Francisco Cajade-Pascual

• Master of Pharmacy
• Complejo Hospitalario Universitario de Santiago

Background and Objectives: The use of artificial intelligence (AI) and, in particular, machine learning (ML) techniques is growing rapidly in the healthcare field. Their application in pharmacokinetics is of potential interest due to the need to relate enormous amounts of data and to the more efficient development of new predictive dose models. The...

Background and Objectives: The use of Artificial intelligence (AI) and, in particular, Machine Learning (ML) techniques is growing rapidly in the healthcare field. Their application in pharma-cokinetics is of potential interest due to the need to relate enormous amounts of data and to the more efficient development of new predictive dose models. Th...

Introduction Linezolid is a broadly used antibiotic to treat complicated infections caused by gram-positive bacteria. Therapeutic drug monitoring of linezolid concentrations is recommended to maximise its efficacy and safety, mainly haematological toxicity. Different pharmacokinetic/pharmacodynamic targets have been proposed to improve linezolid ex...

Background and Importance Magnesium deficiency is mainly manifested in cardiac and neuromuscular disorders. Hypomagnesaemia has been described as a frequent adverse reaction associated with the intravenous administration of liposomal amphotericin B. Aim and Objectives To compare associated hypomagnesaemia in patients with fungal infection receivin...

Background and Importance Obeticholic acid (OCA) is an orphan drug for patients with primary biliary cholangitis (PBC), a rare autoimmune disease, who do not respond adequately to treatment with ursodeoxycholic acid (UDCA) or do not tolerate it. Aim and Objectives To evaluate the efficacy and safety of OCA in patients with PBC. Material and Metho...

Background and Importance Hypothyroidism is a limiting and underestimated adverse effect of metastatic prostate cancer treatments, the impact of which in elderly patients is more significant. Apalutamide and enzalutamide are drugs with similar chemical structure, but differ in terms of adverse effect profile. Hypothyroidism is described as a common...

Background and Importance In the literature, there is an indicator of response to treatment with enzalutamide and apalutamide, defined as PSA90, for patients with metastatic castration-sensitive prostate cancer (mCSPC). However, no early response marker to abiraterone treatment in the setting of synchronous mCSPC has been described. Aim and Object...

Background and Importance Therapeutic drug monitoring in inflammatory bowel disease (IBD) is a useful tool for optimising biologic therapy. The analysis of adalimumab (ADL) concentrations in blood through enzyme-linked immunosorbent assay (ELISA) requires accumulation of samples to make it a cost-efficient technique, delaying the results for severa...

The introduction of point-of-care (POC) assays into clinical practice in patients with inflammatory disease enables on-demand therapeutic decision making. The aim of this study was to compare the POC test Quantum blue (Bühlmann Laboratories) for infliximab (IFX), adalimumab (ADL), and its anti-drug antibodies with the traditional ELISA assay (Promo...