Francisco Sandro Menezes Rodrigues

Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, Brazil · Department of Pharmacology and Neurology and Neurosurgery.

Aims: Although reduced life expectancy in Parkinson's Disease (PD) patients has been related to severe cardiac arrhythmias due to autonomic dysfunctions, its molecular mechanisms remain unclear. To investigate the role of cardiac β1-Adrenergic (β1AR) and A1-Adenosine (A1R) receptors in these dysfunctions, the pharmacological effects of stimulation...

Background: Although several studies suggest that heparins prevent arrhythmias caused by acute myocardial infarction (AMI), the molecular mechanisms involved remain unclear. To investigate the involvement of pharmacological modulation of adenosine (ADO) signaling in cardiac cells by a low-molecular weight heparin (enoxaparin; ENOX) used in AMI the...

Este estudo investigou a relação entre estimulação cognitiva e exercício físico sobre a qualidade do sono, estado de humor e funções cognitivas de idosos saudáveis. Sessenta idosos de ambos os gêneros foram distribuídos em três grupos: Grupo Controle – GC (n=20); Grupo Estimulação Cognitiva – GEC (n=20) e Grupo Exercício Físico – GEF (n=20). A Esca...

Loperamide is a synthetic opioid commonly used as an antidiarrheal due to its activation of u-opioid receptors in the myenteric plexus. In therapeutic doses, it inhibits peristalsis and has anti-secretory and anti-motility effects, until metabolized by intestinal and hepatic CYP3A4 and CYP2C8 into inactive metabolites. Furthermore, loperamide also...

Pacientes oncológicos, geralmente, são submetidos a tratamentos quimioterápicos e radioterápicos, os quais tendem a causar problemas relacionados a intensos processos inflamatórios, de desnutrição, náuseas e êmese. Por isso, realizar a suplementação nestes pacientes é importante e necessário, pois isso favorece o paciente oncológico sob o ponto de...

To evaluate, describe and compare the pharmacological treatments available for heart failure (HF). This is a literature review about the pharmacological treatment of HF based on articles selected from the PubMed database, as well as relevant guidelines, using pertinent keywords and application of inclusion and exclusion criteria. Chronic heart fail...

Introdução: A fluoresceína sódica (FS) é um corante, do tipo xanteno, utilizado no campo cirúrgico tanto para procedimentos oftalmológicos quanto neurocirúrgicos; neste último caso atualmente sendo aplicado à delimitação de barreira hematoencefálica (BHE) em caso de rompimento desta por diversos tipos de tumores cerebrais, como os gliomas. Objetivo...

Introdução: A Erva-baleeira (Varronia curassavica Jacq.) é uma planta medicinal e aromática originária do Brasil. A espécie pertence à família Boraginaceae e tem grande relevância econômica devido ao óleo essencial presente em suas folhas. A planta possui importantes ações, como atividade contra o mosquito Aedes aegypti, no entanto, seu principal e...

Cannabis sativa has been applied for medicinal purposes for thousands of years. Cannabidiol is the main non-psychotropic compound in Cannabis sativa, and has its therapeutic effect extremely linked to the central nervous system, presenting pharmacological properties with great potential for the treatment of several pathologies. The aim is to identi...

Foodborne diseases (FBD) present high prevalence worldwide and more than 250 types have been reported. The main agents are Staphylococcus aureus, Escherichia coli, Salmonella and certain parasites. The habit of consuming foods sold in street markets in the city of São Paulo exposes consumers to the risk of acquiring FBD. 25 samples of vinaigrette s...

Purpose To evaluate the preventive cardioprotective effects of resveratrol and grape products, such as grape juice and red wine, in animal model of cardiac ischemia and reperfusion. Methods Male Wistar rats orally pretreated for 21-days with resveratrol and grape products were anesthetized and placed on mechanical ventilation to surgically induce...

Background: Both the new coronavirus (SARS-CoV-2), the etiological agent, and the pandemic disease caused by it, COVID-19, are currently the most studied subjects in the world, due to the fact that they caused and continue to cause millions of deaths worldwide. To date, many drugs have been and are being used to treat patients with COVID-19, some w...

O vírus da dengue é um arbovírus da família dos flavivírus. Há quatro tipos de vírus: DEN (1, 2, 3 e 4), sendo o DEN3 o mais grave. É transmitido pelo Aedes aegypti. As formas clínicas são: a Dengue Clássica, Dengue com Complicações e a Febre Hemorrágica da Dengue. O Brasil é responsável por 70% dos casos da doença nas Américas. O objetivo deste tr...

Introduction: There are seven known species of human coronavirus capable of causing respiratory diseases. The most recent is SARS-CoV-2, the etiologic agent of COVID-19. Objective: To evaluate the main characteristics of SARS-CoV-2, the pathophysiology of COVID-19 and the main measures for prevention and containment of disease progression. Methods:...

