Francisco Eulógio Martinez

University of São Paulo | USP · Departamento de Pediatria (FM) (São Paulo)

Abstract Background: The effects of antenatal corticosteroids (ANSs) on twins are not well established. Objective: To determine the impact of ANS use according to the number of fetuses. Methods: Retrospective cohort study of newborns between 23 and 33 weeks of gestational age, birth weight from 400 to 1499 g, without malformations, delivered at 2...

Background: The effects of antenatal corticosteroids on twins are not well established. Objective: to determine the impact of ANS use according to the number of fetuses. Methods: Retrospective cohort study of newborns between 23 and 33 weeks of gestational age, birth weight from 400 to 1499 g, without malformations, delivered at 20 public universit...

Breast milk is considered the gold standard nutritional resource for very low birth weight (VLBW) infants in terms of nutrients and protective factors. If mother's milk is not available, the second choice is donated and fortified human milk (HM) from the Human Milk Bank (HMB). This study hypothesized that HM could be lyophilized and used as an addi...

Objective: To compare the neurobehavioral development of preterm infants with postconceptional age between 32 and 36 weeks and 6 days, according to the adequacy of the weight for the gestational age at birth. Methods: A cross-sectional study was performed comparing two independent groups. The 55 preterm infants who were included in the sample we...

Antenatal corticosteroid (ANS) promotes benefits for singleton gestations of preterm infants from 24 to 34 weeks of pregnancy. Data regarding multiple gestations are less clear. To determine the impact of ANS variations according to the number of fetuses. Retrospective cohort study of very low birth weight preterm infants, without malformations, d...

The ideal feeding for premature babies has been the source of extensive debate. The aim of this study was to assess the association between type of feeding at discharge and the nutritional status of very low birth weight infants. This was a retrospective cohort of preterm babies with birth weight ≤1500 g, born between January 2006 and December 2013...

Objective: Feeding intolerance, manifesting as increased gastric residual, is a common finding in preterm neonates. Little is known about the regulation of gastric emptying early in life and the extent to which this plays a role in the preterm infants' feeding tolerance. The goal of this study was to evaluate clinically stable 28- to 32-week gesta...

Background: Preterm infants (PI) requiring the Neonatal Intensive Care Unit (NICU) are exposed to early repetitive pain/distress. Little is known about how pain relief strategies interact with infants'clinical health status, such as severity of illness with pain responses. This study aimed to examine main and interactive effects of routine sucrose...

Objective To verify whether the use of the T-piece resuscitator compared with the self-inflating bag in preterm infants ventilated at birth modifies survival to hospital discharge without major morbidities. Design Pragmatic prospective cohort study. Setting 20 Brazilian university hospitals of Brazilian Network on Neonatal Research. Patients were...

Objective: The aim of this study was to compare temperament and behavior profiles among groups of preterm toddlers differentiated by level of prematurity and the presence of bronchopulmonary dysplasia (BPD) or retinopathy of prematurity (ROP), controlling for neonatal clinical conditions and chronological age. Method: The sample comprised 100 prete...

The causative factors of neonatal feeding intolerance are poorly understood, but potentially related to clinical practices such as empiric antibiotic usage.The objective of this study was to evaluate whether early empiric antibiotic exposure negatively affects preterm infants' enteral feeding tolerance.Data from infants without risk factors for sep...

Children born preterm are at risk for later developmental disorders. The present study examined the predictive effects of neonatal, sociodemographic, and temperament characteristics on behavioral outcomes at toddlerhood, in children born preterm. The sample included 100 toddlers born preterm and with very-low-birth-weight, and their mothers. Neonat...

Children born preterm are more prone to present behavior problems and temperament with poor self-regulation, in comparison to full-term counterparts (Cosentino-Rocha, Klein & Linhares, 2014). The relationships between behavior problems and temperament are well established in the literature (Gartstein, Putnam & Rothbart, 2012); however few studies h...

