Francisco López-Muñoz

Francisco López-Muñoz
Universidad Camilo José Cela | UCJC

MD PhD

About

381
Publications
161,628
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4,285
Citations
Citations since 2016
142 Research Items
2419 Citations
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Additional affiliations
November 2019 - April 2020
Universidad Camilo José Cela
Position
  • Vice Rector

Publications

Publications (381)
Chapter
This chapter analyzes the work of Pierre Deniker on the discovery of the first antipsychotic drugs in the 1950s; chlorpromazine, first drug in the phenothiazine family, and reserpine, a natural alkaloid from Rauwolfia serpentina Benth. The previous situation of antipsychotic therapy is analyzed and the circumstances that led to the discovery of the...
Chapter
This chapter analyzes the work of Heinz E. Lehmann and Nathan S. Kline on the discovery of the first antidepressant drugs in the 1950s; imipramine, the prototypical representative of the tricyclic antidepressants, and iproniazid, a monoamine oxidase inhibitor. The previous situation in antidepressant therapy is considered and the circumstances that...
Chapter
This commentary analyzes the work of Fridolin Sulser and Radhakanta Mishra on the mechanism of action of the tricyclic antidepressants (TCAs) and the advances that occurred in this field until the early 1980s. Thanks to the clinical introduction of imipramine and other tricyclic antidepressants, it was possible to demonstrate the physiopathological...
Chapter
This commentary analyzes the work of Paul Janssen and Jan Tollenaere on the discovery of haloperidol in the 1950s, the first drug from the butyrophenone family. The circumstances that led to the discovery and clinical introduction of haloperidol are described. The development of new molecules of the butyrophenone family is also analyzed after the t...
Article
The multifactorial nature of Alzheimer's disease necessitates the development of agents able to interfere with different relevant targets. A series of 22 tailored chromanones was conceptualized, synthesized, and subjected to biological evaluation. We identified one representative bearing a linker-connected azepane moiety (compound 19) with balanced...
Article
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Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more tolerable and efficient therapy for stroke is being sought that focuses on the control and scav...
Article
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We report herein the synthesis and antioxidant profile of nine novel heterobisnitrones (hBNs) as new α-phenyl-tert-butylnitrone (PBN) analogues. The synthesized hBNs 1–9 were evaluated for their antioxidant activity using different in vitro techniques, while they were also tested as inhibitors of soybean LOX, as an indication of their anti-inflamma...
Article
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Verbal fluency tests are easy and quick to use in neuropsychological assessments. The aim of this study is to explore their relevance through a bibliometric analysis. We performed a search in the Web of Science, involving documents published between 1960 and 2021. We used bibliometric indicators to explore articles distribution, doubling time, and...
Article
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Fundamento: la afectación cognitiva en pacientes con neurocisticercosis es frecuente, por lo tanto, resulta de gran utilidad contar con instrumentos pronósticos para establecer un mejor manejo de esta. Objetivo: proponer una escala predictiva de deterioro cognitivo en pacientes adultos con neurocisticercosis. Métodos: estudio con diseño correlacion...
Article
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Introducción. La neurocisticercosis es la enfermedad parasitaria más frecuente en el sistema nervioso central de los humanos. Objetivo. Establecer la correlación entre variables clínicas y tomográficas en pacientes con neurocisticercosis en la consulta de neurología del Hospital San Vicente de Paúl y el Hospital Instituto Ecuatoriano de Seguridad...
Article
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Fundamento: Muchos pacientes con neurocisticercosis manifiestan deterioro cognitivo, con afectaciones importantes en su calidad de vida. Objetivo: determinar la correlación entre el estado cognitivo y los hallazgos tomográficos en pacientes con neurocisticercosis. Métodos: estudio correlacional, prospectivo y transversal, que incluyó a 93 pacientes...
Article
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Case management is a model of personalized intervention in people with severe mental illness. To explore the treatment adherence and effectiveness of patients with severe schizophrenia (Clinical Global Impression Severity, CGI-S ≥ 5) undergoing treatment in a community-based, case-managed program (CMP) with an integrated pharmacological and psychos...
Article
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Introduction: Neurocysticercosis (NCC) is the most frequent parasitic disease in the central nervous system of humans. Objective: to establish the correlation between clinical and tomographic variables in patients with neurocysticercosis in the neurology consultation of Hospital San Vicente de Paul and Hospital IESS Ibarra, during the year 2020....
