Francis A Farraye

Francis A Farraye
Boston University | BU · Section of Gastroenterology

MD, MSc

About

525
Publications
40,992
Reads
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11,175
Citations
Additional affiliations
November 2000 - present
Boston University
Position
  • Clinical Director
October 2000 - present
Boston Medical Center
Position
  • Clinical Director, Section of Gastroenterology
July 1988 - October 2000
Harvard Vanguard Medical Associates
Position
  • staff Gastroenterologist

Publications

Publications (525)
Article
Health care maintenance is critical for patients with inflammatory bowel disease (IBD), particularly for those receiving immunosuppressive medications. Vaccination recommendations for potentially preventable diseases, cancer prevention recommendations, and assessment of bone health and mood disorders are discussed in this article. Staying up to dat...
Article
Malnutrition is a very common and often underrecognized condition among patients with inflammatory bowel diseases (IBD). This is most commonly due to increased nutritional requirements and gastrointestinal losses, along with reduced oral intake. Screening for malnutrition is an essential component of managing both inpatients and outpatients with IB...
Article
Background Owing to the use of immunosuppressive agents, patients with inflammatory bowel disease (IBD) have an increased risk of vaccine preventable diseases, including infection with hepatitis B virus (HBV). Heplisav-B, an FDA-approved vaccine, is more effective (90% to 100%) than Engerix-B (70.5% to 90.2%) at inducing immunity to HBV in clinical...
Article
Full-text available
Lay Summary Herein, we evaluated the humoral immunogenicity of a third coronavirus disease 2019 messenger RNA vaccine dose in patients with inflammatory bowel diseases. All patients displayed a humoral immune response, and median antibody concentrations were higher after the third dose than after completion of the 2-dose series.
Article
Background & aims: Whether preoperative treatment of inflammatory bowel disease (IBD) with tumor necrosis factor inhibitors (TNFis) increases the risk of postoperative infectious complications remains controversial. The primary aim of this study was to determine whether preoperative exposure to TNFis is an independent risk factor for postoperative...
Article
Lay Summary Biosimilar medications have the potential to significantly reduce the cost of treatment in patients with inflammatory bowel disease. Observational studies have shown similar efficacy and safety of biosimilars to biologic reference products. Shared decision-making is crucial to the successful implementation of these agents.
Preprint
Introduction Most patients with IBD mount an antibody response to mRNA COVID-19 vaccines, but few studies have evaluated the cell mediated immune response (CMIR). Methods We performed a prospective study (HERCULES) to evaluate CMIR among patients with IBD and healthy controls (HC) after completion of the primary series of mRNA COVID-19 vaccines....
Article
Full-text available
Background and study aims Splenic injury (SI) during colonoscopy is an underappreciated adverse event. Our aim was to examine the occurrence and outcomes of patients who developed SI after inpatient colonoscopy using a nationwide dataset. Patients and methods Retrospective, observational study using the National Inpatient Sample (NIS) between 2012...
Article
Background: Patients with inflammatory bowel disease (IBD) are at an increased risk of infections, including vaccine-preventable diseases (VPDs). The aim of this study was to explore the inpatient prevalence of VPD in patients with IBD, as well as inpatient outcomes. Methods: Retrospective study using the 2013-2017 Nationwide Inpatient Sample da...
Article
Full-text available
Inflammatory bowel disease (IBD) can involve multiple organ systems, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases is more frequent in patients with Crohn’s disease and ulcerative colitis than in the general population. Pancreatic manifestations in IBD include a heterogeneous group of disorders...
Article
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has disrupted health care and has resulted in high mortality rates.1 Vaccination is an international priority to mitigate the risks of SARS-CoV-2. The initial trials for development of SARS-CoV-2 vaccines excluded individuals with immunocompromising conditions.2.
Article
Background Active inflammatory bowel disease (IBD) at conception is associated with adverse pregnancy outcomes. Published literature suggests that almost a quarter of women with IBD do not use any form of contraception putting them at risk of unplanned pregnancy. Recent guidelines emphasise the importance of antenatal care in IBD patients, but cont...
Article
