Francesco G Mangano

• DDS, PhD
• Professor (Associate) at Sechenov University

The Cone Morse (CM) implant-abutment junction is designed to improve screw mechanics and minimize bacterial leakage through a process known as “cold fusion”. This research evaluated a clinically stable self-locking CM implant that was retrieved after 30 years of functional loading, focusing on the bone–implant interface. Histological evaluation was...

Aim The aim of this work is to present a new protocol for implant surgical planning which involves the combined use of artificial intelligence (AI) and mixed reality (MR). Methods This protocol involves the acquisition of three‐dimensional (3D) patient data through intraoral scanning (IOS) and cone beam computed tomography (CBCT). These data are l...

Objectives To assess quality, clinical acceptance, time-efficiency, and consistency of a novel artificial intelligence (AI)-driven tool for automated presurgical implant planning for single tooth replacement, compared to a human intelligence (HI)-based approach. Materials and methods To validate a novel AI-driven implant placement tool, a dataset...

Objectives: To validate the virtual-fit alignment, analyze the impact of cement spacing on internal/marginal gaps, and correlate results with conventional trueness measures. Methods: Four dental abutment models were scanned using an industrial reference scanner (one time each), Emerald S (three times each), and Medit i700 (three times each) intrao...

Objectives: Evaluation of the accuracy of fully guided dynamic implant navigation surgery in Kennedy I, II, and III class dental arch defects with two different implant designs using an X-ray free evaluation method. Methods: Polyurethane resin maxillary models simulated posterior edentulous defects. Four cone beam computed tomography (CBCT) scan...

Background: Symmetry is critical in perceived attractiveness, especially in female faces. The palate determines the teeth' alignment and supports facial soft tissues. Therefore, the study aimed to assess the effects of sex, orthodontic treatment, age, and heritability on the directional, anti-, and fluctuational asymmetry in the digital palatal mo...

Temporomandibular joint disorders (TMDs) have always been the subject of studies due to the difficult management of symptoms and the complex stabilization of the so-called therapeutic position. In this effort, digital technologies open new opportunities for such planning, allowing the clinician to digitally assess the situation and verify the stabi...

Purpose: To present a novel protocol for authentic three-dimensional (3D) planning of dental implants, using artificial intelligence (AI) and augmented reality (AR). Methods: The novel protocol consists of (1) 3D data acquisition, with an intraoral scanner (IOS) and cone-beam computed tomography (CBCT); (2) application of AI for CBCT segmentatio...

Objectives To evaluate the effect of different measurement techniques and operators on measured deviations in in vitro implant scans. Methods A 2-piece system that comprises a healing abutment (HA) and a scan body (SB) was mounted onto an implant at right first molar site of a polymethylmethacrylate mandibular dentate model. Model was digitized by...

Objectives The study aimed to compare the precision of ATOS industrial, 3ShapeE4, MeditT710, CeramillMap400, CSNeo, PlanScanLab desktop, and Mediti700 intraoral scanners. The second aim was to compare the trueness of Mediti700 assessed by ATOS and desktop scanners. Methods Four plastic dentate models with 7-12 abutments prepared for complete arch...

Purpose: To report on the results obtained with computer-aided-design/ computer-assisted-manufacturing CAD/CAM custom-made synthetic hydroxyapatite/beta-tricalcium-phosphate (HA/beta-TCP) bone grafts in alveolar ridge augmentation for dental implant placement. Methods: The procedure included: (1) cone-beam computed tomography (CBCT) of the bone...

Purpose: Additive manufacturing (AM) in prosthodontics is used as an alternative to casting or milling. Various techniques and materials are available for the additive manufacturing of the fixed and removable tooth-supported restorations, but there is a lack of evidence on the accuracy of AM fixed implant-supported prostheses. Recent studies inves...

Aim This in vitro study aimed to compare the mechanical performance of 3D printed versus milled zirconia blocks, when subjected to uniaxial compression load, and to investigate the microstructural characteristics of the 3D printed samples, before and after the application of the load. Methods Twenty zirconia blocks (5 × 5 × 5mm³) were prepared: 10...

