415
Publications
63,149
Reads
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9,393
Citations
Citations since 2016
25 Research Items
2098 Citations
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
Additional affiliations
June 2006 - present
International Academy of Osteopathy Ghent Belgium
Position
  • Professor (Full)
Description
  • complementary and alternative medicine (CAM) including nutriceutical treatments and manual therapy.

Publications

Publications (415)
Article
A large tumour mass was detected in a 65-year-old patient during a routine gynaecological examination. This patient had been treated for over 10 years with levothyroxine for Hashimoto's thyroiditis and was also given transdermal oestrogen replacement therapy. Before the operation, detailed imaging by CT scan and MRI was performed. A tumour weighing...
Article
Male reproductive impairment is responsible for at least 50% of cases of couple infertility. Nuclear factor‐kappa B (NF‐κB) has been functionally linked to germ cell apoptosis, which may affect human fertility. The aim of this study was to determine the association between the rs28362491 SNP of the NF‐κB1 gene and infertility in Egyptian men. In th...
Article
Full-text available
Background: It is hypothesized that oxidative and epigenetic alterations to DNA induced by ovarian stimulation for in vitro fertilization (IVF) may be associated with an increased risk of diseases and cancer in the offspring and could possibly be attenuated by preconception food supplementation. Methods: In a prospective randomised open-label tr...
Article
The expression of the main cannabinoid receptors (CBR1 and CBR2) was investigated to evaluate the possible association with the sperm maturation from fertile and infertile individuals. One hundred subjects were classified into fertile (n = 50) and infertile groups (n = 50). Fresh semen samples were collected. Computer‐assisted semen analysis and ac...
Article
Full-text available
“From care for the sick to care for health” implies that age-related diseases and discomforts, which impair the quality of life, should be prevented rather than treated. Healthy lifestyle and nutrition, and hormone supplementation – when needed – are of crucial importance. Food supplementation with nutraceuticals composed of vitamins, oligo-mineral...
Article
Full-text available
Background It is unknown whether lowered steady state levels of sex hormones coupled with changes in those hormones during the menstrual cycle are associated with premenstrual syndrome (PMS).Objective To examine associations between levels of progesterone and oestradiol during the menstrual cycle and PMS considering different diagnostic criteria fo...
Article
Full-text available
Though affecting many thousands of patients, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) should be considered an orphan disease, since the cause remains elusive and no treatment is available that can provide complete cure. There is reasonable insight into the pathogenesis of signs and symptoms, and treatments specifically directed t...
Article
Research question: The cost of IVF treatment remains high, among other factors because of the medication needed for ovarian stimulation. This study investigated the effect of using low-dose human chorionic gonadotrophin (HCG) for the second phase of follicular maturation after corifollitropin alfa induction, to replace the more expensive, either r...
Preprint
Full-text available
Background: It is unknown whether lowered steady state levels of sex hormones coupled with changes in those hormones during the menstrual cycle could be associated with the presence and severity of premenstrual syndrome (PMS). Objective: To examine associations between levels of progesterone and oestradiol during the menstrual cycle and PMS severit...
Preprint
Full-text available
Background: It is unknown whether lowered steady state levels of sex hormones coupled with changes in those hormones during the menstrual cycle could be associated with the presence and severity of premenstrual syndrome (PMS).Objective: To examine associations between levels of progesterone and oestradiol during the menstrual cycle and PMS severity...
Article
Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic disease the pathogenesis of which remains elusive. Pragmatic proof-of-principle of the hypothetical mechanisms causing the clinical symptoms has been delivered, but it is hard to explain why some patients do respond favourably to treatment with sodium dichloroacetate (DCA), wh...
Article
The present paper reports the results of a pragmatic prospective trial in a group of 38 random infertile couples in whom a battery of semen assays were performed before in vitro fertilisation (IVF). Sixteen couples (42.1%) attained ongoing pregnancy. Using logistic regression analysis only the result of the Oxisperm® (P = 0.047) and the HaloSperm G...
Article
Full-text available
Twenty-two consecutive patients suffering from refractory myalgic encephalitis/chronic fatigue syndrome (ME/CFS) were treated with an innovative nutriceutical containing sodium dichloroacetate in a proof-of-principle, pilot, open-label prospective cohort trial. Ten patients experienced significant improvement of their health condition with reductio...
