Francisco Torrens

Francisco Torrens
University of Valencia | UV · Instituto de Ciencia Molecular (ICMol)

About

302
Publications
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3,596
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Publications

Publications (302)
Article
Full-text available
With the advancement of combinatorial chemistry and big data, drug repositioning has boomed. In this sense, machine learning and artificial intelligence techniques offer a priori information to identify the most promising candidates. In this study, we combine QSAR and docking methodologies to identify compounds with potential inhibitory activity of...
Article
The new pandemic produced by coronavirus (SARS-CoV-2) has becomes the biggest challenge that the world is facing today. It has been creating a devastating global crisis, causing countless deaths and great panic. The search for an effective treatment remains a global challenge owing to controversies on available vaccines. A huge research effort (cli...
Article
The enzyme acetylcholinesterase (AChE) is currently a therapeutic target for the treatment of neurodegenerative diseases. These diseases have highly variable causes but irreversible evolutions. Although the treatments are palliative, they help relieve symptoms and allow a better quality of life, so the search for new therapeutic alternatives is the...
Conference Paper
The novel coronavirus SARS-CoV-2 responsible for COVID-19, for which there is no vaccine or any known effective treatment created a sense of urgency for novel drug discovery approaches. One of the most important COVID-19 protein targets is the 3C-like (main) protease for which the crystal structure is known. In this study, we used QSAR methodology...
Article
Full-text available
Introducción: La evaluación de los efectos adversos de los contaminantes sobre los ecosistemas y la predicción de propiedades farmacocinéticas de compuestos, son campos de investigación de gran interés. Objetivos: desarrollar modelos computacionales que permitan la predicción, lo más acertada posible, del potencial ecotoxicológico de sustancias quí...
Article
Full-text available
Based on a set of six vector properties, the partial correlation diagram is calculated for a set of 28 S-alkylcysteine diazomethyl- and chloromethyl-ketone derivatives. Those with the greatest antileukemic activity in the same class correspond to high partial correlations. A periodic classification is performed based on information entropy. The fir...
Article
Full-text available
Neprilysin (NEP, EC: 3.4.24.11) is an enzymatic membrane protein considered the prototype of the M13 zinc metallopeptidase family. Inhibitors of this enzyme constitute therapeutic targets for cardiovascular diseases. In spite of the existing alternatives for the treatment of these pathologies, the quality of life and the prognosis of the patients r...
Book
Biochemistry, Biophysics, and Molecular Chemistry: Applied Research and Interactions provides the background needed in biophysics and molecular chemistry and offers a great deal of advanced biophysical knowledge. It emphasizes the growing interrelatedness of molecular chemistry and biochemistry, and acquaints one with experimental methods of both d...
Book
This new volume is devoted to molecular chemistry and its applications to the fields of biology. It looks at the integration of molecular chemistry with biomolecular engineering, with the goal of creating new biological or physical properties to address scientific or societal challenges. It takes a both multidisciplinary and interdisciplinary persp...
Book
This new volume provides a wealth of practical experience and research on new methodologies and important applications in chemical nanotechnology. It also includes small-scale nanotechnology related projects that have potential applications in several disciplines of chemistry and nanotechnology. In this book, contributions range from new methods to...
Article
Background: Some lactones prevent protein Myb-dependent gene expression. Objective: The object is to calculate inhibitors of Myb-brought genetic manifestation. Methods: Linear quantitative structure-potency relations result expanded, among sesquiterpene lactones of a variety of macrocycles (pseudoguaianolides, guaianolides, eudesmanolides and...
Article
Leishmaniasis is poverty-related disease endemic in 98 countries worldwide, with morbidity and mortality increasing daily. All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit several drawbacks including toxicity, high costs and route of administration. Consequently, the development of new treatments for le...
Conference Paper
Full-text available
Ubiquitin/Proteasome System (UPS) is a highly regulated mechanism of intracellular protein degradation and turnover. Through the concerted actions of a series of enzymes, proteins are marked for proteasomal degradation by being linked to the polypeptide co-factor, ubiquitin. The UPS participates in a wide array of biological functions such as antig...

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Projects

Projects (6)
Project
This editorial project consists of a series of special issues published in the journal Curr Top Med Chem and focused on new experimental and computational methods for drug discovery. The issues have been edited by multiple worldwide collaborators including professors/researchers from UC Berkley; UC Irvine, Univ. of Texas, Oregon State Univ., EMBL-EBI, Univ. of Portsmouth, Trinity College Dublin, Univ. of Perugia, Univ. of Paris Sud, CNRS, CENAM, UPV/EHU, IKERBASQUE, etc. (click project log to read details). Contact Prof. Humbert G. Díaz, CTMC Europe Editor, if you want to become editor/author, email: ctmc.editor.eu@gmail.com
Project
This new volume provides a wealth of practical experience and research on new methodologies and important applications in chemical nanotechnology. It also includes small-scale nanotechnology related projects that have potential applications in several disciplines of chemistry and nanotechnology. In this book, contributions range from new methods to novel applications of existing methods to gain understanding of the material and/or structural behavior of new and advanced systems. The fast growing field of nanotechnology uses a variety of modern methods that give scientists the ability to design multifunctional materials and provide improved products. Understanding the world of nanotechnology is critically important because technology based on nanostructures promises to be hugely important economically. Topics cover computational methods in chemical engineering and chemoinformatics, studies of some of physico-chemical properties of several important nanoalloy clusters, the use of 3D reconstruction of nanofibrous membranes, nanotechnology research for green engineering and sustainability, nanofiltration and carbon nanotubes applications in water treatment, and much more. The information presented in Chemical Nanoscience and Nanotechnology: New Materials and Modern Techniques will be useful for scientists, researchers, faculty, and industry professionals working in chemical nanotechnology.
Project
USEDAT: USA-Europe Data Analysis Training Program, Workshop. (Click Project Log to see detailed info). USEDAT 2021 homepage: https://mol2net-07.sciforum.net/usedat-07