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François Constant Boyer

François Constant Boyer
Université de Reims Champagne-Ardenne France · Physical and Rehabilitation Medicine

PhD, MD, Professor (full)

About

240
Publications
43,491
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Introduction
new genetic therapy and impact on rehabilitation patient reported outcomes and IRT post covid10 rehabilitation vestibular rehabilitation pulmonary rehabilitation endurance and strength training
Additional affiliations
November 1997 - present
Centre Hospitalier Universitaire de Reims
Position
  • Professor (Full)
November 1996 - February 1997
September 2006 - present
Université de Reims Champagne-Ardenne
Position
  • Professor (Full)
Education
September 2006 - September 2014
Reims Champagne Ardenne University (URCA) and Reims University Hospital
Field of study

Publications

Publications (240)
Article
Full-text available
Background In 2017, a new treatment by nusinersen, an antisense oligonucleotide delivered by repeated intrathecal injections, became available for patients with spinal muscular atrophy (SMA), whereas clinical trials had mainly involved children. Since 2020, the oral, selective SMN2-splicing modifier risdiplam has been available with restrictions ev...
Article
Full-text available
Human skin wounds pose a gathering threat to the public health, carrying an immense epidemiologic and financial burden. Pharmacological and non-pharmacological (NP) treatments have been proposed to the management of wound healing. Physical exercise is a strong NP intervention considered for patients in wound healing. Particularly, a type of exercis...
Article
Full-text available
Objective: Chronic Ankle Instability (CAI) or Functional Ankle Instability (FAI) is a condition characterized by laxity and mechanical instability in the ankle joint. This instability interferes with the activities and physical-functional parameters of athletes, which leads to repetitive ankle sprains. The current systematic review was carried out...
Article
In Myotonic Dystrophy type 1 (DM1), combining respiratory symptom screening and respiratory function testing, is crucial to identify the appropriate time for ventilatory support initiation. Dyspnea has been little investigated in DM1. To provide a multidimensional description of dyspnea, questionnaires assessing dyspnea were administered to 34 cons...
Article
Full-text available
Objective: To explore the impact of improved intensive care for COVID-19 patients on the prevalence of post-intensive care syndrome (PICS). Design: Ambispective cohort study. Patients: Post-intensive care unit COVID-19 patients from the first and second waves of COVID-19. Methods: Patients were evaluated at 6 months after infection. PICS was...
Article
Full-text available
Background: Data describing patients hospitalized in medical rehabilitation wards after the acute phase of COVID-19 could help to better understand the rehabilitation needs in the current pandemic situation. Methods: Cohort including all patients with COVID-19 hospitalized in a single, large university hospital in Northeast France from 25 February...
Article
Full-text available
Background Facioscapulohumeral muscular dystrophy (FSHD) is among the most prevalent muscular dystrophies and currently has no treatment. Clinical and genetic heterogeneity are the main challenges to a full comprehension of the physiopathological mechanism. Improving our knowledge of FSHD is crucial to the development of future therapeutic trials a...
Article
Introduction La détresse respiratoire est actuellement la principale cause de décès des patients atteints de dystrophie myotonique de type 1 (DM1). Il est primordial de surveiller une aggravation de leur atteinte respiratoire, en combinant dépistage des symptômes et évaluation fonctionnelle respiratoire, afin d’identifier le moment approprié pour i...
Article
Full-text available
Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that affects both upper and lower motor neurons and is fatal in its course. This evidence-based position paper represents the official position of the UEMS PRM Section. The aim of the paper is to define the role of the physical and rehabilitation medicine (PRM)...
Article
Full-text available
Introduction: Muscular dystrophies present a group of inherited degenerative disorder that are characterized by progressive muscular weakness. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section. The aim of the paper is to evaluate the role of the physical and rehabilitation medici...
Article
Objective: The aim of this systematic review was to assess functional improvement, measured by the 6-minute walk test (6MWT) after the application of a resistance training (RT) protocol in people with chronic obstructive pulmonary disease (COPD). Materials and methods: The search involved the databases ClinicalTrials.gov, Cochrane Central Regist...
Article
Background: Adjunct therapies (ATs) may further improve outcomes after botulinum toxin injections in spastic patients, but evidence was unclear in previous systematic reviews. Objective: To assess the efficacy of non-pharmacological ATs in spastic adults according to the International Classification of Functioning, Disability and Health and buil...
Article
Background and Purpose Additional therapy may improve poststroke outcomes. Self-rehabilitation is a useful means to increase rehabilitation time. Mechanized systems are usual means to extend time for motor training. The primary aim was to compare the effects of self-rehabilitation using a mechanized device with control self-exercises on upper extre...