Temperament indicators integrate the regulatory development processes which are relevant to better understand the behavior problems (Rothbart & Bates, 2006). Children born preterm with very low birth presented more risk for behavioral problems than children born full-term (Arpi & Ferrari, 2013; Clark, Woodward, Horwood, & Moor, 2008). Concerning th...

Introduction: the preterm birth is a risk factor for child developmental and behavioral problems. Objective: to examine whether neonatal clinical characteristics of infants born preterm, as well as temperament assessed in toddlerhood, predict behavior problems during the preschool years. Methods: twenty-one children born preterm with very low birth...

Background: Neonatal Intensive Care Units (NICUs) protect preterm infants; otherwise, this is a stressful environment including painful stimuli. Aims: To compare early neurobehavioral development prior to term-age in preterm infants at 34-36weeks of post-conceptional age in different gestational ages, and to examine the effects of prematurity le...

The aim of the study was examine the predictor effects of the infant`s neonatal characteristics, the cumulative stress-related experiences in Neonatal Intensive Care Unit (NICU), and the temperament on behavior of toddlers born preterm. The sample comprised 55 toddlers at 18-36 months of age. At toddlerhood, the mothers were interviewed using the E...

Objective: To evaluate the influence of body position on the displacement of nasal prongs in preterm infants. Methods: This prospective, randomized, crossover study enrolled infants born at a mean gestational age of 29.7±2 weeks, birth weight of 1353±280g and 2.9±2.2 days of life, submitted to continuous positive airway pressure by nasal prongs. T...

Objective To evaluate the influence of body position on the displacement of nasal prongs in preterm infants. Methods This prospective, randomized, crossover study enrolled infants born at a mean gestational age of 29.7±2 weeks, birth weight of 1.353±280 g and 2.9±2.2 days of life, submitted to continuous positive airway pressure by nasal prongs. Th...

Children born preterm are more prone to having behavior problems in comparison to children born full-term (Klein, Rocha, Martinez, Putnam & Linhares, 2013). However, few are known about the differences at behavior among children born preterm. On one hand, children born extremely preterm presented more behavior problems than children born moderate p...

Objetivo analisar os efeitos da terapêutica adotada para o canal arterial (CA) em recém-nascidos (RN) < 1.000gadmitidos em unidades neonatais (UN) da Rede Brasileira de Pesquisas Neonatais (RBPN), sobre os desfechos: óbito, displasia broncopulmonar (DBP), hemorragia intraventricular grave (HIVIII/IV), retinopatia da prematuridade cirúrgica (ROPcir)...

Objective To compare the efficacy and safety of a new porcine-derived pulmonary surfactant developed by Instituto Butantan with those of animal-derived surfactants commercially available in Brazil, regarding neonatal mortality and the major complications of prematurity in preterm newborns with birth weight up to 1500g and diagnosed with respiratory...

Abstract In Neonatal Intensive Care Units (NICU) the estimative of risk of morbidity and mortality in preterm infants is important for clinical decisions and management. The temperature at ward admission is known as an important factor to predict outcome. VLBW infants have lower temperatures at NICU admission many times due to their need of resusci...

Objective To observe different ways of implementing the techniques of aspiration of preterm infants and verify factors associated with changes in oxygen saturation and contamination of equipment. Methods An observational, prospective, descriptive study. The aspirations of the endotracheal tube in infants with birth weights between 500 and 1500 g we...

The objective was to explore the association between antibiotic use in the first 72 h of life in low risk for infection preterm infants and nutritional performance. Among the 4344 children born between 2010 and 2012 in 16 centres of the BNNR weighing <1495 g, 2395 infants presented no maternal history of chorioamnionitis, <18 h of ruptured membrane...

Maternal mortality has declined by nearly half since 1990, but over a quarter million women still die every year of causes related to pregnancy and childbirth. Maternal-health related targets are falling short of the 2015 Millennium Development Goals and a post-2015 Development Agenda is emerging. In connection with this, setting global research pr...