O estudo pretendeu avaliar a fisiopatologia correlacionada, as diferenças de sexo e as comorbidades associadas à síndrome da apneia e hipopneia obstrutiva do sono. Trata-se de uma revisão de literatura realizada a partir dos dados obtidos pesquisas com as palavras-chaves “Síndrome de Apneia e Hipopneia do Sono”, “Fisiopatologia”, “Fatores de Risco”...

Abstract: Purpose: To evaluate whether the attenuation of mitochondrial Ca2+ overload produced by pharmacological blockade of mitochondrial Ca2+ uniporter (MCU) protects the myocardium against injuries caused by cardiac ischemia and reperfusion (CIR). Methods: CIR was induced in adult male Wistar rats (300-350 g) by occlusion of the left anterior...

Most severe manifestations of COVID‐19 cases, such as multiple organ failure and death, have been linked to coagulation dysfunction markers, such as platelet reduction and increases in prothrombin time, fibrin degradation products and, mainly, D‐dimer [1]. A recent paper by Tang et al. [2] in this journal reported that heparin treatment reduced mor...

A qualidade do ar respirável (AR) utilizado no manejo de paciente tem sido objeto de interesse em medicina, uma vez que, se não adequada, pode oferecer o risco de doenças de várias etiologias, incluindo as de caráter infeccioso. Os sistemas de produção, armazenamento e distribuição do AR medicinal devem garantir condições seguras de funcionamento p...

Ischemic heart diseases (IHD) are the leading cause of death worldwide. Although the principal form of treatment of IHD is myocardial reperfusion, the recovery of coronary blood flow after ischemia can cause severe and fatal cardiac dysfunctions, mainly due to the abrupt entry of oxygen and ionic deregulation in cardiac cells. The ability of these...

Parkinson’s disease (PD) is one of the most common age-related neurodegenerative disorders. Several studies over the last few years have shown that PD is accompanied by high rates of premature death compared with healthy controls. Death in PD patients is usually caused by determinant factors such as pneumonia, and cerebrovascular and cardiovascular...

Introdução: A epilepsia é uma doença que afeta milhões de pessoas em todas as partes do mundo. Crises epilépticas se apresentam nos pacientes de forma parcial ou generalizada, dependendo do grau de atividade da doença. Atualmente, há muitos fármacos disponíveis no mercado, os quais possuem diversos mecanismos de ação e que podem ser utilizados de f...

Purpose: To evaluate the cardioprotective response of the pharmacological modulation of β-adrenergic receptors (β-AR) in animal model of cardiac ischemia and reperfusion (CIR), in spontaneously hypertensive (SHR) and normotensive (NWR) rats. Methods: CIR was induced by the occlusion of left anterior descendent coronary artery (10 min) and reperf...

Objetivo: identificar as manifestações clínicas da necrólise epidérmica tóxica (NET) e síndrome de Stevens Johnson (SSJ). Método: trata-se de uma revisão narrativa. A busca dos artigos utilizou a ferramenta Publish or Perish, que ranqueia os trabalhos com base no número de citações recebidas. Foram realizadas duas buscas, pois apesar das doenças se...

Ischemic heart diseases (IHD) are the leading cause of death worldwide. Although the principal form of treatment of IHD is myocardial reperfusion, the recovery of coronary blood flow after ischemia can cause severe and fatal cardiac dysfunctions, mainly due to the abrupt entry of oxygen and ionic deregulation in cardiac cells. The ability of these...

Purpose: To investigate the cardioprotective effects of ischemic preconditioning (preIC) and postconditioning (postIC) in animal model of cardiac ischemia/reperfusion. Methods: Adult rats were submitted to protocol of cardiac ischemia/reperfusion (I/R) and randomized into three experimental groups: cardiac I/R (n=33), preCI + cardiac I/R (n=7) a...

Purpose: To evaluate in vivo animal model of cardiac ischemia/reperfusion the cardioprotective activity of pancreatic lipase inhibitor of the orlistat. Methods: Adult male Wistar rats were anesthetized, placed on mechanical ventilation and underwent surgery to induce cardiac I/R by obstructing left descending coronary artery followed by reperfus...

Cardioprotective effect of lipstatin derivative orlistat on normotensive rats submitted to cardiac ischemia and reperfusion 1 Abstract Purpose: To evaluate in vivo animal model of cardiac ischemia/reperfusion the cardioprotective activity of pancreatic lipase inhibitor of the orlistat. Methods: Adult male Wistar rats were anesthetized, placed on me...

A baixa estatura infantil está relacionada a fatores como morbidade, mortalidade, baixa estatura na idade adulta, e estado nutricional, podendo ser causada por influências genéticas ou ambientais. Objetivo: Revisar na literatura acerca das técnicas a suplementação do zinco ou a utilização de hormônio GH no crescimento de crianças, comparando suas v...

