Francesco Raudino

Francesco Raudino
Ospedale Valduce-Como · neurologia

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65
Publications
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463
Citations

Publications

Publications (65)
Article
Full-text available
Background: Behavioral disturbances are commonly found in the Mild Cognitive Impairment (MCI) and during the early stages of the Alzheimer's disease. This review examines the typology and frequency of such behavioral symptoms. Method: Medline literature review until January 2019. Results: Although there is a vast and sometimes contradictory literat...
Article
Full-text available
Abstract Introduction: Seizures are common in the course of the Alzheimer’s disease (AD), but are also described as a first sign of the disease. This work aims at reviewing the literature considering epilepsy as a first sign of the AD. Method: Medline search until September 2019. Results: Seizures precede the cognitive deficits in some animal model...
Article
Full-text available
Context: Visual disturbances are frequent in Alzheimer’s disease (AD) and sometimes AD begins with visual disturbances, therefore many researchers have examined the eyes in order to confirm the diagnosis, to monitor the development of the disease or the response to drugs. Evidence Acquisition: Medline literature until March 2018. Results: Several i...
Article
Full-text available
Context: The retina is a part of the Central Nervous System that is easy to study. The visual disturbances are frequent in Alzheimer’s disease (AD) patients and sometimes, the AD begins with visual symptoms. This paper aims to review the existing literature on the involvement of the eye in the AD. In this first part, the animal models and the patho...
Article
Full-text available
Introduction: Autoimmune diseases usually affect central or peripheral nervous system and can affect both only in rare cases. Case Presentation: A 55-year-old female was referred with symptoms of multiple mononeuritis associated with central signs and she had a dramatic improvement with steroid therapy. An attempt to stop steroid therapy after four...
Article
In our knowledge, Pazzaglia and Coll. first described this disease in 1970 in their article "Su di un singolare disturbo della stazione eretta (osservazione di tre casi)" [On an unusual disorder of erect standing position (observation of 3 cases)].
Article
Full-text available
Background: Only few studies evaluated the long-term effectiveness of the prophylactic therapy of migraine. Objectives: In this study we evaluate the optimal length of the prophylaxis in migtaineurs. Patients and Methods: The length of the prophylactic therapy was evaluated in 68 outpatients with migraine without aura. The drugs dosage was adjusted...
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Full-text available
The Alzheimer's disease is considered a progressive cognitive disorder; however, several non-cognitive symptoms accompany all stages of the disease, appearing at times before the cognitive symptoms become manifest. This article reviews the literature on non-cognitive symptoms normally related to the Alzheimer's disease, including gait and balance d...
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The first formal description of the Shaking Palsy is ascribed to James Parkinson. However, a review of the literature shows that several civilizations had know this disease from long before, despite the fact it was often mistaken for other diseases. Equally, therapies of some effectiveness were prescribed since ancient times.
Article
Full-text available
Parkinson's disease (PD) has traditionally ascribed to alpha-synucleinopathy of the substantia nigra; however, several studies have showed widespread alpha-synucleinopathy inside and outside the brain. The potential role of the spinal cord in the genesis of some symptoms has been quite neglected despite the frequent and precocious presence of alpha...
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A healthy 22-year-old man complained of primary stabbing headache (PSH) for about two months. The headache recurred after one year and after a month the pain took on the characteristics of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT). This patient shows some unusual features: juvenile onset, miosis...
Article
The peroneal nerve palsy at the fibular head is quite common but often difficult to diagnose both clinically and electrophysiologically. The purpose of this study was to evaluate the usefulness of the inching in mononeuropathy of the peroneal nerve at the fibular head. Recording from extensor digitorum brevis muscle the nerve was stimulated suprama...
Article
The refractory period of the sural nerve was evaluated in 115 patients with suspected polyneuropathy of various origin. They were asymptomatics or with minor, mainly sensitive, disturbances. In all the conventional neurophysiologic examination (motor and sensory velocities, distal latencies and F-waves of the peroneal, ulnar and sural nerves) was n...
Article
Besides the classic motor swings, many non motor fluctuations may occur in Parkinson's disease, but the clinical spectrum and the frequency of these symptoms are not well recognized. A total of 47 parkinsonian outpatients were questioned about any symptoms associated with off state. Nine patients had no fluctuations, 16 referred only to motor fluct...
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Full-text available
The sensitivity of the Median Nerve Stress Test (Stress Test) described by La Ban et al. and performed hyperextending for one minute the supinated wrist and the distal interphalangeal joint of the index finger and looking for pain in the proximal forearm was evaluated in 140 arms with Carpal Tunnel Syndrome confirmed electrophysiologically. The Str...
Article
Background. To describe the characteristics of the ossification of the posterior longitudinal ligament (OPLL) in Caucasian patients. Methods. Thirty outpatients with radiologically proven OPLL were examined clinically and electromyographycally (EMG). Results. This series differs in some way from the literature data. The male/female ratio is 1.5/2 a...
Article
Besides the classic motor swings, many non-motor fluctuations may occur in Parkinson's disease. The clinical spectrum and the frequency of these symptoms are not well recognized. 41 outpatients were questioned about any symptom associated with off state. 10 patients were free of fluctuations, 15 referred only motor fluctuations and 16 motor fluctua...
Article
We studied 49 patients with Parkinson's disease (PD) by a neuropsychological battery examining the temporo-spatial orientation, short-term memory, comprehension, non-verbal intelligence, long-term memory and anomia and the Auditory Event-Related Potentials. In the patients the latencies of the N100 and N200 waves were prolonged and the amplitude of...
