Francesco Amato

Francesco Amato
Universita' degli Studi di Napoli Federico II · Department of Electrical Engineering and Information Technologies (DIETI)

PhD

About

390
Publications
36,884
Reads
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6,592
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Introduction
Francesco Amato recently (December 1st, 2018) moved to the Department of Electrical Engineering and Information Technologies, Università di Napoli Federico II, as a Full Professor of Bioengineering. The main research fields are: systems and synthetic biology, modeling and control of biomedical systems, finite-time control.
Additional affiliations
April 2003 - present
Universita' degli Studi "Magna Græcia" di Catanzaro
Position
  • Professor (Full)
October 2001 - March 2003
Mediterranean University of Reggio Calabria
Position
  • Professor (Full)
November 1998 - September 2001
University of Naples Federico II
Position
  • Professor (Associate)

Publications

Publications (390)
Article
Full-text available
The quality assessment of training courses is of utmost importance in the medical education field to improve the quality of the training. This work proposes a hybrid multicriteria decision-making approach based on two methodologies, a Likert scale (LS) and the analytic hierarchy process (AHP), for the quality assessment of medical education program...
Article
Full-text available
The impact of neurodegenerative disorders is twofold; they affect both quality of life and healthcare expenditure. In the case of Parkinson’s disease, several strategies have been attempted to support the pharmacological treatment with rehabilitation protocols aimed at restoring motor function. In this scenario, the study of upper limb control mech...
Article
Topological inference of biological interaction networks from experimental data is a fundamental research topic in the broad area of Systems Biology. Several algorithms presented in the literature have been devised in order to infer the topology of a network from time‐course data. The present work introduces a novel method for reverse‐engineering g...
Article
Full-text available
This paper presents the mechatronic design of a biorobotic joint with controllable compliance, for innovative applications of “assist-as-needed” robotic rehabilitation mediated by a wearable and soft exoskeleton. The soft actuation of robotic exoskeletons can provide some relevant advantages in terms of controllable compliance, adaptivity and intri...
Article
This work deals with the Input-Output Finite�Time Stability (IO-FTS) of linear discrete-time systems. In current control science, discrete-time systems play a very important role in many engineering contexts. Moreover, many discrete-time control problems are defined over a finite interval of time, therefore the development and appli�cation of finit...
Article
Full-text available
In the field of electronic fetal health monitoring, computerized analysis of fetal heart rate (FHR) signals has emerged as a valid decision-support tool in the assessment of fetal wellbeing. Despite the availability of several approaches to analyze the variability of FHR signals (namely the FHRV), there are still shadows hindering a comprehensive u...
Conference Paper
Some recent papers have extended the concept of finite-time stability (FTS) to the context of 2-D linear systems, where it has been referred to as finite-region stability (FRS). To this regard, the novel contribution of our work considers an interesting application of FRS to the context of iterative learning control (ILC). In particular, a new proc...
Conference Paper
Given the importance of accelerations of the fetal health rate (FHR) in the monitoring of the fetal wellbeing along the course of the pregnancy, and taking into consideration the contribution of computerized analysis of biosignals as well as the emerging role of artificial intelligence in medicine, this study describes the optimization and use of a...
Conference Paper
In this preliminary study, the nonlinear mixedeffects modeling-based methodology has been chosen to investigate and evaluate the possible implication of some clinical cofactors on the release of biomarker cardiac troponin T (cTnT) in patients with acute myocardial infarction (AMI) and ST-segment elevation (STEMI). The aim of the study consists of t...
Article
Full-text available
The availability of standardized guidelines regarding the use of electronic fetal monitoring (EFM) in clinical practice has not effectively helped to solve the main drawbacks of fetal heart rate (FHR) surveillance methodology, which still presents inter- and intra-observer variability as well as uncertainty in the classification of unreassuring or...
Conference Paper
Prolonged length of stay (LOS) is one of the most significant issues that hospitals must face since it can determine an increase of costs and risk of complications and a decrease of patient satisfaction. The capability of accurately predicting LOS is a valuable tool for helping hospital administrators in resource planning, encouraging quality impro...
