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Françoise Wilhelmi de Toledo

Françoise Wilhelmi de Toledo
Klinik Buchinger Wilhelmi GmbH, Überlingen, Germany

Dr.

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64
Publications
22,929
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667
Citations
Citations since 2016
40 Research Items
490 Citations
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2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140

Publications

Publications (64)
Article
Full-text available
Clinical experience suggests that fasting followed by vegetarian diet may help patients with rheumatoid arthritis (RA). We reviewed the available scientific evidence, because patients frequently ask for dietary advice, and exclusive pharmacological treatment of RA is often not satisfying. Fasting studies in RA were searched in MEDLINE and by checki...
Article
Full-text available
Fasting for medical purpose (fasting therapy) has a long tradition in Europe and is established as a defined therapeutic approach in specialized fasting hospitals or within clinical departments for integrative medicine. In 2002, the first guidelines for fasting therapy were published following an expert consensus conference; here we present a revis...
Article
Full-text available
Only few studies document longer periods of fasting in large cohorts including non-obese participants. The aim of this study was to document prospectively the safety and any changes in basic health and well-being indicators during Buchinger periodic fasting within a specialised clinic. In a one-year observational study 1422 subjects participated in...
Article
Full-text available
This prospective observational trial investigated effects and safety of periodic fasting in subjects with and without type 2 diabetes mellitus (T2DM). The primary end point was set as the change of fatty liver index (FLI) as a surrogate parameter of non-alcoholic fatty liver disease (NAFLD). Six-hundred and ninety-seven subjects (38 with T2DM) were...
Article
Full-text available
Fasting provokes fundamental changes in the activation of metabolic and signaling pathways leading to longer and healthier lifespans in animal models. Although the involvement of different metabolites in fueling human fasting metabolism is well known, the contribution of tissues and organs to their supply remains partly unclear. Also, changes in or...
Article
Full-text available
Objectives The health-promoting effects of fasting are increasingly documented. Long-term fasting according to the Buchinger Wilhelmi program (200 kcal/day, approximately 30 grams of carbohydrates) elicits various health-improving effects. The metabolic switch from glucose to fat oxidation is associated with an elevation in urine ketone concentrati...
Article
Full-text available
Background: Fasting is attracting an increasing interest as a potential strategy for managing diseases, including metabolic disorders and complementary cancer therapy. Despite concerns of clinicians regarding protein catabolism and muscle loss, evidence-based clinical data in response to long-term fasting in healthy humans are scarce. The objectiv...
Article
Full-text available
Purpose Dyslipidemia is a major health concern associated with an increased risk of cardiovascular mortality. Long-term fasting (LF) has been shown to improve plasma lipid profile. We performed an in-depth investigation of lipoprotein composition. Methods This observational study included 40 volunteers (50% men, aged 32–65 years), who underwent a...
Article
Full-text available
Background: Dietary exposure to environmental pollutants in humans is an important public health concern. While long-term fasting interrupts the dietary exposure to these substances, fat mobilization as an energy source may also release bioaccumulated substances. This was, to our knowledge, only investigated in obese people decades ago. This study...
Article
Full-text available
In mice, the plasma concentrations of the appetite-stimulatory and autophagy-inhibitory factor acyl-coenzyme A binding protein (ACBP, also called diazepam-binding inhibitor, DBI) acutely increase in response to starvation, but also do so upon chronic overnutrition leading to obesity. Here, we show that knockout of Acbp/Dbi in adipose tissue is suff...
Article
It is well-established that long-term fasting improves metabolic health, enhances the total antioxidant capacity and increases well-being. MicroRNAs oversee energy homeostasis and metabolic processes and are widely used as circulating biomarkers to identify the metabolic state. This study investigated whether the levels of twenty-four metabolism-as...
Article
Full-text available
BACKGROUND: We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. METHODS AND RESULTS: Subjects underwent a multidisciplinary fasting program with a daily intake...
Article
Obesity and its related metabolic disorders, as well as infectious diseases like covid-19, are important health risks nowadays. We recently documented that long-term fasting improves metabolic health and enhanced the total antioxidant capacity. The present study investigated the influence of a 10-day fasting on markers of the redox status in 109 su...
Article
Full-text available
