Francesco Bellinato

Francesco Bellinato
University of Verona | UNIVR · Department of Medicine

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53
Publications
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226
Citations

Publications

Publications (53)
Article
Background: : Pharmacoeconomic studies comparing the cost of adalimumab biosimilars versus the originator and conventional drugs in psoriasis are lacking. Research design and methods: To assess the cost per responder of adalimumab biosimilars versus the originator and methotrexate for psoriasis treatment. A cost per responder analysis comparing...
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Full-text available
Background: The EXCEED study evaluated the efficacy and safety of secukinumab versus adalimumab in psoriatic arthritis, but it did not include a pharmacoeconomic analysis. The objective of this study was to compare the cost per responder of secukinumab versus adalimumab in patients with psoriatic disease. Methods: The cost per responder was calc...
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Introduction: The real-life effectiveness of adalimumab biosimilars in patients with psoriasis has rarely been investigated. Objective: To investigate drug survival of adalimumab biosimilars in patients with chronic plaque psoriasis and factors associated with its discontinuation. Methods: We carried out a retrospective observational study inc...
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Introduction: Nevoid melanoma (NeM) is a rare variant of melanoma resembling melanocytic nevus. The objective of the study is to systematically review the dermoscopic features of NeM. Evidence acquisition: A hospital-based retrospective study was conducted. Dermoscopic features of NeMs diagnosed through excisional biopsy between 1 January 2015 a...
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Importance: Psoriasis is a chronic inflammatory disease with a relapsing-remitting course. Selected environmental factors such as infections, stressful life events, or drugs may trigger disease flares. Whether air pollution could trigger psoriasis flares is still unknown. Objective: To investigate whether short-term exposure to environmental air...
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Purpose Chronic plaque psoriasis is associated with the presence of non-alcoholic fatty liver disease (NAFLD), but the magnitude of this association remains currently uncertain. We aimed to investigate the magnitude of the association between psoriasis and the risk of prevalent and incident NAFLD, and to assess whether psoriasis severity and/or pso...
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Linked article: T. Gambichler et al. J Eur Acad Dermatol Venereol 2022; 36: 172–180. https://doi.org/10.1111/jdv.17744.
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Background Chronic plaque psoriasis has been associated with metabolic comorbidities, including non-alcoholic fatty liver disease (NAFLD). A causal relationship between NAFLD and chronic kidney disease (CKD) is debated. Objectives To assess whether NAFLD is associated with impaired renal function in patients with psoriasis. Methods A multicenter,...
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Objective: The amniotic fluid contains a large population of stem keratinocytes demonstrating minimal immunological rejection. Recent evidence suggests that stem cells from the amniotic fluid can be employed in the field of tissue engineering. In this work we identified precursors of the epithelial cells and expanded them in vitro. Materials and...
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Patients with history of malignant melanoma (MM) are at risk of developing subsequent primary MM (SPM). Predictors of SPM may be helpful to identify patients at higher risk. The objective of the study is to investigate the phenotypic traits, indirect actinic exposure features and pathological variables associated with the risk of development of SPM...
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Many patients are receiving SARS-CoV-2 vaccinations, which have been associated with a variety of adverse effects. Cutaneous adverse reactions to SARS-CoV-2 vaccinations have been progressively reported, but they have not been reviewed according to their morphological clinical patterns. The objective of this review was to summarize the existing dat...
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Psychological stress has long been recognized as a trigger for plaque psoriasis, and preliminary evidence suggests that psoriasis could be associated with alterations in the hypothalamic-pituitary-adrenal (HPA) axis, resulting in impaired cortisol response to stress. This study aimed to investigate psychological stress, anxiety, depression and sali...
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BACKGROUND: Bullous pemphigoid (BP) is an autoimmune blistering disease caused by antibodies against the hemidesmosomal BP180 and/ or BP230 proteins. There is an increasing evidence that the use of dipeptidyl peptidase-4 inhibitors, also known as gliptins, increases the risk for BP. The gliptins more frequently associated with BP are vildagliptin a...