Introdução: As situações metabólicas que cursam com distúrbios nos processos de digestão e absorção, acarretam vários prejuízos ao equilíbrio do organismo A retirada de 70 a 75% nos segmentos do intestino poderá resultar em doenças que acarretam diversas carências. Quando a ressecção é no colón, aumenta a gravidade do quadro, sendo caracterizada co...

Este relato teve como objetivo mostrar como a implantação do Programa 5S pode melhorar a qualidade do serviço e trazer benefícios a instituição e colaboradores. Foi realizado uma análise do Serviço de Refeição aos Educandos, onde foram observados a estrutura física, os procedimentos realizados e relatórios administrativos. A aplicação da ferramenta...

Segundo o Ministério da Saúde “ter mãos limpas é um direito e um dever” e para promover práticas sociais e de saúde e ensinar hábitos de higiene através de ações educativas, a escola é o espaço ideal. Esse trabalho tem como objetivo avaliar o conhecimento de crianças do 3° ao 5° ano do ensino fundamental, com relação à importância da higiene das mã...

Purpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+IR: intravenous saline infusion following superior mese...

Cancer is a major public health problem and the second leading cause of mortality around the world. Antitumor immunotherapy using monoclonal antibodies is considered selective and efficient in the treatment of different types of tumors, but its cost and toxic effects limit its application. Many tumor microenvironments, including lymphoma and carcin...

Background: Acute myocardial infarction (AMI) is characterized by ischemic lesions that severely compromise the cardiac structure/function, besides the survival of mammals. Although conventional therapy uses cardiac reperfusion, this procedure increases the cardiac damage caused by ischemia. Methods: Adult male Wistar rats (NWR) were anesthetized,...

This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the in...

To study cardioprotective drugs, we developed a simple and efficient methodology to evaluate effects of drugs on cardiac electrical activity using electrocardiogram (ECG) in rats submitted to cardiac ischemia-reperfusion (I/R). Using adult male Wistar rats (14-16-week-old) anesthetized (urethane 1.25 g/kg, i.p.) and kept under mechanical ventilatio...

Introdução: A hipertensão arterial é um dos fatores de risco para doenças cardiovasculares, estando diretamente associada ao elevado consumo de sódio. Objetivo: Avaliar os níveis de marcadores de lesão hepática, renal e cardíaca em ratos hipertensos comparados aos seus controles normotensos, tratados com um salgante isento de sódio, água ou NaCl. M...

Cell signaling is a crucial event for the survival and progress of normal cellular functions. However, mutations of certain genes can lead to the emerging of cancer cells, which can use these signaling mechanisms for their survival, growth and dissemination. Among these mechanisms, we highlight the role of cyclic nucleotides such as cAMP, and Ca2+...

Cardiovascular diseases (CD) are one of the main causes of death in the world, among them is ischemic cardiac disease (ICD). ICD is believed to cause 26 million deaths worldwide by 2030 [1,2]. Among ICD, acute myocardial infarction (AMI) is the most common cause of morbidity and mortality in the world [2,3]. AMI is characterized by a long period, a...

This discusses how pharmacological modulation of the Ca2+/cAMP signaling interaction could be an important neuroprotective and cardioprotective strategy to protect the dopaminergic neurons from cell death related to Parkinson’s disease (PD) and at the same time to prevent the cardiac collapse in sudden unexpected death in PD.

Since 1975, several clinical studies showed that L-type voltage-activated Ca 2+ channels (VACC) blockers used in the antihyper-tensive pharmacotherapy, such as verapamil and nifedipine, produced vasodilation and reduction of arterial pressure associated with a paradoxical increase in plasma catecholamines levels and heart rate. Initially, these res...

Introdução: A displasia ectodérmica anidrótica com imunodeficiência (DEA) é uma doença caracterizada por mutações nos genes que codificam o NF-kB. Objetivo: Avaliar o efeito do NF-B na regulação gênica dos componentes do sistema NADPH oxidase de pacientes com DEA. Métodos: Sangue periférico de pacientes com DEA e indivíduos saudáveis foram coletad...

Este trabalho relata a experiência de um município da grande São Paulo - SP na adoção da pesquisa de satisfação do usuário SUS como ferramenta para a gestão pública. Utilizou-se a metodologia de pesquisa documental e entrevista que se viabilizou por meio de visita técnica ao setor desenvolvedor do projeto de pesquisa de satisfação. Na análise docum...

A obesidade é uma doença de etiologia multifatorial que está diretamente associada à doenças cardiovasculares ou síndrome metabólica, sendo responsável por grande número de mortes em todo o mundo. Diante das consequências que esta pandemia pode trazer, foi realizada uma pesquisa entre 888 alunos de uma Instituição de Ensino Superior para saber a pr...

