François Alla- MD PhD
- University of Bordeaux
François Alla
- MD PhD
- University of Bordeaux
About
531
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Introduction
Current institution
Publications
Publications (531)
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
En la investigación en salud, los enfoques biomédicos y epidemiológicos no permiten comprender la complejidad de las intervenciones en salud poblacional. Sin embargo, es esencial estudiarlas con enfoques adaptados a su complejidad, a la pluralidad de sus mecanismos y a la diversidad de actores y contextos locales. Este es el objetivo de la investig...
Background
Epinephrine increases the chances of return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA), especially when the initial rhythm is non-shockable. However, this drug could also worsen the post-resuscitation syndrome (PRS). We assessed the association between epinephrine use during cardiopulmonary resuscitation (...
Les enjeux de santé publique auxquels nos systèmes de santé ont à faire face sont multiples et impliquent notamment le développement d’interventions, d’organisations et de politiques innovantes en santé des populations, caractérisées par leur complexité. Appréhender la complexité de ces interventions nécessite une approche interdisciplinaire. Si le...
Background
Organ shortage is a major public health issue, and patients who die after out-of-hospital cardiac arrest (OHCA) could be a valuable source of organs. Here, our objective was to identify factors associated with organ donation after brain death complicating OHCA, in unselected patients entered into a comprehensive real-life registry coveri...
Objectives
The transition from experimentation to the scaling up of organizational innovations in public health is arduous. The innovation process requires back-up in view of enhancing the chances of success and generalization. The aim of this article is to present the development of a guide to support the description and analysis of organizational...
Introduction:
We aimed to describe patients with coexisting infective endocarditis (IE) and bacterial meningitis (BM).
Methods:
We merged two large prospective cohorts, an IE cohort and a BM cohort, with only cases of definite IE and community-acquired meningitis. We compared patients who had IE and BM concurrently to patients with IE only and B...
Health promotion research is largely influenced by the biomedical model, which is poorly adapted to the study of complex interventions. According to Chen (2010), this approach “reduces that evaluation’s usefulness and contributes to the gulf between academic and practical communities regarding interventions”. Chen argued that integrative validity,...
Purpose:
Whether epinephrine or norepinephrine is preferable as the continuous intravenous vasopressor used to treat post-resuscitation shock is unclear. We assessed outcomes of patients with post-resuscitation shock after out-of-hospital cardiac arrest according to whether the continuous intravenous vasopressor used was epinephrine or norepinephr...
Résumé
L’évolution actuelle du système de santé, les transformations organisationnelles et développements technologiques, et les nombreux défis auxquels le système de santé est confronté, confèrent un rôle central à l’innovation. Fortement encouragée, de nombreuses expérimentations voient le jour. Pourtant peu d’entre elles parviennent à une mise à...
Purpose: To update a systematic review published in 2012 that identified predictors of cigarette smoking cessation among adolescents.
Methods: The PubMed and Web of Science databases were searched for relevant articles published between September 2010 and January 2018, using the following keywords: smoking OR tobacco OR cessation; quit OR stop; lo...
Objective
To compare the effectiveness of the mobile e-Tabac Info Service (e-TIS) application (app) for helping adult smokers quit smoking with current practices.
Design
Pragmatic randomised controlled trial with a 1-year follow-up (2017–2018).
Setting
France, population-wide level.
Participants
2806 adult smokers who wished to quit smoking were...
Introduction
Le « referral bias » est un biais de sélection dont l’impact sur les résultats des études pronostiques n’a pas encore été complètement évalué. Il survient dans les études recrutant les patients en centres tertiaires, mélangeant ainsi des patients admis directement dans ces centres et ceux qui y sont transférés, tout en excluant par ail...
BACKGROUND: An international workshop on population health intervention research (PHIR) was organized to foster exchanges between experts from different disciplines and different fields. AIMS: This paper aims to summarize the discussions around one of the issues addressed: the place or role of pilot studies in PHIR. Pilot studies are well-establish...
Background
Policies and programs implemented to promote smoking cessation among youth present disparate results. These variations are explained by interventions themselves but also by context, population and implementation characteristics. Our objective was to analyze these factors, related to enrollment and participation in a smoking cessation pro...
Background
Evaluation of complex interventions (CI) is challenging for health researchers and requires innovative approaches. The objective of this work is to present the main methods used to evaluate CI.
Methods
A systematic review of the scientific literature was conducted to identify methods used for the evaluation of CI. We searched MEDLINE vi...
Introduction
L’insuffisance cardiaque à fraction d’éjection préservée (ICFEP) est associée à un pronostic défavorable, probablement lié à un défaut de progrès thérapeutiques. L’absence de mise en évidence de traitement efficace pourrait résulter de l’hétérogénéité de la population en ICFEP. Notre objectif était d’identifier les profils phénotypique...
Introduction
Les objectifs de cette étude étaient d’identifier les typologies des prescriptions médicamenteuses chez les patients atteints d’insuffisance cardiaque à fraction d’éjection réduite (ICFEr) et de décrire l’évolution de ces typologies sur trois ans de suivi après une hospitalisation pour insuffisance cardiaque (IC). Nous avons évalué l’a...