Article
The role played by serendipity in the origin of modern psychopharmacology has proven to be controversial in scientific literature. In its original meaning (Walpole), serendipity refers to discoveries made through a combination of accidents and sagacity. We have implemented an operational definition of serendipity based on finding something unexpect...
Article
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The world faces an exceptional new public health concern caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequently termed the coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO). Although the clinical symptoms mostly have been characterized, the scientific community still doesn´t know how SARS-C...
Article
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Herein, we report the synthesis, antioxidant, and neuroprotective properties of some nucleobase-derived nitrones named 9a–i. The neuroprotective properties of nitrones, 9a–i, were measured against an oxygen-glucose-deprivation in vitro ischemia model using human neuroblastoma SH-SY5Y cells. Our results indicate that nitrones, 9a–i, have better neur...
Article
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El presente trabajo analiza la línea editorial de la revista de educación y psicopedagogía Didascalia, publicada entre 1970 y 1975, fundada por Felipe Segovia Olmo, y posiblemente primera en España con pretensiones formativas de largo alcance en el seno de la profesión docente. La publicación, nacida al mismo tiempo que la reforma educativa de 1970...
Article
The objective of this study was to understand the psychosocial and pharmacological approaches linked to better treatment adherence and outcomes (psychiatric hospitalizations, clinical severity, and suicide attempts) among patients with schizophrenia receiving the standard treatment in mental health units (MHUs) compared with patients in a community...
Article
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La revista de innovación educativa Didascalia, que inició su andadura en la década de 1970, compartiendo acta de nacimiento con la nueva Ley de Educación española, fue una publicación pionera e injustamente olvidada por la historiografía reciente. Por sus páginas no solo pasaron las figuras más pujantes y granadas de la psicopedagogía, la educación...
Article
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Torture is a practice as old as humanity itself, although its objectives have changed throughout history. The participation of medical personnel in the exercise of torture has been common in some historical moments. During the middle ages, torture was the instrument used by justice to obtain confessions, but doctors did not regularly participate in...
Article
Background Diagnosis of schizophrenia lacks of reliable medical diagnostic tests and robust biomarkers applied to clinical practice. Schizophrenic patients undergoing treatment with antipsychotics suffer a reduced life expectancy due to metabolic disarrangements that co-exist with their mental illness and predispose them to develop metabolic syndro...
Article
This paper analyzes the influence of Cuba's independence war on the thought and work of Santiago Ramón y Cajal, Nobel Prize in Medicine and possibly the most relevant neuroscientist in history. During his youth, Cajal participated, as a military doctor, in Cuba’s Ten Years' War and remained on the island for more than a year, treating wounded and s...
Article
Objective: The aim of this study is to analyze the scientific production of the Cuban Academy of Sciences (the Academy, in what follows) using bibliometric tools. Methods: We performed a search in Web of Science, involving documents published between 1968 and 1994, a period in which the Academy acted as a multidisciplinary scientific institution wi...
Article
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The aim of this study is to explore the relevance of scientific production on venture capital using bibliometric and mapping tools. We performed a search in Scopus, involving any document published between 1978 and 2020. We used bibliometric indicators to explore documents production, dispersion, distribution, time of duplication, and annual growth...
Article
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Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, like any other invading microbe, enacts a generalized immune response once the virus contacts t...
Article
Background The evaluation of long-term effectiveness and tolerability of Aripiprazole Once-monthly (AOM) is yet scarce, and severely ill patients have not been specifically studied. Objective The aim of the study was to explore the long-term adherence, effectiveness and tolerability of AOM in the treatment of patients with severe (Clinical Global...
Article
Sigma (σ) receptors represent attractive targets for the development of potential agents for the treatment of several disorders, including Alzheimer's disease and neuropathic pain. In the search for multitarget small molecules (MSMs) against such disorders, we have re-discovered chromenones as new affine σ1/σ2 ligands. 6-(4-(Piperidin-1-yl)butoxy)-...
Article
Purpose The aim of this study is to explore the relevance of scientific production on glaucoma using bibliometric tools. Design Bibliographic study Subjects Original articles published in the timeframe 1900-2019 Methods We performed a search in Web of Science for documents published between 1900 and 2019. We used bibliometric indicators to explo...
Article
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Blister or vesicant chemical warfare agents (CWAs) have been widely used in different military conflicts, including World War I and the Iran-Iraq War. However, their mechanism of action is not fully understood. Sulfur and nitrogen mustard exert toxic effects not only through the alkylation of thiol-bearing macromolecules, such as DNA and proteins,...
