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August 1993 - present
Education
August 1982 - May 1989
Publications
Publications (108)
The accurate determination of kinetics of therapeutic release from drug delivery vehicles is an essential step in the optimized design of such systems for biomedical and pharmaceutical applications. Most methods in current use for quantifying therapeutic release rates are developed to provide consistency, reproducibility, and ease of usage in a lab...
We previously [Borges, F. T. P. Biomacromolecules 2020, 21(12), 5104-5118] introduced a novel methodology for the characterization of the dimensions and architecture of hydrogel networks that provides more detailed information than the classical Flory-Rehner theory [Canal, T.; Peppas, N. A. J. Biomed. Mater. Res. 1989, 23, 1183-1193]. In this artic...
In the early 1940s, Paul Flory and John Rehner published a series of papers on the properties of swellable polymeric networks. Originally intended for vulcanized rubber, their development has since been extensively used and extended to much more complex systems, such as hydrogels, and used to estimate the mesh size of such networks. In this article...
Tissue response to intestinal injury or disease releases pro-inflammatory host stress signals triggering microbial shift to pathogenic phenotypes. One such phenotype is increased protease production resulting in collagen degradation and activation of host matrix metalloproteinases contributing to tissue breakdown. We have shown that surgical injury...
Intestinal disease or surgical intervention results in local changes in tissue and host-derived factors triggering bacterial virulence. A key phenotype involved in impaired tissue healing is increased bacterial collagenase expression which degrades intestinal collagen. Antibiotic administration is ineffective in addressing this issue as it inadvert...
Polyphosphate salts, such as sodium hexametaphosphate (PPi), are effective in the attenuation of collagenase and biofilm production and prevention of anastomotic leak in mice models. However, systemic administration of polyphosphate solutions to the gut presents a series of difficulties such as uncontrolled delivery to target and off‐site tissues....
Local depletion of intestinal phosphate triggers changes in bacterial phenotypes that adversely affect the health of the host. This article describes a process for encapsulating phosphates in crosslinked poly(ethylene glycol) diacrylate (PEGDA) nanoparticles using inverse miniemulsion polymerization as a drug delivery approach for sustained release...
N‐vinyl pyrrolidone (NVP) aqueous‐phase polymerization is known to depend on the degree of hydration of the NVP molecules, resulting in an increase in the rate of propagation with decreasing monomer concentration. When potassium monophosphate and sodium hexametaphosphate are added to the monomer solution the reaction kinetics slow down, with the de...
Peptides that mimic the bioactivity of growth factors are rapidly emerging as therapeutics for a variety of drug delivery applications including therapeutic neovascularization. Neovascularization requires controlled and sustained delivery of proangiogenic factors to stimulate reperfusion of ischemic tissues. To this end, hydrogel nanoparticles were...
Kinetic Monte Carlo (kMC) simulation is available for simulating microstructure of polymer chains with as much detail as one seeks at the expense of convergence tests and computational costs. A new hybrid deterministic–probabilistic method is developed as an alternative to kMC that builds chains one-by-one or chain-by-chain and it is named “Chain-b...
The human gastrointestinal tract is the primary site of colonization of multidrug resistant pathogens and the major source of life-threatening complications in critically ill and immunocompromised patients. Eradication measures using antibiotics carry further risk of antibiotic resistance. Furthermore, antibiotic treatment can adversely shift the i...
We show that the aeration rate in the activated sludge process, which is responsible for the greatest energy burden (up to 50%) in wastewater treatment, can be reduced by more than 60%, while preserving an effluent quality of less than 0.10 mg/L of ammonia and more than 8.5 mg/L of dissolved oxygen. An in-depth survey of the performances of differe...
Engineering programs across the country are increasingly offering outside-the-classroom programs and opportunities that strengthen and increase the value of an engineering education. Such opportunities support students in practicing their knowledge, further developing their ideas, better understanding contemporary world challenges, becoming more en...
