Francis C Lau

Francis C Lau
OLLY PBC · Product Development

Ph.D., FACN, MSCIS, MA, BSc

About

75
Publications
29,957
Reads
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2,098
Citations
Citations since 2017
0 Research Items
722 Citations
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
Additional affiliations
January 2017 - September 2020
Clorox
Position
  • Subject Matter Expert - Nutraceuticals: Renew Life-NeoCell-Natural Vitality-Rainbow Light
March 2014 - January 2017
Shaklee Corporation
Position
  • Researcher
May 2007 - March 2014
InterHealth Nutraceuticals
Position
  • Manager

Publications

Publications (75)
Article
Brain aging is characterized by the continual concession to battle against insults accumulated over the years. One of the major insults is oxidative stress, which is the inability to balance and to defend against the cellular generation of reactive oxygen species (ROS). These ROS cause oxidative damage to nucleic acid, carbohydrate, protein, and li...
Article
The onset of age-related neurodegenerative diseases such as Alzheimer's or Parkinson's disease, superimposed on a declining nervous system, could exacerbate the motor and cognitive behavioral deficits that normally occur in senescence. In cases of severe deficits in memory or motor function, hospitalization and/or custodial care would be a likely o...
Article
Full-text available
It has been reported that an antioxidant-rich, blueberry-supplemented rat diet may retard brain aging in the rat. The present study determined whether such supplementation could prevent impaired object recognition memory and elevated levels of the oxidative stress-responsive protein, nuclear factor-kappa B (NF-kappaB) in aged Fischer-344 rats. Twel...
Article
Sustained microglial activation in the central nervous system (CNS) has been extensively investigated in age-related neurodegenerative diseases and has been postulated to lead to neuronal cell loss in these conditions. Recent studies have shown that antiinflammatory drugs may suppress microglial activation and thus protect against microglial overac...
Article
The onset of age-related neurodegenerative diseases superimposed on a declining nervous system could exacerbate the motor and cognitive behavioral deficits that normally occur in senescence. It is likely that, in cases of severe deficits in memory or motor function, hospitalization and/or custodial care would be a likely outcome. This means that un...
Chapter
Full-text available
Modern Western thinking expresses reliance on nutritional intervention as well as behavioral modalities such as meditation or acupuncture as “alternative medicine,” with our twentieth-century construct of pharmaceutical and surgical interventions cast as “mainstream medicine.” This nomenclature lacks historical perspective, as traditional, largely...
Conference Paper
Full-text available
Objective: There is great consumer interest in using products and programs to support digestive function, improve elimination and enhance feelings of well-being. It is also reported that certain individuals who begin a weight management program will have a variety of possible intestinal side effects that can interfere with their compliance and succ...
Conference Paper
Full-text available
Previously we showed that a physician-supervised, structured meal replacement program was effective in facilitating weight loss. The current study was designed to evaluate whether such a program may promote weight loss through alteration in body composition. The study was conducted as an employee wellness weight loss challenge in a workplace settin...
Article
Full-text available
Previously, it has been shown that strawberry (SB) or blueberry (BB) supplementations, when fed to rats from 19 to 21 months of age, reverse age-related decrements in motor and cognitive performance. We have postulated that these effects may be the result of a number of positive benefits of the berry polyphenols, including decreased stress signalli...
Article
Full-text available
Meratrim is a unique dietary ingredient consisting of extracts from Sphaeranthus indicus flower heads and Garcinia mangostana fruit rind. Clinical studies have demonstrated that Meratrim is effective and well-tolerated in weight management. Herein we assessed the broad spectrum safety of Meratrim in a battery of in vitro and animal toxicological st...
Conference Paper
Full-text available
Objective: AREDS2 formulation (AREDS2) has been shown to slow the progression to advanced AMD. Case studies indicate that remission of AMD, though rare, does occur spontaneously. In this regard, retinal regeneration is possible. The purpose of the current study was to investigate the effects of combining AREDS2 treatment with a resveratrol/polyphen...
Conference Paper
Full-text available
A research poster presented by Dr. Francis Lau, senior scientist of InterHealth Nutraceuticals, took first place honors at the 2014 Scripps Natural Supplement Conference in San Diego. The research summarized data on the impact of Zychrome on maintaining healthy insulin levels. Zychrome is InterHealth's newest patent-pending, chromium containing sup...
