Francisco Carlos Groppo

State University of Campinas (UNICAMP) | UNICAMP ·  Departamento de Ciências Fisiológicas

Purpose This study utilized cone-beam computed tomography images to assess the potential of maxillary sinus (MS) and piriform aperture (PA) measurements in sex prediction and to identify possible correlations between these structures and the MS ostium. Methods A total of 204 images were selected and divided into two groups: 102 for constructing an...

Intranasal topical administration offers a promising route for local and systemic drug delivery, with in vitro permeation and mucoadhesion studies often using porcine models. However, the impact of storage on mucosal integrity after the procedure remains unaddressed. This study aimed to standardize the preparation process and evaluated whether stor...

The study aimed to assess the impact of combining potassium iodide (KI) with methylene blue (MB) in antimicrobial photodynamic therapy (aPDT) within an oral biofilm formed in situ. A single-phase, 14 days in situ study involved 21 volunteers, who wore a palatal appliance with 8 bovine dentin slabs. These slabs were exposed to a 20% sucrose solution...

Background and Objectives: This study investigates the efficacy of 4% articaine buccal infiltration in patients with mandibular molar irreversible pulpitis. The goal is to understand the anatomical factors contributing to articaine's success in mandibular infiltrations. Materials and Methods: A randomized controlled trial was conducted with 50 pati...

To evaluate the positions of the mandibular foramen (MF) and mandibular canal (MC) between different skeletal classes to highlight the implications for bilateral sagittal split osteotomy (BSSO). A cross-sectional study was performed using cone-beam computed tomography on 90 patients classified into classes I, II and III. Linear measurements were pe...

Background: L-arginine (Arg) is an amino acid that contributes to several aspects of human biochemistry. Individuals with malnutrition and certain physical conditions could benefit from arginine intake. However, as Arg is required by certain viruses, it is advised to avoid it in one’s diet and supplementation during viral illnesses. New studies hav...

The oral health-related quality of life of pregnant women and its effects on health conditions are important topics to be investigated in scientific research. The objective of this study was to evaluate the impact of pre-pregnancy obesity on oral health-related quality of life (OHRQoL) in pregnant women. A prospective cohort study was carried out w...

Herpetic Epithelial Keratitis is characterized by a corneal dendritic lesion, and prolonged or recurrent medication such as acyclovir, raises the possibility of resistant strains, necessitating the search for new therapies. An 84-year-old woman, phototype III, reported severe discomfort in the left eye. The presence of a dendritic ulcer was confirm...

Lidocaine is the most commonly used local anesthetic worldwide, known for its rapid onset and moderate duration of anesthesia. However, it is short-lived and does not effectively promote effective topical anesthesia in the oral cavity when used alone. Our aim was to investigate whether an approximate 50% encapsulation of lidocaine in poly(ε-caprola...

Objective: To investigate the association of perforation of the maxillary sinus floor by dental implants with mucosal thickening and to describe its characteristics in perforated cases. Study Design: One-hundred and twenty-nine maxillary sinuses of 93 patients presenting 202 dental implants in the maxillary posterior region were retrospectively ass...

Objectives: The aim of this study was to evaluate the prevalence of comorbidities in patients treated at the FOP-UNICAMP undergraduate clinic. A survey based on patient records obtained between June 2021 and November 2022 was conducted. Comorbidities, such as hypertension, diabetes, and heart diseases, among others, were identified. Additionally, d...

This crossover study aimed to compare the anesthetic effects of buffered 2% articaine with 1:200,000 epinephrine with that of non-buffered 4% articaine with 1:200,000 epinephrine. Forty-seven volunteers were administered two doses of anesthesia in the buccal region of the second mandibular molars in two sessions using 1.8 mL of different local anes...

The present study aimed to compare latency and duration of inferior alveolar nerve block delivered by the carpule syringe or the Morpheus® computerized system. This study was a split-mouth, double-blind, randomized clinical trial with 31 volunteers. The inferior alveolar nerve block was performed with carpule syringe and Morpheus® device. The teeth...

