Florian Tilman Gassert

Florian Tilman Gassert
Technische Universität München | TUM · Institute of Radiology

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30
Publications
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Introduction
Skills and Expertise

Publications

Publications (30)
Article
Full-text available
Background Spirometry and conventional chest x-ray have limitations in investigating early emphysema, while computed tomography, the reference imaging method in this context, is not part of routine patient care due to its higher radiation dose. In this work, we investigated a novel low-dose imaging modality, dark-field chest x-ray, for the evaluati...
Article
Objectives To develop and validate machine learning models to distinguish between benign and malignant bone lesions and compare the performance to radiologists. Methods In 880 patients (age 33.1 ± 19.4 years, 395 women) diagnosed with malignant (n = 213, 24.2%) or benign (n = 667, 75.8%) primary bone tumors, preoperative radiographs were obtained...
Preprint
Full-text available
Medical imaging is performed in daily clinical routine for the assessment of pulmonary involvement in patients infected with COVID-19. As conventional (attenuation-based) chest radiography provides only a low sensitivity for COVID-19-pneumonia, CT is the gold standard for lung imaging in COVID-19 patients. However, CT imaging exposes the patient to...
Article
Background Dark-field chest radiography allows for assessment of lung alveolar structure by exploiting wave optical properties of x-rays. Purpose To evaluate the qualitative and quantitative features of dark-field chest radiography in participants with pulmonary emphysema as compared with those in healthy control subjects. Materials and Methods In...
Article
Full-text available
Objective Pancreatic cancer is portrayed to become the second leading cause of cancer-related death within the next years. Potentially complicating surgical resection emphasizes the importance of an accurate TNM classification. In particular, the failure to detect features for non-resectability has profound consequences on patient outcomes and econ...
Article
Full-text available
Background and Purpose Radiotherapy of thoracic tumours can lead to side effects in the lung, which may benefit from early diagnosis. We investigated the potential of X-ray dark-field computed tomography by a proof-of-principle murine study in a clinically relevant radiotherapeutic setting aiming at the detection of radiation-induced lung damage....
Article
Full-text available
The bone marrow proton density fat fraction (PDFF) assessed with MRI enables the differentiation between osteoporotic/osteopenic patients with and without vertebral fractures. Therefore, PDFF may be a potentially useful biomarker for bone fragility assessment. Introduction: To evaluate whether magnetic resonance imaging (MRI)-based proton density...
Article
Background An artificial intelligence model that assesses primary bone tumors on radiographs may assist in the diagnostic workflow. Purpose To develop a multitask deep learning (DL) model for simultaneous bounding box placement, segmentation, and classification of primary bone tumors on radiographs. Materials and Methods This retrospective study an...
Article
Full-text available
Purpose Rectal cancer is one of the most frequent causes of cancer-related morbidity and mortality in the world. Correct identification of the TNM state in primary staging of rectal cancer has critical implications on patient management. Initial evaluations revealed a high sensitivity and specificity for whole-body PET/MRI in the detection of metas...
Article
Background X-ray dark-field radiography takes advantage of the wave properties of x-rays, with a relatively high signal in the lungs due to the many air-tissue interfaces in the alveoli. Purpose To describe the qualitative and quantitative characteristics of x-ray dark-field images in healthy human subjects. Materials and Methods Between October 20...
Article
Full-text available
We present a method to generate synthetic thorax radiographs with realistic nodules from CT scans, and a perfect ground truth knowledge. We evaluated the detection performance of nine radiologists and two convolutional neural networks in a reader study. Nodules were artificially inserted into the lung of a CT volume and synthetic radiographs were o...
Article
Introduction. Dysphagia affects 1 of 6 adults during their lifetime [1]. There are both benign and malignant forms of dysphagia, commonly caused by esophageal, oropharyngeal and neuromuscular diseases. Even in its benign forms, dysphagia can have a significant impact on quality of life. In current practice, a combination of endoscopy, esophageal ma...
Article
