Francisco López-Muñoz

Camilo José Cela University | UCJC

Objectives: to delve deeper into sexual assault crimes by testing two criminological theories (the situational action theory and the Relationship between low personal morality and impersonal sex with sexual aggression behaviors towards women in a sample of Spanish heterosexual men 110 revised confluence model). Method: a questionnaire with scales o...

The case of what happened with witchcraft and sorcery between the 14th and 18th centuries is paradigmatic when it comes to understanding the evolution of the consideration of crime as a mental illness between the 19th and 20th centuries. Witchcraft went from being considered as an exceptional crime very difficult to prove by conventional means, req...

Stroke is a leading cause of death worldwide, yet current therapeutic strategies remain limited. Among the neuropathological events underlying this disease are multiple cell death signaling cascades, including autophagy. Recent interest has focused on developing agents that target molecules involved in autophagy to modulate this process under patho...

The intestinal microbiota and the human body are in a permanent interaction. There is a symbiotic relationship in which the microbiota plays a vitally important role in the performance of numerous functions, including digestion, metabolism, the development of lymphoid tissue, defensive functions, and other processes. It is a true metabolic organ es...

While the scientific community has long acknowledged the significant role of serendipity in shaping the field of contemporary psychopharmacology, its impact has not undergone a comprehensive analysis using operational methodologies. Serendipity, originally defined as discoveries stemming from a blend of luck and astuteness by Walpole, has been oper...

This research studies the dose–plasma level (PL) relationship of second-generation antipsychotics, together with the treatment outcomes achieved, in seriously ill people with schizophrenia. An observational, prospective, one-year follow-up study was carried out with patients (N = 68) with severe schizophrenia treated with paliperidone three-month (...

It is now an accepted principle that epigenetic alterations cause cellular dyshomeostasis and functional changes, both of which are essential for the initiation and completion of the tumor cycle. Oral carcinogenesis is no exception in this regard, as most of the tumors in the different subsites of the oral cavity arise from the cross-reaction betwe...

Biometry is a critical aspect of ophthalmology, since it facilitates the measurement of several ocular parameters and aids in the diagnosis of conditions like glaucoma. The advent of the IOLMaster in 1999 marked a pivotal moment in biometry by introducing non-contact and highly precise measurements that revolutionized the field. Low-coherence optic...

The aim of this review is to explore the relationship between melatonin, free radicals, and non-excitatory amino acids, and their role in stroke and aging. Melatonin has garnered significant attention in recent years due to its diverse physiological functions and potential therapeutic benefits by reducing oxidative stress, inflammation, and apoptos...

The breakdown of German psychiatry with the coming to power of the National Socialist regime in 1933 resulted in a revival after the war of bioethical issues, the immediate effect of which was the enactment of the Nuremberg Code. In many ways, this breakdown was the result of the historical evolution of psychomedical knowledge and the mass dissemin...

The role of inflammation and immunity in the pathomechanism of neurodegenerative diseases has become increasingly relevant within the past few years. In this context, the NOD-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in the activation of inflammatory responses by promoting the maturation and secretion of pro-inflammatory cyt...

Antecedentes: Los pacientes con cáncer son más propensos a presentar trastornos afectivos. Los tratamientos antidepresivos requieren semanas para surtir efecto. La evidencia sugiere que la ketamina suministrada por cualquier vía trata estos síntomas, convirtiéndola en una alternativa para los pacientes oncológicos que presentan depresión, ansiedad...

Herein we describe the design and synthesis of Contilisant+Tubastatin A hybrids as polyfunctionalized indole derivatives for the treatment of a broad diversity of cancers, such as glioblastoma. The new Contilisant+Tubastatin A hybrids have been designed as a Multi-Target-Directed (MTD) small molecules, able to inhibit HDAC6, cholinesterase and mono...

The co-occurrence of substance use disorders (SUD) and other mental disorders (OMD) is assumed to be high, but the details are uncertain in Spain. The objective of the present study was to know the prevalence of this comorbidity, as well as the pharmacological treatment, both in specific addiction treatment networks and in mental health networks, w...

Herein we describe the design and synthesis of Contilisant+Belinostat hybrids as polyfunctionalized indole derivatives for the treatment of a broad diversity of cancers and neurodegenerative diseases, such as glioblastoma, and Alzheimer’s disease (AD). The new Contilisant+Belinostat hybrids have been designed as a Multi-Target-Directed (MTD) small...