In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the effects of the main forms of fas...
Article
Full-text available
Fasting is increasingly practiced to improve health and general well-being, as well as for its cytoprotective effects. Changes in blood redox status, linked to the development of a variety of metabolic diseases, have been recently documented during calorie restriction and intermittent fasting, but not with long-term fasting (LF). We investigated so...
Article
Full-text available
Fasting is increasingly popular to manage metabolic and inflammatory diseases. Despite the role that the human gut microbiota plays in health and diseases, little is known about its composition and functional capacity during prolonged fasting when the external nutrient supply is reduced or suppressed. We analysed the effects of a 10-d periodic fast...
Article
Full-text available
Objectives: The aim of this study was to investigate the feasibility of measuring the effects of a 14-day Periodic Fasting (PF) intervention (<200 cal) on multi-organs of primary interest (liver, visceral/subcutaneous/bone marrow fat, muscle) using non-invasive advanced magnetic resonance spectroscopic (MRS) and imaging (MRI) methods. Methods: One...
Data
Raw data of Fig 3. Changes in systolic and diastolic blood pressure according to the fasting length. (XLSX)
Data
Effect of fasting on clinical parameters, well-being and ketosis. (PDF)
Data
Effect of fasting on lipid parameters and glycaemia. (PDF)
Data
Raw data of Fig 4. Changes in emotional and physical well-being during fasting. (XLSX)
Data
Raw data of Fig 2. Changes in weight and abdominal circumference according to the length of fast and gender. (XLSX)
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Raw data of Table 1. Baseline characteristics of the subjects. (XLSX)
Data
Raw data of Fig 5. Fasting-induced changes in lipid metabolism. (XLSX)
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Raw data of Fig 6. Changes of blood glucose and glycated haemoglobin. (XLSX)
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Raw data of Table 2. Mild symptoms and adverse effects. (XLSX)
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Raw data of Table 3. Blood cells pre- and post-fasting. (XLSX)
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Raw data of S1 Fig. Occurrence of self-reported mild symptoms during fasting. (XLSX)
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Raw data of S4 Table. Effect of fasting on lipid parameters and glycaemia. (XLSX)
Data
Occurrence of self-reported mild symptoms during fasting. (PDF)
Data
Raw data of Table 4. Blood parameters pre- and post-fasting. (XLSX)
Data
Raw data of S1 Table. Effect of fasting on clinical parameters, well-being and ketosis. (XLSX)
Data
Raw data of S2 Fig. Evolution of a pre-existing health complaint. (XLSX)
Data
Evolution of a pre-existing health complaint. A subgroup of 404 subjects indicated to have a major health complaint previous to the fasting. (PDF)
Chapter
An eine Unterbrechung der Nahrungszufuhr passt sich der Organismus durch eine Reihe von physiologischen Umstellungen sowie Stoffwechsel- und Verhaltensänderungen an. Diese Anpassungsmechanismen sorgen für die Aufrechterhaltung der Vitalfunktionen durch Mobilisation gespeicherter Reserven an Makro- und Mikronährstoffen. So ist zum einen die Energiep...
Article
Full-text available
ZusammenfassungHintergrund: Therapeutisches Fasten hat verschiedene metabolische und endokrine Effekte. Auch eine Wirkung auf die Blutgerinnung ist bekannt. Die Datensammlung untersucht die Wirkung des Fastens nach der Buchinger-Methode im Vergleich zu einer ovo-lacto-vegetarischen Diät von ca. 1800 kcal/Tag auf die INR (International Normalized Ra...
Chapter
Überleben aus gespeicherter Nahrung ist ein physiologisches Grundprinzip, das überall in der Natur anzutreffen ist. Der Mensch setzt diese Fähigkeit zum Fasten aus verschiedenen Gründen freiwillig ein; es entwickelten sich Fastenkulturen. So wird Fasten seit alters her auch therapeutisch genutzt. Inwiefern sich das Fasten vom bloßen Hungern untersc...
Chapter
Fermentation zählt zu den ältesten Konservierungsverfahren. Dabei werden Lebensmittel einer milchsauren Vergärung ausgesetzt, die die Nährstoffzusammensetzung verändert. Neben Geschmack und Geruch ändern sich somit auch die ernährungsphysiologisch bedeutsamen Parameter. In Mitteleuropa sind vor allem fermentierte Milchprodukte (Jogurt) von Bedeutun...
Article
In a retrospective clinical investigation with 112 inpatients on a 250 kcal/day diet (high in carbohydrate, low in protein) corresponding to 899 fasting periods of 15 or more days (42 men with 373 and 70 women with 526 fasting periods) the association between the rate of weight loss and age, gender, body mass index, and fasting experience was studi...
Article
In a retrospective clinical investigation with 24 inpatients on a 250 kcal/day diet (high in carbohydrate and low in protein) corresponding to 49 fasting periods of 25 or more days it was shown that the course of weight loss during the treatment can be described with high precision (<1.1%) by an exponential model of the form W(t) = W s(0)e -bt star...

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