Undergraduate (UG) research is an important component of today's engineering education. Research experiences allow students to explore beyond the classroom by applying concepts towards scientific discovery and the development of products and technologies that impact society. The number of UG engineering students interested in participating in resea...
The benefits to students who engage in undergraduate engineering research are significant. Not only can students apply and extend knowledge they have learned in the classroom, they have an opportunity to engage in creative, abstract and critical thinking that leads to concrete, hands-on engineering applications. However, in many engineering program...
Study of autocatalytic reactions has been a popular practice in complex systems science, as a result of the generalizable results of such analysis, which has implications reaching out to broad fields such as population dynamics [1−2], RNA polymerization, DNA replication [3−5] and stock market dynamics [6−8]. In the past, several studies were carrie...
NOTE TO READERS: The full paper is now available as M. C. Ozturk, F. Martin Serrat and F. Teymour, Chemical Engineering Science, vol. 139, pp. 1-14.
Wastewater treatment plants are known to utilize excessive amounts of air in activated sludge tanks in order to maintain sufficient growth of biomass and proper mixing. This approach requires intensi...
A comprehensive investigation of wastewater treatment operation is provided through utilization of a validated dynamic model, historical data from a real plant, and bifurcation theory. Bifurcation analysis was carried out with wastewater flow rate, stormwater flow rate, airflow rate, water temperature, and influent ammonia concentration as the free...
PEGDA hydrogels copolymerized with NVP using free-radical photopolymerization are used in biomedical applications. These networks consist of a poly(acrylate-co-vinyl pyrrolidone) backbone crosslinked with PEG chains whose crosslink density is dependent on the backbone molecular weight and composition. Insight into the network structure and characte...
Poly(ethylene glycol) diacrylate (PEGDA) hydrogel have been extensively used as extracellular matrix (ECM) mimics for tissue engineering applications. A mathematical model for poly(ethylene glycol) diacrylate (PEGDA) formed by free-radical visible light photo-polymerization is presented. This model describes the light dynamics and predicts the bioc...
Bifurcation Analysis of Stickney Water Reclamation Plant
Wastewater treatment plants (WWTPs) are an integral part of modern day communities, ensuring a clean environment and providing clean water. For almost a century, several technical enhancements to WWTPs have been made to improve the treatment process. However, as with many industrial process...
A super absorbent polymer material is contacted with an aqueous medium to absorb at least a portion of the aqueous medium. At least portion of the aqueous medium absorbed super absorbent material is subsequently regenerated to release water therefrom and to form a regenerated super absorbent material suitable for the contacting with a second quanti...
A common method of prolonging the lifetime of wireless sensor networks is to use low power duty cycling protocol. Existing protocols consist of two categories: sender-initiated, and receiver-initiated. In this paper, we present SA-MAC, a Self-stabilizing Adaptive MAC protocol for wireless sensor networks. SA-MAC dynamically adjusts the transmission...
Cover: Poly(ethylene glycol) hydrogels embedded with gradients play a critical role in directing cell behavior and tissue regeneration. Perfusion based frontal photopolymerization is used to create scaffolds with tunable gradients. The influence of polymerization conditions on the speed of the hydrogel front as well as on gradients in hydrogel swel...
Poly(ethylene glycol) diacrylate (PEGDA) hydrogels are extensively used as scaffolds in tissue engineering. The ability to spatially control hydrogel properties is critical for designing scaffolds that direct cell behavior and tissue regeneration. To this end, we have recently developed a polymerization technique, perfusion‐based frontal photopolym...
In this paper we investigated the water deswelling properties of Poly(acrylic acid sodium salt), lightly cross-linked superabsorbent polymer material under electrical stimulation. The effects of electric voltage, swollen water salinity, swollen water pH and electrodes distance on deswelling properties are presented. The results indicate that deswel...