Most dental procedures require the use of local anesthetics. The Morpheus™ anesthetic computerized injector (Morpheus™ injector) provides painless needle insertion and satisfactory anesthesia with lower volumes of local anesthetic. The use of the intraseptal Alveolar Crest Spongy Bone Area (ACSBA) anesthesia technique with the Morpheus™ injector is...

Introduction: Anxiety is one of the components of patient stress in the dental office and is recognized as one of the main factors that negatively affect treatment. The use of phytotherapics represents an option for the control of conventional anxiety. Thus, the objective of this study is to evaluate the effect of the association between Valeriana...

Accurate mandibular canal (MC) detection is crucial to avoid nerve injury during surgical procedures. Moreover, the anatomic complexity of the interforaminal region requires a precise delineation of anatomical variations such as the anterior loop (AL). Therefore, CBCT-based presurgical planning is recommended, even though anatomical variations and...

Objective: Evaluate the effectiveness of blood pressure control in hypertensive patients using bloodletting on ear apex technique before tooth extraction. Methods: This observational prospective case series carried out on 65 volunteers who needed simple tooth extraction and had blood pressure above 140 / 90mmHg. The blood pressure measurement occur...

Objective: The aim of this study was to evaluate the influence of binarization methods (BnMs) on the fractal dimension (FD) of the alveolar bone in digital radiographic images. Study design: Five identical periapical radiographs were obtained from each of 20 anatomic regions. Using ImageJ/Fiji software, a standardized region of interest was posi...

Objective: The present study compared three models of induction of osteoarthritis (OA) and rheumatoid arthritis (RA) in the temporomandibular joint (TMJ) of rats. Design: The induction method was by injection of complete Freund's adjuvant (CFA) + type II bovine collagen (CII). Twenty-four adult male rats were divided into four groups (n = 6): G1...

To avoid the reactivation of latent viruses of the herpesvirus family, is important the lysine/arginine balance in the diet with a high control of arginine intake. To control the multiplicativa of the virus, when active, an increase in the supply of L-Lysine ( an arginine antagonist ) and a reduction in the intake of L-Arginine are indicated.

The study aimed to assess the influence of excessive use of a photostimulable phosphor plate (PSP) on the density, image noise, and contrast of radiographs. For that, radiographs of an acrylic block were acquired with a PSP of the Express intraoral system to assess the density and image noise. Initially, five images were obtained and exported (firs...

We evaluated the influence of population size (POP), HDI (Human Development Index) and GDP (gross domestic product) on the COVID-19 pandemic in the Southeast region of Brazil, between February 2020 and May 2021. Methods: Cases, deaths, incidence coefficient, mortality rate and lethality rate were compared among states. The cities were divided int...

Objective : To evaluate the influence of extensive use of a photostimulable phosphor (PSP) receptor on the diagnosis of proximal carious lesions. Study Design : Forty posterior teeth were paired and mounted in 20 phantoms. Using a PSP receptor of the Express intraoral system, one radiograph of each phantom was acquired, totaling 20 radiographs (Gr...

Introduction: Hancornia speciosa Gomes is a plant used in traditional Brazilian medicine. Its therapeutic activity can be explained by the presence of secondary metabolites. It is found in biomes such as the Amazon, Brazilian semiarid (caatinga), Atlantic forest and cerrado. The objective of this study was to review the literature, compiling inform...

Objective : To evaluate the efficacy of methylene blue (MB)-mediated antimicrobial photodynamic therapy (aPDT) doped with potassium iodide (KI) against oral microcosms biofilms cultured in dentin. Methods : A saliva-glycerol stock formed from pooled human saliva was diluted in McBain artificial saliva with 1% sucrose (1:1), inoculated on bovine de...

Objetivo: Investigar a correlação entre o crescimento do número de ocorrências por lesão corporal dolosa e internações por queda, com ênfase no primeiro ano da pandemia de COVID-19 (2020). Métodologia: Estudo do tipo observacional ecológico. Para avaliação econômica parcial do custo da doença, foram extraídos dados sociodemográficos do Datasus. Em...

Knowledge about viral characteristics, mechanisms of entry into the host cell and multiplication/dissemination can help in the control and treatment of viral pathologies. Several nutritional factors linked to the host may favour viral multiplication and their control, may lead to new prophylactic alternatives and/or antiviral therapies. The objecti...

