Francisco Raga

Francisco Raga
University of Valencia | UV · Department of Paediatrics, Obstetrics and Gynecology

MD., PhD.

About

180
Publications
66,207
Reads
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3,273
Citations
Additional affiliations
January 1997 - December 1998
Stanford University
Position
  • PostDoc Position
January 1997 - December 1998
Center for Special Minimally Invasive & Robotic Surgery
Position
  • PostDoc Position
January 1993 - present
Hospital Clínico Universitario de Valencia
Position
  • Head of Department

Publications

Publications (180)
Conference Paper
Full-text available
Objectives: To explore the predictive capacity of feto-placental Doppler performed at 37 gestational weeks in identifying fetal growth restriction (FGR) and adverse perinatal outcome (APO). Methods: A prospective cohort of unselected singleton pregnancies scanned at 37 gestational weeks was constructed. At inclusion, biometry for estimated fetal we...
Presentation
Objectives: The precise estimation of follicle numbers in woman ovaries is a crucial and still challenging task in the field of reproductive medicine. Therefore, it is important to identify accurate markers that can reliably assess the ovarian reserve. The aim of this prospective study was to evaluate the accuracy of different ultrasonographic mode...
Poster
Objectives: The recent introduction of ulipristal acetate, a progesterone receptor modulator in the armamentarium of the gynecologist to deal with the symptoms generated by the most common gynecological tumor (myoma) has been a real revolution. In addition to its beneficial effect on fibroids, gynecologists need to get used to the associated endome...
Article
Full-text available
Cotyledonoid dissecting leiomyoma, also known as a “grape-like” myoma or Sternberg tumor, is a particularly uncommon variant of uterine fibroma that imitates malignant gross characteristics; however this tumor is a benign neoplasm clinically and pathologically. The name cotyledonoid leiomyoma originates from the characteristic macroscopic appearanc...
Article
Full-text available
In this case report the diagnosis of a uterine lipoleiomyoma is depicted by means of a three-dimensional radiance mode. The advent of radiance or silhouette mode as a new tool in ultrasound diagnosis is intended to assist by generating additional realistic image visualization and a better distinction among different tissues.
Article
STUDY QUESTION Could cell therapy using autologous peripheral blood CD133+ bone marrow-derived stem cells (BMDSCs) offer a safe and efficient therapeutic approach for patients with refractory Asherman's syndrome (AS) and/or endometrial atrophy (EA) and a wish to conceive?
Article
Objective: To demonstrate that the use of 3D/4D HDLive increases the image quality in the diagnosis of benign cystic ovarian teratomas. Materials and methods: 3D/HDLive ultrasound (US) was used in 31 cases of suspected ovarian cystic teratoma using vaginal 2D US. The following pathognomonic images of mature cystic teratomas were considered for d...
Article
Full-text available
The use of three-dimensional/four-dimensional (3D/4D) ultrasound has become ‘universal’ in the increasingly precise diagnosis of fetal malformations. The introduction of new ultrasound modes, such as the HDlive or the Radiance System Architecture (RSA), which improve even more the quality of images, makes it easier to examine normal embryos and fet...
Article
Full-text available
Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting reproductive-aged women. The exact etiology of this condition remains elusive and the definition of the syndrome has undergone several revisions in which ovarian morphology plays a central role. This review describes several and modern three-dimensional (3D) ultrasound mode...
Article
Full-text available
Modern three-dimensional (3D) ultrasound tools, HDlive and radiance system architecture or silhouette offer unique ways for assessing women with ovarian masses; providing realistic 3D reconstructions of the ovarian tumors, together with essential information to facilitate the differentiation between benignity and malignancy of ovarian masses. How...
Article
HDlive;diagnosis;cystic myoma;ulipristal acetate;degeneration;vascular
Article
Full-text available
Abdominal and/or vaginal two dimensional (2D) and threedimensional (3D) ultrasound (US) are the ‘gold standard’ technology on which diagnosis and control of gynecological tumors depend. In recent years, a series of software that initially generated enormous interest, have been introduced to improve 2D/3D US image quality and diagnostic accuracy. Ma...
Article
Full-text available
The development of the female genital system is a complex embryological process. Congenital malformations of the female genital tract may occur isolated or in combination with urologic defects. The aim of this review is to describe novel ultrasonographic advances to improve diagnostic accuracy of Müllerian malformations and to facilitate decisions...
Article
Full-text available
Herein a case of sirenomelia diagnosed in week 12 by using HDlive and three-dimensional (3D) imaging. These new technologies allowed for an early diagnosis and also depicting realistic images. How to cite this article Bonilla-Musoles F, Caballero O, Castillo JC, Bonilla F Jr, Raga F. HDlive and Three-Dimensional Imaging in Prenatal Diagnosis of Si...