Article
Fertility of both men and women has been negatively influenced by external factors and life style in recent decennia. Mechanisms of hormone disruption, oxidative damage, and epigenetic DNA changes play a pivotal role in this process. In Belgium, strict regulations have been imposed to reduce the exposure to xeno-estrogens, which has resulted in a p...
Article
Ten patients suffering from pathology considered to be refractory ME/CFS have been prospectively offered treatment with a novel nutriceutical that increases the activity of pyruvate dehydrogenase and enhances mitochondrial energy production by the aerobic metabolism of the Kreb’s cycle. Whereas half of the patients presented highly significant impr...
Article
A composite nutriceutical containing extracts of Momordica charantia, pine bark extract, hematococcus pluvialis, red yeast rice, the antioxidants alpha-lipoic acid and oxidoreductase ubiquinone Q10, vitamins B9 and B12, and selenomethionine was given to 23 patients suffering from hyperinsulinemia and/or hyperlipemia as part of an open-label prospec...
Article
Full-text available
It is the opinion of the authors that the disease called chronic fatigue syndrome (CFS), or fibromyalgia, or myalgic encephalomyelitis, is primarily due to a disorder of the immune system and should rather be called " systemic immune disorder ". This disorder probably results from external factors such as inadequate stress adaptation, or a (retro)-...
Article
STUDY QUESTION Does a 3-month adjuvant hormonal treatment of mild peritoneal endometriosis after laparoscopic surgery influence the outcome of IVF stimulation in terms of number of mature oocytes obtained per cycle? SUMMARY ANSWER Complementary medical treatment of mild peritoneal endometriosis does not influence the number of oocytes per treatmen...
Conference Paper
Behandeling van insulineresistentie, metabool syndroom, diabetes, lipidenstoornissen, atheromatose en NAFLD met behulp van innovatieve nutricijnen. Prof. em. Frank Comhaire MD. PhD. frank@comhaire.com De biologische afwijkingen die verantwoordelijk zijn voor de aandoeningen in de titel betreffen hyperinsulinemie als reactie tegen de insulineresiste...
Article
In recent decades, an increasing number of couples have consulted professionals about infertility. In at least half of these a male factor was involved. Aside from well-known causes, such as varicocele, accessory gland infection, and congenital abnormalities, environmental and lifestyle factors play an important role. Hormone-disrupting agents, xen...
Article
Purpose: To determine the variability in DNA methylation of the human telomerase reverse transcriptase (hTERT) promotor in cells of follicular fluid of patients receiving ovarian stimulation for treatment with in vitro fertilization (IVF), in connection with possible cancer related health risk in offspring. Materials and method: The pilot study ana...
Article
The long-term intake of a judiciously composed nutriceutical containing low-dose vitamins, antioxidants, minerals and particular herbal preparations seems justified for older persons who take medication, or who consume an unbalanced diet, or who are exposed to environmental toxins. Recent reports suggest these nutriceuticals may delay age-related d...
Research
Full-text available
treating patients suffering from hyperinsulineamia due to insulin resistence with the extract (4:1) of Momordica charantia (bitter melon) reduces insulin and c-peptide concentrations to 25% of the initial value, and reduced gamma-glutamyl transferase concentration suggesting a favourable effect on non-alcoholic fatty liver disease 5NAFLD).
Article
To assess whether hormone replacement therapy influences longevity, an analysis was made of published life tables allowing for the calculation of the relative benefit of hormone replacement therapy on longevity in men with late onset hypogonadism and in post-menopausal women. It was found that testosterone replacement therapy of men suffering from...
Article
In developed countries, women spend more than one-third of their life in the menopause and at least half of them experience vasomotor symptoms that impair their normal function and well-being. Long-term estrogen replacement therapy (HRT) with estrogen can suppress typical menopausal symptoms and prevents osteoporosis. When estrogen-only HRT is star...
Article
Long-term estrogen replacement therapy with estrogen has benefits for many postmenopausal women. However, some women prefer non-steroidal substitution with herbal preparations. The effectivity against vasomotor symptoms has been evidenced for the extracts of pine bark, of linseed and of Lepidium meyenii (Maca), whereas there is controversy about th...
Article
The estrogen concentration has been determined in breast tissue, focusing largely on samples obtained from breast cancers. In this study, estradiol concentration was determined in normal breast tissue obtained from women undergoing esthetic, and oncoplastic surgery. Normal breast tissue was obtained during 68 operations for esthetic or reconstructi...
