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Francisco Jose Rosales

Francisco Jose Rosales
Ventura Translational Research LLC · R&D and Medical Affairs

M.D. Sc.D.

About

52
Publications
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1,203
Citations

Publications

Publications (52)
Article
Full-text available
Rett syndrome (RTT) is a postnatal neurodevelopmental disorder that primarily affects girls, with 95% of RTT cases resulting from mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Choline, a dietary micronutrient found in most foods, has been shown to be important for brain development and function. However, the exact effects and mechanis...
Article
Full-text available
Rett syndrome (RTT) is a postnatal neurodevelopmental disorder that primarily affects girls. Mutations in the methyl-CpG-binding protein 2 (MECP2) gene account for approximately 95 % of all RTT cases. To model RTT in vitro, we generated induced pluripotent stem cells (iPSCs) from fibroblasts of two RTT patients with different mutations (MECP2 R306C...
Article
Full-text available
Nutrient deficiencies during childhood have adverse effects on child growth and health. In a single-arm 48-week long-term intervention, we previously reported the efficacy of oral nutritional supplementation (ONS) and dietary counselling on catch-up growth and growth maintenance in nutritionally at-risk Filipino children. The present analysis was d...
Article
Full-text available
Background The benefits of short-term oral nutritional supplementation (ONS) in undernourished children are well-established. The benefits of long-term ONS in promoting longitudinal growth and health in children who are at risk of undernutrition have not been reported previously.Methods In this 48-week prospective, single-arm, multicentre trial, 20...
Article
Full-text available
Cite this article: Rosales FJ (2015) Post-infectious Irritable Bowel Syndrome: an opportunity for prebiotics as an adjunct therapy of oral rehydration salts/ solutions. J Hum Nutr Food Sci 3(1): 1056.
Article
Full-text available
Background Hospital malnutrition is a significant problem that still remains under-recognised and under-treated in India. The present study assessed the effects of oral nutritional supplementation (ONS) in conjunction with dietary counselling versus dietary counselling (control) alone in malnourished patients when given in hospital and post-hospita...
Patent
Full-text available
A novel method for determining the bioactivity of TGF-β in a sample of milk, raw protein source, or nutritional composition is provided. The method includes particular reconstitution steps, centrifugation steps, incubation steps, and activation steps. The bioactivity of the TGF-β in the sample may be measured in a HT-2 cell bioassay or a cellomics...
Article
Full-text available
Taurine is a sulfur-containing amino acid present in high concentrations in mammalian tissues. It has been implicated in several processes involving brain development and neurotransmission. However, the role of taurine in hippocampal neurogenesis during brain development is still unknown. Here we show that taurine regulates neural progenitor cell (...
Article
Full-text available
The preschool years (i.e. 1-5 years of age) is a time of rapid and dramatic postnatal brain development (i.e. neural plasticity), and of fundamental acquisition of cognitive development (i.e. working memory, attention and inhibitory control). Also, it is a time of transition from a direct maternal mediation/selection of diet-based nutrition to food...
Article
Oddy WH, Rosales F. A systematic review of the importance of milk TGF-β on immunological outcomes in the infant and young child. Pediatr Allergy Immunol 2010: 21: 47–59. © 2009 Mead Johnson Nutrition Journal compilation © 2009 John Wiley & Sons A/S Cytokines in milk like transforming growth factor-beta (TGF-β) have been shown to induce oral toleran...
Article
Full-text available
This symposium examined current trends in neuroscience and developmental psychology as they apply to assessing the effects of nutrients on brain and behavioral development of 0-6-year-olds. Although the spectrum of nutrients with brain effects has not changed much in the last 25 years, there has been an explosion in new knowledge about the genetics...
Article
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Vitamin A (VA) kinetics was studied in rats with marginal VA stores before, during, and after inflammation. Rats received orally [11,12-(3)H(N)]retinol ([(3)H]VA; day 0), and inflammation was induced on day 21 with lipopolysacchride (LPS) for 3 days (n = 5) or recombinant human interleukin-6 (rhIL-6) for 7 days (n = 5). Both the fraction of [(3)H]V...
Article
Full-text available