Objectives: To present a solid index (SI), a 3D-printed replica of a patient's preexisting complete denture, which allows the dentist to accurately capture the position of the implants and the dental technician to model a bar for overdenture (OD) in CAD software with the use of reverse implant libraries. Materials and methods: A patient in need...

Célkitűzés: Célunk egy parodontális defektus regeneratív-rekonstruktív sebészi ellátásának és a műtétek digitális tervezésének bemutatása hibrid virtuális modell alapján, továbbá a pre- és postoperatív cone-beam computer tomográf (CBCT) felvételek pontos térbeli illesztésével a változások digitális kiértékelése. Vizsgálati anyag és módszer: Félauto...

Titanium specimens have been proven to be safe and effective biomaterials in terms of their osseo-integration. To improve the bioactivity and develop customized implants titanium, the surface can be modified with selective laser melting (SLM). Moreover, the design of macro-porous structures has become popular for reaching a durable bone fixation. 3...

Purpose: To compare the trueness and precision of 3D-printed versus milled monolithic zirconia crowns (MZCs). Methods: A model of a maxilla with a prepared premolar was scanned with an industrial scanner (ATOSQ®, Gom) and an MZC was designed in computer-assisted-design (CAD) software (DentalCad®, Exocad). From that standard tessellation language...

Introduction: In fixed prosthetic rehabilitations, the restorations must be designed and fabricated in a proper maxillomandibular relationship, with correct vertical dimensions of occlusion (VDO) and centric relations (CR). This short communication introduces a novel digital technique that allows to obtain the maxillomandibular record and transfer...

Purpose: To investigate and compare the production tolerances of six different commercially available implant scan bodies (SBs), with the null hypothesis that there would be no tolerances in the production or significant differences between the different SBs. Materials and methods: Six different implant SBs (IO 6A-B and IO 2B-B, Nobel Biocare; R...

Purpose: To evaluate the clinical performance of lithium disilicate (LiDiSi) computer-aided- design/computer-assisted-manufacturing (CAD/CAM) veneers with feather-edge margins. Methods: Over 4 years (2015-2019), 1075 LiDiSi veneers with feather-edge margins were fabricated with a fully digital workflow and cemented on 105 patients. The outcome v...

Purpose: Accumulating evidence has shown that vitamin D deficiency has been linked with an up to 300% increase in early implant failure. The aim of this study was to investigate a comprehensive pre-surgical dental support program (DentaMedica) on its ability to increase vitamin D and antioxidant levels prior to implant surgery. Materials and meth...

Background In the regenerative treatment of intrabony periodontal defects, surgical strategies are primarily determined by defect morphologies. In certain cases, however, direct clinical measurements and intraoral radiographs do not provide sufficient information on defect morphologies. Therefore, the application of cone-beam computed tomography (C...

Objectives To assess the trueness of a solid index (SI) in the full-arch (FA) implant impression, and to compare it with that of two intraoral scanners (IOSs). A type-IV gypsum model of a completely edentulous patient with 8 implant scanbodies (SBs) was scanned with a desktop scanner (7Series®) to obtain a reference virtual model (RVM), and with tw...

Statement of problem Information about the accuracy of intraoral scanners for the edentulous maxilla is lacking. Purpose The purpose of this in vitro study was to compare the accuracy of 3 different intraoral scanner techniques on a completely edentulous maxilla typodont. Material and methods Two completely edentulous maxillary typodonts with (wr...

Statement of problem: Information about the accuracy of intraoral scanners for the edentulous maxilla is lacking. Purpose: The purpose of this in vitro study was to compare the accuracy of 3 different intraoral scanner techniques on a completely edentulous maxilla typodont. Material and methods: Two completely edentulous maxillary typodonts with...

Statement of problem: Intraoral scanners are promising options for removable prosthodontics. However, analog aids, including occlusion rims, are still used, as a completely digital workflow is challenging and scientific evidence on the topic is scarce. Purpose: The purpose of this in vitro study was to assess and compare the trueness and precision...

