Francisco A Tomás-Barberán

Francisco A Tomás-Barberán
Spanish National Research Council | CSIC · Centro de Edafología y Biología Aplicada del Segura

Doctor of Pharmacy

About

525
Publications
167,179
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43,757
Citations
Citations since 2016
130 Research Items
23148 Citations
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201620172018201920202021202201,0002,0003,0004,000
201620172018201920202021202201,0002,0003,0004,000

Publications

Publications (525)
Article
Full-text available
This review of analytical methods for pot-honey research is intended to provide concise references to our contributions to a 35-day post-harvest at 30 °C, in an integrated study. Diverse methods were selected from specialized literature, from the AOAC (Association of Official Analytical Chemists), and the International Honey Commission. Besides the...
Article
Full-text available
In general, food processing and its conditions affect nutrients, bioactive compounds, and sensory characteristics of food products. This research aims to use a non-targeted metabolomics approach based on UPLC-ESI-QTOF-MS to determine how fruit processing can affect the metabolic profile of fruits and, through a comprehensive metabolic analysis, ide...
Chapter
El.la.gi.bac'ter. N.L. neut. n. acidum ellagicum ellagic acid; N.L. masc. n. bacter rod; N.L. masc. n. Ellagibacter ellagic acid‐transforming rod. Actinomycetota / Coriobacteriia / Eggerthellales / Eggerthellaceae / Ellagibacter The genus Ellagibacter accommodates human intestinal bacteria capable of transforming dietary phenolic compounds such as...
Article
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Different technologies commonly employed by the fruit processing industry affect the phenolic content. This study aimed to establish the extent to which different processing techniques and conditions, tested at an industrial scale, affect phenolics, color, and sensory attributes of fresh strawberries and apples. The effects of freezing, thermal tre...
Article
The beneficial health effects of phytochemicals depend on their bioavailability and the form under which they reach systemic circulation, usually as phase II metabolites. The lack of authentic standards for these metabolites makes their quantification in biological samples challenging. A new analytical approach to get a more accurate quantification...
Article
This review of analytical methods for pot-honey research is intended to provide concise references to our contributions to a 35-day post-harvest at 30 °C, in an integrated study. Diverse methods were selected from specialized literature, from the AOAC (Association of Official Analytical Chemists), and the International Honey Commission. Besides the...
Article
Full-text available
Ellagitannins (ETs) and ellagic acid (EA) are dietary polyphenols poorly absorbed but extensively metabolized by the human gut microbiota to produce different urolithins (Uros). Depending on the individuals' microbial signatures , ETs metabolism can yield the Uro metabotypes A, B, or 0, potentially impacting human health after consuming ETs. Human...
Article
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Gut microbes have been recognized to convert human bile acids by deconjugation, dehydroxylation, dehydrogenation, and epimerization of the cholesterol core, but the ability to re-conjugate them with amino acids as an additional conversion has been recently described. These new bile acids are known as microbially conjugated bile acids (MCBAs). The a...
Article
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Urolithins (dibenzo-pyran-[b,d]-6 one derivatives) are human gut microbiota metabolites produced from the natural food antioxidant ellagic acid. Urolithins are better absorbed than ellagic acid and demonstrate biological activities that suggest that they are responsible for the health effects observed after consuming ellagitannin- and ellagic acid-...
Article
Berry fruits are rich in polyphenolic compounds (PCs) and may promote health benefits. Anthocyanin (ACN) concentrations of red raspberry (RR) (Rubus idaeus) extracts were 887.6 ± 262.8 μg g-1, consisting mainly of cyanidin-3-sophoroside (C3S) equivalents. To test the efficacy of RR in diabetes treatment, seven patients with type 2 diabetes mellitus...
Chapter
Gor.do.ni.bac'ter. N.L. masc. n. bacter, a rod; N.L. masc. n. Gordonibacter, a rod named after Jeffrey I. Gordon, the Dr. Robert J. Glaser Distinguished University Professor and Director of the Center for Genome Sciences at Washington University School of Medicine, St. Louis, MO, USA; N.L. masc. n. bacter a rod; N.L. masc. n. Gordonibacter a rod na...
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The health effects of (poly)phenols (PPs) depend upon their bioavailability that, in general, is very low and shows a high interindividual variability. The low bioavailability of PPs is mainly attributed to their low absorption in the upper gastrointestinal tract as a result of their low water solubility, their presence in foods as polymers or in g...
Article
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Urolithins, metabolites produced by the gut microbiota from the polyphenols ellagitannins and ellagic acid, were discovered by our research group in humans almost twenty years ago. Pioneering research suggested urolithins as pleiotropic bioactive contributors to explain the health benefits after consuming ellagitannin‐rich sources (pomegranates, wa...
