Francis A Faduyile

Lagos State University | LASU · Department of Pathology and Forensic Medicine

Amniotic fluid embolism is a rapid, serious birth complication that occurs in pregnant women especially during labor following any manipulation/trauma that leads to leak of amniotic fluid and setting up a cascade of allergic-like reaction. It causes rapid cardio-vascular collapse and usually affects both mother and fetus. Prompt detection and rapid...

Background: Motorcycle use is associated with fatal crashes. The government of Lagos State, Nigeria has introduced legislation and policies to address this issue. Aim: To examine trends in motorcycle accident mortality in Lagos over a 10-year period (January 2010 - December 2019) and consider the impact of transportation legislation and policy chan...

Original Article

Introduction Deaths in custody are a matter of global concern. However, such information is often missing in developing countries. This study aimed to examine retrospectively the profile, cause and manner of deaths amongst cases of custodial deaths in Lagos State, Nigeria. Method An 11-year study (June 2008–June 2019) was done of all autopsy cases...

Background Suffocation is a major class of asphyxial deaths encountered in forensic post-mortem examinations. Several studies have described the patterns of different types of suffocation deaths but there is a paucity of studies and autopsy findings of suffocation in the Nigerian environment. This study is aimed at determining the prevalence and pa...

Plumbago zeylanica, Linn. is an important plant with numerous medicinal values. This study was aimed to evaluate the biochemical and toxicological effects of the administration of the ethylacetate fraction of the methanolic extract of Plumbago zeylnica root (EAME). In sub-chronic study, extract doses of 100, 200 and 400 mg/kg body weight were admin...

Nigerian insurance industry is beset with a number of challenges, the most prominent is the low awareness level among the insuring public. This may be resolved through effective personal selling as promotional tool for insurance services. Personal selling is a unique element of marketing, it does not only create awareness and provide information ab...

Introduction: Hypertension is an important and major public health concern globally. One of the major causes of sudden death worldwide is hypertension. This study is to present the morphological pattern of deaths at autopsy of those patients who were brought-in-dead (BID) and who had hypertensive heart disease (HHD) as the underlying illness. Mat...

BACKGROUND: An important cornerstone in health care delivery is the field of surgical pathology and one of its major aims is to provide a complete, precise and comprehensive diagnosis within a short period of time. In achieving this, the clinician needs to properly fill a surgical pathology requisition form. METHOD: All the consecutive requisition...

igerian motorists perceive motor risks differently, thus, the demand for insurance is expected to be motivated by how risk is perceived. Risk perception therefore is the process by which an individual organizes and selects a product with distinct characteristics which can either be intrinsic or extrinsic. This paper examines the implication of the...

Background There are many cases that present to the emergency room as brought in dead (BID) and in such cases, previous medical history of the deceased is unknown. Many of the medical problems are either preventable or treatable if managed on time. This study is aimed to determine the age, gender and causes of BID. ResultsThis is a 6 year retrospec...

Introduction The aim of the present study was to evaluate the hepatoprotective activities of the ethanolic roots extract of Ageratum conyzoides (AC) in alloxan-induced hepatic damage in diabetic rats. Materials and Methods Diabetes was induced in Wistar rats by the administration of alloxan (150 mg/kg, intraperitoneal). The ethanolic roots extract...

Introduction: Myocardial infarction is one of the complications of Coronary Artery Disease (CAD). Recent study has shown that the incidence of acute myocardial infarction is on the increase in developing countries such as Nigeria. Autopsy based studies have proven to be a reliable and valuable method for studying this disease. Aim: To determine the...

This study models some risk factors for some topographies of cancer in South West of Nigeria (Osun, Ondo, Ogun, Ekiti, Oyo and Lagos states). Data on various topographies of cancer are collected by transcription from cancer registry and patients' case note of different hospitals (teaching hospitals and medical centres) across the six states. Binary...

In this study, alterations in lipid metabolism associated with acute aflatoxin B1 (AFB1) induced hepatotoxicity and gene expression changes underlying these effects were investigated. Rats were orally administered three doses (0.25 mg/kg, 0.5 mg/kg and 1.0 mg/kg) of AFB1 for seven days; after which blood was collected and liver excised. Lipid profi...

BACKGROUND: Deaths from motorcycle accident injuries have remained a major public health issue in Nigeria over the years. AIM: The study is to determine the age and gender distribution of the victims and to identify the cause of death and the anatomical pattern of injuries seen. METHODOLOGY: This is a 5-year autopsy-based study of all motorcycle...

Cancer is a public health problem worldwide affecting all ages. It is the second commonest cause of death in developed countries and among the three leading causes of death in developing countries. WHO reported that about 24.6 million people live with cancer world-wide. There are 12.5% of all deaths are attributable to cancer and if the trend conti...