Background: Late-onset sepsis (LOS) is an important cause of morbidity and mortality in very low birth weight (VLBW) infants. Aim: To determine the incidence, risk factors and etiology of LOS. Methods: LOS was investigated in a multicenter prospective cohort of infants at eight public university neonatal intensive care units (NICUs). Inclusion...

The present study characterized the opinions of health professionals about strategies for assessing and managing pediatric pain in a public teaching hospital. The sample consisted of 92 health professionals who worked in pediatric wards, pediatric intensive care, and neonatal intensive care. The sample included 45 doctors, 18 nurses, 16 psychologis...

Sucrose solution is recommended as relevant pain relief management in neonates during acute painful procedures; however, only a few studies have analyzed the potentially adverse effects of sucrose administration to preterm neonates. The goal of this study was to examine the potential side effects of sucrose for pain relief in preterm infants, asses...

Objectives: to determine the prevalence of pulmonary hemorrhage in newborns and evaluate the associated risk factors and outcomes. Methods: this was a retrospective case-control study involving 67 newborns who met the criteria for pulmonary hemorrhage. A control was selected for each case: the next-born child of the same gender, similar weight (...

Cluster-based studies in health research are increasing. An important characteristic of such studies is the presence of intracluster correlation, typically quantified by the intracluster correlation coefficient (ICC), that indicate the proportion of data variability that is explained by the way of clustering. The purpose of this manuscript was to e...

To determine the prevalence of pulmonary hemorrhage in newborns and evaluate the associated risk factors and outcomes. This was a retrospective case-control study involving 67 newborns who met the criteria for pulmonary hemorrhage. A control was selected for each case: the next-born child of the same gender, similar weight (± 200g) and gestational...

Background: Early and repeated experiences of pain may have long-term effects on vulnerable newborns hospitalized in the Neonatal Intensive Care Unit (NICU), and neonatal pain responses may be affected by a variety of factors that neonates encounter. We tested the hypothesis that male preterm neonates exhibited greater pain sensitivity than female...

This study evaluated whether the use of continuous positive airway pressure (CPAP) in the delivery room alters the need for mechanical ventilation and surfactant during the first 5 days of life and modifies the incidence of respiratory morbidity and mortality during the hospital stay. The study was a multicenter randomized clinical trial conducted...

To evaluate the effect of body position on the cardiorespiratory indicators of preterm newborns receiving nasal continuous positive airway pressure (CPAP). Analytical, observational, prospective, cross-sectional, randomised crossover study was carried out on sixteen newborns that received nasal CPAP. The infants had a mean gestational age of 29.7 ±...

The purpose of the present study was to examine the temperament and behavior problems of 32 toddlers born preterm and very low birth weight and 25 toddlers born full-term without medical problems. Mothers completed the Early Childhood Behavior Questionnaire and the Child Behavior Checklist-1.5-5 for assessing toddler`s temperament and behavior prob...

The objective of this study was to determine the feasibility of the use of continuous positive airway pressure installed prophylactically in the delivery room (DR-CPAP), for infants with a birth weight between 500 and 1000 g in settings with limited resources. During 23 months, infants with a birth weight between 500 and 1000 g consecutively receiv...

Preterm newborns have higher thoracic compliance, providing less stability to the different forces of distortion imposed on the rib cage, leading to instability of the chest. Adequate body position may reduce this instability and facilitate respiratory work. To assess the oxygen saturation response of preterm newborns receiving rib cage stabilizati...

Purpose: We aimed to test the convergent validity of the COMFORT scale and the Cardiac Analgesic Assessment Scale (CAAS) and to evaluate changes in physiological parameters over time in response to a painful procedure in neonates and infants following cardiac surgery. Methods: From October 2006 to May 2008, 16 children were prospectively evaluat...