The photography of the deceased, especially those taken during their years of public splendor, became a highly demanded product, not only for its emotional value as a reminder of the deceased, or as an aid to the psychological transition of mourning for close relatives, but also for its value as a sociocultural artifice. The post-mortem photography...

Ischemic stroke is the leading cause of disability and the second leading cause of death worldwide. However, current therapeutic strategies are scarce and of limited efficacy. The abundance of information available on the molecular pathophysiology of ischemic stroke has sparked considerable interest in developing new neuroprotective agents that can...

Leer y escribir sobre vampiros y vampirismo parece ya una tarea vana. De todo se ha dicho y en todos los formatos acerca de estos monstruos culturales. Tanto que ya casi parece absurdo perder el tiempo en profundizar en sus andanzas con cualquier afán que re-base las fronteras del mero entretenimiento. Sin embargo, se trata de una impresión ilusori...

The purpose of this systematic review is to provide an overview of the existing knowledge on the therapeutic potential of melatonin to counteract the undesirable effects of chemotherapy in breast cancer patients. To this aim, we summarized and critically reviewed preclinical- and clinical-related evidence according to the PRISMA guidelines. Additio...

The present work describes the design, and synthesis of the polyfunctionalized indole derivative Contilistat for the treatment of a broad diversity of cancers, and neurodegenerative diseases such as glioblastoma, and Alzheimer’s disease (AD). Contilistat has been designed as a Multi-Target-Directed (MTD) small molecule, able to inhibit HDAC6, choli...

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weight nitrone, that is readily synthesized from commer...

Public health is funded with government funds gathered from tax revenues, whether national, provincial or municipal. The health system therefore suffers during economic crisis periods, whether due to disinvestment, loss of purchasing power among health care personnel or the decrease in the number of professionals. This worsens the situation, as it...

Tras años de confusiones y debates, el concepto de profiling -perfilación- ha comenzado a caer en desuso para verse reemplazado por el más ajustado de “análisis de conducta”. En realidad, y frente a décadas de errores en la interpretación de su labor, el analista de conducta no determina el “quién”, sino que trata de desentrañar motivaciones en bus...

After years of confusion and debate, the concept of ‘profiling’ has begun to fall into disuse and has been replaced by the more accurate term ‘behaviour analysis’. In reality, and in the face of decades of errors in the interpretation of his work, the behavioural analyst does not determine the ‘who’, but rather tries to unravel motivations in searc...

Cerebral ischemia is a condition affecting an increasing number of people worldwide, and the main cause of disability. Current research focuses on the search for neuroprotective drugs for its treatment, based on the molecular targets involved in the ischemic cascade. Nitrones are potent antioxidant molecules that can reduce oxidative stress. Here w...

Sulfur and nitrogen mustards, bis(2-chloroethyl)sulfide and tertiary bis(2-chloroethyl) amines, respectively, are vesicant warfare agents with alkylating activity. Moreover, oxidative/nitrosative stress, inflammatory response induction, metalloproteinases activation, DNA damage or calcium disruption are some of the toxicological mechanisms of sulfu...

Background: The success of breast cancer (BC) treatment depends largely on the clinical-histological characteristics of the patient. Immunohistochemical (IHC) Breast Cancer Subtypes are crucial for therapeutic purposes. Aim: To determine the relevance and prevalence of the histopathological parameters and molecular subtypes of BC among women atten...

This article analyzes the relationship between per capita expenditure and financial and macroeconomic variables in the framework of mental health, in regions where the prevailing system is public healthcare governed by the state and in regions where the prevailing system is that of public ownership. The period 2006–2017 was analyzed. A simple linea...

This chapter analyzes the work of Pierre Deniker on the discovery of the first antipsychotic drugs in the 1950s; chlorpromazine, first drug in the phenothiazine family, and reserpine, a natural alkaloid from Rauwolfia serpentina Benth. The previous situation of antipsychotic therapy is analyzed and the circumstances that led to the discovery of the...

This chapter analyzes the work of Heinz E. Lehmann and Nathan S. Kline on the discovery of the first antidepressant drugs in the 1950s; imipramine, the prototypical representative of the tricyclic antidepressants, and iproniazid, a monoamine oxidase inhibitor. The previous situation in antidepressant therapy is considered and the circumstances that...