An adaptive hierarchical framework for process supervision and fault-tolerant control with agent-based systems is presented. The framework consists of modules for fault detection and diagnosis (FDD), system identification and distributed control, and a hierarchical structure for performance-based agent adaptation. Multivariate continuous process mo...
In this paper, the design and implementation of an agent-based framework to safeguard an auto-catalytic reactor network against external disturbances is discussed. The autocatalytic reactor network producing a robust, host species is attacked by an unmeasured, un-sustained disturbance of a non-robust invading species. The invading species adversely...
Synthetic hydrogels of poly(ethylene glycol) diacrylate (PEGDA) formed by free-radical photopolymerization have been extensively investigated as extracellular matrix (ECM) mimics for tissue engineering applications. However, the ability to predict and control the spatial and temporal presentation of biochemical and mechanical properties for guiding...
Controlling the individual reactors of a chemical reactor network producing different grades of a product requires intelligent reconfiguration strategies. Agent-based approaches are ideal for such distributed manufacturing processes, since they provide flexible, robust, and emergent solutions under dynamically changing process conditions. This pape...
An adaptive agent-based hierarchical framework for fault type classification and diagnosis in continuous chemical processes is presented. Classification techniques such as Fisher’s discriminant analysis (FDA) and partial least-squares discriminant analysis (PLSDA) and diagnosis tools such as variable contribution plots are used by agents in this su...
The study of complex systems under the banner of complexity theory has demonstrated some fascinating properties that these inherently possess, and some interesting phenomena that emerge from their dynamic interaction, and has led to the discovery of new universality classes that span across all disciplines.
Armed with this heightened level of und...
Poly(ethylene glycol) Diacrylate (PEGDA) hydrogel is an important biomaterial exhibiting excellent biocompatibility and offering many possibilities for bio-modification. However, most applications require a high degree of control and fine-tuning of the hydrogel properties. To this end, we have developed a computational model for predicting bio-func...
Poly(ethylene glycol) diacrylate (PEGDA) hydrogels immobilized with peptides and proteins formed by free-radical photopolymerization of PEGDA with N-Vinylpyrrolidone (NVP) monomers have been extensively investigated as scaffolds in tissue engineering. The resultant properties of these biomaterials are highly dependent on alterations in polymerizati...
Using algae as an alternative energy source is a widely accepted concept believed to have the potential of displacing a considerable proportion of the fossil-based carbon dioxide emissions. Algae grow rapidly, are carbon neutral, and can be cultivated using marine water or wastewater, in a manner that does not compete with food supplies, so there a...
As part of the “Emerald Forest” concept proposed in previous work by the authors (Teymour, Al-Hallaj, Eltayeb, & Khalil, 2009), photobioreactors for large-scale algae production are developed. Optical waveguides are used to overcome light limitations, and to maximize light collection and optimize light distribution. The finite volume discrete ordin...
It is highly desirable to have a statistical process monitoring (SPM) system that detects the abnormalities in process operations quickly with as few missed and false alarms as possible while the process operates under various operating conditions. An agent-based combined monitoring and fault detection framework is proposed in this study. In this f...
In this paper, we show that heterogeneous networks can be configured and reconfigured to operate in flexible spatial patterns. The concept is demonstrated by using a square grid of continuous stirred tank reactors with nearest neighbor interactions and hosting multiple cubic autocatalytic species. Asymmetry is introduced in the system by allowing f...
W. Harmon Ray's contributions are widely recognized in the fields of Polymer Reaction Engineering, and Process Control Theory. His pioneering contributions to nonlinear dynamics and complex systems, specifically to the introduction of bifurcation theory to chemical engineering are mostly known to researchers practicing in this field. However, the f...
Multivariate statistical monitoring techniques have been used for monitoring large scale distributed chemical processes with many variables. These techniques rely on the availability of normal operation data that is used in the statistical model building to detect the deviations from normal operation. However, there are some drawbacks related to us...