Introduction: Patients with inflammatory bowel disease (IBD) are at increased risk for herpes zoster (HZ). HZ is caused by reactivation of the varicella zoster virus (VZV) and is prevented by strong VZV-specific cell mediated immunity. The aim of our study was to evaluate if patients with IBD had lower or equivalent protection compared to healthy...
Chapter
Patients with ulcerative colitis (UC) presenting with severe fulminant disease or acute severe ulcerative colitis (ASUC) should be hospitalized for inpatient management. A thorough history and physical examination is performed and vital signs monitored regularly. A medication history must be obtained including use of NSAIDs, antibiotics, and opioid...
Article
Full-text available
Background Accurate estimates for the risk of COVID-19 in IBD, and an understanding of the impact of COVID-19 on IBD course and the risk of incident post-infectious IBD are needed. Aims To estimate the risk of COVID-19 in IBD and study its impact on IBD course and the risk of incident post-infectious IBD. Methods A retrospective propensity score...
Article
Objective: Although an additional COVID-19 vaccine dose for immunocompromised persons has been recommended in some countries, further data to guide vaccination strategies for patients with Inflammatory Bowel Disease (IBD) is urgently needed. We sought to identify factors affecting initial humoral immune response to SARS-Cov-2 vaccines among patien...
Preprint
Full-text available
Herein, we evaluated the humoral immunogenicity of a third COVID-19 mRNA vaccine dose in patients with IBD. All patients were seropositive and had higher antibody concentrations after the third dose than after completion of the two-dose primary series.
Article
Background Severe acute respiratory syndrome coronavirus 2 vaccination is recommended for all individuals with inflammatory bowel disease (IBD), including those on immunosuppressive therapies; however, little is known about vaccine safety and efficacy in these patients or the impact of vaccination on IBD disease course. Methods We evaluated corona...
Article
Background Early endoscopic evaluation of patients with ulcerative colitis enables assessment of disease activity and accurate diagnosis based on exclusion of other similarly presenting conditions including infections. Early endoscopy is also associated with improved outcomes of patients with active ulcerative colitis. The aim of this study was det...
Article
Full-text available
Purpose of review This review serves as a summary of healthcare maintenance items that should be addressed when managing patients with inflammatory bowel disease (IBD). This manuscript discusses vaccine-preventable illnesses, cancer prevention recommendations, and other screenings that are important to gastroenterologists and primary care physician...
Article
Background Patients with inflammatory bowel disease (IBD) have low vaccination rates for vaccine-preventable diseases. Fear of adverse reactions (AEs) appear to negatively affect vaccination efforts. We aimed to systemically review the risks for AEs following immunization for patients with IBD. Methods We searched PubMed and Embase until April 15,...
Article
Introduction: Patients with inflammatory bowel disease (IBD) on immune-modifying therapies may have a lower vaccine response to certain vaccines. The aim of our study was to evaluate humoral immunogenicity of mRNA coronavirus disease 2019 (COVID-19) vaccines among patients with IBD and healthy controls (HCs). Methods: We performed a prospective...
Article
Background Oral contraceptive pill (OCP) use in the general population is associated with a failure rate as low as 0.3 % with perfect use but as high as 9% with typical use. Women with Crohn’s disease (CD) may have malabsorption in the setting of small bowel disease or resection, which could affect absorption of OCPs. Our aim was to determine the i...
Article
Pouchitis, Crohn's disease of the pouch, cuffitis, polyps, and extraintestinal manifestations of inflammatory bowel disease are common inflammatory disorders of the ileal pouch. Acute pouchitis is treated with oral antibiotics and chronic pouchitis often requires anti-inflammatory therapy, including the use of biologics. Aetiological factors for se...
Article
Aim Update the existing literature, assessing the use of surgery in patients with ulcerative colitis in more recent years. Methods Retrospective observational study identifying all patients with ulcerative colitis within the National Inpatient Sample years 2009-2018. All patients with International Classification of Diseases, Ninth and Tenth Revis...
Conference Paper
Full-text available
Introduction Artificial intelligence (AI) is making rapid in-roads in various aspects of gastroenterology (GI). Early studies have shown potential for the use of AI in the diagnosis and management of inflammatory bowel disease (IBD). Our aim was to explore the current understanding of clinicians for the role of AI in GI and IBD in particular. Meth...