Objectives To evaluate the influence of digital filters of intraoral radiographic systems on the diagnosis of simulated internal and external root resorptions and image quality. Materials and methods Internal root resorption (IRR) and external root resorption (ERR) were simulated in 34 teeth. For image acquisition, two radiographic systems were us...

Although rare, complications can occur with anesthetic procedures. The posterior superior alveolar nerve (PSAN) block anesthetic technique has a high success rate, but positive aspiration can cause bruising, transient diplopia, blurred vision, and temporary blindness in approximately 3% cases. When edema occurs, it is occasionally massive, especial...

Objective To verify the effectiveness of acupuncture using Traditional Chinese Medicine tools (pulse and tongue), for several clinical conditions, in the public health service. This is a retrospective clinical study running in a single healthcare referral center in Brazil. Seventy-two patients participated (retrospective review of medical records)....

The aim of this study was to emphasize the importance of monitoring vital signs, especially blood pressure, during dental care. Through a narrative review, the changes in blood pressure that may occur during outpatient procedures and the measures to be taken were discussed. The available literature was consulted in databases (PubMed, Scielo, Web of...

Introduction: The aim of this study was to assess the agreement between oral and maxillofacial radiologists (OMFR) and oral and maxillofacial surgeons (OMFS) for the detection of bifid mandibular canal (BMC) and accessory mental foramen (AMF) using cone-beam computed tomography (CBCT). Material and Methods: This retrospective study involved 22 exam...

Objective To evaluate the effect of polyunsaturated fatty acid-type omega 3 (ω3) on the temporomandibular joint (TMJ) of ovariectomized rats (OVX) with rheumatoid arthritis (RA). Design Rheumatoid arthritis was induced using complete Freund's adjuvant and type II bovine collagen injected at the base of the tail. Twenty-four adult female rats were...

This study aimed to evaluate the effects of omega-3 (ω3) polyunsaturated fatty acids, in association with aspirin (AA), on the morphology of cytokine release in the temporomandibular joint (TMJ) of rats induced with rheumatoid arthritis (IR) by injecting 100 μL of complete Freund’s adjuvant with bovine type II collagen at the tail base. Thirty-two...

Objectives This randomized, triple-blind, crossover clinical trial aimed to evaluate the efficacy, onset, length of pulp and soft tissue anesthesia, and pain during injection of 2% buffered articaine and 4% non-buffered articaine solutions. Methods Each volunteer received two maxillary supraperiosteal anesthesia infiltrations in canine area. The i...

Permeation assays are important for the development of topical formulations applied on buccal mucosa. Swine buccal and esophageal epithelia are usually used as barriers for these assays, while frozen epithelia have been used to optimize the experimental setup. However, there is no consensus on these methods. In transdermal studies, barrier integrit...

Evaluating factors that may influence the nose dimensions and, therefore, contribute to the singularity of a person, is important for obtaining a precise facial reconstruction (FR) in forensic anthropology. Thus, the aim in this study was to evaluate the influence of sex, skeletal class, and facial type on nose dimensions of Brazilian individuals u...

Introduction: Sex estimates are generally based on the evaluation of qualitative and quantitative aspects of anatomic structures, however, the latter has better reproducibility and reliability. Objective: Aiming to evaluate the viscerocranium as a tool for sexual prediction and verify the possibility of creation of a logistic regression model for s...

The present study correlated the mineralization of third molars to chronological age using a modified classification based on Demirjian’s stages in a Brazilian subpopulation and compared with the original classification. A total of 1082 patients with age ranging from 6 to 26 years were included in the sample, with at least one third molar on panora...

Objectives This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction. Methods The volunteers underwent extraction of their third mandibular molars in a randomized, placebo-controlled, triple-blind, and parallel clinical trial. Pas...

To determine whether the permeation capacity and analgesic efficacy of articaine (ATC) could be increased and cytotoxicity decreased by encapsulation in poly(ɛ-caprolactone) nanocapsules (ATCnano), aiming at local or topical anesthesia in dentistry. Cellular viability was evaluated (using the MTT test and fluorescence microscopy) after 1 h and 24 h...