This commentary analyzes the work of Fridolin Sulser and Radhakanta Mishra on the mechanism of action of the tricyclic antidepressants (TCAs) and the advances that occurred in this field until the early 1980s. Thanks to the clinical introduction of imipramine and other tricyclic antidepressants, it was possible to demonstrate the physiopathological...

This commentary analyzes the work of Paul Janssen and Jan Tollenaere on the discovery of haloperidol in the 1950s, the first drug from the butyrophenone family. The circumstances that led to the discovery and clinical introduction of haloperidol are described. The development of new molecules of the butyrophenone family is also analyzed after the t...

The objective of this study was to characterize the Cuban research potential in the field of ataxias and its temporal evolution. A search was carried out in the Web of Science database and all the documents published from 1993 to 2020 were retrieved. Bibliometric indicators were applied to explore the production, dispersion, distribution and annual...

To assess the impact of the route of administration and doses of second-generation antipsychotics (SGAs) on treatment adherence, hospital admissions, and suicidal behaviour in patients with severe schizophrenia (Clinical Global Impression–Severity–CGI-S ≥ 5), we implemented an observational 5-year follow-up study. A total of 37.5% of the patients o...

The purpose of this study is to determine the possible alterations that may occur in the thickness of the retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), and macular thickness in patients with chronic migraines compared with healthy controls. Hence, we examined some of the possibilities that are offered by optical coherence tomography...

La atención en Salud Mental ha sufrido una radical transformación a lo largo de la historia, tanto desde el punto de vista asistencial como de la consideración de la enfermedad, siendo el punto de inflexión definitivo el momento en que la cobertura de las enfermedades mentales se integró dentro del Sistema de Salud. Desde entonces, la organización...

In 1886, the neurologist Richard Von Krafft-Ebing published his bookPsychopathia Sexualis and offered the first explanations about paraphilias such as vampirism. This phenomenon has usually maintained in the margins of clinical research because of its rarity, receiving a literary treatment. Whenever science stopped estimating it as another medical...

The multifactorial nature of Alzheimer's disease necessitates the development of agents able to interfere with different relevant targets. A series of 22 tailored chromanones was conceptualized, synthesized, and subjected to biological evaluation. We identified one representative bearing a linker-connected azepane moiety (compound 19) with balanced...

Fundamento la creciente demanda de nuevos analgésicos y sustancias neuromoduladoras en general para el tratamiento del dolor, hace necesario estandarizar el uso de estos. En el caso de la ketamina, la mayoría de las investigaciones giran en torno a su uso en el abordaje de los dolores agudos en situaciones de emergencias médicas. Objetivo realizar...

Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more tolerable and efficient therapy for stroke is being sought that focuses on the control and scav...

We report herein the synthesis and antioxidant profile of nine novel heterobisnitrones (hBNs) as new α-phenyl-tert-butylnitrone (PBN) analogues. The synthesized hBNs 1–9 were evaluated for their antioxidant activity using different in vitro techniques, while they were also tested as inhibitors of soybean LOX, as an indication of their anti-inflamma...

Verbal fluency tests are easy and quick to use in neuropsychological assessments. The aim of this study is to explore their relevance through a bibliometric analysis. We performed a search in the Web of Science, involving documents published between 1960 and 2021. We used bibliometric indicators to explore articles distribution, doubling time, and...

Fundamento La afectación cognitiva en pacientes con neurocisticercosis es frecuente, por lo tanto, resulta de gran utilidad contar con instrumentos pronósticos para establecer un mejor manejo de esta. Objetivo proponer una escala predictiva de deterioro cognitivo en pacientes adultos con neurocisticercosis. Métodos estudio con diseño correlaciona...

Fundamento: la afectación cognitiva en pacientes con neurocisticercosis es frecuente, por lo tanto, resulta de gran utilidad contar con instrumentos pronósticos para establecer un mejor manejo de esta. Objetivo: proponer una escala predictiva de deterioro cognitivo en pacientes adultos con neurocisticercosis. Métodos: estudio con diseño correlacion...