Article
The aim of this study was to present two patients with the same alterations in their genital system. These alterations are not included in the classical classification of Müllerian malformations because of their co-occurrence. An accurate diagnosis is essential for correct management, because the identification of septate uterus with double cervix...
Article
This article shows week by week the embryonic and fetal images appeared during the development using HDlive. We show in this chapter different images of normal and pathological fetuses till the 14th gestational week. As said before, HDlive improves image quality compared to 3D/4D. How to cite this article Bonilla-Musoles F, Esquembre MJ, Bonilla F...
Article
Mature cystic ovarian teratomas are the most common benign ovarian tumors. For their diagnosis, the following ultrasound (US) images can be considered as pathognomonic: • A cystic lesion (unilocular, very frequent, or multiple, with a densely echogenic tubercle (Rokitansky nodule). • A diffuse or partially echogenic mass with the echogenic area usu...
Article
The evaluation of the following assisted human reproduction situations using HDlive are described: natural cycles and corpus luteum, IVF stimulated cycles, gynecological pathologies related with infertility and Müllerian malformations. How to cite this article Castillo JC, Caballero O, Bonilla F Jr, Raga F, Bonilla-Musoles F. HDlive in Assisted Hu...
Article
The different IUDs types (Mirena, Copper T and Ancora) are shown using HDlive. This new technology allows a better vision of the levonorgestrel IUD, extremely difficult to observe with 2D. How to cite this article Bonilla-Musoles F, Raga F, Caballero O, Esquembre MJ, Bonilla F Jr, Castillo JC, Machado LE. Assessment of Long-Acting Reversible Intra...
Article
Full-text available
Abdominal and/or vaginal two-dimensional (2D) and threedimensional (3D) ultrasound (US) are the ‘gold standard’ technology on which diagnosis and control of gynecological tumors depend. In recent years a series of software that initially generated enormous interest, have been introduced to improve 2D/3D US image quality and diagnostic accuracy. Man...
Article
Los ultrasonidos de alta definición en tiempo real (HDLive US) incorporan un software que calcula la propagación de la luz a través de superficies y en relación con la dirección de la misma. Esta fuente de luz puede ser posicionada libremente con el fin de iluminar las áreas de interés deseadas, permitiendo así imágenes de mejor calidad, una mayor...
Article
HDlive (high-definition live or real-time US), a new ultrasound software, combines a movable virtual adjustable light source in a software that calculates the proportion of light reflecting through surface structures, depending on light direction. The light source can be manually positioned to illuminate the desired area of interest. The ultrasound...
Article
Two-dimensional (2D) ultrasonography is the fundamental technology on which diagnosis, management, and control in reproductive medicine depends. Over the years there have been efforts to improve 2D ultrasound image quality. In recent years, a series of software has appeared that has generated enormous interest. The goal of these modes has been to i...
Article
An adequate endometrial receptivity is a crucial factor for embryo implantation. We describe endometrial morphology (endometrial appearance or pattern, endometrial thickness, volume, and delimitation), based on the concepts and possibilities of the new ultrasound modalities (3-dimensional/4-dimensional ultrasound, automatic volume calculation, virt...
Article
Full-text available
High definition real-time ultrasound (HDLive US) incorporates software that calculates the propagation of light through surface structures in relation to the light direction. This light source can be freely positioned in order to illuminate the desired area of interest allowing a better image quality, a better sensation of deepness and easier visua...
Article
A prospective study of 63 singleton pregnancies between 11 + 0 and 13 + 6 weeks gestation underwent semi-automatic nuchal translucency (NT) measurement and were compared with two-dimensional ultrasonography (2D US). Inter-observer variation and the repeatability were evaluated. Sono T automatically achieves mid-sagittal plane views and measures the...
Article
We report a case of isolated agnathia, detected at 21+4 weeks’ gestation by two and three-dimensional (3D) ultrasound when routine morphological scan was performed. The scan showed an alteration of the fetal profile suggesting mandible agenesis, as well as cleft lip and palate, and low implantation ears. No midline alterations were found. Midsagitt...
Article
The volume ultrasound technology software known as the HDlive technique represents an innovative tool, a step towards an even more realistic anatomical visualization of pelvic organ structures. HDlive can help improve physician-patient communication with the aid of life-like images and might prove useful in the field of assisted reproduction treatm...