Conference Paper
Full-text available
Introduction The increasing incidence and prevalence of inflammatory bowel disease (IBD) has fuelled the need for innovative models of care. We aimed to compare effectiveness of e-health interventions with standard care in management of IBD. Methods We searched Medline, Embase, PubMed, CINAHL, PsychInfo, Clinical trials registry and Cochrane datab...
Article
Background: Avoidant/restrictive food intake disorder (ARFID) is a newly described eating disorder. The aims of this study were to evaluate the prevalence of ARFID in patients with inflammatory bowel disease (IBD) and assess provider recognition of an eating disorder in these patients. Methods: One hundred patients with IBD seen at the Mayo Clin...
Article
Background: Severe Crohn's disease (CD) can result in extensive bowel resections and need for creation of an ileostomy. Fecal calprotectin (FC) is well studied in CD management though its role in patients who have an ileostomy is unclear. Our aim is to understand if FC is a useful adjunct to radiographic or endoscopic studies in identifying recurr...
Article
Introduction: Vulvar involvement is a rare complication of Crohn's disease (CD). The optimal treatment of vulvar CD is unknown. Methods: We conducted a 25-year retrospective cohort study of vulvar CD from 3 referral centers. Clinical features and outcomes were studied. Results: Fifty patients were identified. The most common vulvar symptoms we...
Article
Full-text available
Background and aims: Prevention of vaccine-preventable diseases is important in the care of patients with inflammatory bowel disease (IBD). Thus, accurate immunization histories are critical. Many providers rely on patient self-report when assessing immunization status. The primary aim of our study was to determine the accuracy of self-reported in...
Article
Purpose While COVID-19 vaccine emergency use authorization (EUA) deemed the vaccines to be effective and safe for public use, the phase 3 trials leading to EUA predominantly excluded patients with immunocompromising conditions. Immunocompromised patients make up a significant proportion of the population, and in light of recent mass vaccination eff...
Article
Restorative proctocolectomy with ileal pouch-anal anastomosis is an option for most patients with ulcerative colitis or familial adenomatous polyposis who require colectomy. Although the construction of an ileal pouch substantially improves patients' health-related quality of life, the surgery is, directly or indirectly, associated with various str...
Article
Full-text available
Background Obesity may affect efficacy and safety of biologic treatments for ulcerative colitis (UC). Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of UC. Aims To assess efficacy and safety of tofacitinib in patients with UC, by baseline body mass index (BMI). Methods This post hoc analysis evaluated patients wit...
Article
Full-text available
The introduction of therapeutic monoclonal antibodies directed against tumor necrosis factor-α has revolutionized the treatment of inflammatory bowel disease (IBD) by improving quality of life, decreasing the frequency and length of hospital admissions, and reducing corticosteroid use. Nevertheless, biologics are very expensive, substantially contr...
Article
Full-text available
Endometriosis is a rare cause of large bowel obstruction and has been infrequently reported in patients with inflammatory bowel disease. We present an unusual case of a young woman with ulcerative colitis, who presented with a large bowel obstruction with colonic stricture and peripancreatic mass concerning for malignancy. The evaluation revealed e...
Article
Background and Aims Patients with Inflammatory bowel disease (IBD) are at an increased risk of developing herpes zoster (HZ). The effectiveness of the recombinant zoster vaccine (RZV) in patients with IBD is unknown. Methods In this retrospective cohort study using Explorys (October 2017–April 2020; IBM Corporation, Somers, NY, USA), the effective...
Article
The recent emergency use authorization of a third COVID-19 vaccine means that most patients with inflammatory bowel disease (IBD) will soon be eligible to be vaccinated. Gastroenterology clinicians should be prepared to address patients’ concerns regarding safety and efficacy of vaccines. They should also strongly recommend that all their patients...
Article
Ileocolic resection (ICR) is the most common surgical procedure in Crohn disease (CD). There are many surgical techniques for performing ICRs and subsequent anastomoses. Recurrence of CD after ICR is common, often clinically silent, and thus requires monitoring including periodic use of endoscopy to detect early active disease. There is emerging ev...