Background: Obesity and bariatric surgery may be related with mental and oral disorders. Aim: To evaluate the impact of bariatric surgery on anxiety, initial dental caries lesion and gingival bleeding in obese patients. Methods: Eighty-nine patients were divided in two groups: Control Group (CG) - obese patients and Experimental Group (EG) - p...

Pityriasis Rosea (PR) is a dermatological disease with an erythemato‐papulosquamous manifestation, distributed on the trunk and extremities affecting healthy people, especially children and young people between 10 and 35 years of age. The evolution is 6 to 8 weeks and may remain for 3 to 6 months. It regresses spontaneously and can leave changes in...

Pityriasis Rosea (PR) is a dermatological disease with an erythemato‐papulosquamous manifestation, distributed on the trunk and extremities affecting healthy people, especially children and young people between 10 and 35 years of age. The evolution is 6 to 8 weeks and may remain for 3 to 6 months. It regresses spontaneously and can leave changes in...

PURPOSE To verify the influence of computer-aided design/computer-aided manufacturing (CAD/CAM) implant-supported prostheses manufactured with cobalt-chromium (Co-Cr) and zirconia (Zr), and whether ceramic application, spark erosion, and simulation of masticatory cycles modify biomechanical parameters (marginal fit, screw-loosening torque, and stra...

Objectives The aim of this study was to evaluate glycemic levels in diabetic patients before, during, and after extractions using 2% lidocaine with 1:100,000 epinephrine (Lido/Epi) and 3% prilocaine with 0.03 IU/mL felypressin (Prilo/Fely).Materials and methodsA double-blind, randomized clinical trial was conducted to evaluate changes in body param...

The objective of the present study was to evaluate discomfort and safety of microneedle (MN) insertion in several intraoral regions. A device was developed to standardize MN insertions. MNs were inserted in the following regions of the oral cavity: gingiva, palatine alveolar process, buccal mucosa, dorsum of the tongue and inner portion of the lowe...

Objectives To compare the pulp volume of individuals with altered and normal systemic blood pressure (BP) in order to verify if high BP promotes dimensional modifications in the pulp space.Materials and methodsCone beam computed tomography scans of 91 patients (49 females and 42 males, mean age 31.7 ± 6.38 years) who had a healthy maxillary canine...

Objective: To evaluate the radioprotective effect of a homeopathic solution in salivary function and in parotid glands morphology of irradiated rats. Materials and Methods: The sample consisted of 150 rats randomly divided in 6 groups. The groups were named based on the substance administered: Control- saline solution; Irradiated Control- saline so...

Objective The aim of this study was to compare the local anesthesia efficacy of ropivacaine 0.75% compared to lidocaine 2% with 1:100,000 epinephrine for postoperative analgesia following extraction of impacted mandibular third molar. Study Design In this crossover, double-blind, randomized clinical trial, 30 participants underwent surgical remova...

Objectives: To present the ballistic gelatin as a new material capable of simulating the soft tissues in cone-beam CT (CBCT) images. Methods: CBCT images of three piglet heads were acquired with their soft tissues intact (standard group). Subsequently, the piglet heads were fixed in a container using metallic pins and moulded with acrylic resin;...

Introduction: According to some studies, the source of cholesterol inside periapical lesions may be partially from the condensation and crystallization of cholesterol in the cyst wall. Further, the cholesterol can be derived from local metabolic products or the vascular circulation. Objective: This study aimed to analyze the relationship between th...

The person‐to‐person transmission of SARS‐CoV‐2 may occur directly or indirectly through saliva, and a preoperational use of antimicrobial mouthwash is considered to reduce the number of oral microbes. 1 Chlorhexidine mouthwash has been a common antiseptic agent used in dentistry, both preoperative and postoperative use reducing post‐surgical infec...

Glycosamine is an amino-monosaccharide present in connective and cartilage tissues that contribute to the maintenance, resistance, flexibility and elasticity of these tissues. This study aimed to determine the in vivo effects of glucosamine sulfate (GS) on the temporomandibular joint (TMJ) of ovariectomized rats (OVX).Thirty-two rats were distribut...

