Francisco C. Ceballos

Francisco C. Ceballos
Instituto de Salud Carlos III | ISCIII · CIBER of Rare Diseases (CIBERER)

PhD
Human Genetics & Biostatistics.

About

31
Publications
24,552
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561
Citations
Introduction
I'm a population geneticist with a huge interest in Biometrics and Conservation Genetics.
Additional affiliations
August 2020 - September 2021
Instituto de Salud Carlos III
Position
  • COVID-19 Research
June 2019 - June 2020
Middle East Technical University
Position
  • PostDoc Position
May 2016 - January 2017
The University of Edinburgh
Position
  • PostDoc Position
Education
September 2012 - February 2014
University of Santiago de Compostela
Field of study
  • Statistics
September 2009 - July 2013
University of Santiago de Compostela
Field of study
  • Population Genetics
September 2005 - May 2008
University of Santiago de Compostela
Field of study
  • Biomedicine

Publications

Publications (31)
Article
Full-text available
Switching dual therapy with dolutegravir (DTG) plus rilpivirine (RPV) was assessed in the SWORD-1 and SWORD-2 studies. Real-life data regarding the immunological impact of this approach on CD4+ and CD8+ T lymphocyte counts and the CD4/CD8 ratio are scarce. We evaluated this strategy on the basis of clinical practice data. A multicentric retrospecti...
Article
Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10−8) was crossed for varia...
Article
Full-text available
Human gut microbiome research focuses on populations living in high-income countries and to a lesser extent, non-urban agriculturalist and hunter-gatherer societies. The scarcity of research between these extremes limits our understanding of how the gut microbiota relates to health and disease in the majority of the world’s population. Here, we eva...
Article
Full-text available
Background: MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. Methods and...
Article
Background & Aims People who inject drugs (PWID) and other marginalized populations with high hepatitis C virus (HCV) infection rates represent a unique challenge for treatment initiation due to health, administrative and social barriers. We analyzed the HCV cascade of care (CoC) in some vulnerable subpopulations in Madrid, Spain, when using a mobi...
Conference Paper
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Article
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Background: The link between coagulation system disorders and COVID-19 has not yet been fully elucidated. Aim: Evaluating the association of non-previously reported coagulation proteins with COVID-19 severity and mortality. Design: Cross-sectional study of 134 COVID-19 patients recruited at admission and classified according to the highest COVID-19...
Article
The history of human inbreeding is controversial. In particular, how the development of sedentary and/or agricultural societies may have influenced overall inbreeding levels, relative to those of hunter-gatherer communities, is unclear. Here, we present an approach for reliable estimation of runs of homozygosity (ROHs) in genomes with ≥3× mean sequ...
Article
Full-text available
The analysis of the effects of autozygosity, measured as the change of the mean value of a trait among offspring of genetic relatives, reveals the existence of directional dominance or overdominance. In this study we detect evidence of the effect of autozygosity in 4 out of 13 cardiometabolic disease-associated traits using data from more than 10,0...
Preprint
Full-text available
The history of human inbreeding is controversial. The development of sedentary agricultural societies may have had opposite influences on inbreeding levels. On the one hand, agriculture and food surplus may have diminished inbreeding by increasing population sizes and lowering endogamy, i.e. inbreeding due to population isolation. On the other hand...
Article
Full-text available
The South Asian subcontinent is characterized by a complex history of human migrations and population interactions. In this study, we used genome-wide data to provide novel insights on the demographic history and population relationships of six Indo-European populations from the Indian State of West Maharashtra. The samples correspond to two castes...
Article
Full-text available
Massive genotyping of single nucleotide polymorphisms (SNP) has opened opportunities for analyzing the way in which selection shapes genomes. Artificial or natural selection usually leaves genomic signatures associated with selective sweeps around the responsible locus. Strong selective sweeps are most often identified either by lower genetic diver...
Article
Background: The “Habsburg jaw” has long been associated with inbreeding due to the high prevalence of consanguineous marriages in the Habsburg dynasty. However, it is thought that mandibular prognathism (MP) is under the influence of a dominant major gene. Aim: To investigate the relationship between the “Habsburg jaw” and the pedigree-based inbree...
Article
Full-text available