Article
F-waves were recorded from the abductor digiti minimi in 60 healthy subjects aged between 22 and 65 years. F-waves following 80 supramaximal stimuli were recorded. The F with minimal latency (Fmin), the mean latency (Fmean) and chronodispersion (CD) were calculated for each set of ten stimuli. In each subject the values after 10, 20, 30 etc. stimul...
Article
The effect of i.v. methylprednisolone megadoses (IVMP) on the relapse rate was tested in a retrospective study on 27 patients with a definite, relapsing-remitting, multiple sclerosis (MS) regularly visited at our Neurological Department for a follow-up period ranging from 6 months to 3 years. Thirty-four exacerbations occurred during the follow-up...
Article
The aim of this paper is to compare the potentials from the extensor digitorum brevis (EDB) with those from the tibialis anterior (TA) stimulating the peroneal nerve proximally and distally the fibular head in patients suffering of peroneal nerve palsy at the fibular head. In 8/30 limbs the electrophysiological studies were normal. According to ele...
Article
Full-text available
In ischaemic stroke, thrombolytic drugs speed the recanalisation of intracerebral arteries. The effects of aspirin are not known. A trial was conducted to determine whether, separately or together, streptokinase and aspirin have clinical benefits in acute ischaemic stroke similar to those in acute myocardial infarction. 622 patients with acute isch...
Article
In 100 subjects with Carpal Tunnel Syndrome (CTS) and any other illness, the conduction velocity of the radial sensory nerve (RSN) was studied on the hypothesis that, because of the relation with the tendon of the brachioradialis and extensor carpi radialis longus muscles, microtrauma can injure the RSN. In 13 patients, for a total of 15 limbs invo...
Article
Full-text available
SYNOPSIS In 26 patients suffering from temporomandibular dysfunction (TMD) the silent period (ES), which consists of an early (ES1) and a late (ES2) inhibition which interrupts the voluntary electromyographic activity after an electrical stimulus, was recorded from the masseter muscles. Several different patterns were identified: in 8 patients (gro...
Article
Supine and after standing F wave studies were performed in 22 healthy subjects, in 14 patients with L5 root compression and in 11 patients with low back pain. Unlike previous works, the latency of the F minimal wave, F maximal, F mean and F chronodispersion before and after standing are similar. It is possible that the positional changes of the F w...
Article
SYNOPSIS The occurrence of limb pain in close temporal relationship with headache was sought in 245 (185 women and 60 men) patients. Eleven patients (4.4% three men and eight women) had referred pain at least once, in one or more limbs in close temporal relationship with headache. Usually the pain was located in the upper limbs, was concomitant wit...
Article
The acoustic P300 wave was elicited in 47 healthy subjects aged between 16 and 83 years. The neurophysiological data were correlated with scores from the State-Trait Anxiety Inventory Test in the X1 and X2 forms and with scores from the Middlesex Hospital Questionnaire. The amplitude of the N2 wave and the N2-P3 time recorded at Cz significantly co...
Article
Among 115 subjects suffering from peripheral neuropathies of various origins, in 71 (61.7%) no fasciculations were noticed in the lower limbs, while they were present in 27 (23.4%); 17 (14.7%) reported the presence of fasciculations that, however, were not observed during the neurological examination or on EMG. The only difference between the subje...
Article
SYNOPSIS To investigate the involvement of the trigeminal system in cluster headache, in twelve subjects the electrically-elicited blink reflex during a symptomatic period was examined. In eleven cases, the amplitude of the contralateral R2 response on the symptomatic side was significantly lower. at the same stimulus intensity, than on the asympto...
Article
With electrophysiological methods the possible presence of anomalous innervation and/or of anastomosis between the median and ulnar nerve in the intrinsic hand muscles was studied in 34 limbs. The abductor pollicis brevis was supplied by the ulnar nerve in 12% to 38%, the first dorsal interosseus by the median nerve in 4.2% to 19.6%; the abductor d...
Article
The axon reflex (AR) is an intermediate response evoked by submaximal stimulation and eliminated by supramaximal stimulation: peripheral late wave (PWL) is a late motor response that appears with supramaximal stimulation and is regularly repeated. The PWL has been studied in 185 subjects and has been obtained in 70 cases (36 cases of polyneuropathi...
Article
SYNOPSIS Using pattern reversal stimuli, visual evoked potentials (VEP) were measured between attacks in 40 (6 classic and 34 common) migraine sufferers, and in 20 control subjects. While there were no statistically significant differences between the groups in mean P wave latency or in mean P wave amplitude, there were some intriguing individual f...
Article
Peripheral late wave (PWL) is a late motor response, that appear with supramaximal stimulation and which latency is reduced with proximal stimulation. It has been registered in 31 subjects over 60 with stimulation of the posterior tibial nerve and in no subject over 65 with stimulation of the medial or ulnar nerve. Probably, it is to attribute to a...
Article
It has been studied the answer to the LSI in migraine subjects (166) and with tension headache (198). Only in tree cases, which on migraine and two with tension headache, the answer given is anomalous to the LSI, with a frequency like those found in "normal" population.
Article
The incidence of periodic syndrome and headache in 316 children, of whom 147 were male and 169 female, of an age between three and six years and three months old, has been found. 98 of those children (31,33%) present periodic syndrome: cyclical vomiting was found in 7 cases (2,21%), recurrent abdominal pains in 16 cases (5,06%), recurrent pyrexia i...
Article
Presented is a case of a focal crisis caused by stroboscopy in a 48 yr old man. Then considered are the cases present in the literature and the hypothesis introduced by several authors is briefly discussed.

Questions

Question (1)
Question
A female aged 51 years showed first signs concerning the peripheral nervous system and after the central nervous system with good response to steroid therapy prolonged for many years. A daughter aged of 50 years showed rheumatoid arthritis and another daughter aged 60 years Loeffler's syndrome (pulmonary eosinophilia). What may be the possible link between these three autoimmune disorders?

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