Article
Lettuce is one of the most commonly consumed leafy vegetables worldwide and is available throughout the entire year. Lettuce is also a significant source of natural phytochemicals. These compounds, including glycosylated flavonoids, phenolic acids, carotenoids, the vitamin B groups, ascorbic acid, tocopherols, and sesquiterpene lactones, are essent...
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Diabetes remains one of the leading causes of deaths and co-morbidities in the world, with tremendous human, social and economic costs. Therefore, despite therapeutics and technological advancements, improved strategies to tackle diabetes management are still needed. One of the suggested strategies is the consumption of (poly)phenols. Positive outc...
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Polyphenols are important bioactive compounds that are affected by processing. The consumer’s demand for minimally processed products contributes to the increase in non-thermal technologies such as high-pressure processing (HPP) in the food industry. This review is aimed at critically discussing the positive and negative effects of thermal treatmen...
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The consumption of a high-fat diet can cause metabolic syndrome and induces host gut microbial dysbiosis and non-alcoholic fatty liver disease (NAFLD). We evaluated the effect of polyphenol-rich jaboticaba peel and seed powder (JPSP) on the gut microbial community composition and liver health in a mouse model of NAFLD. Three-month-old C57BL/6 J mal...
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The relevance of environmental triggers in Crohn's disease remains poorly explored, despite the well‐known association between industrialization and disease onset/progression. We have aimed at evaluating the influence of endocrine disrupting chemicals in CD patients. We performed a prospective observational study on consecutive patients diagnosed o...
Article
Jaboticaba, a popular Brazilian berry, has been studied due to its relevant polyphenol composition, health benefits and potential use for the development of derived food products. Considering that around 200 articles have been published in recent years, this review aims to provide comprehensive and updated information, as well as a critical discuss...
Article
Prediction of retention times (RTs) is increasingly considered in untargeted metabolomics to complement MS/MS matching for annotation of unidentified peaks. We tested the performance of PredRet (http://predret.org/) to predict RTs for plant food bioactive metabolites in a data sharing initiative containing entry sets of 29–103 compounds (totalling...
Article
Untargeted metabolomics identified urinary biomarkers able to discriminate between the intake of fresh hand-squeezed and industrially processed orange juices. Processing led to an upregulation in the excretion of hydroxy-polymethoxyflavone sulfates, abscisic acid, and sinapic acid 4'-glucuronide. The demethylated polymethoxyflavone metabolites were...
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Inflammation is a fundamental pathophysiological process which occurs in the course of several diseases. The present work describes the capacity of phytoprostanes (PhytoPs) and phytofurans (PhytoFs) (plant oxylipins), present in plant-based foods, to modulate inflammatory processes mediated by prostaglandins (PGs, human oxylipins) in lipopolysaccha...
Article
Cagaita (Eugenia dysenterica DC) is an ellagitannin-containing Myrtaceae fruit from Cerrado biome. This fruit seems to be a promising candidate for an adjuvant in glucose regulation in healthy subjects. However, it is not known whether cagaita juice would have the same effect on dysglycemic subjects with metabolic syndrome (MetS). Therefore, the pr...
Article
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Large interindividual variations in the biological response to citrus flavanones have been observed, and this could be associated with high variations in their bioavailability. The aim of this study was to identify the main determinants underlying interindividual differences in citrus flavanone metabolism and excretion. In a randomized cross-over s...
Chapter
The microbiota of the digestive tract has a direct contact with food and food components, and the interactions between them follow a 2-way relationship. The composition of the microbiota is largely shaped by diet while the microbes living in this tract metabolize the food components to produce metabolites with improved bioavailability or biological...
Chapter
The most relevant food components in the interaction with gut microbes are (poly)phenols and complex carbohydrates (prebiotics). (Poly)phenols include a large family of secondary metabolites that ubiquitous in plant-derived foods. Their absorption in the small intestine is very low, and therefore they have extensive interaction with the gut microbi...
Chapter
The 2-way interaction of dietary phytochemicals, other than (poly)phenols, with human intestinal microbes leads to many new metabolites that can have biological effects and modulate the gut microbiota composition that can also be associated with changes in human health. Terpenoids and nitrogen-containing compounds are present in significant amounts...
Chapter
The gut microbiota transforms most dietary polyphenols (90%) in the intestine of humans and other mammals. This conversion is often essential for absorption and controls the biological activity of these compounds. Different studies have been performed to understand how gut microbiota transforms the different polyphenols into smaller molecules calle...