Multiagent systems provide a powerful framework for developing real-time process supervision and control systems for distributed and networked processes by automating adaptation and situation-dependent rearrangement of confidence to specific monitoring and diagnosis techniques. An agent-based framework for monitoring, analysis, diagnosis, and contr...
A mathematical model has been developed for surface‐initiated photopolymerization of PEG‐DA forming cross‐linked hydrogel membranes on the surface of a substrate. The existing model was extended to apply the NF technique, which made it possible to describe the progression of photopolymerization through gelation, and to calculate gelation time, cros...
Multiagent systems provide a powerful framework for developing real-time process supervision and control systems for distributed and networked processes by automating adaptability and situation-dependent rearrangement of confidence to specific monitoring and diagnosis techniques. An agent-based framework for monitoring, analysis, diagnosis, and con...
Spatially distributed systems hosting autocatalytic species are an excellent test bed as a complex network because of their non-linear structure and ability to display a rich spectrum of behavior. The network system is designed to produce a robust, autocatalytic host species. It so happens that an invasion in the form of another autocatalytic speci...
This paper proposes a management layer for performance evaluation of adaptive agent-based control systems for a Continuous Stirred Tank Reactor (CSTR) network, using different decentralized spatial reconfiguration techniques. In each reactor of this network, autocatalytic product species are competing against each other, providing a nice example fo...
In spatially distributed, large chemical processes, holistic monitoring and fault detection using the highly correlated, nonlinear process data is difficult and may lead to too many false and missed alarms that would render the monitoring process as unreliable. The performance of the monitoring method is also dependent on the process operating regi...
The catalytic effect of carbon on free radical polymerization, mediated by benzoyl peroxide initiation, has been previously reported by our group [1,2]. These studies have concluded that the carbon nanoparticles are involved in a mechanism that catalyzes the dissociation of the initiator on their surface. Consequently, the polymerization proceeds a...
Multi-agent systems provide a powerful platform for supervision and control of distributed and complex processes. This work focuses on controlling the product grade distribution in RAFT polymerization reactor networks for smooth transition between different product grades or maintaining the targeted product grade despite various disturbances using...
Supervision of distributed manufacturing processes producing different grades of a product requires intelligent reconfiguration strategies during grade transition phases to minimize off-spec production. Agent-based approaches are ideal for such problems and they provide flexible, robust, and emergent solutions during dynamically changing process co...
Controlling reactors in distributed manufacturing processes producing different grades of a product requires intelligent reconfiguration strategies. Agent-based approaches are ideal for such cases, since they can provide flexible, robust, and emergent solutions during dynamically changing process conditions. A hierarchical, agent-based system with...
Gas phase olefin polymerizations are now widely achieved in fluidized bed reactors. In fluidized bed poly-olefin reactors, small catalyst particles (20–80μm) are introduced into the bed, and when exposed to the gas flow (monomer), polymerization occurs. At early stage of polymerization, the catalyst particles fragment into a large number of small p...
A mathematical model for the crosslinking copolymerization of a vinyl and divinyl monomer was developed and applied to the case of methyl methacrylate and ethylene glycol dimethacrylate batch polymerization. Model results compare favorably to the experimental findings of Li and Hamielec 23 for the system investigated. The model presented utilizes t...
Control of spatially distributed systems is a challenging problem because of their complex nature, nonlinearity, and generally high order. The lack of accurate and computationally efficient model-based techniques for large, spatially distributed systems leads to challenges in controlling the system. Agent-based control structures provide a powerful...
Several studies of melt rheological properties of polystyrene have been conducted over the past 50 years. Several approaches, including empirical models, have been developed to understand the behavior of materials using simple equations. The existing melt rheology models are best suited for high-molecular-weight polymers whose Tg does not vary. In...