Article
Full-text available
UC-II contains a patented form of undenatured type II collagen derived from chicken sternum. Previous preclinical and clinical studies support the safety and efficacy of UC-II in modulating joint discomfort in osteoarthritis and rheumatoid arthritis. The purpose of this study was to assess the efficacy and tolerability of UC-II in moderating joint...
Article
Full-text available
Exposing young rats to particles of high energy and charge, such as 56Fe, enhances indices of oxidative stress and inflammation and disrupts behavior, including spatial learning and memory. In the present study, we examined whether gene expression in the hippocampus, an area of the brain important in memory, is affected by exposure to 1.5 Gy or 2.5...
Conference Paper
Full-text available
We investigated the efficacy and safety of LOWAT a novel herbal weight management formula comprising of extracts Piper betle and Dolichos biflorus. In a randomized, double-blind, placebo-controlled study, subjects (n=25) received 900 mg/day of LOWAT for 8 weeks and maintained a standard 2000 calorie daily diet. Body weight, BMI, clinical chemistry...
Conference Paper
Full-text available
We investigated the efficacy and tolerability of a synergistic formulation (Merastin) comprising the extracts of Sphaeranthus indicus and Garcinia mangostana for weight management in obese human subjects. Sixty obese subjects (37.5% male; 62.6% female; ages 22–50 years) with BMI of 30 to 40 were included in a randomized, double-blind, placebo-contr...
Chapter
IntroductionCarcinogenesis and BiomarkersPesticide-Induced DNA Damage and Oxidative StressPesticides and Hormonal CarcinogenesisEpidemiological Cancer StudiesConclusion References
Chapter
Structurally diverse toxicants in the environment are responsible for the production of reactive oxygen species (ROS) in biological systems. The accumulation of ROS results in oxidative stress and causes damage to macromolecules such as DNA, proteins, lipids and carbohydrates. Consequently, exposure to environmental oxidants increases the occurrenc...
Article
Full-text available
The safety of Garcinia cambogiaextract, its active ingredient (-)-hydroxycitric acid (HCA), and the marketed weight management formula, Super CitriMax(®) (HCA-SX), is supported by numerous in vitro and animal experimental studies as well as several clinical studies. HCA-SX has been shown to reduce appetite, inhibit fat synthesis, and decrease body...
Article
Full-text available
Chromium(III) is an essential trace element required for normal protein, fat and carbohydrate metabolism. It also helps in energy production and increasing lean body mass. Chromium(III) dinicocysteinate (CDNC) is a unique form of bioavailable chromium(III). This study was focused on determining the broad spectrum safety of CDNC. Acute oral, acute d...
Book
Full-text available
Modern food biotechnology is now a billion-dollar industry, producing functional foods and nutraceuticals that offer a whole host of increased health benefits. This book begins with an overview of the advances in biotechnology and their contributions to food science. It then examines the impact of genetic modification on functional foods.
Conference Paper
Full-text available
Garcinia cambogia-derived (–)-hydroxycitric acid (HCA-SX) has shown promise in weight management. In a randomized, double-blind clinical study (n=90), HCA-SX reduced body weight (BW), BMI, serum leptin, LDL, triglycerides and total cholesterol, while increasing HDL and excretion of urinary fat metabolites. We investigated the effects of HCA-SX (500...
Book
Full-text available
The nutraceutical and functional food field is rapidly growing in diverse sectors, including academic, commercial and government. This has brought a corresponding shift in research focus and in public awareness. Understanding the relevance of the scientific principles in determining the safety and effectiveness of functional foods and nutraceutical...
Chapter
Introduction Nutritional Genomics Omics in Future Nutrition Research References
Chapter
Micronutrients and phytonutraceuticals have gained considerate popularity as dietary supplements in weight management. The transitional metal chromium (III) and the active constituent of Garcinia cambogia, (−)-hydroxycitric acid (HCA), have been used in weight loss regimen. We have shown that the niacin-bound chromium(III) (NBC) complex and calcium...
Book
The nutraceutical and functional food field is rapidly growing in diverse sectors, including academic, commercial and government. This has brought a corresponding shift in research focus and in public awareness. Understanding the relevance of the scientific principles in determining the safety and effectiveness of functional foods and nutraceutical...
Article
Full-text available
Previous research has shown that undenatured type II collagen is effective in the treatment of arthritis. The present study evaluated the broad-spectrum safety of UC-II by a variety of toxicological assays including acute oral, acute dermal, primary dermal irritation, and primary eye irritation toxicity. In addition, genotoxicity studies such as Am...