Conference Paper
Some recent papers have extended the concept of finite-time stability (FTS) to the context of 2-D linear systems, where it has been referred to as finite-region stability (FRS). FRS methodologies make even more sense than the classical FTS approach developed for 1-D systems, since the state variables of 2-D systems often depend on a pair of space c...
Conference Paper
The Emergency Department (ED) is a zone of a hospital where usually the healthcare staff has to face sudden and serious heathy problems. On the other side, patients find themselves in a situation of great emotion, discomfort and anxiety, aggravated by the expectation that, in cases of lesser severity, it can be long and badly tolerated. Furthermore...
Conference Paper
In the acne severity evaluation, the quantification of inflammatory lesions on the patients’ face is a fundamental step. The aim of this work is to develop a method that automatically performs acne lesions counting. We acquired high-resolution multi-polarization images of facial skin using the visible spectrum. 1089 patients with acne grading rangi...
Article
This paper presents a dynamic model for the identification of asymmetric hysteresis in the force response of the fingertip under cyclic local deformation of the fingertip soft tissues. Viscoelastic effects, marked anisotropy and nonlinearity contribute to the hysteretic behaviour of the force of the fingertip undergoing indentation. The fingertip f...
Article
Full-text available
Health Technology Assessment (HTA) and Six Sigma (SS) have largely proved their reliability in the healthcare context. The former focuses on the assessment of health technologies to be introduced in a healthcare system. The latter deals with the improvement of the quality of services, reducing errors and variability in the healthcare processes. Bot...
Article
Full-text available
Background and objectives: The most advanced technologies and continuous innovations in the medical field require a necessary interaction between the clinical and the engineering world. In this context, software applications are proposed as a bridge between the two scientific fields and, therefore, as powerful tools, easy to use, and with great an...
Article
Full-text available
In the current clinical practice, the diagnosis of Rheumatoid Arthritis (RA) draws on the qualitative evaluation of pain sensitivity thresholds which is affected by several source of uncertainties, due to an operator-dependent diagnostic protocol. Taking our cue from the diagnostic shortcomings, we have explored the possibility of automating the me...
Article
Background and Objective Cardiotocography (CTG) is the most employed methodology to monitor the foetus in the prenatal phase. Since the evaluation of CTG is often visual, and hence qualitative and too subjective, some automated methods have been introduced for its assessment. Methods In this paper, a custom-made software is exploited to extract 17...
Article
Full-text available
Quantitative analysis of biochemical parameters is crucial for a correct diagnosis and prognosis of patients subject to acute myocardial infarction (AMI). In order to achieve a quantitative understanding of the dynamics of cardiac biomarkers, we have developed a mathematical model that can be exploited to extrapolate the release curve of cardiac tr...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Conference Paper
Nowadays rehabilitation robotics has increasingly widespread applications into the biomedical field. One of the most promising strategies for the control of rehabilitation robots is the “assist-as-needed” approach, which is conceived to adapt the level of assistance of the robot on the basis of the physical characteristics and ability of the patien...
Article
Full-text available
In this study, the authors tackle some control problems related to the class of continuous-time, stochastic linear time-varying systems with Markov switching. First, the annular stochastic finite-time stability problem is considered, and two sufficient conditions are derived by considering the Itô formalism. Both conditions require the solution of...
Article
In this study, the authors tackle some control problems related to the class of continuous-time, stochastic linear time-varying systems with Markov switching. First, the annular stochastic finite-time stability problem is considered, and two sufficient conditions are derived by considering the Itô formalism. Both conditions require the solution of...
Chapter
It is well known that the interpretation of cardiotocographic (CTG) signals is still subjective and prone to misinterpretations; as a consequence, there has been an increase of cesarean sections, often not necessary, and initial expectations of significantly reducing perinatal morbidity and mortality have been unattended. Nevertheless, in developed...