Article
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Paliperidone palmitate every three months (PP3M) is expected to facilitate patient’s treatment compliance and satisfaction. The objective here was to compare PP3M treatment compliance and satisfaction, effectiveness and tolerability, with paliperidone palmitate-monthly (PP1M) in patients with severe schizophrenia. A 24-month prospective, open-label...
Article
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Herein, we report the neuroprotective and antioxidant activity of 1,1′-biphenyl nitrones (BPNs) 1–5 as α-phenyl-N-tert-butylnitrone analogues prepared from commercially available [1,1′-biphenyl]-4-carbaldehyde and [1,1′-biphenyl]-4,4′-dicarbaldehyde. The neuroprotection of BPNs1-5 has been measured against oligomycin A/rotenone and in an oxygen–glu...
Article
The objective here is to compare the effectiveness of long-acting injectable antipsychotics (LAI-APs) and oral ones (OAPs) in patients with severe (Global Clinical Impression-Severity ≥ 5) schizophrenia (N = 688). A 5-year follow-up study has been conducted in patients undergoing standard treatment in mental health units (MHUs) or on a severe menta...
Article
Melatonin is a molecule that has attracted a great deal of attention from the scientific community in the last 50 years. The aim of this study is to analyze the scientific production on related to melatonin using bibliometric tools. We performed a search in Web of Science, involving documents published between 1958 and 2019. We used bibliometric in...
Article
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INTRODUCCIÓN En el campo de los estudios literarios, pocas cuestiones resultan tan obvias y complejas al mismo tiempo como el poder de la imaginación: lo que parece claro en un primer momento resulta luego ser sorprendentemente difícil de aprehender. Esto es concretamente lo que ocurre con la denominada literatura gótica, y, en concreto, con su des...
Article
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Microglia controls the immune system response in the brain. Specifically, the activation and dysregulation of the NLRP3 inflammasome is responsible for the initiation of the inflammatory process through IL-1β and IL-18 release. In this work, we have focused on studying the effect of melatonin on the regulation of the NLRP3 inflammasome through α7 n...
Article
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p>“Le Horla” nos presenta el diario del narrador para deleite del lector y desesperación de ambos. Los detalles aparentemente insignificantes, el entorno familiar transformado en ominoso, el dramatismo que aumenta con la lectura… todo ello conduce al lector y al protagonista a un sentimiento extremo y magistral de angustia. Frente al inicio casi bu...
Article
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Resumen: Guy de Maupassant nos presenta en "Le Horla" a un narrador que nos ofrece su diario para deleite del lector y desesperación de ambos. Los detalles aparentemente insignificantes con la intención de sorprender al lector, el entorno familiar que se convierte en ominoso, el dramatismo que aumenta con la lectura… todo ello conduce al lector y a...
Article
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Introduction Sickle cell disease is an autosomal recessive genetic disease caused by a single point mutation in the β-globin chain of the hemoglobin. It has been recognized by the World Health Organization as a public health priority since 2006. Methods The Scopus database was used in this study with the search descriptors: “sickle cell” and “sick...
Article
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Clásicamente, el tratamiento farmacológico de la depresión se ha realizado con antidepresivos monoaminérgicos, que presentan una serie de limitaciones, como un lento inicio de acción, una inadecuada respuesta antidepresiva, disfunción sexual o tolerabilidad mejorable. En esta revisión analizaremos nuevos mecanismos fisiopatológicos implicados en la...
Article
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Herein we report in vitro metabolic stability in human liver microsomes (HLMs), interactions with cytochrome P450 isoenzymes (CYP3A4, CYP2D6, and CYP2C9), and cytotoxicity analyses on HEK-293, HepG2, Huh7, and WTIIB cell lines of our most recent multitarget directed ligands PF9601N, ASS234, and contilisant. Based on these results, we conclude that...
Article
Full-text available
Herein we report the synthesis, antioxidant and neuroprotective power of homo-tris-nitrones (HTN) 1-3, designed on the hypothesis that the incorporation of a third nitrone motif into our previously identified homo-bis-nitrone 6 (HBN6) would result in an improved and stronger neuroprotection. The neuroprotection of HTNs 1-3, measured against oligomy...
