Franco King‐Chi Leung

Franco King‐Chi Leung
The Hong Kong Polytechnic University | PolyU · Department of Applied Biology and Chemical Technology

PhD

About

20
Publications
3,550
Reads
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596
Citations
Introduction
Franco studied his BSc in Chemistry at The Hong Kong Polytechnic University where he carried out his Masters research in catalysis and chemical biology under supervision of Prof. Man Kin Wong. He expanded his research scopes in his PhD to supramolecular chemistry and material science under guidance of Prof. Takanori Fukushima in Tokyo Institute of Technology (Japan). In April 2017, he joined Prof. Ben L. Feringa's group (2016 Nobel Laureate in Chemistry) in University of Groningen, the Netherlands, as a postdoc fellow where he is developing photo-responsive soft materials of molecular motors and switches. His main research interests are dynamic supramolecular polymers, functional molecular assembly, and biocompatible functional materials. Group Page: http://francokingchileung.com/
Additional affiliations
June 2019 - present
The Hong Kong Polytechnic University
Position
  • Professor (Assistant)
April 2017 - June 2019
University of Groningen
Position
  • PostDoc Position
April 2014 - March 2017
Tokyo Institute of Technology
Position
  • PhD Student

Publications

Publications (20)
Article
Full-text available
A striking feature of living systems is their ability to produce motility by amplification of collective molecular motion from the nanoscale up to macroscopic dimensions. Some of nature's protein motors, such as myosin in muscle tissue, consist of a hierarchical supramolecular assembly of very large proteins, in which mechanical stress induces a co...
Article
Full-text available
Three-dimensional organized unidirectionally aligned and responsive supramolecular structures have much potential in adaptive materials ranging from biomedical components to soft actuator systems. However, to control the supramolecular structure of these stimuli responsive, e.g., photoactive materials and control their actuation remains a major cha...
Article
Three‐dimensional unidirectionally aligned and responsive supramolecular hierarchical assemblies have much potential in adaptive materials for biomedical and soft actuator applications. However, to achieve systematical control of the motion of stimuli‐responsive materials by orthogonal external stimuli and to complete a series of complicated tasks...
Article
Full-text available
Stimuli-responsive supramolecular assemblies controlling macroscopic transformations with high structural fluidity, i.e., foam properties, have attractive prospects for applications in soft materials ranging from biomedical systems to industrial processes, e.g., textile coloring. However, to identify the key processes for the amplification of molec...
Article
Full-text available
Amphiphilic molecules, comprising hydrophobic and hydrophilic moieties and the intrinsic propensity to self-assemble in aqueous environment, sustain a fascinating spectrum of structures and functions ranging from biological membranes to ordinary soap. Facing the challenge to design responsive, adaptive, and out-of-equilibrium systems in water, the...
Article
Supramolecular assemblies of gold complex‐based amphiphiles in aqueous media are highly structural sensitive to external environments, providing an attractive prospect for its application in soft functional materials. Notably, the development of a supramolecular assembly transformation of gold (III) amphiphile directly controlled by counterion exch...
Article
Full-text available
Mimicking the native extracellular matrix (ECM) as a cell culture scaffold has long attracted scientists from the perspective of supramolecular chemistry for potential application in regenerative medicine. However, the development of the next-generation synthetic materials that mimic key aspects of ECM, with hierarchically oriented supramolecular s...
Article
Full-text available
Controlling supramolecular polymerization by external stimuli holds great potential toward the development of responsive soft materials and manipulating self-assembly at the nanoscale. Photochemical switching offers the prospect of regulating the structure and properties of systems in a noninvasive and reversible manner with spatial and temporal co...
Article
Full-text available
Dynamic self‐assembly of photoresponsive molecular amphiphiles at Gibbs monolayers, i.e., air–water interfaces, and in solutions, ranging from isotropic assembly transformations to anisotropic three‐dimensional structures, provides the amplification of molecular motion to macroscopic functions. Abstract Amphiphilic molecules, comprising hydrophobi...
Article
Full-text available
The incorporation of photoswitchable molecules into solid-state materials holds promise for the fabrication of responsive materials, the properties of which can be controlled on-demand. However, the possible applications of these materials are limited due to the restrictions imposed by the solid-state environment on the incorporated photoswitches,...
Article
We report multi-modal-control over the assembly behaviour of a first-generation molecular motor bola-amphiphile in water by light, pH and the choice of counter-ions. These findings open up opportunities for the...
Article
Three‐dimensional unidirectionally aligned and responsive supramolecular hierarchical assemblies have much potential in adaptive materials for biomedical and soft actuator applications. However, to achieve systematical control of the motion of stimuli‐responsive materials by orthogonal external stimuli and to complete a series of complicated tasks...
Article
Full-text available
1-Methoxy-8-(diphenylphosphino)triptycene (1), featuring high structural rigidity and steric bulkiness around the phosphine functionality, was synthesized as a new chiral monophosphine ligand for transition metal-catalyzed reactions. In the presence of 5–10 mol ppm (i.e., 0.0005–0.001 mol %) Pd(OAc)2 and 1 (2 equiv for Pd), Suzuki–Miyaura cross-cou...
Article
Tailoring structurally anisotropic molecular assemblies while controlling their orientation on solid substrates is an important subject for advanced technologies that use organic thin films. Here we report a supramolecular scaffold based on tripodal triptycene assemblies, which enables functional molecular units to assemble into a highly oriented,...
Article
Full-text available
An efficient method for photooxidative amidation of aldehydes with secondary amines has been developed. With the use of a readily available photocatalyst Rose Bengal, tertiary amides (with examples of oligosaccharides and endoperoxide artemisinin) were obtained in good yields with high chemoselectivity and functional group compatibility under mild...
Article
A new class of hydrogen bond donor-acceptor-donor (HB-DAD) organocatalysts has been developed for conjugate addition of benzylidene barbiturates. HB-DAD organocatalyst 1a (featuring para-chloro-pyrimidine as the hydrogen bond acceptor (HBA), N-H as the hydrogen bond donor (HBD) and a trifluoroacetyl group as the electron withdrawing group (EWG)) is...
Article
A series of cyclometallated gold(III) complexes [Au(equation image)Cl2] 1a–l (Hequation image=arylpyridines) and a PEG-linked complex 1m were synthesized. Complexes 1a–m are effective in catalyzing the synthesis of propargylic amines, chiral allenes and isoxazoles. Six-membered ring cyclometallated gold(III) complexes 1f–l exhibited higher catalyti...
Article
A site-specific and efficient method for N-terminal modification of peptides using oxone for selective oxidation of N-terminal α-amino groups of peptides to oximes followed by transoximation with O-substituted hydroxylamines has been developed.
Chapter
[184034-09-1] C25H14Cl2O5 (MW 465.28) InChI = 1S/C25H14Cl2O5/c26-18-9-13-5-1-3-7-16(13)20-21-17-8-4-2-6-14(17)10-19(27)23(21)25(30)32-12-15(28)11-31-24(29)22(18)20/h1-10H,11-12H2 InChIKey = FQVCXRGPRMNZCY-UHFFFAOYSA-N (a chiral ketone reagent used for enantioselective olefin epoxidations, kinetic resolution of acyclic secondary allylic silyl ethers...

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