Background: The literature has not yet validated the use of intraoral scanners (IOSs) for full-arch (FA) implant impression. Hence, the aim of this in vitro study was to assess and compare the trueness of 12 different IOSs in FA implant impression. Methods: A stone-cast model of a totally edentulous maxilla with 6 implant analogues and scanbodie...

Background: In the regenerative treatment of intrabony periodontal defects, surgical strategies are determined by defect morphologies. Clinical direct measurements and intraoral radiographs are the main tools in periodontal diagnostics and surgical planning, however in certain cases they don’t provide sufficient amount of information. Therefore, th...

Background: One of the most recent innovations in bone augmentation surgery is represented by computer-aided-design/computer-aided-manufacturing (CAD/CAM) customized titanium meshes, which can be used to restore vertical bone defects before implant-prosthetic rehabilitations. The aim of this study was to evaluate the effectiveness/reliability of t...

Purpose: To present the results obtained with the "Continuous Scan Strategy" (CSS), a direct intraoral scanning technique based on the connection of the implant scan bodies (SBs) with thermoplastic resin. Methods: 40 patients were restored with 45 long-span monolithic implant-supported zirconia restorations (10 partial prostheses [PP] and 35 ful...

Purpose: To compare the reliability of five different intraoral scanners (IOSs) in the capture of implant scanbodies (SBs) and to verify the dimensional congruence between the meshes (MEs) of the SBs and the corresponding library file (LF). Methods: A gypsum cast of a fully edentulous maxilla with six implant analogues and SBs screwed on was sca...

Purpose: Several studies showed that the sintering temperature of 1250 °C could affect the formation of α-Ca3(PO4)2, which is responsible for the reduction of the hardness value of biphasic calcium phosphate biocomposites, but they did not evaluate the inference of the sintering time at peak temperature on transition of β-Ca3(PO4)2 to α-Ca3(PO4)2....

Purpose: To compare the accuracy of 6 desktop 3D printers in dentistry. Methods: A parallelepiped (PP) with known geometry and holes of different diameters was designed and printed with 6 desktop 3D printers (Sheraprint 40®; Solflex 350®; Form 2®; MoonRay D75®; Vida HD®; XFAB 2000®). For each printer, 9 PPs were printed with proprietary material...

Background: Artificial intelligence (AI) is a branch of computer science concerned with building smart software or machines capable of performing tasks that typically require human intelligence. We present a protocol for the use of AI to fabricate implant-supported monolithic zirconia crowns (MZCs) cemented on customized hybrid abutments. Methods...

Background: Long-term success of implant-supported restorations can be affected by the accuracy of the prosthodontic workflow which may differ between conventional and digital techniques. Purpose: The purpose was to compare the fit of two-implant-supported restorations, fabricated using conventional and digital workflows and to assess the influe...

Purpose: To present the application of custom-made 3D-printed subperiosteal implants for fixed prosthetic restoration of the atrophic posterior mandible of elderly patients. Methods: Between January 2017 and June 2018, all partially edentulous patients aged over 65 years, with two or more missing teeth in the posterior atrophic mandible, and who...

Purpose: To present an experimental strategy for successfully capturing the margins of prepared single teeth with an intraoral scanner (IOS). Methods: The protocol was as follows: (1) an intraoral impression was captured with an IOS, without taking care of the visibility of the margins; (2) a partial analog impression was taken by means of a 3D-pri...

Aim: The purpose of this article is to present the preliminary clinical results obtained with a novel hybrid digital-analog technique, the solid index impression protocol (SIIP), which uses a solid index to capture accurate impressions of multiple implants for the fabrication of implant-supported fixed full arches (FFAs). Materials and methods:...

Background This retrospective clinical study aims to present results of experience with a novel guided surgery system with a sleeveless, open-frame structure, in which the surgical handpiece (not the drills used for preparation) is guided. Methods This study was based on an evaluation of the records of partially edentulous patients who had been tr...

Purpose: To present a digital method that combines intraoral and face scanning for the computer-assisted design/computer-assisted manufacturing (CAD/CAM) fabrication of implant-supported bars for maxillary overdentures. Methods: Over a 2-year period, all patients presenting to a private dental clinic with a removable complete denture in the maxi...

