Francis Finot

Francis Finot
GenEvolutioN · Direction

MSc

About

29
Publications
5,721
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73
Citations
Additional affiliations
April 2015 - December 2016
NewCo
Position
  • Co-Founder

Publications

Publications (29)
Poster
Full-text available
In this work the objective is to minaturize the classical Cell Transformation Assay. In a second step, the aim is to etablish a more specific and sensitive labeling of transformed foci. Finally we would like to identify transcriptomics markers impacted by a Non-intentionally added substances (NIAS).
Poster
Full-text available
he NanoAmes"' is a promising tool to identify low quantities of genotoxic agents in mixtures and might constitute a significant advancement in the toxicology field (e.g., food, cosmetics and pharma). We look forward to assessing the performance of this method with environ mental samples.
Article
Full-text available
Cosmetic products need to have a proven efficacy combined with a comprehensive toxicological assessment. Before the current Cosmetic regulation N°1223/2009, the 7th Amendment to the European Cosmetics Directive has banned animal testing for cosmetic products and for cosmetic ingredients in 2004 and 2009, respectively. An increasing number of altern...
Poster
Full-text available
The objective is to perform Ames test using a very few amount of test item ie µg , ng level
Article
Purpose: Biological dosimetry, based on the relationship between the absorbed dose after exposure to ionizing radiation and the frequency of scored aberrations, has been and continues to be an important tool for estimating the dose after exposure. Dicentric chromosomes are considered to be the most specific and sensitive aberration related to radi...
Poster
Full-text available
Our work is dedicated to the development of an in silico methodology that automatically highlights potential structural alerts correlated to Carcinogen, Mutagen and Reproductive toxicity (CMR) properties [Lepailleur, 2013]. These triggering structures are then used for machine learning classification purposes within a decision-support system [Yang,...
Article
Full-text available
The cover image, by F. Finot et al., is based on the Research Article Genotoxic risk of ethyl-paraben could be related to telomere shortening, DOI 10.1002/jat.3425.
Article
The ability of parabens to promote the appearance of multiple cancer hallmarks in breast epithelium cells provides grounds for regulatory review of the implication of the presence of parabens in human breast tissue. It is well documented that telomere dysfunction plays a significant role in the initiation of genomic instability during carcinogenesi...
Poster
Full-text available
the use of semi-automated MN-TC scoring has permitted a reevaluation of the sensitivity of CBMN assay as well as the reduction of MN baseline in circulating lymphocytes of healthy donors and the establishment of reliable dose response curve. These improvements market new step in the management and the follow-up of population exposed to genotoxic ag...
Conference Paper
Guideline EMEA/HMPC/107079/2007 is used for testing the potential genotoxicity of Herbal Medical Products (HMPs). In general, the Ames test should be performed and interpreted in conformity with existing OECD 471. The set of different Salmonella typhimurium strains (TA98, TA100, TA1535, TA1537 and TA102) in presence or in absence of metabolic activ...
Conference Paper
Full-text available
Since March 2004, publication date of Directive 2004/24/EC [1] establishing an European legislation for traditional herbal medicinal products (THMPs), new common quality, safety and efficacy standards for licensing HMPs have been progressively implemented including the assessment of genotoxic potential. HMPs present a number of characteristics that...
Conference Paper
Full-text available
Telomere length has been proposed as a marker of mitotic cell age and as a general index of human organism aging. Recent studies have documented the role of telomere dysfunction in breast carcinoma [1] the presence of parabens were detected in the human breast at concentrations up to the microgram per gram tissue range [2]. The impact of telomere s...
Conference Paper
Full-text available
F.Finot1, L.Morat2, A.Essahli1, N.Prigent1, O.Cariou1, F.Paillard1, L.Heidingsfelder3, M.Ricoul2, W.Hemplel2, R.M’kacher2, L.Sabatier2 1 Covance Laboratory SAS, Porcheville, France 2Radiobiology and Oncology laboratory, CEA, DSV/iRCM, Fontenay-aux-Roses, France 3MetaSystems GmbH, Robert-Bosch-Str. 6 D-68804. Altlussheim, Germany A new tool for gen...
Article
Full-text available
The culture liver slices are mainly used to investigate drug metabolism and xenobiotic-mediated liver injuries while apoptosis and proliferation remain unexplored in this culture model. Here, we show a transient increase in LDH release and caspase activities indicating an ischemic injury during the slicing procedure. Then, caspase activities decrea...
Conference Paper
An in vitro chromosome aberration test or in vitro micronucleus test can be used to assess the potential genotoxicity of a drug candidate prior to Phase 1 clinical testing. One advantage of the micronucleus test is the possibility to automate the scoring. At Covance Laboratory SAS (Porcheville – France), we perform the in vitro micronucleus test us...
Conference Paper
Full-text available
Les modèles d'hépatocytes primaires et de tranches de foie de rat in vitro sont largement utilisés pour l'étude des mécanismes d'hépatotoxicité et de métabolisme. Malgré les différences évidentes entre ces deux systèmes (tranches d'organe versus cellules isolées) une des questions fondamentales reste ouverte : à savoir ces modèles donnent-ils le mê...
Article
The new strategies for development of pharmacologically interesting compounds pose some limitations for standard toxicity assessment approaches due to: (1) increase in the number of compounds to be tested and (2) decrease in the amount of substance available for testing. In vitro methods are thus the only way to overcome such limitations. In this c...

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