Article
Full-text available
We herein report the synthesis, antioxidant power and neuroprotective properties of nine homo-bis-nitrones HBNs1–9 as alpha-phenyl-N-tert-butylnitrone (PBN) analogues for stroke therapy. In vitro neuroprotection studies of HBNs1–9 against Oligomycin A/Rotenone and in an oxygen-glucose-deprivation model of ischemia in human neuroblastoma cell cultur...
Article
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We carry out a bibliometric analysis on neurological and ophthalmological pathologies based on retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT). Documents were selected from Scopus database. We have applied the most commonly used bibliometric indicators, both for production and dispersion, as Price’s law o...
Article
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Quarantine has been the most general response of all countries affected by the coronavirus pandemic (SARS-CoV-2). There are sufficient studies on the complications that quarantine causes in the population. The severity of emotional responses derived from quarantine depends on several factors, which can occur during or after the quarantine; the pres...
Article
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Phytoestrogens can have a neuroprotective effect towards ischemia-reperfusion-induced neuronal damage. However, their mechanism of action has not been well described. In this work, we investigate the type of neuronal cell death induced by oxygen and glucose deprivation (OGD) and resupply (OGDR) and pinpoint some of the signaling mechanisms whereby...
Book
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El estudio y el conocimiento del alma, la mente, la conciencia, o como se la quiera catalogar, ha constituido un severo problema para el ser humano que viene de muy antiguo. Tanto como la Humanidad misma. Este conocimiento ha preocupado por igual a las religiones, a las escuelas filosóficas y a la ciencia y ha recibido multitud de abordajes, que ha...
Article
Tacrine was the first acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease although its use has been limited and finally abandoned because of side effects including hepatic toxicity. Based on 1,2,3,4‐tetrahydroquinolino[2,3‐b]quinoxalin‐12‐amine (QT78), a recently reported cholinesterase inhibitor, less toxic and potent...
Article
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In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (QN1-19) and 13 dihydroquinolinones (DQN1-13) designed as potential multitarget small molecules (MSM) for Alzheimer’s disease therapy. Contrary to our expectations, none of them showed significant human recombinant MAO inhib...
Article
For centuries, the understanding of conciousness has been one of the topic issues of intellectual development, and a context in which the different sociocultural, scientific, philosophical and ideological perceptions of the human being have been defined and redefined. Far from being a solved problem, it’s a theme that, reformulated again and again...
Article
The Conversation <https://theconversation.com/los-manicomios-del-cine-de-terror-y-el-plan-kirkbride-para-los-enfermos-mentales-136354>
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Previous research has identified a critical role of executive function and memory in self-awareness, a metacognitive capacity often impaired in acquired brain injury. Through this observational study, we aimed to explore the effect of cognitive rehabilitation on the predictive value of these variables, as also whether any of them can predict the le...
Article
Aims: To determinate if offspring of alcohol-dependent patients (OA) process affective stimuli and alcohol-related cues in a different manner than control subjects do. Methods: Event-related potentials (early posterior negativity [EPN]/ late positive potential [LPP]) and event-related oscillations (Theta) were obtained by electroencephalographic...
Article
In this review we focused our attention on sulfur mustard [bis(2-chloroethyl) sulphide], the main vesicant chemical warfare agent (CWA), which has been widely used in different military conflicts, including World War I and the Iran-Iraq war. Moreover, the evolution of the recent Iraq and Syria conflicts suggests that terrorist groups are aware of t...
Poster
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La segunda mitad del siglo XIX implicó una ruptura definitiva con la etapa precientífica en el conocimiento de la glándula pineal, marcado fundamentalmente por la preeminencia que René Descartes (1956-1650) le otorgara. Ruptura que vino acompañada del nacimiento de la química sintética en los laboratorios universitarios y, por tanto del nacimiento...
Article
There is a lack of effective therapies for stroke patients; its treatment is even more difficult considering the unexpected onset of the disease. In the last decade, melatonin has emerged as a promising neuroprotective agent which is able to cross the blood-brain-barrier (BBB) and with a low toxicity profile. The aim of this systematic review was t...
Article
Full-text available
Alexithymia, as a theoretical psychotherapeutic construct, finds its origins in psychosomatic medicine, actually being quite old. However, beyond the specific observations and case studies, their characterization and systematization is relatively recent. However, from an epistemological point of view, it remains the subject of debate and therefore...
Article
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Introduction: Self-awareness impairment is a common symptom of patients after suffering acquired brain injury, affecting the rehabilitation process and achievements in terms of patients's daily living functionality. Patients and methods: A systematic review was performed using Scopus and PubMed databases of scientific articles that address self-...