Objectives:
The aim was to describe the impact of infective endocarditis (IE) on functional, cognitive and nutritional statuses, and to estimate the influence of these parameters on surgical management and mortality.
Method:
This was a prospective study over 13 months in 14 French hospitals, including patients ≥75 years of age with definite or p...
This appendix formed part of the original submission and has been peer reviewed.
Supplement to: GBD 2017 SDG Collaborators. Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. L...
Background
Population health intervention research raises major conceptual and methodological issues. These require us to clarify what an intervention is and how best to address it.
This paper aims to clarify the concepts of intervention and context and to propose a way to consider their interactions in evaluation studies, especially by addressing...
État de la question
L’insuffisance cardiaque à fraction d’éjection préservée (ICFEP) est associée à un pronostic défavorable, probablement lié à un défaut de progrès thérapeutiques. Ce défaut de médicament efficace pourrait résulter de l’hétérogénéité de la population en ICFEP. Notre objectif était d’identifier les profils phénotypiques de patients...
Background:
The accuracy of surgical scores in predicting in-hospital mortality for nonsurgically treated patients with infective endocarditis (IE) has not yet been explored.
Methods:
Patients with definite IE who did not undergo valve surgery were selected from the database of seven French administrative areas (Association pour l'Étude et la Pr...
Background
Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use stan...
This paper estimated mortality for 282 causesof death in 195 countries from 1980 to 2017, adding 18 causes to its estimates compared to GBD 2016. In 2017, the GBD study added numerous data sources, including 127 country-years of vital registration data and 502
country-years of cancer registry data.
Background Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use stan...
Background: Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used...
Background
Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. He...
Background
The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has le...
Background
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved method...
Background
Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used...
Background
Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-leve...
Background
How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifi...
BACKGROUND:
Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used...
Background
The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has le...
Summary
Background: How long one lives, how many years of life are spent in good and poor health, and how the population’s state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which...
Background
Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-leve...
Summary
Background: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improv...
Background
Targeted interventions among vulnerable youth populations represent an important approach to the reduction of health inequalities. We must, however, ensure that impacts are not unequally distributed according to the range of resources available to them. We explore these concerns among youth in vocational training to be enrolled in a smok...
Background:
In 2009, the World Health Organization's Commission on Social Determinants of Health set out its recommendations for action, which included establishing equity from early childhood onwards by enabling all children and their mothers to benefit from a comprehensive package of quality programmes. In order to address social inequalities in...
Objectives:
Time to blood culture positivity (TTP), a routinely available parameter in automated blood culture systems, may be a proxy for infectious burden in patients with bloodstream infections. We aimed to study the association between TTP and infective endocarditis (IE), or death, in patients with Staphylococcus aureus bacteraemia.
Methods:...
Data S2. Supporting information
Table S1. Median gestational age in weeks after the LMP observed in the PMSI in 2014 and interquartile range
Table S2: Study drugs
Table S3: Distribution of pregnancy outcomes identified by the algorithm and official data for 2014
Table S4. Number of pregnancies exposed to AEDs (and prevalence rates per 1000 pregnancies) by year and AED class
Figur...
Data S3. Supporting information
Background:
Following the economic crisis in Greece in 2010, the country's ongoing austerity measures include a substantial contraction of health-care expenditure, with reports of subsequent negative health consequences. A comprehensive evaluation of mortality and morbidity is required to understand the current challenges of public health in Greec...
Background: A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and R...
Staphylococcus aureus induces severe infective endocarditis (IE) where embolic complications are a major cause of death. Risk factors for embolism have been reported such as a younger age or larger IE vegetations, while methicillin resistance conferred by the mecA gene appeared as a protective factor. It is unclear, however, whether embolism is inf...
A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and Risk Factors...
Supplement to: GBD 2016 Healthcare Access and Quality Collaborators. Measuring
performance on the Healthcare Access and Quality Index for 195 countries and
territories and selected subnational locations: a systematic analysis from the
Global Burden of Disease Study 2016. Lancet 2018; published online May 23.
http://dx.doi.org/10.1016/S0140-6736(18)...
Purpose
Access to claims databases provides an opportunity to study medication use and safety during pregnancy. We developed an algorithm to identify pregnancy episodes in the French health care databases and applied it to study antiepileptic drug (AED) use during pregnancy between 2007 and 2014.
Methods
The algorithm searched the French health ca...
Introduction:
Public health tries to modify existing social norms by setting up strategies to promote the emergence of norms that are more adapted to the objectives of good health and well-being. Prevention policies and the corresponding interventions concern health behaviours and are designed to modify the individual's habits, and contribute to d...
Background:
β-blockers have been among the first medications shown to improve outcomes after acute myocardial infarction (AMI). With the advent of reperfusion therapy and other secondary-prevention medications, their role has become uncertain, and large-scale experience after AMI in the contemporary era is lacking. In particular, the effect of sto...