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Background: The association between chronic plaque psoriasis and lympho-haematological malignancies (LHM) remains controversial. Objective: To investigate the risk of LHM in patients with psoriasis according to the best evidence. Methods: A systematic review and meta-analysis of observational cohort studies that assessed the association of pso...
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Background: Plaque psoriasis has been associated with anxiety, depression, suicidal ideation and various personality traits. However, studies on hypochondriasis, i.e. the belief of serious illness despite having no or only mild symptoms, are currently scarce. Objective: The aim of this study was to assess hypochondriasis and personality traits i...
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Background Acquired perforating dermatoses (APDs) are characterized by trans-epidermal elimination of skin materials. Altered glycation of dermal components may be involved in pathogenesis. Objectives To assess whether patients affected by APDs have increased cutaneous advanced glycation end-products (AGEs) levels. Methods A cross-sectional contr...
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Many health‐care systems have responded the COVID‐19 pandemic by delaying and/or cancelling elective surgical procedures, particularly during the lockdown.1‐3 There is a concern that this could have affected the early diagnosis of malignant melanoma (MM) that is critical to improve its prognosis.4,5 The objective of this observational study was to...
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IntroductionThe use of telemedicine has significantly increased since the outbreak of the SARS-CoV-2 pandemic. In the dermatological setting, patients with stable plaque psoriasis on maintenance therapy with biological drugs may be suitable candidates for telemedicine, although their preference for telemedicine has not yet been investigated. The ai...
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Objective To estimate the incidence of psoriatic arthritis (PsA) in patients with psoriasis who had received a continuous treatment with biological disease-modifying antirheumatic drugs (bDMARDs) compared with phototherapy. Methods A retrospective non-randomised study involving patients with moderate-to-severe plaque psoriasis, who were prescribed...
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Alopecic and aseptic nodule of the scalp/Pseudocyst of the scalp is a rare but probably underdiagnosed nonscarring alopecia with good prognosis and doxycycline is a safe and effective option treatment. image
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Psoriasis is a common immune-mediated chronic skin disease. Disease severity is influenced by several factors including the extent and localization of skin lesions, severity of pruritus and comorbidities, such as psoriatic arthritis. Moderate to severe psoriasis is defined when cutaneous involvement is diffuse, covering more than 10% of the body su...
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IntroductionDistinct skin lesions associated with coronavirus disease 2019 (COVID-19) have been described, but data regarding their time of onset during the COVID-19 course are scant. Our objective was to systematically review the studies reporting the time of onset of selected skin lesions with respect to the reported onset of the COVID-19 core sy...
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Introduction The treatment of moderate to severe plaque psoriasis in patients with history of malignancy is challenging. Objective To review the studies reporting the experience with IL‐17A inhibitors in patients with psoriasis and history of malignancy; secondly, to investigate cancer recurrence in a series of patients with a prior malignancy and...
Article
Hydroxychloroquine is an established therapy for several rheumatological disorders, and very recently it has been proposed as a possible treatment for the new coronavirus disease 2019 even if recent randomised trials did not prove any benefit. Notably, hydroxychloroquine has been associated with a heterogeneous range of cutaneous and extra-cutaneou...
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Background: Infectious urethritis are classified in N. gonorrhoeae (NG) urethritis and nongonococcal urethritis, caused commonly by C. trachomatis (CT) or M. genitalium (MG) in Western Europe. The primary objective of the study is to evaluate the association between the clinical profile and the pathogens. Secondly, to assess the prevalence of co-i...
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Psoriasis is a chronic inflammatory skin disease usually treated with immunomodulatory/immunosuppressive agents. The use of these agents has been associated with an increased susceptibility to infections. Vaccination might represent a critical aspect in the management of patients with psoriasis treated with immunomodulatory/immunosuppressive therap...