Introducción. La neurocisticercosis es la enfermedad parasitaria más frecuente en el sistema nervioso central de los humanos. Objetivo. Establecer la correlación entre variables clínicas y tomográficas en pacientes con neurocisticercosis en la consulta de neurología del Hospital San Vicente de Paúl y el Hospital Instituto Ecuatoriano de Seguridad...

Fundamento: Muchos pacientes con neurocisticercosis manifiestan deterioro cognitivo, con afectaciones importantes en su calidad de vida. Objetivo: determinar la correlación entre el estado cognitivo y los hallazgos tomográficos en pacientes con neurocisticercosis. Métodos: estudio correlacional, prospectivo y transversal, que incluyó a 93 pacientes...

Case management is a model of personalized intervention in people with severe mental illness. To explore the treatment adherence and effectiveness of patients with severe schizophrenia (Clinical Global Impression Severity, CGI-S ≥ 5) undergoing treatment in a community-based, case-managed program (CMP) with an integrated pharmacological and psychos...

Background The figure of Luis Simarro Lacabra is not well-known outside Spain, but within the country became a character of special scientific and public importance. Luis Simarro, a person of a marked progressist spirit, not only was involved from his youth for in political matters, showing great interest in the modernization of a nation anchored i...

Introduction: Neurocysticercosis (NCC) is the most frequent parasitic disease in the central nervous system of humans. Objective: to establish the correlation between clinical and tomographic variables in patients with neurocysticercosis in the neurology consultation of Hospital San Vicente de Paul and Hospital IESS Ibarra, during the year 2020....

Fundamento: el dolor por cáncer sigue siendo difícil de tratar, especialmente cuando el paciente es resistente a los opioides. Cada vez más se buscan alternativas para contrarrestar y mejorar los síntomas provocados por la enfermedad. Uno de ellos es la ketamina, que actúa como antagonista de los receptores de N-metil-daspartato que se asocian como...

Fundamento: el pronóstico y la terapéutica del cáncer de mama están estrechamente relacionados con las características histopatológicas del paciente. Estas permiten establecer grupos pronósticos, como apoyo en la decisión de tratamientos individuales efectivos. Sin embargo, la información existente sobre la relación entre estos aspectos y los subti...

Fundamento: Muchos pacientes con neurocisticercosis manifiestan deterioro cognitivo, con afectaciones importantes en su calidad de vida. Objetivo determinar la correlación entre el estado cognitivo y los hallazgos tomográficos en pacientes con neurocisticercosis. Métodos estudio correlacional, prospectivo y transversal, que incluyó a 93 pacientes...

Resumen: René Descartes encarna el espíritu contradictorio de la modernidad, no solo por encontrarse atrapado entre la filosofía idealista y la ciencia materialista, o entre el cuerpo y el alma, sino también porque tal vez consideró que no existía contradicción de fondo en ello. Su obra trató de aunar lo que estimó valioso de entre lo antiguo y lo...

The role played by serendipity in the origin of modern psychopharmacology has proven to be controversial in scientific literature. In its original meaning (Walpole), serendipity refers to discoveries made through a combination of accidents and sagacity. We have implemented an operational definition of serendipity based on finding something unexpect...

The world faces an exceptional new public health concern caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequently termed the coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO). Although the clinical symptoms mostly have been characterized, the scientific community still doesn´t know how SARS-C...

Herein, we report the synthesis, antioxidant, and neuroprotective properties of some nucleobase-derived nitrones named 9a–i. The neuroprotective properties of nitrones, 9a–i, were measured against an oxygen-glucose-deprivation in vitro ischemia model using human neuroblastoma SH-SY5Y cells. Our results indicate that nitrones, 9a–i, have better neur...

El presente trabajo analiza la línea editorial de la revista de educación y psicopedagogía Didascalia, publicada entre 1970 y 1975, fundada por Felipe Segovia Olmo, y posiblemente primera en España con pretensiones formativas de largo alcance en el seno de la profesión docente. La publicación, nacida al mismo tiempo que la reforma educativa de 1970...

Introducción: El presente trabajo aborda el análisis de la producción científica de la Academia de Ciencias de Cuba (ACC) mediante el empleo de herramientas bibliométricas, en el periodo comprendido entre el año 1995 hasta la actualidad, etapa donde la institución, a partir del Decreto Ley 163 de 1996, pasa a funcionar como un órgano consultor y as...

