
Francesca SibiliaUniversity of Southern California | USC · Keck School of Medicine
Francesca Sibilia
PhD
About
17
Publications
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Introduction
Publications
Publications (17)
Background
Although many studies have shown that traumatic brain injury (TBI) and post‐traumatic stress disorder (PTSD) regardless of their severity, are associated with a significantly increased risk of all‐cause dementia, the specific pathophysiological mechanisms that underlie these associations remain poorly understood, resulting in discordance...
Background
Although many studies have shown that traumatic brain injury (TBI) and post‐traumatic stress disorder (PTSD) regardless of their severity, are associated with a significantly increased risk of all‐cause dementia, the specific pathophysiological mechanisms that underlie these associations remain poorly understood, resulting in discordance...
Background
Perivascular spaces (PVS) are fluid-filled spaces surrounding the brain parenchymal vasculature. Literature suggests that PVS may play a significant role in aging and neurological disorders, including Alzheimer’s disease (AD). The aim of this study is to investigate whether the relationship between MRI-visible PVS and stress is influence...
Adolescence is a crucial period for physical and psychological development. The impact of negative life events represents a risk factor for the onset of neuropsychiatric disorders. This study aims to investigate the relationship between negative life events and structural brain connectivity, considering both graph theory and connectivity strength....
Perivascular spaces (PVS) are fluid-filled spaces surrounding the brain vasculature. Literature suggests that PVS may play a significant role in aging and neurological disorders, including Alzheimer’s disease (AD).
Cortisol, a stress hormone, has been implicated in the development and progression of AD. Hypertension, a common condition in older adu...
Perivascular spaces (PVSs) are fluid‐filled spaces in the brain surrounding blood vessels. Their function is to facilitate the cerebrospinal fluid (CSF) drainage between the interstitial space and the blood vessel space, allowing the outflow of waste soluble proteins in the brain. Aging leads to the increase of PVS number and volume, especially in...
In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste products and their association with neurological diseases...
Background
Traumatic brain injury (TBI) can alter brain structure and lead to onset of persistent neuropsychological symptoms. This study investigates the relationship between brain injury and psychological distress after mild TBI (mTBI) using multimodal magnetic resonance imaging (MRI).
Methods
Eighty-nine mTBI patients from the TRACK-TBI (Transf...
The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age-related differences in fractional anisotropy - a measure of white matter integrity. Here, we used...
The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age-related differences in fractional anisotropy - a measure of white matter integrity. Here, we used...
Background
Traumatic brain injury (TBI) can alter brain structure and lead to onset of persistent neuropsychological symptoms. This study investigates the relationship between brain damage and psychological distress after mild TBI (mTBI) using multimodal magnetic resonance imaging (MRI).
Methods
Eighty-nine mTBI patients from the TRACK-TBI (Transf...
The noradrenergic theory of Cognitive Reserve (Robertson, 2013–2014) postulates that the upregulation of the locus coeruleus—noradrenergic system (LC–NA) originating in the brainstem might facilitate cortical networks involved in attention, and protracted activation of this system throughout the lifespan may enhance cognitive stimulation contributi...
The noradrenergic theory of Cognitive Reserve (Robertson, 2013-2014) postulates that the upregulation of the Locus Coeruleus - Noradrenergic System (LC-NA) originating in the Brainstem might facilitate cortical networks involved in attention, and protracted activation of this system throughout the lifespan may enhance cognitive stimulation contribu...
The noradrenergic theory of Cognitive Reserve (Robertson, 2013-2014) postulates that the upregulation of the Locus Coeruleus - Noradrenergic System (LC-NA) originating in the Brainstem might facilitate cortical networks involved in attention, and protracted activation of this system throughout the lifespan may enhance cognitive stimulation contribu...
Introduction
The earliest changes in the brain due to Alzheimer’s disease are associated with the neural networks related to memory function. We investigated changes in functional and structural connectivity among regions that support memory function in prodromal Alzheimer’s disease, i.e., during the mild cognitive impairment (MCI) stage.
Methods...
The aim of this study was to investigate the aging-related structural changes of the cingulum, one of the major components of the limbic network, which has a critical role in emotion, attention and memory. 35 healthy young adults (22.3 ± 2.7 years) and 33 healthy older adults (69.5 ± 3.5 years) were recruited. Diffusion weighted imaging data were a...