Article
Full-text available
Aim: To investigate whether standard general osteopathic treatment can influence the static configuration of the vertebral column or pelvis. Material and Methods: One hundred thirteen persons, 72 females and 41 males, either symptomfree volunteers or patients with mild idiopathic back pain, were investigated using the DIERS formetric® system, befor...
Article
Many women develop vasomotor complaints and psychological problems in their menopause. Hormonal substitution is the most efficient treatment to alleviate these symptoms. Some women are reluctant to take hormones or are not allowed to use them for medical reasons. Therefore, they request natural alternatives. Controlled trials indicate that soy or i...
Article
Objective: To estimate the possible effectiveness of a novel nutraceutical for the prevention of attacks of migraine. Materials and methods: Six months open-label “proof-of-principle” prospective cohort trial in 15 consecutive patients with refractory migraine using a novel nutriceutical. Results: Five patients were considered non-responders. In th...
Article
Full-text available
Authors' contributions The sole author designed, analyzed and interpreted and prepared the manuscript. ABSTRACT Aims: Approximately one out of every 8 couples is confronted with a problem of infertility. The diagnostic and therapeutic management, taking into account the WHO recommendations, may be complemented by nutriceutical food supplementation....
Article
Many patients with myalgic encephalopathy (fibromyalgia/chronic fatigue syndrome) localise the beginning of their disease at a time period of emotional, or professional, or social stress, or an infectious or traumatic/surgical incident. It is suggested that these may have temporarily suppressed their immunological system, after which a "rebound" of...
Article
Belgian women spend more than one third of their lives in the menopause, more than half of them experiencing vasomotor symptoms, impairing their normal functioning and wellbeing. Long-term hormone replacement therapy (HRT) can suppress the typical menopausal symptoms; it also prevents osteoporosis.
Article
The metabolic syndrome leads to serious health damage through several pathogenic mechanisms, including insulin resistance, chronic inflammation and oxidative overload. Aside from adaptation of diet and life style, medication is prescribed to the majority of patients. Some patients need bariatric surgery. Complementary and alternative medicine (CAM)...
Article
Objectives: To assess the relation between the prevalence of canine hip dysplasia, inbreeding and genetic diversity by breed. Methods: Retrospective pedigree analysis of 9 breeds based on a ref-erence population of 41,728 individuals, and hip dysplasia assessment in 1745 dogs. Results: Hip dysplasia was less common among breeds with higher coeffici...
Article
Samenvatting Infertiliteit van het paar vergt een grondig onderzoek van beide partners. De behandeling moet rekening houden met de doeltreffendheid, de kosten-batenanalyse en de mogelijke ongunstige effecten op de nako-meling(en). Het "number needed to treat" (NNT) is een klinisch relevante maatstaf voor de doeltreffendheid van de behandeling en we...
Article
Congenital factors have been thoroughly explored in recent years revealing the role of genetic mutations and polymorphisms, and highlighting the contribution of epigenetics in the pathogenesis of certain forms of infertility. Acquired male infertility is commonly due to varicocele, male accessory gland infection, immunological infertility, and idio...
Article
In Belgium, women spend more than one third of their lives in the menopause. Many women reveal vasomotor symptoms. Hormonal substitution remains an efficient treatment to relieve these symptoms. Numerous misconceptions exist concerning hormonal substitution. This therapy is perceived as bad for the blood vessels and ultimately resulting in an incre...
Article
Objective: To assess the possible benefit of food supplementation with the nutriceutical Improve® for the treatment of the infertile couple. Methods: The treatment of diseases causing male or female infertility should be completed by the prescription of a judiciously formulated composite nutriceutical (Improve® Nutriphyt Inc, Oostkamp, Belgium) whi...
Article
To compare the clinical efficiency of different modes of treatment of infertile couples and to estimate the possible benefit of nutraceutical food supplementation (NFS), the numbers needed to treat (NNT) was calculated in 4143 infertile couples based on controlled trials in recent literature and personal data. The NNT expresses the number of indivi...
Article
An eleven-year-old spayed American Akita bitch rapidly developed a mammary tumour which was surgically removed. The histological examination revealed the tumour to be a sarcoma that presented positive immunohistochemical staining against vimentin and protein S 100. There was no staining against pan-actin. Based on the histological aspect and the pa...
Article
Varicocele, male accessory gland infection, immunological infertility, and idiopathic oligozoospermia are the main causes of male infertility. Disturbances of ovulation, pelvic inflammatory disease, and endometriosis are common causes of female reproductive failure. The mechanisms by which these causes interfere with male and female reproduction ar...