Nutritional surveys use acute phase protein (APP) biomarkers such as C-reactive protein (CRP) and alpha1-acid glycoprotein (AGP) to identify the influence of inflammation on the distribution of iron status biomarkers. Few, however, have examined which biomarker better identifies persons with spurious elevations in iron status markers. We explored t...
Article
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We examined the association between alpha(1)-acid glycoprotein (AGP), all-trans-retinol (retinol), and albumin concentrations in a longitudinal animal model of IL-6-induced inflammation. Vitamin A-sufficient (VAS) male Sprague-Dawley rats were administered recombinant human IL-6 [n = 4, 65 mug/(kg.d)] or PBS (n = 4) continuously for 7 d via osmotic...
Article
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JPER is a multi-disciplinary journal that promotes the health of the preterm infant.
Article
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Free holo-retinol binding protein (RBP) [i.e., unbound to transthyretin (TTR)] plays a role in transporting vitamin A across the placenta during pregnancy. In a cross-sectional study of clinically healthy urban women, we assessed the association among clinical and biochemical factors on estimated concentrations of free holo-RBP during the last trim...
Article
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We assessed the effects of prolonged reduction of plasma retinol concentrations (hyporetinolemia) on the distribution of tissue vitamin A (VA) and of its active compounds using a model of continuous recombinant human interleukin-6 (rhIL-6) infusion via osmotic minipumps in VA-sufficient male rats. Plasma retinol and retinol-binding protein (RBP) co...
Article
The effects of iron on zinc status, oxidative stress, and inflammation were assessed in a randomized placebo-controlled trial; 66 children aged 8 to 11 years received iron (20 mg/d of elemental iron), zinc (42.5 mg/d of elemental zinc), or iron and zinc combined (20 and 42.5 mg/d, respectively) for 8 weeks. Hemoglobin, plasma ferritin (FT), and zin...
Article
Iron deficiency is a public health problem in infancy. We assessed the efficacy of iron supplements in infants with inflammation on iron status and subsequent inflammation. This was a prospective, nested, case-control study of 6- to 12-mo-old infants participating in the International Research on Infant Supplementation study, Indonesia. Cases (n =...
Article
The purpose of this study was to determine a cut-off value of the molar ratio of retinol-binding protein to transthyretin (RBP:TTR) to indicate marginal vitamin A (VA) deficiency. Plasma RBP and TTR were measured by radial immunodiffusion in two groups of patients, i.e., surgical patients with known hepatic VA stores, and a cohort of children resid...
Article
Full-text available
This is an a posteriori analysis of previously published data to assess whether improving vitamin A (VA) status resolves measles-related pneumonia (MP). Nonhospitalized acute measles patients (2 d of rash onset) had their VA status determined based on the molar ratio of retinol-binding protein to transthyretin (RBP/TTR). Using a cutoff value of </=...
Article
Acute phase proteins (APPs) are associated with malaria-induced hyporetinemia (serum retinol <0.70 micromol/L); however, the degree of the association is not well documented. The association between malaria-induced hyporetinemia and APPs was assessed. In a cross-sectional study, 90 children with serum retinol concentrations from <0.35 to >1.05 micr...
Article
Full-text available
It is currently unknown whether the capacity of the liver to esterify and store vitamin A (VA) changes as a function of long-term VA intake or age. The objective of this study was to investigate whether age and/or VA status are factors for the hepatic expression of cellular retinol-binding protein (CRBP), the esterification of retinol by lecithin:r...
Article
Full-text available
We assessed whether iron deficiency alters the concentration of vitamin A (VA) in plasma or liver and the chemical distribution between hepatic unesterified and esterified retinol. Weanling male Sprague-Dawley rats (n = 10/group) were allocated to one of four diet groups: low iron (ID3, 3 mg of elemental iron/kg diet), marginal iron (ID15, 15 mg/kg...
Article
To assess whether the molar ratio of retinol-binding protein (RBP) to transthyretin (TTR) is of utility in detecting vitamin A (VA) deficiency during inflammation, we analyzed data from a rat model of endotoxin-induced inflammation and from a previously reported randomized, placebo-controlled trial of VA supplementation in children with acute measl...
Article
Full-text available