The study of runs of homozygosity (ROH) can shed light on population demographic history and cultural practices. We present a fine-scale ROH analysis of 1679 individuals from 28 sub-Saharan African (SSA) populations along with 1384 individuals from 17 worldwide populations. Using high-density SNP coverage, we could accurately identify ROH > 300 kb...
Article
Full-text available
In the Original article published, the figure number 5: Genomic distribution of ROH is incorrectly published. The correct figure is given below.
Preprint
The study of runs of homozygosity (ROH), contiguous regions in the genome where an individual is homozygous across all sites, can shed light on the demographic history and cultural practices. We present a fine-scale ROH analysis of 1679 individuals from 28 sub-Saharan African (SSA) populations along with 1384 individuals from 17 world-wide populati...
Article
Full-text available
Background: Runs of Homozygosity (ROH) are genomic regions where identical haplotypes are inherited from each parent. Since their first detection due to technological advances in the late 1990s, ROHs have been shedding light on human population history and deciphering the genetic basis of monogenic and complex traits and diseases. ROH studies have...
Article
Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding gives rise to such autozygosity; however, genome-wide data reveal that ROH are universally common in human genomes even among outbred individuals. The number and length of ROH...
Preprint
Full-text available
Runs of Homozygosity (ROH) are sequences that arise when identical haplotypes are inherited from each parent. Since their first detection due to technological advances in the late 1990s, ROHs have been shedding light on human population history and deciphering the genetic basis of monogenic and complex traits and diseases. ROH studies have predomin...
Article
Full-text available
Charles Darwin’s lifetime illness with its many disabling symptoms may be explained by an inherited pathological mtDNA mutation. Although such a diagnosis explains Darwin’s illness and the strange illnesses that afflicted his Wedgwood maternal forebears, it does not explain the illnesses that affected Darwin’s children. The sicknesses of the childr...
Article
Objective: The impact of inbreeding in the two branches of the Habsburg dynasty, the Spanish and the Austrian Habsburgs, is investigated to explain why the Spanish lineage was extinguished at the end of the 17th century and the Austrian lineage not. Methods: Kinship and inbreeding coefficients for the Habsburgs were computed from pedigree analys...
Article
Full-text available
Charles Darwin, who was married to his first cousin Emma Wedgwood, was the first experimentalist to demonstrate the adverse effects of inbreeding. He documented the deleterious consequences of self-fertilization on progeny in numerous plant species, and this research led him to suspect that the health problems of his 10 children, who were very ofte...
Article
Mammalian studies have shown a link between serotonin (5-HT) and neuropeptide Y (NPY) in the acute regulation of feeding and energy homeostasis. Taking into account that the actions of 5-HT and NPY on food intake in fish are similar to those observed in mammals, the objective of this study was to characterize a possible short-term interaction betwe...
Article
Full-text available
The European royal dynasties of the Early Modern Age provide a useful framework for human inbreeding research. In this article, consanguineous marriage, inbreeding depression and the purging of deleterious alleles within a consanguineous population are investigated in the Habsburgs, a royal dynasty with a long history of consanguinity over generati...
Article
Full-text available
Hypertension and congenital aortic valve malformations are frequent causes of ascending aortic aneurysms. The molecular mechanisms of aneurysm formation under these circumstances are not well understood. Reference genes for gene activity studies in aortic tissue that are not influenced by aortic valve morphology and its hemodynamic consequences, ao...
Article
Full-text available
Charles Darwin, who was married to his first cousin, Emma Wedgwood, was one of the first experimentalists to demonstrate the adverse effects of inbreeding and to question the consequences of consanguineous mating. He documented the phenomenon of inbreeding depression for numerous plant species, and this caused him to worry about the health of his o...
Article
Full-text available
The kings of the Spanish Habsburg dynasty (1516-1700) frequently married close relatives in such a way that uncle-niece, first cousins and other consanguineous unions were prevalent in that dynasty. In the historical literature, it has been suggested that inbreeding was a major cause responsible for the extinction of the dynasty when the king Charl...

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Projects

Projects (2)
Project
Using Runs of Homozygosity (ROHs) in African and World populations disclose the natural history of communities and to understand the genetic architecture of complex diseases and traits in general.