Article
Full-text available
To assess the reproducibility of the Fédération Cynologique Internationale (FCI) classification over time, and between assessors and to evaluate the benefit of computer-assisted measurement of the Norberg angle and of its percentile ranking by breed for the diagnosis of canine hip dysplasia, and for the selection of couples for breeding. During the...
Article
In male infertility, complementary treatment with antioxidant-containing food supplements quadruples the spontaneous pregnancy rate and reduces the cost per pregnancy by 60%.
Article
Couple infertility commonly results from the synergistic negative influence of several factors. External factors, related to life-style and environmental exposure, reinforce the effects of congenital or acquired damage through direct toxicity, hormone disruption and overload of reactive oxygen species. Combating obesity, correcting inappropriate di...
Chapter
Un vecchio adagio medico dice che i migliori strumenti diagnostici sono un’accurata anamnesi e un esame obiettivo minuzioso, e che l’uso più appropriato dell’imaging e degli esami di laboratorio selettivi serve a conferma della diagnosi clinica. Un altro metodo consiste nel prescrivere un gran numero di test ematici di screening, di MRI total-body,...
Chapter
Il testicolo ha due funzioni essenziali: la produzione dei gameti maschili, gli spermatozoi, in un processo chiamato la spermatogenesi e la sintesi e la liberazione controllata di testosterone come principale androgeno, denominata la steroidogenesi. I testicoli sono organi pari di forma ovale sospesi fuori dalla cavità pelvica addominale, nella qua...
Chapter
Nella pratica quotidiana, il medico si confronta con pazienti che lo consultano per diversi problemi legati al vasto campo dell’andrologia.
Chapter
L’andrologia è una nuova branca medica multidisciplinare, il cui nome deriva dalla parola greca «andros», che tratta i problemi dei soggetti di sesso maschile, con un’attenzione particolare alla fisiologia e alla fisiopatologia delle funzioni riproduttive maschili. Di conseguenza, l’interesse clinico principale è rappresentato dalla diagnosi e dal...
Chapter
Nessuna funzione fisiologica rimane inalterata dal processo di invecchiamento, che determina ineluttabilmente una diminuzione della capacità funzionale e dell’efficacia dei meccanismi regolatori omeostatici. Tutti i sistemi ormonali vengono colpiti in gradi diversi dal fenomeno dell’invecchiamento e l’asse gonadico dell’uomo non fa eccezione, anche...
Chapter
Un’assistenza sanitaria efficace è un diritto universale degli esseri umani. Purtroppo, questo diritto può essere rivendicato solo da una parte della popolazione mondiale e molti sono coloro che, in vaste regioni, ne sono privati. D’altra parte, il costo economico dell’applicazione di questo diritto, sia nelle regioni povere che in quelle più ricch...
Chapter
Nella medicina moderna razionale e scientifica, la pressione della società sui medici è in costante aumento. La salute è considerata un diritto piuttosto che un privilegio, e l’aspettativa della popolazione è che le malattie siano guarite rapidamente ed efficacemente. Ciò si applica a tutte le malattie, compresa l’infertilità.
Chapter
Il differenziamento sessuale e la fertilità maschili sono il risultato di una sequenza di segnali che comprende fattori cellulari, genetici ed endocrini. Le manifestazioni cliniche delle anomalie dello sviluppo sessuale maschile sono l’ipogonadismo, l’inversione sessuale e lo stato intersessuale. Esse possono essere dovute ad anomalie nella determi...
Chapter
In questa sezione sono descritte alcune tecniche chirurgiche spesso utilizzate sugli organi genitali maschili. Questi interventi sono spesso delegati a dei medici inesperti, cosa che può provocare delle invalidità a vita; così, la circoncisione dell’adulto deve essere eseguita con attenzione, al fine di non rimuovere troppa cute della guaina penien...
Chapter
In passato sono state tenute conferenze e workshop per stilare delle linee guida sui diversi aspetti dell’andrologia. Questi hanno affrontato, tra l’altro, le seguenti tematiche: l’utilità delle tecniche diagnostiche avanzate di analisi del liquido seminale (ESHRE 1996; Comhaire 1997; Fraser et al. 1997), la gestione dei tumori a cellule germinali...