Large-scale spatially distributed systems provide control challenges because of their nonlinearity, spatial distribution and generally high order. The control structure for these systems tend to be both discrete and distributed. A layered control structure interfaced with complex arrays of sensors and actuators provides a flexible supervision and c...
A general mathematical model has been developed to describe the surface initiated photopolymerization of PEG‐DA forming crosslinked hydrogel membranes upon the surface of a substrate. Such membranes are formed by photopolymerizing a PEG‐DA prepolymer solution by initiation with eosin‐Y‐functionalized surfaces and TEA using VP as accelerator. Experi...
Control of spatially distributed systems is a challenging problem because of their complex nature, nonlinearity, and generally high order. Agent-based control structures provide a powerful tool for managing distributed systems by utilizing local and global information obtained from the system. A hierarchical, agent-based system with local and globa...
A novel method for the sequential formation of hydrogel multilayers is described. Formation of the first layer is based on surface initiated photopolymerization of hydrogel precursors on eosin derivatized surfaces. In order to attach subsequent layers it is necessary to be able to functionalize intermediate hydrogel layers with eosin. In the presen...
Copolymer chains are characterized by chain length, chain composition, and sequence length distributions. Despite the wealth of information these distributions provide, they are incapable of determining the microstructure and concentration of individual chain types along the conversion path at the level of “polymeric isomers”, which are chains of s...
Large-scale spatially distributed systems provide a unique and difficult control challenge because of their nonlinearity,
spatialdistribution and generally high order. The control structure for these systems tend to be both discrete and distributed
as well and contain discrete and continuous elements. A layered control structure interfaced with com...
Spatially distributed systems such as reactor networks hosting multiple autocatalytic species demonstrate a rich spectrum of complex behavior. From a control systems perspective, spatially distributed systems offer a difficult control challenge because of their distributed nature, nonlinearity, and high order. Furthermore, manipulation of the netwo...
Systems with high steady-state multiplicity and rich dynamic behavior are difficult to investigate using conventional reductionist methods. A network of more than five reactors hosting cubic autocatalytic reactions may potentially have more than 102 steady states and many distinct dynamic regimes, all for the same parameter set. This paper discusse...
A bifurcation analysis for continuous nonlinear free-radical polymerization subject to gel formation is presented. The analysis uses the Numerical Fractionation technique and studies the multiplicity and dynamics of the sol and gel polymer properties for bulk, nonisothermal, vinyl−divinyl copolymerization. The bifurcation analysis has revealed s-sh...
An experimental investigation of the free-radical high-temperature (>300 degreesC) polymerization of styrene/divinyl benzene in a steady-state continuous-stirred tank reactor is reported. Under these conditions, backbiting followed by beta-scission, which is the dominant chain degradation mechanism, is very aggressive. This allows for utilization o...
From a control system perspective, spatially distributed systems offer challenges because of their distributed nature, nonlinearity, and high order. in addition, the control structure for these spatially distributed networks combine discrete and distributed components, in the form of complex arrays of sensors and actuators. Manipulation of the netw...
An experimental study designed to elucidate mechanistic details regarding the thermal polymerization of styrene between 260 and 340°C is reported. The data show that back-biting to the third or fifth carbon from the chain end, followed by β scission, is the dominant chain-producing reaction in the molecular weight development. This conclusion is su...
A new methodology termed “Digital Encoding of Polymeric Chains” was developed by Debling and Teymour (Macromol. Symp. 182 (2002) 195). It involves replacing distinguishable features of the chain such as monomer units, branches, functionality, etc., with a numeric code that can be translated into a unique decimal equivalent number. This technique pr...
We describe a new method that allows photopolymerization of hydrogels to occur on surfaces functionalized with eosin. In this work, glass and silicon surfaces were derivatized with eosin and photopolymerization was carried out using visible light (514 nm). This mild condition may have advantages over methods that use ultraviolet (UV) light (e.g., f...
