François M Lemoine

Sorbonne Université | UPMC

This study focuses on utilizing the increasing availability of satellite trajectory data from global navigation satellite system‐enabled low‐Earth orbiting satellites and their precision orbit determination (POD) solutions to expand and refine thermospheric model validation capabilities. The research introduces an updated interface for the GEODYN‐I...

Chronic exposure to environmental pollutants is often associated with systemic inflammation. As such, cigarette smoking contributes to inflammation and lung diseases by inducing senescence of pulmonary cells such as pneumocytes, fibroblasts, and endothelial cells. Yet, how smoking worsens evolution of chronic inflammatory disorders associated with...

We present our latest high‐resolution lunar gravity field model of degree and order 1200 in spherical harmonics using Gravity Recovery and Interior Laboratory (GRAIL) data. In addition to a model with the standard spectral Kaula regularization constraint, we determine models by applying a constraint based on topography called rank‐minus‐one (RM1)....

Currently, there is a lack of systems for studying the role of hepatitis B viral proteins, such as HBeAg and HBcAg, on liver injury. It is necessary to develop an original tool in order to clarify the role of these viral proteins in hepatic stellate cell activation, and to understand the molecular mechanisms of liver injury. HepaRG are the most rel...

NASA maintains and operates a global network of Very Long Baseline Interferometry (VLBI), Satellite Laser Ranging (SLR), and Global Navigation Satellite System (GNSS) ground stations as part of the NASA Space Geodesy Program. The NASA Space Geodesy Network (NSGN) provides the geodetic products that support Earth observations and the related science...

Clinical trials with direct administration of synthetic mRNAs encoding tumor antigens demonstrated safety and induction of tumor-specific immune responses. Their proper delivery to dendritic cells (DCs) requires their protection against RNase degradation and more specificity for dose reduction. Lipid-Polymer-RNA lipopolyplexes (LPR) are attractive...

Data from the Gravity Recovery and Interior Laboratory (GRAIL) mission have revealed that ∼98% of the power of the gravity signal of the Moon at high spherical harmonic degrees correlates with the topography. The remaining 2% of the signal, which cannot be explained by topography, contains information about density variations within the crust. Thes...

Key Points BRAF V600E mutations are detectable in hematopoietic stem and progenitors in adults with histiocytosis. Transplantation of CD34+ cells from histiocytosis patients can give rise to genetically and phenotypically accurate xenografts.

Uveitis is a sight-threatening primary intraocular inflammation of various origins in mainly young and active patients. Due to the absence of biomarkers in most of the cases, the current treatment of noninfectious entities remains nonspecific, using corticosteroids, conventional immunosuppressors, and more recently biological agents. Identification...

Aims: Restoration of sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA2a) activity through gene transfer improved cardiac function in experimental and pilot studies in humans with heart failure. The AGENT-HF (NCT01966887) trial investigated the impact of adeno-associated virus (AAV1)/SERCA2a on ventricular remodelling using multimodality non-invasi...

The CCL2 chemokine receptor CCR2 drives cancer by mediating recruitment of monocytes and myeloid-derived suppressor cells to the tumor microenvironment. In this study, we extend the significance of CCR2 in this setting by identifying a new role for it in mediating recruitment of CD4+ T regulatory cells (Treg). Following tumor initiation, an expande...

Gene-directed enzyme pro-drug therapy (GDEPT) consists of expressing, in tumor cells, a suicide gene which converts a pro-drug into cytotoxic metabolites, in situ. In a previous work, we demonstrated that the combination of the suicide gene CYP2B6TM-RED (a fusion of a triple mutant of CYP2B6 with NADPH cytochrome P450 reductase) and cyclophosphamid...

In the context of the 2014 realization of the International Terrestrial Reference Frame (ITRF2014), the International DORIS Service (IDS) has delivered to the IERS a set of 1140 weekly SINEX files including station coordinates and Earth orientation parameters, covering the time period from 1993.0 to 2015.0. From this set of weekly SINEX files, the...

Despite current therapy, head and neck squamous cell carcinomas (HNSCCs) arising from various mucosal sites of the upper aero-digestive tract frequently relapse in a loco-regional manner and have a poor prognosis. Our objective was to validate an innovative mucosal route of vaccination using plasmo virus-like particles (pVLPs) in a pre-clinical ort...

Significance The control of a microbial infection by effector T cells is intrinsically linked to their migration. However, little is known about the mechanisms that control effector T-cell egress after infection. Sphingosine-1-phosphate receptor-1 (S1PR1) is a G-coupled protein receptor that plays an important role in naive T-cell egress from lymph...

The NASA GSFC DORIS analysis center has processed data from January 1993 to December 2014 and provided 1141 weekly solutions in the form of normal equations for incorporation into the DORIS solution for ITRF2014. The solution time series, designated as gscwd26, were based on tracking data to eleven DORIS satellites divided generally into seven-day...