Articaine (ATC) is one of the most widely used local anesthetics in dentistry. Despite its safety, local toxicity has been reported. This study aimed to develop an ATC-2- hydroxypropyl-β-cyclodextrin inclusion complex (ATC HPβCD) and to assess its toxicity in vitro. The inclusion complex was performed by solubilization, followed by a fluorimetric a...

The aim in this study was to evaluate the influence of skeletal class, facial type, and sex on soft tissue thickness (STT) of the craniofacial midline in a Brazilian subpopulation. Thus, 121 cone beam computed tomography (CBCT) scans (54 males and 67 females, age 21 to 40 yrs) composed the study sample. Patients were classified according to skeleta...

Objective: To investigate whether academic stress changes the salivary microbiota and its relationship with salivary parameters, evaluating the effects on the production of volatile sulfur compounds (VSCs) in healthy women. Methods: Fifty-five women enrolled in a four-year Dentistry course were assessed for academic stress by the questionnaire M...

Background Antiproliferative and cytotoxic effects of lidocaine has been reported in tumor cells. However, the use of these drugs is restricted due to their short action with rapid dispersion from injected site. The complexation of local anesthetics in 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) are able to improve pharmacological features. Objective...

Background The aim of this study was to compare the ability of liposomal and non-liposomal lidocaine and prilocaine in hydrogel formulations to promote topical anesthesia in palatal mucosa during upper molar extractions. Methods In this randomized, cross over, triple-blinded clinical trial, a liposomal and a non-liposomal formulation of the eutect...

Objective This observational, cross-sectional study aimed to evaluate the association between pre-pregnancy overweight/obesity, periodontitis during the third trimester of pregnancy, and the infants' birth weight. Methodology The sample set was divided into 2 groups according to the preconception body mass index: obesity/overweight (G1=50) and nor...

Objective To create a new phantom design to evaluate the real impact of artefacts caused by titanium on bone structures in CBCT images considering different positions and quantity of metals in the dental arch, with and without Metal Artefact Reduction (MAR). Methods A three cylindrical polymethyl methacrylate (PMMA) plate phantom was designed cont...

Aim : The objective of this crossover clinical study was to evaluate the effectiveness of Energy Regulation with Acupuncture in clinical occurrences in impacted lower third molar surgeries. Methods: The sample consisted of 22 patients with two impacted third molars, in symmetrical position; divided into two groups: Test Group (TG) with Real Energy...

A partir do paradigma de que a determinação do sexo post mortem pode ser realizada em qualquer osso humano, o presente estudo observacional analítico foi realizado em 191 ossadas de brasileiros, sendo 109 do sexo masculino e 86 do sexo feminino, existentes no Biobanco Osteológico e Tomográfico Prof. Dr. Eduardo Daruge da FOP/UNICAMP, que não aprese...

O presente estudo analítico observacional tem a finalidade de verificar a presença de dimorfismo sexual em ossadas brasileiras por meio de medidas lineares realizadas no crânio (o losango formado pelo forame incisivo – forame palatino maior (direito e esquerdo) e forame palatino maior – básio (direito e esquerdo)), pelve (diâmetro vertical do acetá...

This study evaluated the effect of systemic administration of omega-3 on the expression of interleukins IL-1β and IL-10 and tumour necrosis factor alpha (TNF-α) and on the thickness of cartilage in the temporomandibular joint (TMJ) inflammatory model induced by complete Freund’s adjuvant (CFA). Thirty-two adult rats were divided equally into four g...

Objective To evaluate the systemic and periodontal conditions, as well as the determinants of health in pregnant women with and without obesity/overweight during the second and third trimesters of pregnancy and after delivery. Materials and methods In the second trimester (T1), 93 pregnant women were divided into two groups with either excessive w...

ABSTRACT Objective: to address the possible causes, complications and management of the hypertensive crisis in a case report in the area of Implantology. Case report: a 64-year-old male, 56 kg, with 7 compromised dental elements in the anteroposterior region of the mandible, had as its treatment plan their removal and the installation of immediate...