Chapter
Skin is the largest organ that is under constant assault by environmental oxidative stress including ultraviolet radiation (UVR), air pollutants, and chemical oxidants. Premature skin aging may occur due to factors such as external oxidative stress as well as smoking, imbalanced nutrition, excessive dieting, and mental stress. Studies suggest that...
Article
Full-text available
Dihydroterrein (1) and terrein (2) were isolated from methanol extracts of the solid culture of Asperillus novofumigatus IFM 55215. Both 1 and 2 inhibited human platelet aggregation induced by collagen at a concentration of 5.0 × 102 μmol/L in vitro and they displayed slight inhibitory effects when platelet aggregation was induced by adenosine diph...
Article
Full-text available
Previous studies have shown that undenatured type II collagen (UC-II) is effective in the treatment of rheumatoid arthritis, and preliminary human and animal trials have shown it to be effective in treating osteoarthritis (OA). The present clinical trial evaluated the safety and efficacy of UC-II as compared to a combination of glucosamine and chon...
Article
The teratogenic potential of a niacin-bound chromium (III) complex (NBC, commercially known as ChromeMate) was investigated in a multi-generation reproduction toxicity model. Sprague-Dawley rat pups (∼30/sex/group) were selected randomly from the F2b generation and were grown to 10–12 weeks before mating to start the teratology study. NBC exposure...
Article
Full-text available
Treatment of BV2 microglial cells with blueberry extracts has been shown to be effective in reducing lipopolysaccharide (LPS)-induced proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), inducible NO synthase (iNOS), and cyclooxygenase 2 (COX2). The current study explored the possibil...
Article
This two-generation study was conducted to evaluate the effects of niacin-bound chromium (III) complex (NBC, commercially known as ChromeMate) on the reproductive systems of male and female rats, the postnatal maturation and reproductive capacity of their offspring. Across two generations, Sprague Dawley rats (30/sex/group) were maintained on feed...
Article
The objective of this study was to evaluate the effects of a novel oxygen-coordinated niacin-bound chromium(III) complex (NBC) on the reproductive systems of male and female rats, the postnatal maturation and reproductive capacity of their offspring, and possible cumulative effects through multiple generations. Sprague-Dawley rats were maintained o...
Article
The objective of the present study was to evaluate the teratogenic potential of a novel oxygen-coordinated niacin-bound chromium complex (NBC) in Sprague-Dawley rats. Due to its potential to affect fat synthesis and reduce food intake, processes which are often crucial in normal fetal development, this teratology study was undertaken as part of a m...
Book
Full-text available
The link between eating habits, health, and physical appearance is becoming increasingly evident and has made consumers all over the world open to the concept of ingestible beauty products. For this highly interesting, fast-growing market segment, DMV International developed a natural ingredient from whey that has been shown in several consumer stu...
Article
Human toxicity of castor beans (ricin) and jequirity seeds (abrin) has been acknowledged throughout medical history, worldwide. Ricin and abrin are natural protein toxins isolated from plant seeds Ricinus communis and Abrus precatorius, respectively. Ricin and abrin share extensive identity and structural similarities of two polypeptide chains: an...
Article
Full-text available
Insulin resistance has been shown to be the major contributing factor to the metabolic syndrome, which comprises a cluster of risk factors for metabolic aberrations such as obesity, dyslipidemia, hypertension, and hyperglycemia. Additionally, insulin resistance has been associated with the occurrence of cardiovascular disease and type 2 diabetes. E...
Article
Full-text available
Cognitive impairment in age-related neurodegenerative diseases such as Alzheimer's disease may be partly due to long-term exposure and increased susceptibility to inflammatory insults. In the current study, we investigated whether polyphenols in blueberries can reduce the deleterious effects of inflammation induced by central administration of kain...
Article
Full-text available
Recent advances in molecular biology combined with the wealth of information generated by the Human Genome Project have fostered the emergence of nutrigenomics, a new discipline in the field of nutritional research. Nutrigenomics may provide the strategies for the development of safe and effective dietary interventions against the obesity epidemic....
Article
Full-text available
We have shown previously that dietary blueberry (BB) extract supplementation (S) reversed several parameters of neuronal and behavioral (e.g., cognition) aging in rodents. Additionally, findings indicate that COS-7 cells transfected with muscarinic receptor subtypes (e.g., M1) showed decrements in Ca2+ clearance following depolarization (Ca2+ Recov...