Es conocido el hecho de que un mecanicista de manual, incluso fundacional, como lo fue René Descartes (1596-1650) (figura 1), admitió la existencia de una mente inmaterial o alma -res cogitans-, liberada por completo de las leyes de la mecánica y a cuyas percepciones íntimas llamó “pasiones” en la línea del pensamiento de la época (López-Muñoz & Ál...

The objective of this study was to understand the psychosocial and pharmacological approaches linked to better treatment adherence and outcomes (psychiatric hospitalizations, clinical severity, and suicide attempts) among patients with schizophrenia receiving the standard treatment in mental health units (MHUs) compared with patients in a community...

La revista de innovación educativa Didascalia, que inició su andadura en la década de 1970, compartiendo acta de nacimiento con la nueva Ley de Educación española, fue una publicación pionera e injustamente olvidada por la historiografía reciente. Por sus páginas no solo pasaron las figuras más pujantes y granadas de la psicopedagogía, la educación...

Torture is a practice as old as humanity itself, although its objectives have changed throughout history. The participation of medical personnel in the exercise of torture has been common in some historical moments. During the middle ages, torture was the instrument used by justice to obtain confessions, but doctors did not regularly participate in...

Background Diagnosis of schizophrenia lacks of reliable medical diagnostic tests and robust biomarkers applied to clinical practice. Schizophrenic patients undergoing treatment with antipsychotics suffer a reduced life expectancy due to metabolic disarrangements that co-exist with their mental illness and predispose them to develop metabolic syndro...

This paper analyzes the influence of Cuba's independence war on the thought and work of Santiago Ramón y Cajal, Nobel Prize in Medicine and possibly the most relevant neuroscientist in history. During his youth, Cajal participated, as a military doctor, in Cuba’s Ten Years' War and remained on the island for more than a year, treating wounded and s...

Objective: The aim of this study is to analyze the scientific production of the Cuban Academy of Sciences (the Academy, in what follows) using bibliometric tools. Methods: We performed a search in Web of Science, involving documents published between 1968 and 1994, a period in which the Academy acted as a multidisciplinary scientific institution wi...

The aim of this study is to explore the relevance of scientific production on venture capital using bibliometric and mapping tools. We performed a search in Scopus, involving any document published between 1978 and 2020. We used bibliometric indicators to explore documents production, dispersion, distribution, time of duplication, and annual growth...

Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, like any other invading microbe, enacts a generalized immune response once the virus contacts t...

Background The evaluation of long-term effectiveness and tolerability of Aripiprazole Once-monthly (AOM) is yet scarce, and severely ill patients have not been specifically studied. Objective The aim of the study was to explore the long-term adherence, effectiveness and tolerability of AOM in the treatment of patients with severe (Clinical Global...

Background Miguel de Cervantes (1547–1617) was a Spanish writer, who has often been considered as the greatest writer in the Spanish language and one of the world's outstanding novelists. His novel Don Quixote , is a work often cited as both the first modern novel and one of the best works of world literature. The life of Cervantes has been full of...

Sigma (σ) receptors represent attractive targets for the development of potential agents for the treatment of several disorders, including Alzheimer's disease and neuropathic pain. In the search for multitarget small molecules (MSMs) against such disorders, we have re-discovered chromenones as new affine σ1/σ2 ligands. 6-(4-(Piperidin-1-yl)butoxy)-...

Purpose The aim of this study is to explore the relevance of scientific production on glaucoma using bibliometric tools. Design Bibliographic study Subjects Original articles published in the timeframe 1900-2019 Methods We performed a search in Web of Science for documents published between 1900 and 2019. We used bibliometric indicators to explo...

Blister or vesicant chemical warfare agents (CWAs) have been widely used in different military conflicts, including World War I and the Iran-Iraq War. However, their mechanism of action is not fully understood. Sulfur and nitrogen mustard exert toxic effects not only through the alkylation of thiol-bearing macromolecules, such as DNA and proteins,...

Paliperidone palmitate every three months (PP3M) is expected to facilitate patient’s treatment compliance and satisfaction. The objective here was to compare PP3M treatment compliance and satisfaction, effectiveness and tolerability, with paliperidone palmitate-monthly (PP1M) in patients with severe schizophrenia. A 24-month prospective, open-label...