Article
Objective Despite a wide clinical spectrum, the adult form of Pompe disease is the most common one, and represents more than 90% of diagnosed patients in France. Since the marketing of enzyme replacement therapy (alglucosidase alfa, Myozyme®), all reports to date in adults demonstrated an improvement of the walking distance, and a trend toward stab...
Article
Objective: To compare patients with upper limb spasticity who did or did not receive abobotulinumtoxinA (Dysport®) in shoulder muscles during 2 international clinical studies. Design: Phase 4 Upper Limb International Spasticity Study-II (ULIS-II; NCT01020500) endpoints: primary goal selection and achievement. Phase 3 Adult Upper Limb open-label...
Article
Quality of life (QoL) is one of the most important health outcome concepts expressed subjectively. Chronic pain (CP) is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Taking into account the poor QoL and the CP already described in metabolic syndrome (MSy) individuals, this study aimed to evaluate...
Article
Full-text available
Introduction: Efficacy and safety of abobotulinumtoxinA in adults with lower limb spasticity (LLS) are well-established. Objective: To examine safety and efficacy of abobotulinumtoxinA in patients previously treated with botulinum toxin type A (BoNT-A) products other than abobotulinumtoxinA. Design: Secondary analysis from a phase 3, double-bl...
Article
Full-text available
This study evaluated the effects of 6 weeks of whole-body vibration (WBV) exercise on flexibility and the rating of perceived exertion (RPE) in metabolic syndrome (MetS) individuals using 2 biomechanical conditions (fixed frequency [FF] and variable frequency [VF]). Nineteen MetS individuals were randomly allocated in FF-WBV (n = 9, 7 women and 2 m...
Article
Full-text available
Introduction: Metabolic syndrome (MetS) is characterized bya group of cardiovascular risk factors, such as hypertension,hyperglycemia, hypercholesterolemia, low high-density cholesteroland increased abdominal fat. Over the years, changesin body composition occur, with accelerated loss of lean massand increased fat mass, favoring cardiometabolic dis...
Article
Introduction: Motor nerve blocks with anesthetic drug for local anesthesia are commonly used in physical and rehabilitation medicine (PRM), especially in the field of spasticity. Guidelines in this context are currently lacking. Method: Eighteen experts selected on the basis of their recognized experience by the scientific committees of the Fren...
Article
Approximately two-thirds of patients survive following a cerebral vascular accident (stroke), nevertheless about half are left with a physical incapacity. The clinical picture is frequently a combination of motor, sensory, visual and cognitive deficits. Mechanically, the use of ankle-foot orthosis (AFO) appear a good option. The objective of this s...
Article
Background: Low back pain (LBP) is the most common type of musculoskeletal pain, thus it is one of the most commonly encountered conditions in Physical and Rehabilitation Medicine. The physicians who are primarily responsible for the nonsurgical management of LBP are physiatrists. Objective: The present study aimed to investigate the approaches...
Article
Full-text available
Introduction: Home-based self-rehabilitation programmes combined with botulinum toxin injections (BTIs) appear to be a relevant approach to increase the recommended intensive rehabilitation of patients with spasticity following a stroke. The literature highlights a lack of evidence of beneficial effects of this adjuvant therapy to reduce limitatio...
Article
Full-text available
Introduction/Background The hyperventilation syndrome is a complex entity whose management is poorly codified. A Cochrane review in 2013 [1] highlighted the lack of proof in the treatment of this disease. The aim of this presentation is to expose the different options used in hyperventilation syndrome and to discuss their efficacy. Material and me...
Article
Full-text available
Introduction/Background Respiratory muscle weakness is well-known in Chronic obstructive pulmonary disease (COPD), and it is an argument to the rational of respiratory muscle training. The aim of this review is to identify the most appropriate training modality of respiratory muscle and to investigate the effects of this training. Material and met...
Article
Full-text available
Introduction/Background Shoulder spasticity post-stroke or -traumatic brain injury (TBI) may cause pain and restrict joint range of motion (ROM). Few studies have investigated botulinum toxin injections into shoulder muscles for spasticity treatment. Here we present data for sub-populations of patients receiving shoulder injections of abobotulinumt...
Conference Paper
Introduction/Background The “Quality of Life in genetic Neuromuscular Disease” questionnaire (QoL-gNMD) is a new patient reported outcome (PRO) measure tool specifically designed for patients with a slowly-progressive neuromuscular disease with genetic predominant muscular damage. The QoL-gNMDhas been developped in 3 domains: “Impact of Physical Sy...