The goal of this study was to examine the prevalence, assessment and management of pediatric pain in a public teaching hospital. The study sample consisted of 121 inpatients (70 infants, 36 children, and 15 adolescents), their families, 40 physicians, and 43 nurses. All participants were interviewed except infants and children who could not communi...

The biobehavioural pain reactivity and recovery of preterm infants in the neonatal period may reflect the capacity of the central nervous system to regulate neurobiological development. The aim of the present study was to analyse the influence of the neonatal clinical risk for illness severity on biobehavioural pain reactivity in preterm infants. F...

Objective: To verify, in extremely preterm infants, if disagreement between obstetricians and neonatologists regarding proactive management is associated with early death. Study design: Prospective cohort of 484 infants with 23(0/7) to 26(6/7) weeks, without malformations, born from January 2006 to December 2009 in eight Brazilian hospitals. Pro...

Background: The effects of body positioning (BP) of preterm infants (PT) receiving nasal CPAP was not well evaluated in the literature.Objective: To evaluate the possible effect of four BP (prone, supine, left and right lateral) on respiratory parameters of PT using nasal CPAP.Methods: Sixteen infants with < 37 weeks and < 2500g receiving nasal CPA...

The purpose of the present study was: a) to describe the theme of verbalizations about breastfeeding in mothers' pre-term (M-PT) and full-term (M-FT) infants; b) to examine the association between these themes and mother's anxiety and depression indicators and socio-demographic characteristics and, neonatal characteristics of the infants. The sampl...

To test the hypothesis that red blood cell (RBC) transfusions in preterm infants are associated with increased intra-hospital mortality. Variables associated with death were studied with Cox regression analysis in a prospective cohort of preterm infants with birth weight <1500 g in the Brazilian Network on Neonatal Research. Intra-hospital death an...

Introduction: Low birth weight and intrauterine growth restriction are associated to high morbidity and mortality. A compromised maternal nutritional status and placental failure could be responsible for intrauterine growth insufficiency.Objectives: To describe mothers' body composition of adequate for gestational age (AGA) and small for gestationa...

Obj ective: To evaluate perinatal factors as sociated with early neonatal death in preterm infants with birth weights (BW) of 400 -1,500 g. Methods: A multicenter prospective cohort study of all infants with BW of 400-1,500 g and 23-33 weeks of gestational age (GA), without malformations, who were born alive at eight public university tertiary hosp...

The occurrence of preterm birth remains a complex public health condition. It is considered the main cause of neonatal morbidity and mortality, resulting in a high likelihood of sequelae in surviving children. With variable incidence in several countries, it has grown markedly in the last decades. In Brazil, however, there are still difficulties to...

To evaluate the C-reactive protein (CRP) and interleukin-6 (IL-6) as diagnostic tools for early onset infection in preterm infants with early respiratory distress (RD). CRP and IL-6 were quantified at identification of RD and 24 h after in 186 newborns. Effects of maternal hypertension, mode of delivery, Apgar score, birth weight, gestational age,...

OBJETIVO: Revisar ensaios clínicos randomizados, publicados entre 2002 e 2009, sobre a eficácia de intervenções em Cuidado ao Desenvolvimento em recém-nascidos pré-termo em Unidade de Terapia Intensiva Neonatal. FONTES DE DADOS: Foram selecionados estudos randomizados dos bancos de dados Medline, PsycINFO, ISI Web of Science, LILACS e SciELO, usand...

OBJECTIVE: To review randomized clinical trials published from 2002 to 2009 focusing on the efficacy of Developmental Care interventions in preterm infants in a Neonatal Intensive Care Unit. DATA SOURCE: Randomized trials were selected from Medline, PsycINFO, ISI Web of Science, LILACS, and SciELO databases using the keywords "developmental care" a...