Article
In this paper we investigate some finite-time control problems for stochastic linear time-varying systems, described by an Itô type differential equation. In particular, the annular stochastic finite-time stability control problem is dealt with. In this context it is required that the norm of the state variables remains bounded between an inner and...
Article
Full-text available
The study of networks pervades science. The techniques of networks are recently being applied to biomedical disciplines, where the complexity of biomedical systems requires new schemes that can process elevated volumes of data with high efficiency. Artificial neural networks, on which much of artificial intelligence relies, are statistical models p...
Conference Paper
In the present work, we introduce a novel technique to identify the infarct time from time-series meaurements of the cardiac troponin T (cTnT) into plasma. Although this information is extremely valuable from a clinical standpoint, it is not always possible to establish with certainty the exact infarct time. Here, we show how the infarct time can b...
Preprint
Full-text available
Cardiovascular diseases represent, to date, the major cause of mortality worldwide. Diagnosis of the most frequent of such disease, Acute Myocardial Infarction (AMI), requires the evaluation of time-series measurement of specific cardiac biomarkers concentration. The aim of this work is to provide the clinicians with a quantitative tool to analyze...
Article
Purpose: The first aim of this work is to present a novel deep convolution neural network (DCNN) multiplane approach and compare it to single-plane prediction of synthetic computed tomography (sCT) by using the real computed tomography (CT) as ground truth. The second aim is to demonstrate the feasibility of magnetic resonance imaging (MRI)-based...
Article
This paper deals with the finite-time boundedness (FTB) of linear time-varying (LTV) systems; in this context, the novel contribution of our work goes in several directions. The first result is a sufficient condition for FTB when the plant input is generated by an exo-system; it is worth noting that constant, norm bounded signals, which most part o...
Conference Paper
Full-text available
The diagnosis of an acute myocardial infarction (AMI) is based, among other things, on the measurement of the level of cardiac biomarkers in the plasma. In order to optimize and speed up the analysis of cardiac Troponin T (cTnT), we have previously developed a mathematical model, which can be used to estimate the patient-specific cTnT release curve...
Conference Paper
In this paper we tackle some control problems related to the class of continuous-time, Markov jump linear systems. First of all, the annular stochastic finite-time stability problem is considered, and two different sufficient conditions are derived. Both conditions require the solution of a feasibility problem based on differential linear matrix in...
Article
Full-text available
These days, biomimetic and compliant actuators have been made available to the main applications of rehabilitation and assistive robotics. In this context, the interaction control of soft robots, mechatronic surgical instruments and robotic prostheses can be improved through the adoption of pneumatic artificial muscles (PAMs), a class of compliant...
Article
Full-text available
In embryogenesis, mesenchymal condensation is a critical event during the formation of many organ systems, including cartilage and bone. During organ formation, mesenchymal cells aggregate and undergo compaction while activating developmental programmes. The final three-dimensional form of the organ, as well as cell fates, can be influenced by the...
Article
In this paper, we investigate the finite-time output feedback control problem for continuous-time Markov jump linear systems. In this context, the first result is a sufficient condition for stochastic finite-time stability, requiring the solution of a feasibility problem constrained by differential linear matrix inequalities. Afterward, we consider...
Article
Full-text available
A long-standing goal of neuroscience is a theory that explains the formation of the minicolumns in the cerebral cortex. Minicolumns are the elementary computational units of the mature neocortex. Here, we use zinc oxide nanowires with controlled topography as substrates for neural-cell growth. We observe that neuronal cells form networks where the...
Conference Paper
This paper tackles the problem of Finite-Time Stability (FTS) and stabilization for the class of linear timevarying stochastic systems. In particular, we consider the case when the domains, where the state trajectories are required to belong in a given bounded time interval, do not contain the origin of the state-space. This can be the case of seve...
Article
Full-text available
Diagnostics: Proton state of secreted proteins in blood helps identify cancer A blood test that measures whether molecules secreted by cells contain titratable proton atoms can accurately discriminate between patients who have cancer and those who don’t. Titratable species may in turn influence the protonation state of a solution, i.e. the number o...