Article
Full-text available
Introduction/Background Guided self-rehabilitation contracts (GSC) are a diary-based and antagonist-targeting strategy, in which therapists identify muscles against which to prescribe patients daily, home-based self-stretching and active training programmes. Patients record a diary of exercises performed between visits. The ENGAGE study assesses ef...
Article
Because of the scarcity of the literature on the comparative efficiency of Partial Body Cryotherapy versus Whole Body Cryotherapy, it appears that the decision to switch from the former to the latter is purely arbitrary and does not actually meet any scientifically established criterion. The motivation of this study is to draw up an objective obser...
Article
Background: Botulinum toxin (BTX) injection alone is not sufficient to treat spasticity in children, notably those with cerebral palsy; thus, there is an emerging trend for adjunct therapies to offer greater outcomes than BTX alone. Objective: The aim of this systematic review was to evaluate the general effectiveness of adjunct therapies regard...
Article
Introduction/Background Fibromyalgia is a chronic disease that causes muscle pain and fatigue. Our objective was to determine whether Whole Body Cryotherapy (WBC) can result in improved functional status and pain in fibromyalgia patients. It was hypothesized that positive effects will be realized due to the cold-induced modulation of the inflammati...
Article
This paper introduces a new concept of manual wheelchair (MWC), consisting in different modules enabling customizations based on specific pathologies as well as patients’ environment. This wheelchair is as maneuverable as an electric wheelchair while remaining lighter, more convenient and less costly. The module concept allows adaptability aimed at...
Poster
Full-text available
Presented at the Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, September 13–16, 2017, Phoenix, AZ, USA. Previously presented at TOXINS, January 18–21, 2017, Madrid, Spain.
Article
Full-text available
Objective Few studies have assessed the treatment interval during repeated injections of botulinum toxin. In a double-blind (DB), single-treatment study followed by a long-term open-label (OL) extension study, abobotulinumtoxinA (aboBoNT-A, Dysport®) was efficacious and did not generate unexpected safety findings (Esquenazi et al. Am Acad Phys Med...
Article
Objective Pain management in children undergoing invasive and painful care is an important clinical matter. The aim of this study was to describe and to evaluate pain management effectiveness during intramuscular botulinum toxin A injections in spastic children. Material/patients and methods Prospective study including 30 consecutive injection ses...
Conference Paper
Objective The aim of this lecture is to provide evidence-based recommendations for the practice of pulmonary rehabilitation (PR) in chronic pulmonary disease. About ten practice guidelines have been published over the past ten years. More than 50 meta-analysis are listed about pulmonary rehabilitation. Who can benefit from a rehabilitation program,...
Article
Full-text available
Introduction: The efficacy of single injections of abobotulinumtoxinA (Dysport®) is established in adults with upper limb spasticity. This study aimed to assess the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods: Patients (n=258 safety population) received 500U, 1000U or 1500U (1500U dose included 500U shoulder injecti...
Article
Background: The efficacy of enzyme replacement therapy (ERT) in patients at an advanced stage of Pompe disease has only been addressed in a few studies. Our objective was to assess the long term effects of ERT in a cohort of patients with severe Pompe disease. Methods: We identified patients from the French Pompe Registry with severe respiratory...
Article
Full-text available
Introduction: Slowly-progressive, genetic neuromuscular diseases (gNMDs) often lead to important motor deficiencies and functional limitations. The QoL-gNMD is a new health-related quality of life questionnaire developed for these patients. The purpose of the present study was to validate the French version of the QoL-gNMD and to calibrate its mea...
Article
Gait analysis has been used for the assessment of gait-related disabilities and to provide detailed information. The gait characteristics of a healthy adult population have often been utilised to evaluate and monitor a subject's walk and patterns. This paper summarises a study that aims to compare the Functional Ambulation Performance (FAP) scores...
Article
This article establishes the basics of a theoretical model for the constitutive law that describes the skin temperature and thermolysis heat losses undergone by a subject during a session of whole-body cryotherapy (WBC). This study focuses on the few minutes during which the human body is subjected to a thermal shock. The relationship between skin...
Article
The hyperventilation syndrome is a complex entity whose management is poorly codified. We report a synthesis about the management of adult patients diagnosed with hyperventilation syndrome. A systematic literature review has identified fifteen articles dealing, among them three studies about drug treatment and the others about non-pharmacological a...
Conference Paper
Objective The “quality of life in neuromuscular disease” questionnaire (QoL-NMD) is a new health-related quality of life measurement tool specifically designed for patients with a slowly-progressive neuromuscular disease with motor deficiency. The QoL-NMD is structured into 3 domains: “impact of physical symptoms”, “self-perception” and “activities...