PURPOSE: To determine the frequency of retinopathy of prematurity at the Clinical Hospital of Ribeirão Preto Medical School (HCFMRP-USP) and verify the association of retinopathy of prematurity with known risk factors. METHODS: Prospective analysis of 70 patients born in the HCFMRP-USP, weighing less than 1,500 grams, in a period of 1 year. The pat...

To determine the frequency of retinopathy of prematurity at the Clinical Hospital of Ribeirão Preto Medical School (HCFMRP-USP) and verify the association of retinopathy of prematurity with known risk factors. Prospective analysis of 70 patients born in the HCFMRP-USP, weighing less than 1,500 grams, in a period of 1 year. The patients were divided...

Guidelines for red blood cell (RBC) transfusions exist; however, transfusion practices vary among centers. This study aimed to analyze transfusion practices and the impact of patients and institutional characteristics on the indications of RBC transfusions in preterm infants. RBC transfusion practices were investigated in a multicenter prospective...

To determine the mass of colostrum ingested by exclusively breastfed newborn infants during the first 24 hours of extrauterine life. Milk ingested during the first 24 hours of life by 90 healthy newborn infants was evaluated by use of a scale with high sensitivity. The masses were measured during 8-hour periods. Associations of the mass measured wi...

Pain reactivity may reflect underlying mechanisms of constitutional aspects of temperament. To examine whether the neonatal biobehavioral reactivity and recovery responses from pain and distress, as well as the gestational age, the illness severity and the amount of painful procedures undergone the Neonatal Intensive Care Unit (NICU) stay, predict...

The objective of this study was to evaluate and compare symptoms of anxiety and depression before and after psychological intervention in mothers of babies born preterm with very low birth weight, hospitalized in the Neonatal Intensive Care Unit. Fifty nine mothers, without psychiatric antecedents, were distributed into two groups according to the...

There is an increasing interest about the use of stable isotopes for body composition analysis in pediatrics. To ensure the success of total body water analysis by the deuterium dilution method, it is fundamental to determine the equilibrium time (plateau) of deuterium in the body fluid studied. We report here the equilibration time of deuterium ox...

To compare presence and severity of clinical symptoms of anxiety, dysphoria, and depression in mothers of preterm and of full-term infants and to observe changes in symptoms of mothers of preterm infants during hospitalization of the infants and after discharge, 50 mothers of preterm infants and 25 mothers of full-term infants completed the State-T...

Studies on acute-procedural pain in neonates have been based more on single behavioral scores than on response patterns. To assess the individual reactivity and recovery pattern to the painful procedure of blood collection. A cross-sectional, within-group comparison trial. Forty-eight preterm and very low birth weight neonates hospitalized in a Neo...

O objetivo do estudo foi avaliar indicadores de desenvolvimento de crianças nascidas pré-termo e comparar o desempenho nas faixas de 5 a 7 e 10 a 14 meses de idade corrigida. Foram relacionados indicadores do desenvolvimento com variáveis neonatais e do ambiente familiar e sexo. Trinta crianças foram avaliadas pelo Denver-II. As cuidadoras responde...

The aim of the study was to assess the development of children born preterm and to compare the performance in the ranges of 5-7 and 10-14 months of corrected age. The children&apos;s development indicators and the variables of neonatal period and familial environment were correlated. Thirty children were assessed by Denver-II. The caregivers were i...

The objective of the present study was: (a) to identify the concerns, verbally expressed, of 50 mothers regarding their preterm infants (PT) and then compare their verbal expression with those of 25 mothers of full-term infants (FT); and (b) to correlate the mothers' verbal expressions with maternal and infant variables. The following instruments w...

The purpose of this study was: (a) to assess and to compare anxiety and depression symptoms in mothers of preterm neonates during hospitalization in the Neonatal Intensive Care Unit, after discharge, and at the end of the infants' first year of life; and (b) to assess the child's development at 12 months of chronological corrected age (CCA). Thirty...