The goal of this study is to enable the utilization of recycled rubber particles in aqueous media by producing amphiphilic particulate phase semi-interpenetrating polymer networks (PPSIPNs). Rubber granulates obtained from post-consumer rubber items were pulverized into fine particles using a solid state shear extrusion (SSSE) process. Reaction mix...
Several recent studies on autocatalytic reactions in single and coupled continuous stirred-tank reactor (CSTR) networks have demonstrated a rich spec-trum of complex behavior. From a control systems perspective, the operating regime of a CSTR network can be manipulated by changing the flow rates between the reactors. Systems of more than one CSTR r...
The static and dynamic behavior of the autocatalytic reaction R + 2P → 3P with decay P → D is studied in networks of coupled continuous stirred tank reactors (CSTRs). Numerical bifurcation studies of the system are performed, resulting in rich steady-state bifurcation structures with multiple steady states and isolas. The heterogeneity of the netwo...
Slight changes in raw material properties or operating conditions during critical periods of operation of batch and semi-batch polymerization reactors may have a strong influence on reaction mechanism and impact final product quality. Online process monitoring, fault detection, fault diagnosis, and product quality prediction in real-time ensure saf...
The hydrophobic nature of recycled rubber particles presently limits their use only in non-aqueous media. Recycled rubber particles were chemically modified by preparation of amphiphilic semi-interpenetrating polymer networks using poly(acrylic acid) as the hydrophilic polymer. The resulting composite particles are water dispersible and suitable fo...
The Continuous Stirred Tank Reactor (CSTR) has provided a chemical paradigm for nonlinear complex dynamics for almost a century. Advances in this regard are reviewed with special emphasis on polymerization.
A proposed theory for evaluating the chain length distribution (CLD) using the numerical fractionation (NF) technique was extended to the vinyl‐divinyl (VDV) copolymerization. The CLD is reconstructed for this system, in which pendant double bond propagation leads to crosslinking and gel formation. The method was earlier developed for a non‐linear...
Two types of nonlinear feedback control schemes are introduced and analyzed for their capability of recovering the original state of an isothermal continuous-flow stirred tank reactor with one robust cubic autocatalytic species, perturbed by a temporary disturbance of an invading cubic autocatalytic species in the inflow. The control objectives are...
A comprehensive kinetic model for the thermal polymerization of styrene at temperature values between 250 and 350 °C, capable of calculating monomer kinetics, oligomer concentrations, and molecular weight and terminal double bond (TDB) distributions, is described. The model, based on the mechanism described in the first part of this work (Macromole...
An experimental study of the high-temperature polymerization of styrene in a CSTR, investigating the effect of reaction temperature (260−343 °C), and residence time (5−90 min) on monomer conversion and average molecular weight and distribution is reported. A kinetic analysis of these experimental data demonstrates that the dominant chain production...
Fluidized-bed reactors are widely used in chemical and biochemical processes, including polymerization (Kunii, D. G.; Levenspiel, O. Fluidization Engineering; Wiley: New York, 1969). To enhance the efficiency of the fluidized-bed reactors, more flexibility in controlling the residence time of particles of different sizes, particularly very fine pa...
The paradigm of cubic autocatalytic replicators with decay in coupled isothermal continuous stirred tank reactors is selected as a model to study complex behavior in population dynamics of sexually reproducing species in a heterogenous environment. It is shown that, even a setup with single species in two coupled environments may have regions in pa...
A model of competition between cubic autocatalators is applied to model the population dynamics of multiple species living in a certain ecology. The two species scheme is studied by many researchers, and is shown to have steady state multiplicity in the form of mushrooms and isolas. When two or more species compete pure and simply (in the sense tha...
Mixed Mode Polymerization (MMP) is introduced and defined as any polymerization process that combines chainwise and stepwise mechanisms, which both contribute to the growth and structure modification of its polymer product. The large difference in activation energies of the growth steps of these two mechanisms provides great flexibility for polymer...