Natural regulatory T-cells (Tregs) may have a great therapeutic potential to induce tolerance in allogeneic cell and organ transplantations. In mice, we showed that alloantigen specific Tregs (spe-Tregs) were more efficient than polyclonal Tregs (poly-Tregs) in controlling graft versus host disease (GVHD). Here, we describe a clinical grade complia...

Targeting viral entry is the most likely gene therapy strategy to succeed in protecting the immune system from pathogenic HIV-1 infection. Here, we evaluated the efficacy of a gene transfer lentiviral vector expressing a combination of viral entry inhibitors, the C46 peptide (an inhibitor of viral fusion) and the P2-CCL5 intrakine (a modulator of C...

Introduction La maladie d’Erdheim-Chester (MEC) est une histiocytose non langerhansienne caracterisee par une infiltration tissulaire par des histiocytes spumeux CD68+ CD1a−. La mise en evidence d’une mutation somatique BRAF V600E dans ces histiocytes ainsi que l’association frequente de la MEC a une histiocytose langerhansienne (forme mixte) est a...

Introduction La fumée de cigarette, source de stress oxydant, majore la sévérité de diverses maladies inflammatoires chroniques par des mécanismes peu connus. Le rôle pathogène des lymphocytes T CD4⁺ (LTCD4⁺) producteurs d’IL17 (Th17) dans est établi dans ces maladies, dont la bronchopneumopathie chronique obstructive (BPCO), maladie respiratoire i...

We present updated global and local gravity field models of the Moon using GRAIL data only.

During its low-altitude gravity campaign, MESSENGER was tracked to altitudes down to 25 km. We present an updated, higher-resolution gravity field of Mercury.

A detailed characterization of human oral immune cells is needed to better understand local mechanisms associated with allergen capture following oral exposure. Oral immune cells were characterized by immunohistology and immunofluorescence in biopsies obtained from 3 healthy individuals and 23 birch pollen-allergic patients with/without Oral Allerg...

The accuracy of state-of-the-art global barotropic tide models is assessed using bottom pressure data, coastal tide gauges, satellite altimetry, various geodetic data on Antarctic ice shelves, and independent tracked satellite orbit perturbations. Tide models under review include empirical, purely hydrodynamic (“forward”), and assimilative dynamica...

Leukemia is one of the leading journals in hematology and oncology. It is published monthly and covers all aspects of the research and treatment of leukemia and allied diseases. Studies of normal hemopoiesis are covered because of their comparative relevance.

Head and neck cancers are a major public health problem because of their high frequency. They represent the third most frequent cancers in France among the male population. Although our knowledge about their development has improved, the prognosis of these cancers still remains poor. Indeed, the survival rate of the patients does not exceed 20% at...

Gene-directed enzyme prodrug therapy (GDEPT) consists in targeted delivery to tumor cells of a suicide gene responsible for in situ conversion of a prodrug into cytotoxic metabolites. One of the major limitations of this strategy in clinical application was the poor prodrug activation capacity of suicide gene. We built a highly efficient suicide ge...

A GRAIL S21 value implies a misalignment of principal axes derived by Lunar Laser Ranging. A fluid outer core shaped by internal gravity can affect axes.

A high-resolution view of the Orientale Basin and surroundings from the Gravity Recovery and Interior Laboratory (GRAIL).

The static gravity field and the thermosphere of Mars from radio science data of the Mars Reconnaissance Orbiter (MRO) mission.

We present high-resolution gravity field models of the Moon using GRAIL primary and extended mission data.

Subsurface thermal density anomalies related to the 3:2 resonance-driven surface temperature distribution may explain Mercury's second-degree shape and geoid.

Ideally, the origin of the Terrestrial Reference Frame (TRF) is defined as the center of mass of the whole Earth system, the time evolution of its orientation is such that no global net rotation of the whole Earth’s surface is possible and the TRF scale is specified through the adoption of some physical constants and time-scale. These parameters ne...

The type of T cell polarization and simultaneous production of multiple cytokines have been correlated with vaccine efficacy. ELISpot is a T cell detection technique optimized for the measurement of a secreted cytokine at the single cell level. The FluoroSpot assay differs from ELISpot by the use of multiple fluorescent-labeled anticytokine detecti...

Papillomavirus (HPV)-16 infection has been recently associated with oropharyngeal head and neck cancers (HNCs) that express the viral E6 and E7 oncoproteins. The licensed vaccines are efficient for the prevention of HPV infection, but not for established tumors. Therefore innovative therapeutic vaccines targeting HPV oncogenes are required. Recentl...

In recent years non-tidal Time Varying Gravity (TVG) has emerged as the most important contributor in the error budget of Precision Orbit Determination (POD) solutions for altimeter satellites’ orbits. The Gravity Recovery And Climate Experiment (GRACE) mission has provided POD analysts with static and time-varying gravity models that are very accu...

Purpose Papillomavirus (HPV)-16 infection has been recently associated with oropharyngeal head and neck cancers (HNCs) that express the E6 and E7 oncoproteins. The licensed vaccines are efficient for the prevention of HPV infection, but not for established tumors. Therefore innovative therapeutic vaccines targeting HPV oncogenes are required. Prev...