Book
L’andrologia è una disciplina ancora giovane, ma in grande espansione, che spazia su alcuni aspetti fondamentali della vita dell’uomo: dalla sessualità alla riproduzione, dalle patologie tumorali del sistema urogenitale alle patologie andrologiche dell’invecchiamento. Questo volume, tradotto dall’edizione originale inglese, consiste di due parti....
Article
A case-control study of clinical, endocrine and seminal characteristics in 86 infertile men and a prospective study of conception rates during 804 follow-up cycles among 75 infertile couples with male immune infertility were performed. Genito-urethral infections or surgery, and palpable epididymal abnormalities were more common among the immunologi...
Article
Summary The clinical efficacy of conventional and advanced methods of treatment was assessed in 814 couples with infertility due to a male factor. The monthly and effective cumulative rate of ongoing or term pregnancies was calculated during 4712 couple-months. Treatment of varicocele by transcatheter embolization, resulting in 3.9% pregnancies per...
Article
The hypo-osmotic swelling test was claimed to assess an independent functional characteristic of human spermatozoa bearing relevance to their fertilizing capacity. To test this claim, we have studied the relationship between the result of the hypo-osmotic swelling test with that of conventional semen analysis and sperm motility patterns, the semen...
Article
During 774 spontaneous cycles and 87 cycles of assisted reproduction, the conception rates were evaluated in 48 infertile couples in whom unilateral cryptorchidism was the causal factor. In spite of adjuvant therapy of the male partner, the spontaneous conception rate was very low (1% per cycle). Intra-uterine insemination (IUI) and conventional in...
Article
The male partner of an infertile couple was found to have anti-spermatozoal antibodies (ASA) of the IgG and IgA class in his semen as well as agglutinating and cytotoxic antibodies in serum. His wife conceived twice after IVF-ET with ongoing pregnancies.Zusammenfassung: Kasuistische Mitteilung über eine Beobachtung von immunologisch bedingter Infer...
Article
Static measurements of immuno-reactive inhibin have proven of little relevance in the diagnosis of testicular disorders. Dynamic evaluation of the inhibin secretory reserve might detect a specific Sertoli cell defect in a subgroup of infertile men. We compared the response of inhibin and steroids to an intravenous injection of pure FSH (Metrodin, S...
Article
The sperm function of fertile men (control), infertility patients (experimental), and men with varicocele were compared. The bioassays used were the follicular fluid-induced acrosome reaction, the binding to the zona pellucida, and the penetration of zona-free hamster oocytes. The percentage (mean +/- SEM) of reacted spermatozoa was 35 +/- 3 in the...
Article
To evaluate the precision, reproducibility, and clinical usefulness of measuring the Norberg angle (NA) by means of a computerized system of image analysis. 1,182 consecutive radiographs of hip joints of various breeds of dogs assessed for hip dysplasia and 72 radiographs of hip joints of German Shepherd Dogs. Radiographs were assessed by a panel o...
Article
Sperm lipids are important for sperm viability, maturity and function. This study aimed to identify cholesterol and desmosterol composition of human spermatozoa of two sperm populations separated on Sil-Select gradient. Forty-eight males were divided into four groups namely healthy men (n = 13), asthenozoospermia (n = 11), asthenoteratozoospermia (...
Article
A 25 year old man, the partner of a barren marriage of 3 years duration, presented with bilateral inguinal testes, azoospermia and elevated serum gonadotrophin levels. After surgical correction the testes remained in the scrotum and within 16 months the semen contained 22 million spermatozoa per ml. Although the motility and morphology of the sperm...
Article
To compare the results of 2 canine registries for classification of the hip joints for dysplasia by breed, and to relate the percentage of dysplastic dogs with body metric characteristics. Data on the ranking order of hip dysplasia by breed from 2 registries for 156 dog breeds. The prevalence of hip dysplasia listed by the Orthopedic Foundation for...
Chapter
Par le passé, plusieurs ateliers et réunions ont été tenus afin de parvenir à un consensus concernant les différents aspects de l’andrologie. Ceux-ci ont abordée, parmi d’autres sujets, les questions suivantes: l’utilité des techniques diagnostiques avancées d’analyse du sperme (ESHRE 1996; Comhaire 1997; Fraser et al. 1997), la prise en charge des...
Article
INTRODUCTION, Andrologists are medical doctors who practice the clinical management of typically male problems, including congenital malformations of the male genital tract, abnormal pubertal development, male infertility, sexual dysfunction, and male aging. In Europe, an andrologist may be a specialist in endocrinology or urology who has acquired...