Chapter
The hydrolyzable tannins ellagitannins (ETs) and ellagic acid (EA) are polyphenols present in food sources such as pomegranates, berries, and walnuts. However, they are poorly absorbed on consumption, but the gut microbiota metabolizes them. In recent decades, an extensive literature has attributed a wide range of beneficial effects to these natura...
Article
The maternal−infant transmission of several urolithins through breast milk and the gut colonization of infants by the urolithin-producing bacterium Gordonibacter during their first year of life were explored. Two trials (proof-of-concept study: n = 11; validation study: n = 30) were conducted, where breastfeeding mothers consumed walnuts as a dieta...
Chapter
(Poly)Phenolic compounds or polyphenols are the most common and ubiquitous groups of secondary metabolites widely distributed in the plant kingdom. These metabolites are involved in important roles in plants, such as pigmentation, growth and reproduction functions, protection against ultraviolet (UV) radiation, resistance to pathogens and herbivore...
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Scope: Gut microbiota converts dietary phytochemicals into metabolites and modulates their health effects. The microbial metabolism of dietary terpenoids, as the sesquiterpene lactones of leafy vegetables, is unknown. Methods & results: In vitro fermentation of lactucopicrin, lactucin, and romaine lettuce with gut microbiota from independent don...
Article
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There is a lack of focus on the protective health effects of phy-tochemicals in dietary guidelines. Although a number of chemical libraries and databases contain dietary phytochemicals belonging to the plant metabolome, they are not entirely relevant to human health because many constituents are extensively metabolized within the body following ing...
Article
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IntroductionData analysis during UPLC-MS non-targeted metabolomics introduces variation as different manufacturers use specific algorithms for data treatment and this makes untargeted metabolomics an application for the discovery of new biomarkers with low confidence in the reproducibility of the results under the use of different metabolomics plat...
Article
Gordonibacter urolithinfaciens and Ellagibacter isourolithinifaciens are two human gut bacterial species that convert ellagic acid into urolithins. Urolithins are bioactive postbiotics produced by dehydroxylation reactions catalyzed by different dehydroxylases. The metabolic ability of these anaerobic bacteria on other dietary- phenolic compounds i...
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Oxidative damage and chronic inflammation have been proven as one of the major factors associated with obesity, which increases the incidence of non-communicable chronic diseases. In this sense, the development of new functional products aiming at the palliation of oxidative stress and inflammatory disruption can be a determining factor for public...
Article
Algae and bacteria establish complex relationships reciprocally influencing their growth. Associated bacterial communities alter microalgae metabolism and physiology, affecting biomass yield and quality. In this study, 203 bacterial isolates (33 different genera), recovered from Tetraselmis suecica F&M-M33 cultures, were identified and phenotypical...
Article
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Carotenoids are important secondary metabolites in wine grapes and play a key role as potential precursors of aroma compounds (i.e., C13-norisoprenoids), which have a high sensorial impact in wines. There is scarce information about the influence of pre-harvest inactivated yeast treatment on the norisoprenoid aroma potential of grapes. Thus, this w...
Article
The full consensus on the role of dietary polyphenols as human health‐promoting compounds remains elusive. The two‐way interaction between polyphenols and gut microbiota (GM) (i.e., modulation of GM by polyphenols and their catabolism by the GM) is determinant in polyphenols’ effects. The identification of human metabotypes associated with a differ...
Article
Food phytochemicals are increasingly considered to play a key role in the cardiometabolic health effects of plant foods. However, the heterogeneity in responsiveness to their intake frequently observed in clinical trials can hinder the beneficial effects of these compounds in specific subpopulations. A range of factors, including genetic background...
Article
The polyphenolic content in date seeds, a promising functional ingredient for food, was characterised in three forms viz., date seed powder (DSP), date seed pita bread (DSB) and date seed extract (DSE). Bioaccessibility of the polyphenols from the samples was assessed by in-vitro digestion coupled with transport using Caco-2 cells. HPLC-ESI-UV/MS/M...
Article
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Purpose The quality of the study design and data reporting in human trials dealing with the inter-individual variability in response to the consumption of plant bioactives is, in general, low. There is a lack of recommendations supporting the scientific community on this topic. This study aimed at developing a quality index to assist the assessment...
Article
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Purpose Evidence exists regarding the beneficial effects of diets rich in plant-based foods regarding the prevention of cardiometabolic diseases. These plant-based foods are an exclusive and abundant source of a variety of biologically active phytochemicals, including polyphenols, carotenoids, glucosinolates and phytosterols, with known health-prom...
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Purpose Research has identified plant-based diets as the most protective for our health; it is now essential to focus on good food associations and the beneficial constituents in plant foods. From a growing body of evidence, some categories of food phytochemicals are increasingly considered to play a crucial role in the cardiometabolic health effec...