We compute a series of Jason-2 GPS and SLR/DORIS-based orbits using ITRF2005 and the std0905 standards (Lemoine et al., 2010). Our GPS and SLR/DORIS orbit data sets span a period of 2 years from cycle 3 (July 2008) to cycle 74 (July 2010). We extract the Jason-2 orbit frame translational parameters per cycle by the means of a Helmert transformation...

Human papillomavirus (HPV) is involved in the development of anogenital tumors, but also in the development of oropharyngeal head and neck carcinomas where HPV-16, expressing the E6 and E7 oncoproteins, is the most frequent serotype. While vaccines containing L1 and L2 capsid HPV proteins are efficient for the prevention of HPV infection, they are...

The GRAIL extended mission has provided gravity models that are being used to map the upper crust of the Moon in unprecedented detail.

Analyses of GRAIL data indicate a relatively thin lunar crust, leading to the conclusion that the Moon is not enriched in refractory elements compared to Earth.

GRAIL gravity data show that the crust of the Moon has been highly fractured by billions of years of impact cratering.

The inventory of lunar basins revealed by GRAIL does not indicate a more extensive history of lunar impacts as has been previously suggested.

We present high-resolution lunar gravity field models derived from GRAIL primary and extended mission data.

We present an updated gravity field of Mercury based on nearly two years of MESSENGER tracking data.

The lunar gravity field solutions obtained with the GRAIL data alone provide significant improvements to the orbit reconstruction quality of the LRO spacecraft.

GRAIL analyses provide lunar gravity field, Love number, and moment of inertia with improved uncertainties.

New and improved models of the lunar gravity field to 420×420 in spherical harmonics have been derived from the analysis of the Gravity Recovery And Interior Laboratory (GRAIL) intersatellite Ka-band tracking data. We discuss the measurement and force modeling applied to the analysis of the GRAIL data from the primary mission (March 1 to May 29, 20...

Head and neck cancers positive for human papilloma virus (HPV) have a more favorable clinical outcome than HPV-negative cancers, but it is unknown why this is the case. We hypothesized that prognosis was affected by intrinsic features of HPV-infected tumor cells or differences in host immune response. In this study, we focused on a comparison of re...

Waldenström's macroglobulinemia (WM) is a clonal B-cell lymphoproliferative disorder (LPD) of post-germinal center nature. Despite the fact that the precise molecular pathway(s) leading to WM remain(s) to be elucidated, a hallmark of the disease is the absence of the immunoglobulin heavy chain class switch recombination. Using two-dimensional gel e...

Substantial advances in our geophysical understanding of the lunar crust are now possible due to recent and ongoing acquisition of high resolution topography and gravity data sets from the LOLA and GRAIL missions.

Requirements for the ITRF have increased dramatically since the 1980s. The most stringent requirement comes from critical sea level monitoring programs: a global accuracy of 1.0 mm, and 0.1mm/yr stability, a factor of 10 to 20 beyond current capability. Other requirements for the ITRF coming from ice mass change, ground motion, and mass transport s...

For the preparation of ITRF2008, the IDS processed data from 1993 to 2008, including data from TOPEX/Poseidon, the SPOT satellites and Envisat in the weekly solutions. Since the development of ITRF2008, the IDS has been engaged in a number of efforts to try and improve the reference frame solutions. These efforts include (i) assessing the contribut...

We present the results on precision orbit determination from the radio science investigation of the Lunar Reconnaissance Orbiter (LRO) spacecraft. We describe the data, modeling and methods used to achieve position knowledge several times better than the required 50–100m (in total position), over the period from 13 July 2009 to 31 January 2011. In...

We discuss the implications of Mercury’s gravity field as revealed by MESSENGER and Earth-based measurements of its spin-state for the planet’s internal structure. Results indicate that Mercury has a large core with a potentially unique structure.

The Gravity Recovery And Interior Laboratory (GRAIL) mission is on track to initiate its science phase on March 8, 2012. GRAIL will determine the structure of the lunar interior, and advance understanding of lunar thermal evolution.

A gravity field of Mercury is developed from MESSENGER orbital observations. In addition to the radiometric tracking data, altimetric crossovers base on the MLA data are used.

γ-Sarcoglycanopathy or limb girdle muscular dystrophy type 2C is an untreatable disease caused by autosomal recessively inherited mutations of the γ-sarcoglycan gene. Nine non-ambulatory patients (two males, seven females, mean age 27 years; range 16-38 years) with del525T homozygous mutation of the γ-sarcoglycan gene and no γ-sarcoglycan immunosta...

By revisiting CD90, a GPI-anchored glycoprotein, we show that CD90 is expressed by a subset of CD4(+) and CD8(+) human T cells. CD4(+)CD90(+) cells share similarities with Th17 cells because they express the Th17-specific transcription factor RORC2 and produce IL-17A. CD4(+)CD90(+) cells are activated memory T cells that express the gut mucosal mar...