Chapter
It is estimated that by the year 2050 the elderly (aged 65 or older) population will double the population of children (aged 0–14) for the first time in history. The expansion of the elderly population has already taken a toll on health care systems. In order to alleviate the health care costs and increase the quality of living in the aging populat...
Data
Full-text available
It is estimated that by the year 2050 the elderly (aged 65 or older) population will double the population of children (aged 0–14) for the first time in history. The expansion of the elderly population has already taken a toll on health care systems. In order to alleviate the health care costs and increase the quality of living in the aging populat...
Article
It is becoming increasingly clear that although there is a great deal of research being devoted to elucidating the molecular mechanisms involved in aging, practical information on how to forestall or reverse the deleterious effects of aging may be years away. Therefore, it may be beneficial to determine other methods to improve the quality of life...
Conference Paper
Full-text available
Berryfruits contain a wide diversity of polyphenols belonging to different chemical structural classes; e.g., blueberries (BB) predominate in proanthocyanidins, whereas strawberries (SB) predominate in ellagitannins, although both berries contain anthocyanins. The types and relative amounts of polyphenols in different berries vary, possibly account...
Conference Paper
Full-text available
Polyphenols found in berry fruits have been reported to exhibit substantial pharmacological and biological activities including anti-inflammatory and neuroprotective properties. Previously, we have shown that treatment with blueberry extracts was effective in reducing lipopolysaccharide (LPS)-induced pro-inflammatory mediators such as nitric oxide...
Chapter
Despite the progress being made by researchers, Alzheimer's disease, along with other age-related neurodegenerative disorders, continues to exact a tremendous toll on our society. However, we are beginning to see a relationship that ties degenerative disorders to oxidative stress and lifestyle, suggesting the possibility for prevention and interven...
Chapter
Full-text available
It is estimated that by the year 2050 the elderly (aged 65 or older) population will double the population of children (aged 0-14) for the first time in history. The expansion of the elderly population has already taken a toll on health care systems. In order to alleviate the health care costs and increase the quality of living in the aging populat...
Article
Brain aging is characterized by the continual concession to battle against insults accumulated over the years. One of the major insults is oxidative stress, which is the inability to balance and to defend against the cellular generation of reactive oxygen species (ROS). These ROS cause oxidative damage to nucleic acid, carbohydrate, protein, and li...
Article
Full-text available
Leaner mice carry a homozygous, autosomal recessive mutation in the mouse CACNA1A gene encoding the Alpha1A subunit of P/Q-type calcium channels, which results in an out-of-frame splicing event in the carboxy terminus of the Alpha1A protein. Leaner mice exhibit severe ataxia, paroxysmal dyskinesia and absence seizures. Functional studies have revea...
Conference Paper
Full-text available
NEW ORLEANS, Nov. 8-Eating certain foods can help protect you from heart disease, some types of cancers and other illnesses. But can your diet also help protect your brain if you should suffer a stroke or accidental head injury? Or keep your thinking and memory skills strong as you age? Some scientists believe it might. They even think eating the "...
Chapter
In response to the use of genetically-enigneered mice in the biomedical research revolution in technology, this book brings together the collective expertise of many specialists to cover the approaches to organ-specific evaluations, to provide examples of many currently available mutant mice, to illustrate how specific defects can be studied, and t...
Article
Homozygous leaner mice carry an autosomal recessive mutation in the Ca2+ channel subunit gene, alpha1A, causing them to exhibit severe ataxia, petit-mal-like epilepsy and a myoclonus-like movement disorder. Expression of alpha1A mRNA in cerebella from 20-day-old homozygous leaner mice was compared to control mice, using in situ hybridization histoc...
Article
Purpose: We wished to determine whether chronic phenytoin (PHT) exposure could impair neural development and if any morphological alterations could be linked to changes in gene expression. Methods: Pregnant SWV mice were chronically administered PHT 40 mgkglday from gestational day (GD) 0:12 (day:h) until they were killed at various timepoints thro...

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Mobile App for dietary and lifestyle assessment and recommendation.