O presente estudo teve por objetivo avaliar o comportamento exploratório em situação de brincar de 20 bebês nascidos pré-termo com muito baixo peso, aos 10 meses de idade cronológica corrigida, em grupos diferenciados quanto ao risco para problemas de desenvolvimento. A amostra foi dividida em dois grupos, de acordo com o desempenho no Teste de Den...

The aim of the study was to assess the development of children born preterm and to compare the performance in the ranges of 5-7 and 10-14 months of corrected age. The children's development indicators and the variables of neonatal period and familial environment were correlated. Thirty children were assessed by Denver-II. The caregivers were interv...

The purpose of this study was to assess the behavioral and physiological reactivity of preterm neonates during different phases of a blood collection procedure involving arterial puncture. The sample consisted of 43 preterm and very low birth weight neonates with a postnatal age of 1 to 21 days who were hospitalized in the Neonatal Intensive Care U...

OBJECTIVE:To evaluate perinatal factors associated with early neonatal death in preterm infants with birth weights (BW) of 400-1,500 g. METHODS: A multicenter prospective cohort study of all infants with BW of 400-1,500 g and 23-33 weeks of gestational age (GA), without malformations, who were born alive at eight public university tertiary hospital...

The aim of the present study was to examine the efficacy and potential side effects of repeated doses of oral sucrose for pain relief during procedures in NICU. Thirty-three preterm neonates were randomly allocated in blind fashion into two groups, the sucrose group (SG=17) and the control group (CG=16). The responses of neonates to pain and distre...

Current study analyzes the relation between mother's anxiety, pre-term neonatal status and developmental outcome in 12-month-old (corrected age) infants. Fourteen preterm children with very low weight at birth were assessed by Bayley-II Scales and mothers were evaluated by State-Trait Anxiety Inventory. Resolution problems, permanence of objects, i...

Current study analyzes the relation between mother’s anxiety, pre-term neonatal status and developmental outcome in 12-month-old (corrected age) infants. Fourteen preterm children with very low weight at birth were assessed by Bayley-II Scales and mothers were evaluated by State-Trait Anxiety Inventory. Resolution problems, permanence of objects, i...

To evaluate perinatal factors associated with early neonatal death in preterm infants with birth weights (BW) of 400-1,500 g. A multicenter prospective cohort study of all infants with BW of 400-1,500 g and 23-33 weeks of gestational age (GA), without malformations, who were born alive at eight public university tertiary hospitals in Brazil between...

O objetivo do presente estudo longitudinal foi comparar o desenvolvimento de crianças nascidas pré-termo, em dois grupos diferenciados quanto à presença (G1) ou ausência (G2) de sintomas de ansiedade e depressão materna no período neonatal do bebê. A amostra foi composta por 32 crianças nascidas pré-termo, atendidas em seguimento psicológico desde...

The aim of this longitudinal study was to compare the developmental outcomes of preterm infants allocated into two different groups taking into account the presence (G1) or lack (G2) of mothers&apos; anxiety and depression symptoms during the neonatal period of the babies. The sample was based on 32 preterm infants who had a psychological follow up...

OBJECTIVE: To describe an intervention to provide support and encouragement to mothers of preterm newborns and to evaluate its effect on breastfeeding rates in the first 6 months after hospital discharge. METHODS: One hundred newborns and their mothers were selected consecutively and prospectively according to order of birth. The mother-infant dyad...

The aim of this longitudinal study was to compare the developmental outcomes of preterm infants allocated into two different groups taking into account the presence (G1) or lack (G2) of mothers' anxiety and depression symptoms during the neonatal period of the babies. The sample was based on 32 preterm infants who had a psychological follow up from...

To describe an intervention to provide support and encouragement to mothers of preterm newborns and to evaluate its effect on breastfeeding rates in the first 6 months after hospital discharge. One hundred newborns and their mothers were selected consecutively and prospectively according to order of birth. The mother-infant dyads were alternately a...