Background: Maternal mortality is the death of a woman while pregnant or within 42 days of termination of pregnancy, irrespective of the duration and the site of the pregnancy. Nigeria is among the six countries that record over 50% of all maternal deaths in the world. There are few papers on autopsy based causes of maternal mortality. This paper...

Background and purpose: Worldwide, stroke is the second most common leading cause of death and also one of the leading causes of disability. In the last decades, more studies have focused on ischemic stroke. This study focused on intracerebral haemorrhage which is a common subtype of stroke. Method: This is a -ten year retrospective study of all au...

Forensic odontology or forensic dentistry is that aspect of forensic science that uses the application of dental science for the identification of unknown human remains and bite marks. Deaths resulting from mass disasters such as plane crash or fire incidence have always been given mass burial in Nigeria. This was obviously due to the fact that For...

Forensic investigations have been embraced in many developed countries to help investigate homicidal cases in their legal system amongst others. It is however still in infancy state in many developing countries, including Nigeria, making the use of this very vital tool very limited to prosecute cases. Some of the reasons include the low knowledge b...

This paper is to establish the present state of things in the country in terms of legal framework and the availability of personnel with a view to presenting an overview of proper mass disaster investigations. This is a retrospective review of mass disasters in Nigeria that occurred within the last 20 years. The study therefore reviews the state of...

Abstract: Introduction: The present study was designed to evaluate the nephroprotective activities of ethanolic roots extract of Pseudocedrela kotschyi against oxidative stress and nephrotoxicity in alloxan induced diabetic albino rats. Methodology: Diabetes was induced in Albino rats by administration of alloxan monohydrate (150 mg/kg, i.p). The e...

Aims: The study was designed to investigate the testiculo protective effects of ethanolic roots extract of Pseudocedrela kotschyi on alloxan-induced testicular damage in diabetic rats. Study Design: Experimental diabetes using animal models. Place and Duration of Study: Department of Anatomy, College of Medicine, Lagos State University, Ikeja, Lago...

Nephroblastoma or Wilms’ tumour is the most common primary renal malignancy of childhood. Despite being a malignant tumour, a survival rate of over 90% is now seen today (compared to 30% in the thirties) and this resulted from the success of collaborative trials and the use of multimodal therapy. Black children have a 2.5 times increased incidence...

Cementifying fibroma is an uncommon fibro-osseous lesion presenting in the oral cavity, which may present in children as an aggressive juvenile subtype of either psammomatoid or trabecular variant. Appropriate management, to achieve local control and prevent destructive expansion, requires early diagnosis, which fine-needle aspiration cytology (FNA...

Idiopathic orbital inflammation (IOI) is a benign inflammatory process usually confined to the orbit, with preponderance for extraorbital extension (EOE). We describe a case of IOI with possible extension to the parotid gland, a presentation yet to be reported in the literature.

Background: The immediate and early sequelae of burns such as vascular collapse and wound sepsis have been extensively studied. Some studies now show that burns cause significant changes in most body systems including the male reproductive system. Only few studies have addressed the reproductive consequences of burns in the male however. Objective:...

Our study evaluates the effect of an educational programme on awareness and uptake of the cervical cancer screening test (Pap smear) by women in a model market in Lagos Nigeria. This was a quasi-experimental study using a multistage sampling technique. A total of 350 women were divided into two groups. A baseline survey on awareness of the Pap test...

Primary squamous cell carcinoma of the breast (SCCB) is a very rare malignancy of the breast and is generally aggressive. It is even rarer during the gestational period. Only few cases have been reported during pregnancy and lactation (Rokutanda et al., 2000). SCCB seen within the gestational period tends to be very aggressive and has a larger size...

Children are the most risk prone in cases of burns. The previous epidemiologic study of paediatric burns in Lagos-Nigeria was carried four decades ago. A new study becomes necessary in view of the increasing incidences of petroleum related fire disasters in Nigeria. : Children up to the age of 14 years admitted for major burns at the Lagos State Un...

Myxomas are the most common primary cardiac tumors in adults. They are more common in the third to sixth decades of life but infrequent in the pediatric age group. Among pediatric patients, the most often affected patients are teenagers. Their presentation is often enigmatic because of vague constitutional findings. The vague and unusual symptomato...

Cervical cancer is one of the most common forms of carcinoma among women worldwide, accounting for about 12% of all cancers. Tragically, studies have shown generally low awareness levels on its symptoms, risk factors and prevention. This study evaluated the effect of a health education program on knowledge of cervical cancer amongst women at risk i...

Malignant tumours of the gastro-intestinal tract are not as rare as previous studies suggest. Recent studies have indicated increasing incidence. To document the pattern, age and sex distribution as well as histopathology characteristics of malignant tumours of the gastro-intestinal system in Lagos and Sagamu in Southwestern Nigeria. The paraffin e...