Conference Paper
Objective A major aim of hospitalization programs in physical and rehabilitation medicine (PRM) department is to obtain long term adherence to exercise into daily life for maintaining the effects. The prevention of most chronical diseases is made by physical activities, education, food balance and drugs. We describe the follow-up of chronically ill...
Article
Purpose: A qualitative work is conducted to enable later the construction of a health-related quality of life (HRQL) questionnaire for patients with slowly-progressive neuromuscular disease (NMD) such as myopathies and muscular dystrophies. Methods: The formation of focus groups is an efficient method to perform an in-depth exploration of the as...
Article
Background: Dystrophinopathies are mostly caused by copy number variations, especially deletions, in the dystrophin gene (DMD). Despite the large size of the gene, deletions do not occur randomly but mainly in two hot spots, the main one involving exons 45 to 55. The underlying mechanisms are complex and implicate two main mechanisms: Non-homologo...
Article
Full-text available
Background: Myotonic Dystrophy type 1 (DM1) is one of the most heterogeneous hereditary disease in terms of age of onset, clinical manifestations, and severity, challenging both medical management and clinical trials. The CTG expansion size is the main factor determining the age of onset although no factor can finely predict phenotype and prognosi...
Article
Full-text available
Subjective health measurements using Patient Reported Outcomes (PRO) are increasingly used in randomized trials, particularly for patient groups comparisons. Two main types of analytical strategies can be used for such data: Classical Test Theory (CTT) and Item Response Theory models (IRT). These two strategies display very similar characteristics...
Article
After a vestibular deficit some patients may be affected by chronical postural instability. The aim of this study was to identify the emotional and cognitive factors of these symptomatic patients. In particular, the double cognitive task and the anxiety disorder were identified by our patients. Through a retrospective study, 14 patients (65.4 ±18 y...
Article
Background Resistance from antagonistic muscle groups might be a crucial factor reducing function in chronic hemiparesis. The resistance due to spastic co-contraction might be reduced by botulinum toxin injections. We assessed the eff ects of abobotulinumtoxinA injection in the upper limb muscles on muscle tone, spasticity, active movement, and fun...
Article
Full-text available
The possible effects of Kineso-Tape (KT) on the dynamic balance in healthy adults is investigated. A total of 24 healthy males with no foot or lower limb deformities participated in the study. The study was composed of 2 experiments (A and B). The “A” experiment consisted of a comparison between the effects of KT and rigid tape on standing balance....
Conference Paper
Introduction Medical care and treatments of patients suffering from slowly-progressive neuromuscular disease (NMD) mainly aim to improve health-related quality of life (HRQOL). To date there is no French HRQOL-measurement tool specifically designed for these patients. Recent works allowed developing a new questionnaire of 26 items named “Quality of...
Article
Full-text available
To build a questionnaire to assess health-related quality of life (HRQL) in patients suffering from slowly progressive neuromuscular disease (NMD) using item response theory (IRT). A pool of 64 items and a validated questionnaire (WHOQOL-BREF) were administered to 159 patients recruited in eight NMD referral centers. Exploratory statistical analysi...
Article
Full-text available
Quality of life is a subjective point of view of the patient. Its measurement is complex, but useful to personalize interventions and to evaluate the effect of care, particularly in Physical medicine. to determine the psychometric properties of the Duke Health Profile (DHP) in neuromuscular disease. This instrument was chosen for its excellent acce...
Conference Paper
Full-text available
Objectifs La maladie de Parkinson idiopathique est progressivement invalidante et incomplètement contrôlée par les thérapeutiques médicamenteuses. La prise en charge initiale s’adjoint volontiers de nouvelles approches intéressantes non médicamenteuses parmi lesquelles le réentraînement à l’effort. L’objectif de ce travail est, à partir des données...
Conference Paper
Full-text available
The main aim of this study is to determine the influence of low-frequency vibrations in the lower limb bones (femur, tibia and fibula). Various biography results are presented in this study. They showed the positive impact of the stimulus by vibration in osteoporosis, sarcopenia and metabolic syndrome. In our study the methodology of scanning laser...
Poster
Introduction and Objectives: Few extensive studies have assessed the effects of botulinum neurotoxin A in adults with upper limb spasticity (ULS) poststroke/traumatic brain injury (TBI) on muscle tone, spasticity, active range of motion (AROM), and function. The aim of this study was to assess the efficacy and safety of abobotulinumtoxinA (Dysport)...
Article
Full-text available
Our objective is to introduce a new device designated to reduce shoulder dislocation (METHOD-2) compared to a manual technique (METHOD-1). Eighteen shoulders in 20 right-handed participants (22±5) were evaluated as non-traumatic posterior instability. Patients recorded scores ranging between 71.6 and 88.42% when performing the Japanese orthopaedic...