Article
Full-text available
Diatomaceous earth, or diatomite, is produced through the accumulation of diatom (Bacillariophyceae) skeletons (i.e. cell walls called frustules) made of amorphous silica. The porous, highly symmetrical structure and microscopic size of diatom cell walls make them ideal constituents of sensing devices and analytical chips. Here, we propose chemical...
Article
Full-text available
Secretome of primary cultures is an accessible source of biological markers compared to more complex and less decipherable mixtures such as serum or plasma. The protonation state (PS) of secretome reflects the metabolism of cells and can be used for cancer early detection. Here, we demonstrate a superhydrophobic organic electrochemical device that...
Chapter
This chapter considers a generalized definition of input‐output finite‐time stability (IO‐FTS) that takes into account a nonzero initial state, namely IO‐FTS with nonzero initial conditions (IO‐FTS‐NZIC). It defines the input‐output operator associated to the linear time‐varying (LTV) system under consideration, which also takes into account the no...
Article
The interest in finite-time control has continuously grown in the last fifteen years. This book systematically presents the input-output finite-time stability (IO-FTS) analysis of dynamical systems, with specific reference to linear time-varying systems and hybrid systems. It discusses analysis, design and robustness issues, and includes applicatio...
Chapter
This chapter investigates the problem of the input‐output (IO) finite‐time stabilization of impulsive dynamical linear systems (IDLSs), both in presence of bounded signal and square integrable signal exogenous inputs. It focuses on the design problem for the IDLSs. The chapter then provides a sufficient condition for the existence of a dynamical ou...
Chapter
This chapter introduces the concept of structured input‐output finite‐time stability (IO‐FTS), which allows us to take into account some constraints on the amplitude of the control inputs. It provides definition of structured IO‐FTS and the statement of the structured IO finite‐time stabilization problem via constrained state feedback. The chapter...
Chapter
This chapter deals with the input‐output finite‐time stability (IO‐FTS) analysis of impulsive dynamical linear systems (IDLSs); IDLSs are useful to study the behavior of discontinuous dynamical systems, such as the rocking response of rigid blocks and the automatic gear‐box in cruise control. It derives necessary and sufficient conditions for the I...
Chapter
This chapter introduces the mixed H ∞/finite‐time stability (FTS) control problem with respect to the open loop certain system. It considers the robustness problem in the input‐output finite‐time stability (IO‐FTS) setting. The chapter provides a computationally tractable necessary and sufficient condition for quadratic IO‐FTS with an H ∞ bound. It...
Chapter
This chapter proposes a hybrid architecture that can be used to implement controllers whose design is based on finite‐time stability techniques, such as the input‐output finite‐time stability (IO‐FTS) methodology. The IO‐FTS approach is useful to refine the system behavior during the transient phase, while classical IO stability is a fundamental re...
Chapter
This chapter provides some conditions for the existence of a linear memoryless state feedback controller that input‐output (IO) finite‐time stabilizes the closed‐loop system. It first considers the case of square integrable signal exogenous inputs, and then deals with bounded signal exogenous inputs. The chapter also considers design problems of th...
Chapter
This chapter investigates the input‐output finite‐time stability (IO‐FTS) problem for linear time‐varying (LTV) systems. The chapter provides the following two classes of exogenous inputs: bounded signals and square integrable signals. It also provides necessary and sufficient conditions to check IO‐FTS of system for square integrable signal inputs...
Chapter
This chapter considers the case where the resetting times of the impulsive dynamical linear systems (IDLS) under consideration are uncertain. In particular, sufficient conditions that guarantee that a given IDLS, under various assumptions on the resetting times knowledge, is input‐output finite‐time stability (IO‐FTS) over a specified time interval...
Article
Introduction: The evaluation of Acne using ordinal scales reflects the clinical perception of severity but has shown low reproducibility both intra- and inter-rater. In this study, we investigated if Artificial Intelligence trained on images of Acne patients could perform acne grading with high accuracy and reliabilities superior to those of exper...