Article
High definition real time ultrasound (HDLive US) incorporates software that calculates the propagation of light through surface structures in relation to light direction. This light source can be freely positioned in order to illuminate the desired area of interest allowing better image quality, better sensation of deepness and easier visualization...
Article
Full-text available
The use of three-dimensional (3D) ultrasonography since the first trimester of pregnancy allows the diagnosis and follow-up of cord entanglement throughout the entire pregnancy and delivery. This technology permits a more accurate diagnosis when compared with two-dimensional (2D) ultrasonography or Doppler The vast majority of cord entanglements ob...
Article
Objective To determine whether anti-Müllerian hormone (AMH) and antral follicle count (AFC) could be used as predictors of ovarian reserve.
Article
Full-text available
The acardius fetuses or TRAP, consequence of vascular anastomoses in the placenta, may disrupt organogenesis in the recipient.They are classified as acardius amorphous, acormus, acephalus and anceps. Diagnosis is now possible during the first trimester by using trasnvaginal 3D Doppler Angiography. Conjoined twins are variants of monozygotic twins t...
Article
Heterotopic pregnancy consists of simultaneous intra and extrauterine pregnancy. The incidence is low in spontaneous pregnancies, but these pregnancies are more common when assisted reproductive technologies are used; therefore, diagnosis requires a high index of suspicion. We report the case of a 34-year-old woman with no history of interest and a...
Article
Ogilvie's syndrome is acute colonic pseudo-obstruction without mechanical obstruction, is a tipical complication of caesareas and hips surgery. It is difficult to diagnose, mainly, by having clinic similar to paralytic ileus, but with a much higher gravity. Its complications are ischemia and perforation, which can have when establishing a mortality...
Article
Full-text available
We report a case of anterior hypospadias, diagnosed at 26th week in a 37 years-old primigravida with normal 46XY kariotype through amniocentesis carried out at 16th week. Sonographic examination with 2D showed a short and curved penis. The use of three orthogonal planes, Tomographic Ultrasound Image (TUI) and VOCAL allowed an exact prenatal diagnos...
Article
The purpose of our retrospective observational series was to determine whether the sonographic characteristics of fetal megacystic bladders can be used to reliably establish the most likely diagnosis in fetuses with this condition. The sonographic records of pregnant patients referred to our institutions over a 10-year period who were found on init...
Article
Full-text available
Introduction Previous research has focused on miscarriage risk in the next pregnancy as a prognostic marker in women with recurrent miscarriage (RM) but the range of reported risk estimates is wide. We found no long-term follow-up studies on live birth outcome in patients with RM. We propose that live birth rate per time unit is a more reproducible...
Article
Full-text available
Recent development of three-dimensional (3D) and four-dimensional ultrasound (4D), specially using tomographic ultrasound image (TUI), inverse mode, automatic volume calculation (AVC) and virtual organ computer-aided analysis (VOCAL), provided us with new possibilities to study fetal low urinary obstructions before 24th week. Ultrasound scan studie...
Article
Spontaneous hepatic rupture associated with HELLP syndrome (hemolysis, elevated liver enzyme levels and low platelet count) is a very rare phenomenon that is frequently associated with a substantial rate of complications and mortality. In these cases, urgent management based on prompt delivery, blood transfusion and hepatic hemostasis is required.W...
Article
This study compares AFC and AMH values in 80 IVF cycles including low and normo responder patients with previous ART failure. The AFC obtained with 2D and 3D vaginal ultrasound scanning using inverse mode, AVC and VOCAL showed that the later were clearly superior. The correlation between AMH and AFC was statistically significant and shows that both...
Article
The purpose of this series was to determine whether the use of different 3-dimensional (3D) sonographic modes allows better definition of umbilical cord cysts and pseudocysts in utero. Two cases of umbilical cord cysts and 1 of a pseudocyst were analyzed and compared with 2-dimensional (2D), 3D, angiopower Doppler, tomographic ultrasound imaging (T...
Article
IntroductionUterine arteriovenous malformation (AVM) is more common than it is reported to be and is a potentially life-threatening condition often secondary to uterine trauma or pregnancy. Congenital origin is also reported but is less common.
Article
Based on our own studies using autoradiography, transmission and scanner electronmicroscopy, we describe the mechanisms of ovocitary demise along intrauterine life and years after birth. These findings tray to explain the key factors of the premature ovarian failure.
Article
This review focuses on the origin, action and production of HAM during follicular development and its importance for the knowledge of ovarian reserve. Based on recent publications, clinical applications are described, specially in cases of controlled ovarian stimulation, pathological conditions (high response, low response, PCOS, OHSS), prediction...