Plasma retinol is reduced during numerous infections, and inflammation alters the hepatic synthesis of retinol-binding protein (RBP). In this study, we have investigated the effects of endotoxin-induced inflammation on vitamin A (VA) supplementation in a rat model of marginal VA deficiency. Marginally VA-deficient rats received an intraperitoneal d...
Article
To assess the combined use of plasma RBP and TTR in interpreting whether low plasma retinol is due to a deficiency of vitamin A (VA) or to inflammation, we have used a rat model and data from a randomized controlled community trial of VA supplementation in post-measles infected children. Plasma retinol, RBP and TTR concentrations were determined in...
Article
Few studies of aging have been conducted in animals whose nutritional status has been controlled throughout their lifetime. Previously, vitamin A (VA) has been implicated in immune functions in acute studies of VA deficiency and retinoid repletion. We have evaluated how chronic VA nutritional status affects plasma retinol, its transport proteins, l...
Article
Full-text available
The acute inflammatory response to tissue injury and infection is associated with low concentrations of plasma retinol and its specific transport proteins, retinol-binding protein (RBP) and transthyretin (TTR). To examine the kinetics and mechanism of hyporetinemia, we have induced acute inflammation with lipopolysaccharide (LPS, from Pseudomonas a...
Article
Full-text available
The authors assessed the efficacy of the World Health Organization (WHO) recommendation of 200,000 IU of vitamin A in oil to treat acute non-xerophthalmic measles patients. Acute measles patients who did not require hospitalization were enrolled in a randomized, double-masked, clinical trial of vitamin A (n=90) versus placebo (n=110) carried out in...
Article
To assess whether urinary retinol excretion is due to inflammation or to other causes, vitamin A-marginal and -sufficient rats (4/ group) were treated i.p. with 50 μg of lipopolysaccharide (LPS) from P. aeruginosa/ 100 g of b.w. In a second experiment, 16 marginal rats were treated with LPS or saline, followed six hours later by an oral dose of 2 m...
Article
This trial assessed the effect of vitamin A on reversing measles-induced unresponsiveness to recall antigens and on enhancing measles antibody production. These assessments were part of a randomized, double-masked clinical trial of the efficacy of 210 mumol of retinol as retinyl palmitate for reducing measles-associated morbidity. Two hundred child...
Article
Vitamin A toxicity is a concern among health care providers, especially when present recommendations for vitamin A may result in multiple dosing during a short period of time. We observed no vitamin A toxicity in 5 children who received multiple high doses of vitamin A. These 8-month to 5-year-old children were part of a community trial of vitamin...
Article
We performed a case-control study in 46 Guatemalan adults aged 26 to 79 years with a recent history of cataract extraction and 46 controls matched for sex, age (±5 years), and altitude of residence (±400m). The aetiological variables studied included: (i) effect of lactose digesting capacity as reflected by chance in breath hydrogen concentration;...
Article
Sir.—The article by Frieden et al1 in the February 1992 issue of AJDC provided useful information about the changes in plasma retinol during measles infection in young children. In this report, as well as in other studies, plasma and/or serum retinol levels were markedly reduced during the acute phase of measles, but only Frieden et al have reporte...
Article
To examine the association between methane (CH4) excretion and experimental colonic carcinogenesis, we measured CH4 excretion in rats treated with the colonic carcinogen azoxymethane (AOM, 7 mg/kg weekly for 10 weeks) and paired controls. CH4 excretion was not initially detected in either experimental or control groups, but all animals acquired pos...
Article
Full-text available
In vitro studies of lactose hydrolysis in milk with 20-125 neutral lactase units (NLUs) carried out at 38.0 degrees C for 15 min with a beta-galactosidase derived from Kluyveromyces lactis (Lactaid, Lactaid Inc, Pleasantville, NJ) resulted in 85-95% of the hydrolysis observed with standard incubation conditions (24 h at 4-5 degrees C with 1000 NLU/...

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This review emphasizes the clinical importance of Post-Infectious IBS (PI-IBS) in contributing to IBS prevalence and highlight the alterations of the intestinal microbiota observed in IBS. Based on the microbiota changes, the implementation of pre- biotics as an adjunct therapy of ORS may be a preventive measure of IBS in susceptible individuals.

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