In dental districts, successful bone regeneration using biphasic calcium phosphate materials was recently explored. The present study aimed to perform a comparative study between 3D-printed scaffolds produced by laser light stereo-lithography (SLA) and traditionally sintered biphasic calcium phosphate scaffolds by an integrated morphological, morph...

Background: Until now, a few studies have addressed the accuracy of intraoral scanners (IOSs) in implantology. Hence, the aim of this in vitro study was to assess the accuracy of 5 different IOSs in the impressions of single and multiple implants, and to compare them. Methods: Plaster models were prepared, representative of a partially edentulou...

Background: Previous studies have suggested that mucosal height is related to the bone level and soft tissue thickness. The purpose of this pilot study was to investigate the ratio between the height and width of the tissues around single implants with a conical connection and platform switching. Methods: All patients receiving single implants (Any...

Purpose: To present a novel, full-digital protocol for the design and fabrication of implant-supported monolithic translucent zirconia crowns cemented on customized hybrid abutments. Methods: The present retrospective clinical study was based on data from patients who had been treated with single Morse-taper connection implants (Exacone®, Leone...

Background: Guided implant surgery appears to have several benefits, such as the possibility of inserting flapless implants in a prosthetically driven manner, avoiding dangerous anatomical structures. However, to date, only a few surgeons routinely use guided surgery in partially edentulous patients. Aim: To present the results obtained with tooth-...

Background. Since osseointegration depends on bone metabolism, low levels of vitamin D in the blood may negatively affect bone formation around dental implants. To date, only a few studies have investigated the possible connection between serum levels of vitamin D and early dental implant failure (EDIF), i.e. failure that occurs within 4 months aft...

The Root Membrane Technique: A Retrospective Clinical Study With Up to 10 Years of Follow-up Konstantinos D. Siormpas, DDS,* Miltiadis E. Mitsias, DDS, MSc, PhD,† Georgios A. Kotsakis, DDS, MS,‡ Isaac Tawil, DDS, MSc,§ Michael A. Pikos, DDS,¶ and Francesco G. Mangano, DDS, PhDk Purpose: Immediate implant placement in conjunction with intentional r...

Purpose: Immediate implant placement in conjunction with intentional root retention is a recently introduced technique, but the majority of existing documentation is limited to short-term reports with low level of evidence. Hence, the aim of this study was to document the long-term clinical and radiographic results of the root membrane technique....

Background : Direct metal laser Sintering (DMLS) is an additive manufacturing technique that allows fabrication of dental implants and related components with a highly porous surface. To date, no human studies have investigated the soft tissue adhesion and presence of inflammatory infiltrate with porous DMLS healing abutments (HAs), nor have they c...

Background: Direct metal laser Sintering (DMLS) is an additive manufacturing technique that allows fabrication of dental implants and related components with a highly porous surface. To date, no human studies have investigated the soft tissue adhesion and presence of inflammatory infiltrate with porous DMLS healing abutments (HAs), nor have they co...

Background: Personalized maxillary expansion procedure has been proposed to correct maxillary transversal deficiency; different protocols of stem cell activation have been suggested and rapid maxillary expansion (RME) is the most commonly used among clinicians. The present study aimed to quantify in three-dimensions (3D) the osteo-regeneration of...

Aim To compare the outcome of digital versus analog procedures for the restoration of single implants. Methods Over a two-year period (2014-2016), all patients who had been treated in a dental center with a single implant were randomly assigned to receive either a monolithic zirconia crown, fabricated with digital workflow (test group), or a metal...

Background: Intraoral scanners are devices for capturing digital impressions in dentistry. Until now, several in vitro studies have assessed the trueness of digital impressions, but in vivo studies are missing. Therefore, the purpose of this study was to introduce a new method to assess trueness of intraoral scanners and digital impressions in an...

Stem cells are undifferentiated cells, capable of renewing themselves, with the capacity to produce different cell types to regenerate missing tissues and treat diseases. Oral facial tissues have been identified as a source and therapeutic target for stem cells with clinical interest in dentistry. This narrative review report targets on the several...