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Chronic plaque psoriasis is an inflammatory skin disease affecting 2–3% of the general population. Approximately one-third of patients are candidates for systemic immunosuppressive treatments, such as synthetic or biological disease-modifying antirheumatic drugs, because of disease extensions, localization in sensitive or visible areas and/or resis...
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Background: Psoriasis is an inflammatory skin disease presenting with erythematous and desquamative plaques with sharply demarcated margins, usually localized on extensor surface areas. Objective: To describe the common differential diagnosis of plaque psoriasis classified according to its topography in the scalp, trunk, extremities, folds (i.e....
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The safety of methotrexate in psoriasis patients with metabolic syndrome could be argued because of increased risk of liver toxicity. To investigate the safety of methotrexate compared to secukinumab in psoriasis patients with metabolic syndrome. A controlled, open trial in psoriasis patients with metabolic syndrome, candidate to methotrexate or se...
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Grover's disease (GD) is an itchy acantholytic disorder occurring on the trunk of middle‐aged men. Based on the best evidence, this study aimed to provide a summary of the clinical characteristics, disease course and treatments of GD. A systematic review was performed according to PRISMA guidelines for original articles published between 01.01.1970...
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Zusammenfassung Der Morbus Grover (MG) ist eine juckende akantholytische Erkrankung, die bei Männern mittleren Alters am Rumpf auftritt. Ziel dieser Studie war es, eine Zusammenfassung der klinischen Charakteristika, des Krankheitsverlaufs und der Behandlungen des MG auf Grundlage der besten Evidenz zu erstellen. Entsprechend den PRISMA‐Leitlinien...
Article
Background: Bullous pemphigoid (BP) is an autoimmune blistering disease caused by antibodies against the hemidemosomal BP180 and/or BP230 proteins. There is an increasing evidence that the use of dipeptidyl peptidase-4 inhibitors, also known as gliptins, increases the risk for BP. The gliptins more frequently associated with BP are vildagliptin an...
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Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is associated with higher rates of psychological disorders, but limited evidence supported the association with alexithymia, a psychoaffective dysfunction. Objectives: This study was aimed to investigate the occurrence of alexithymia in AD patients, compared to healt...
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Introduction: Psoriatic arthritis (PsA) is chronic inflammatory disease associated with psoriasis in 20-30% of patients. PsA presents as a heterogeneous disease involving different domains and burdened by an important impact on function and quality of life. Areas covered: Dermatologists play an important role in the early detection of PsA because i...
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Biologics are a fundamental therapeutic resource for patients with moderate to severe chronic plaque psoriasis because they well conjugate effectiveness and safety. Several classes of biologics are available, including TNF‐α inhibitors (infliximab, etanercept, adalimumab and certolizumab pegol), IL‐12/23 inhibitor (ustekinumab), IL‐17 inhibitors (s...
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Full-text available
Psoriasis is a chronic, systemic immune-mediated disease characterized by development of erythematous, indurated, scaly, pruritic plaques on the skin. Psoriasis is frequently associated to comorbidities, including psoriatic arthritis, cardiovascular diseases, diabetes mellitus, obesity, non-alcoholic fatty liver disease, and inflammatory bowel dise...
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Pityriasis lichenoides (PL) represents a spectrum of inflammatory skin diseases comprising pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). This study aimed to provide a summary of effective treatments for PL. A systematic review was performed according to PRISMA guidelines for studies investigating P...
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There is increasing interest in discontinuing biological therapies in patients with chronic plaque psoriasis (PsO) who achieve a complete clinical remission, provided patients maintain clinical benefit. Real life data about the disease course after the discontinuation of biological agents in PsO patients are scarce,1‐4 and focused primarily on psor...
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Histiocytosis are a heterogenous group of diseases resulting from the abnormal proliferation of cells derived from macrophages‐monocytes or dendritic cells at various sites, including bones, soft tissues and skin. Histiocytosis comprises the Langerhans group (L group), including Langerhans cell histiocytosis (LCH), the cutaneous and mucocutaneous h...

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Project (1)
Project
To study the factors associated with incidence and severity of rheumatic musculoskeletal diseases (RMDs)