Article
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Background A healthy diet and optimal lifestyle choices are amongst the most important actions for the prevention of cardiometabolic diseases. Despite this, it appears difficult to convince consumers to select more nutritious foods. Furthermore, the development and production of healthier foods do not always lead to economic profits for the agro-fo...
Article
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Purpose The health-promoting potential of food-derived plant bioactive compounds is evident but not always consistent across studies. Large inter-individual variability may originate from differences in digestion, absorption, distribution, metabolism and excretion (ADME). ADME can be modulated by age, sex, dietary habits, microbiome composition, ge...
Article
Jabuticaba is a Brazilian berry rich in phenolic compounds (PC), which are mainly concentrated in its peel and seed (JPS), fractions that are not usually consumed. Thus, to develop a powder with potential functional properties, we investigated the effect of pressurization and dehydration methods on the chemical composition of JPS, with emphasis on...
Article
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A cross-over study was conducted in 16 healthy adult volunteers to describe the urinary excretion of polyphenols from date seeds and investigate the antioxidant effect after consumption of different doses of date seeds powder (DSP), bread (DSB) and extract (DSE). After 12 h of fasting, one of the six treatments (0.25 g and 0.5 g/kg bodyweight DSP,...
Article
Urolithins are bioactive gut microbiota metabolites of ellagic acid. Here we have identified four unknown urolithins in human feces after the intake of a pomegranate extract. The new metabolites occurred only in 19% of the subjects. 4,8,9,10-Tetrahydroxy urolithin (urolithin M6R), was unambiguously identified by 1H NMR, UV, and HRMS. Three metaboli...
Article
Short-chain fatty acids (SCFAs) are gut microbiota-derived products that participate in maintaining the gut barrier integrity and host's immune response. We hypothesize that reduced SCFA levels are associated with systemic inflammation, endotoxemia, and more severe hemodynamic alterations in cirrhosis. Patients with cirrhosis referred for a hepatic...
Article
As part of the 256th American Chemical Society National Meeting that was held in Boston (MA, USA) in August 2018, the symposium on “Health Promoting Food Ingredients” was organized in collaboration with Dr. Agnes Rimando (R.I.P). This symposium aimed to present the latest advances related to food ingredients (e.g. pure compounds, extracts, or addit...
Article
This is the first study on ellagitannin metabolism in a non-European population, through consumption of jabuticaba, a Brazilian berry. From 35 volunteers (19 normoweight and 16 overweight or obese), 63% reported the occurrence of diarrhea, probably caused by the high amount of ellagitannins consumed. Urolithin excretion showed high interindividual...
Article
The metabolism of phenolic compounds is a key factor in the development of wound-induced enzymatic browning of fresh-cut lettuce. In the present study, the lettuce midribs discriminant metabolites, selected in a previous untargeted metabolomics study, were thoroughly identified. Our results showed that their basal contents correlated with browning...
Article
The two-way interaction of food (poly)phenols with the human gut microbiota has been studied throughout the past ten years. Research has shown that this interaction can be relevant to explain the health effects of these phytochemicals. The effect of the food matrix and food processing on this interaction has only been partially studied. In this art...
Article
Interindividual Variability in Absorption, Distribution, Metabolism, and Excretion of Food Phytochemicals Should Be Reported
Article
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Although deficiencies in polyphenol intake do not result in specific deficiency diseases, adequate intake of polyphenols could confer health benefits, especially with regard to chronic diseases. Tea, cocoa, fruits, and berries, as well as vegetables, are rich in polyphenols. Flavan-3-ols from cocoa have been found to be associated with a reduced ri...
Article
Proanthocyanidins (PAs) were characterized in husk, membranes, arils and seeds of ‘Mollar de Elche’ pomegranate cultivar using LC-ESI-IT MS/MS after acid-catalysis in the presence of phloroglucinol (phloroglucinolysis). PAs were also evaluated in commercial juice and in the juice made in the laboratory by pressing fresh arils. Pomegranate PAs were...
Article
This study assessed sixteen different honey samples in order to select the better one for therapeutic purposes. First, a study of honeys´ main bioactive compounds was carried out. Then phenolic profiles were determined and specific compounds quantified using a HPLC system coupled to a mass spectrometer. Then, antioxidant activity, by three in vitro...
Article
Full-text available
Intestinal permeability to translocation of bacterial products is increased in cirrhosis. Regulatory T cells (Tregs) remain central to the interplay between the host and microbial milieu. We propose that Tregs are involved in promoting gut barrier integrity and a balanced interaction with gut microbiota–derived short‐chain fatty acids (SCFAs). Carb...