Introdução: Os alimentos são facilmente contaminados por microrganismos, e esta contaminação pode estar presente na natureza, na sua manipulação e no seu processamento. A presença e o número de microrganismos patogênicos acima dos padrões estabelecidos podem diminuir a qualidade e a durabilidade do produto, além de apresentar sérios riscos à saúde...

Introduction: Common variable immunodeficiency (CVID) is an immunological disorder characterized by defective antibody production. Objectives: To study lymphocytes number, surface activation molecules, cell markers, lymphoproliferative response, cytokine production, and cell death. Methods: A study was led on thirty four patients with CVID selected...

The present study evaluated electrocardiographic alterations in rats with epilepsy submitted to an acute myocardial infarction (AMI) model induced by cardiac ischemia and reperfusion. Rats were randomly divided into two groups: control (n=12) and epilepsy (n=14). It was found that rats with epilepsy presented a significant reduction in atrioventric...

Introduction: Nucleic acid methylation may have major effects on gene expression patterns and, by consequence, on the development of autoimmunity, like Systemic Lupus Erythematosus (SLE). Objective: To investigate the pattern of global DNA methylation in SLE patients and compare this pattern with laboratory parameters. Methods: Genomic DNA was isol...

The demand and consumption of fish and their derivatives has increased considerably in recent years. However, fish are ideal hosts of numerous parasites, highlighting the need to develop new research methodologies for its detection. The aim of present study was to compare the efficacy of Ascocotyle metacercariae (Trematoda: Digenea) extraction from...

RESUMO Os hormônios glicocorticóides regulam vários processos fisiológicos, incluindo a gliconeogênese, reatividade vascular as catecolaminas, respostas inflamatória e imune e a atividade do SNC. O uso clínico dos glicocorticóides é indicado na deficiência suprarrenal congênita ou adquirida, doenças reumáticas, renais, alérgicas, infecciosas, oftal...

Skeletal muscle contraction is triggered by acetylcholine induced release of Ca(2+) from sarcoplasmic reticulum. Although this signaling pathway is independent of extracellular Ca(2+), L-type voltage-gated calcium channel (Cav) blockers have inotropic effects on frog skeletal muscles which occur by an unknown mechanism. Taking into account that ske...

β(2)-Adrenoceptor (β(2)-AR) agonists increase skeletal muscle contractile force via activation of G(s) protein/adenylyl cyclases (AC) and increased generation of cAMP. Herein, we evaluated the possible dual coupling of β(2)-AR to G(s) and G(i) proteins and the influence of the β(2)-AR/G(s)-G(i)/cAMP signaling cascade on skeletal muscle contraction....

Introduction: Spinocerebellar ataxias (SCA) are genetic neuro-degenerative diseases that are characterized by a progressive loss of cerebellar neurons. In Brazil, the most common form of SCA is the SCA3, also known as Machado-Joseph Disease (MJD). Objective: To describe the feelings and expectations of the MJD patients about their own illness. Meth...

Seven-transmembrane receptors mediate diverse skeletal muscle responses for a wide variety of stimuli, via activation of heterotrimeric G-proteins. Herein we evaluate the expression and activation of rat diaphragm or cultured skeletal muscle G-proteins using [(35)S]GTPγS. Total membrane Gα subunit content was 4-7 times higher in rat primary culture...

Introduction: Acute (ARF) or chronic (CRF) renal failure are frequent complications of individuals hospitalized in the Intensive Care Unit (ICU). Objective: To quantify in these patients the incidence of ARF and CRF, and underlying diseases that may progress to these conditions in order to provide information for a systematization of care for patie...

Introduction: Chronic Renal Failure (CRF) is characterized by progressive reduction of kidney function. When his terminal stage settles, it becomes necessary to implement some of the modalities of Renal Replacement Therapy (RRT) as, for example, hemodialysis (HD). Objective: To identify the most prevalent etiologies in patients with CRF in HD. Meth...

Introduction: The kidneys are responsible for maintaining the stability of the internal environment of the organism. Renal failure is a condition in which the kidneys fail in the attempt to remove the end products of metabolism. Treatment with Renal Replacement Therapy (SRT) is recommended when renal function is less than 10-15%, and hemodialysis (...

Objetivos: A litíase urinária (LU) é uma doença de grande prevalência mundial que gera muitos custos aos sistemas de saúde. Objetiva-se neste estudo identificar a prevalência e recorrência de LU em uma amostra de estudantes universitários da cidade de São Paulo. Dos 125 participantes (29M/96F,28±6anos), foram coletados dados com respeito a idade, s...

Objectives: Staff telemarketing are up to 6 hours sitting with difficult access to water and breaks pre-determined to urinate. Quantify the presence of signs suggestive of kidney stones could provide evidence of increased predisposition to calculi in this group of workers. Method: Sex, age, weight, height, ethnicity, color and smell of urine, prese...