Florian Heinke

University of Applied Sciences Mittweida | HSMW · Department of Applied Informatics and Biosciences

The age determination of blood traces provides important hints for the chronological assessment of criminal events and their reconstruction. Current methods are often expensive, involve significant experimental complexity and often fail to perform when being applied to aged blood samples taken from different substrates. In this work an absorption s...

p-Hydroxybenzoate hydroxylase (PHBH; EC 1.14.13.2) is a microbial group A flavoprotein monooxygenase that catalyzes the ortho-hydroxylation of 4-hydroxybenzoate to 3,4-dihydroxybenzoate with the stoichiometric consumption of NAD(P)H and oxygen. PHBH and related enzymes lack a canonical NAD(P)H-binding domain and the way they interact with the pyrid...

In recent years, the automated, efficient and sensitive monitoring of social networks has become increasingly important for the criminal investigation process and crime prevention. Previously, we have shown that the detection of opinion leaders is of great interest in forensic applications to gather important information. In the current work, it is...

Digital anthropometric pattern matching encompasses biometric identification on the basis of a combination of anthropometric measurements depicting the proportions of the human body from image or video material. In a previous publication, maximum likelihood density estimation of distributions of anthropometric measurement distances allowed for esti...

Video and image material is becoming increasingly ubiquitous thus its potential as evidence in forensic investigations is growing. Once faces are hidden however, the value of surveillance footage is restricted unless there is another biometric trait that can be observed by camera such as linear body measurements. There is much biological evidence f...

With the rapid growth of public protein structure databases, computational techniques for storing as well as comparing proteins in an efficient manner are still in demand. Proteins play a major role in virtually all processes in life, and comparing their three-dimensional structures is essential to understanding the functional and evolutionary rela...

Die Untersuchung von Knochenmaterial aus forensischen oder geschichtlichen Gründen geht mit dem Problem einher, dass die zugrundeliegenden Knochenbibliotheken immer nur an einem Untersuchungsort physisch vorliegen können. Simultane Forschung wird durch diesen Umstand erschwert und die geschichtliche Aufarbeitung entdeckter Gräberfelder erstreckt si...

In recent years, the automated, efficient and sensitive monitoring of social networks has become increasingly important for criminal investigations and crime prevention. Previously, we have shown that the detection of opinion leaders is of great interest in forensic applications. In the present study, it is argued that state of the art opinion lead...

Serious crime scenes or disaster sites with many victimsafter natural disasters, airplane crashes or terrorist attacksrequire extensive and comprehensive investigations to clarify allcircumstances leading to the event, to identify the victims andto find the responsible people. The results of investigations donot only serve to prosecute the perpetra...

Major incidents can disturb the state of balance of a society and it is important to increase the resilience of the society against such disturbances. There are different causes for major incidents, one of which are groups of individuals, for example at demonstrations. The ideal way to handle such events would be to prevent them, or at least provid...

Efficient and sensitive monitoring of social networks has become increasingly important for criminal investigations and crime prevention during the last years. However, with the growing amount of data and increasing complexity to be considered, monitoring tasks are difficult to handle, up to a point where manual observation is infeasible in most ca...

A variety of mathematical models is used to describe and simulate the multitude of natural processes examined in life sciences. In this paper we present a scalable and adjustable foundation for the simulation of natural systems. Based on neighborhood relations in graphs and the complex interactions in cellular automata, the model uses recurrence re...

Thin-layer chromatography (TLC) is an experimental separation technique for multi-compound mixtures widely applied in various fields of industry and research. In contrast to comparable techniques, TLC is straightforward, cost- and time-efficient, and well-applicable in field operations due to its flexibility. In TLC, after applying a mixture sample...

Mobile devices are a popular means for planning, appointing and conducting criminal offences. In particular, short messages (SMS) and chats often contain evidential information. Due to the terms of their use, these types of messages are fundamentally different from other forms of written communication in terms of their grammatical and syntactic str...

In molecular biology, reliable protein structure models are essential in order to understand the functional role of proteins as well as diseases related to them. Structures are derived by complex and resourcedemanding experiments, whereas in silico structure modeling and refinement approaches are established to cope with experimental limitations. N...

Major damaging events with many victims or environmental contamination hazards, such as natural disasters, airplane crashes, train accidents or terroristic acts, are shocking events to society. Fast and comprehensive information acquisition of event sites ensures appropriate and safe actions for rescue forces and investigators, and increases resili...

In hindsight of the previous decades, a rapid growth of data in all fields of life sciences is perceptible. Most notably is the general tendency of retaining well established techniques regarding specific biological requirements and common taxonomies for data classification. Therefore a change in perspective towards advanced technological concepts...

To understand the molecular function of biopolymers, studying their structural characteristics is of central importance. Graphics programs are often utilized to conceive these properties, but with the increasing number of available structures in databases or structure models produced by automated modeling frameworks this process requires assistance...

Degradation-related poor quality of ancient DNA from long-time stored biological material (e.g. historical skeletal remains) often leads to a loss of information in molecular genetic characterisation. A new generation of DNA quantification and STR technologies consider mentioned issue by an optimised primer design combined with active master mix co...

We used the machine learning strategy Generalized Matrix Learning Vector Quantization (GMLVQ) to separate enzyme classes solely by structural motif representation. As unique characteristic, GMLVQ rates the contribution of each feature to the classification performance. Remarkably, the set of valuable features differs significantly for the investiga...

Increasing the resilience of the society against disorders, such as disasters, attacks or threatening groups, is a major challenge. Recent events highlight the importance of a resilient society and steps which are required to be taken in resilience engineering. textit{A priori} the optimal way to handle such adverse events is to prevent them, or at...

Proteins are macromolecules that facilitate virtually every biological process. Information on functional and structural characteristics of proteins is invaluable in life sciences, but remain difficult to obtain, both computationally and experimentally. In recent work, we have introduced a novel method for functional characterization, which we refe...

Over the last decades, a lot of effort has been taken in developing computational methodologies to infer protein structure and function from protein sequence. Although the number of available approaches is virtually overwhelming, deriving reliable information about the structure and function of a protein of interest remains challenging. Protein ene...

Motivation. Membrane proteins play essential roles in cellular processes of organisms. Photosynthesis, transport of ions and small molecules, signal transduction, and light harvesting are examples of processes which are realised by membrane proteins and contribute to a cell's specificity and functionality. The analysis of membrane proteins has show...

Gaining information about structural and functional features of newly identified proteins is often a difficult task. This information is crucial for understanding sequence–structure–function relationships of target proteins and, thus, essential in comprehending the mechanisms and dynamics of the molecular systems of interest. Using protein energy p...

Textual information or data annotated with textual information (meta-information) are regular targets of securing or confiscating relevant material in the field of criminal proceedings. In general evaluation of relevant material is complex, especially the manual (re)search in the increasing amount of data as a result of cheaper storage capacity ava...

Diabetes insipidus (DI) is a rare endocrine, inheritable disorder with low incidences in an estimated one per 25,000-30,000 live births. This disease is characterized by polyuria and compensatory polydypsia. The diverse underlying causes of DI can be central defects, in which no functional arginine vasopressin (AVP) is released from the pituitary o...