Article
Fetal ovarian cysts are the most common cause of prenatally diagnosed intra-abdominal cystic mass, with an incidence around 30%. They are usually an incidental finding on a routine ultrasound and anomalies are not associated. They may be resolved spontaneously or lead to complications such as cyst rupture, intracystic hemorrhage and ovarian torsion...
Article
Full-text available
Los quistes ováricos fetales son la causa más frecuente de masa quística intraabdominal diagnosticada prenatalmente, con una incidencia en torno al 30%. Normalmente son un hallazgo casual en una ecografía de rutina y no se encuentran anomalías asociadas. Pueden resolverse espontáneamente o presentar complicaciones como rotura del quiste, hemorragia...
Article
To evaluate the hemostatic efficacy and handling of gelatin-thrombin matrix in abdominal myomectomy. Prospective and randomized trial. University teaching hospital. Women (n = 50) with uterine fibroids with a uterine size equivalent to > or =16 weeks gestation. Gelatin-thrombin matrix (FloSeal Matrix; Baxter Healthcare Corp., Fremont, CA) was deliv...
Article
To compare the messenger RNA (mRNA) expression of vascular endothelial growth factor (VEGF) receptors (KDR, Flt-1, and sflt) in the different endometrial locations of septate uterus and normal uterus. Prospective, observational study. University teaching hospital. Twelve women with complete septate uterus undergoing hysteroscopic metroplasty and 12...
Article
We describe a cotyledonoid dissecting leiomyoma in a 33-year-old nulliparous woman treated by laparoscopy.
Article
To determine whether treatment of severe ovarian hyperstimulation syndrome (OHSS) with high-dose gonadotropin-releasing hormone (GnRH) antagonist, due to its luteolytic effect, is an effective method of management. Six infertile patients who had been scheduled for embryo transfer and developed early-onset severe OHSS with ascites and hemoconcentrat...
Article
Full-text available
El tumor de Brenner es un tumor raro que representa aproximadamente el 1,5% de los tumores de ovario. Se define como un tumor de células transicionales compuesto por células uroteliales dispuestas en agregados sólidos o quísticos embebidos en un estroma fibroso. Se clasifica en tumor de Brenner benigno (95%), borderline (3-4%) y maligno (1%). Prese...
Article
Brenner's tumor is a rare tumor that represents approximately 1.5% of the tumors of ovary. It is defined as a tumor of transitional cells composed by cells uroteliales arranged in solid or cystic acccumulations absorbed in a fibrous estroma. It qualifies in tumor of benign Brenner (95%), borderline (3-4%) and malignantly (1%). We present the clinic...
Article
In the last 3 years, numerous revisions and new ultrasound modalities have emerged, such as ultrasound tomography, VOCAL, STIC, inverse mode, reverse mode, etc. These state of the art technologies have improved and/or completed the diagnosis of fetal malformations.These 3D-4D techniques can be applied to most malformations. In combination with feta...
Article
Human endometrium is an active site of cytokine production and action. Among these cytokines, the interleukin-1 (IL-1) system seems to be relevant to the embryonic implantation process. We have previously reported the production of GnRH-I by human blastocyst, as well as the presence of GnRH-I receptor in human endometrium. This suggests a close int...
Article
We report a case of a congenital cystic adenomatoid malformation of the lung (CCAM). At 12 weeks of gestation, an echogenic lung associated to a hydrothorax was detected. Despite the results of the combined test that informed of a high risk of chromosomopathy, normal karyotype was confirmed after an amniocentesis. The three-dimensional ultrasound i...
Article
We report a pregnancy in which the fetus showed increased nuchal translucency in the first trimester and normal karyotype on amniocentesis. At 33 weeks’ gestation, right fetal hydrothorax, producing mediastinal displacement and associated with polyhydramnios, was noted. Preterm labor occurred at 33.4 weeks, with respiratory distress in the newborn,...
Article
Figure 2 Photograph showing the gross appearance of the giant blind ectopic ureter (arrows) arising from the upper pole moiety and the ureter (arrowheads) arising from the lower pole moiety of the duplex left kidney. the urinary tracts and to facilitate evaluation as well as counseling before birth, and early management and treatment after birth.
Article
Ectopic pregnancy consists of implantation of an embryo outside the uterine cavity. This abnormality has been known since the seventeenth century and the incidence is approximately 11-18 cases per 1,000 deliveries.Ectopic pregnancy is undoubtedly one of the most dangerous complications in pregnancy, and its incidence has risen markedly in the last...
Article
We describe a case of hydrothorax studied by 3D- 4D inverse mode and tomographic ultrasound imaging.The introduction of new ultrasound modalities improves evaluation of abnormalities.