Purpose: The aim of this literature review was to provide an update on the current scientific knowledge in the field of 3D virtual patient science and to identify a possible easy, smart, and affordable method to combine different file formats obtained from different digital devices. Methods: Electronic searches of the Medline database was perfor...

Background. In the current scientific literature there are only few studies on the immediate functional loading of single implants. The aim of the present present study was to evaluate the 4-year survival rate, complication rate and peri-implant marginal bone loss (PIMBL) of immediately loaded single implants inserted in healed ridges and fresh pos...

This report describes a failed blade implant after 25 years in function in the left maxilla and the results of histologic analysis of peri-implant tissues. The blade was retrieved, and histologic findings revealed that it was not osseointegrated despite being successfully in function for so many years. The long-term function of blade implants witho...

Objective: In the anterior regions, the resorption of the buccal bone after tooth extraction leads to a contraction of the overlying soft tissues, resulting in an esthetic problem, particularly with immediate implant placement. In the socket shield technique, the buccal root section of the tooth is maintained, to preserve the buccal bone for immed...

Purpose: To evaluate the long-term cumulative implant survival rate (CISR%) and cumulative implant-crown success rate (CICSR%) of single-tooth Morse-taper connection implants, with particular attention to documenting the incidence of prosthetic complications. Methods: The customized records of all patients who had been treated with single-tooth...

Objective The objective of the present study was to compare patients’ acceptability, comfort and stress with conventional and digital impressions. Materials and Methods Thirty young orthodontic patients (15 males and 15 females) who had no previous experience of impressions were enrolled in this study. Conventional impressions for orthodontic stud...

Purpose. The aim of this scanning electron microscope (SEM) study was to investigate the interface between the bone and a novel nanostructured calcium-incorporated dental implant surface in humans. Methods. A dental implant (Anyridge®, Megagen Implant Co., Gyeongbuk, South Korea) with a nanostructured calcium-incorporated surface (Xpeed®, Megagen I...

Background: Intraoral scanners (IOS) are devices for capturing direct optical impressions in dentistry. The purpose of this narrative review on the use of IOS was to: (1) identify the advantages/disadvantages of using optical impressions compared to conventional impressions; (2) investigate if optical impressions are as accurate as conventional im...

Background: Different surgical procedures have been proposed to achieve horizontal ridge reconstruction of the anterior maxilla; all these procedures, however, require bone replacement materials to be adapted to the bone defect at the time of implantation, resulting in complex and time-consuming procedures. The purpose of this study was to describ...

Objective The aim of this randomized, controlled histologic/histomorphometric study was to compare the early bone formation around immediately loaded implants with nanostructured calcium-incorporated (NCI) and machined (MA) surface, placed in the human posterior maxilla. Materials and methodsFifteen fully edentulous patients (six males; nine female...

Background Direct metal laser sintering (DMLS) is an additive manufacturing technique that allows the fabrication of dental implants layer by layer through the laser fusion of titanium microparticles. The surface of DMLS implants is characterized by a high open porosity with interconnected pores of different sizes; therefore, it has the potential t...

Purpose: To investigate the 10-year survival and complication rates of Morse taper connection implants (MTCIs) placed in grafted sinuses. Methods: This study reports on patients treated with maxillary sinus augmentation (with the lateral window technique (LWT) or the transalveolar osteotomy technique (TOT)) and installed with MTCIs supporting fi...

Background Until now, only a few studies have compared the ability of different intraoral scanners (IOS) to capture high-quality impressions in patients with dental implants. Hence, the aim of this study was to compare the trueness and precision of four IOS in a partially edentulous model (PEM) with three implants and in a fully edentulous model (F...

The aim of this prospective multicenter study was to evaluate the outcomes of single implants subjected to immediate functional loading. Inclusion criteria were single-tooth placement in postextraction sockets or fully healed sites, and sufficient bone height and width to place an implant of at least 3.5 × 10.0 mm. All implants were functionally lo...