Mathematical Modeling of non-linear polymerization systems subject to gel formation is a challenging endeavor. At the gel point, the second and higher molecular weight moments diverge to infinity making it impossible to obtain the molecular weight distribution (MWD). The numerical fractionation (NF) technique utilizes a refinement of the method of...
The competition of two species for a common resource is illustrated using the paradigm of autocatalytic replicators inhabiting a continuous stirred tank reactor (CSTR) environment that is continuously fed with the resource. In most cases presented, one species is robust (appears in reactor feed) while the other is not. The introduction of the secon...
The feasibility of producing homogeneous powder coating formulations without melting is investigated using Solid State Shear Extrusion (SSSE). A detailed comparison between conventional melt extrusion and SSSE processing conditions of identical formulations is accomplished by following the behavior and degree of polymerization during curing. Commer...
As a consequence of their method of production, polymer chains are polydisperse in size, composition and sequence distribution. In this work we present a new method of uniquely identifying these “polymer isomers” termed “Digital Encoding of Polymeric Chains”. The method involves replacing distinguishable features of the chain such as monomer units,...
Static and dynamic properties of multiple cubic autocatalytic reactions in an isothermal continuous stirred tank reactor are investigated. It is shown that in the bifurcation diagram of the system should an n-interaction isola exist, it is to reside in the intersection of all possible (n−1)-interaction isolas of the n species constituting the n-int...
Tetrafunctional chain coupling of polymers is an important process for introducing long-chain branching to modify flow behavior and for forming cross-linked networks. Reactor modeling for polymers branched beyond the gel point is a difficult problem because of the divergence of the moments of the MWD to infinity. A newly developed technique, numeri...
The dynamics of semibatch reactors is often neglected in the literature despite their industrial importance. This article analyzes the stability and dynamic behavior of semibatch polymerization reactors operated according to a flow scheduling strategy designed to impart a steady-state nature to the dynamics of these essentially transient reactors....
A semibatch flow scheduling strategy proposed by Teymour and Ray (1989, 1996) is evaluated for a polymerization reaction conducted in a pilot-plant reactor. The reaction used is the free radical terpolymerization of styrene, α-methyl styrene, and acrylic acid monomers initiated by an organic peroxide initiator and carried out in the presence of a r...
A two-compartment model of an enzyme system with substrate inhibition kinetics and hydrogen ion production is investigated.
The model is used to study the bifurcation, instability, and chaotic behavior of the system. The investigation, although in
a restricted region of the parameters’ space, has uncovered a good part of the rich dynamic characteri...
In this work, the stability structure of process flow sheets described by systems of differential and algebraic equations (DAE's) is analyzed. This general framework allows the study of some of the dynamics and stability problems that arise in polymerization processes. A new numerical driver (ISAAC) which is a part of the dynamic flow-sheeting pack...
A two compartments model of an acetylcholinesterase enzyme system is investigated. The model is used to investigate the bifurcation, instability and chaotic behaviour of the system. The investigation has uncovered a good part of the rich dynamic characteristics of this system, including: period doubling sequence leading to chaos, banded chaos, full...
A two-phase model for the non-isothermal fluidized-bed catalytic reactor with consecutive exothermic reactions has been used to investigate the bifurcation, instability and chaotic characteristics of this unit. The investigation, although in a restricted region of the parameters space, has uncovered a good part of the rich dynamic characteristics o...
The dynamic flowsheeting package, POLYRED, offers the capability to analyze the stability structure of the process. This feature is used to analyze some of the dynamics and stability problems that arise in polymerization processes. Examples are presented of real processes which can become unstable because of the nature of the flowsheet topology and...
The dynamic flowsheeting package, POLYRED, offers the capability to analyze the stability structure of the process. This feature is used to analyze some of the dynamics and stability problems that arise in polymerization processes. Examples are presented of real processes which can become unstable because of the nature of the flowsheet topology and...