Background: Chemical shift encoding-based water-fat separation techniques have been used for fat quantification [proton density fat fraction (PDFF)], but they also enable the assessment of bone marrow T2*, which has previously been reported to be a potential biomarker for osteoporosis and may give insight into the cause of vertebral fractures (i.e...
Article
Full-text available
The aim of this study is to assess whether perifocal bone marrow edema (BME) in patients with osteoid osteoma (OO) can be accurately detected on dual-layer spectral CT (DLCT) with three-material decomposition. To that end, 18 patients with OO (25.33 ± 12.44 years; 7 females) were pairwise-matched with 18 patients (26.72 ± 9.65 years; 9 females) adm...
Article
Full-text available
Background Small soft tissue masses are often falsely assumed to be benign and resected with failure to achieve tumor-free margins. Therefore, this study retrospectively investigated the distribution of histopathologic diagnosis to be encountered in small soft tissue tumors (≤ 5 cm) in a large series of a tertiary referral center. Methods Patients...
Article
Full-text available
Objective Determination of coronary artery calcium scoring (CACS) in non-contrast computed tomography (CT) images has been shown to be an important prognostic factor in coronary artery disease (CAD). The objective of this study was to evaluate the accuracy of CACS from virtual non-contrast (VNC) imaging generated from spectral data in comparison to...
Article
Full-text available
Objectives To evaluate the performance of 3D T1w spoiled gradient-echo (T1SGRE) and ultra-short echo time (UTE) MRI sequences for the detection and assessment of vertebral fractures and degenerative bone changes compared with conventional CT. Methods Fractures ( n = 44) and degenerative changes ( n = 60 spinal segments) were evaluated in 30 patien...
Article
Background Quantitative magnetic resonance (MR) imaging techniques are established for evaluation of cartilage composition and trabecular bone microstructure at the knee. It remains unclear whether quantitative MR parameters predict the midterm morphological outcome after matrix-associated chondrocyte implantation (MACI) with autologous bone grafti...
Article
Purpose To evaluate imaging characteristics obtained from magnetic resonance imaging (MRI) with metal artifact reduction (MAR) to differentiate between periprosthetic joint infection (PJI), aseptic loosening and cases without these pathologies after total hip arthroplasty (THA). Methods Patients with THA (n = 41; mean age 66.4 ± 9.6 years; 25 wome...
Article
Full-text available
Following publication of the original article [1], the authors have reported an error in the 'Histopathology' (under 'Materials and methods') section of the article that compromises the reproducibility of the paper.
Article
Full-text available
Background: Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients' life quality. There is no causal treatment. Symptomatic therapies should start as early as possible to take maximal effect. Hence...
Article
Full-text available
Objective To investigate whether signal to noise (SNR) analysis of contrast-enhanced MRI gives additional benefit for early disease detection by Magnetic Resonance Imaging (MRI) of experimental rheumatoid arthritis (RA) in a small animal model. Methods We applied contrast-enhanced MRI at 7T in DBA mice with or without collagen-induced arthritis (C...
Data
Development of clinical symptoms of RA. Progression of clinical paw score as an average of the sum of all four paws of CIA animals of the RA group (n = 6). At day -1, day 32 and day 42 all animals were scanned with MRI (arrows). Mean values are shown for each group. (TIF)
Data
Histological analysis of control and CIA-induced animals. Movat Pentachrome stained formalin fixed paraffin embedded sections of ankle joints of one representative animal per group are shown. A. Control animal with no pathological change. B. Animal with arthritis and undergone therapy with no pathological changes. C. Animal with arthritis with path...
Data
Region of interest definition. The region of interest (ROI) was drawn from the lower shank, close to the ankle joint, to the metatarsus, including all joints in the foot area. A rectangular region next to the paw was drawn to measure background noise. (TIF)
Article
Full-text available
Human mesenchymal stem cells (hMSCs) are a promising tool for cartilage regeneration in arthritic joints. hMSC labeling with iron oxide nanoparticles enables non-invasive in vivo monitoring of transplanted cells in cartilage defects with MR imaging. Since graft failure leads to macrophage phagocytosis of apoptotic cells, we evaluated in vitro and i...

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