Florent Angelo Occelli

University of Lille · Laboratoire de Génie Civil et géoEnvironnement (ULR4515 LGCgE)

Assessing environmental exposure to pollution is a challenging task, and scientists often use distance-based or proximity indicators when field or modeled data are unavailable. Although buffers are commonly used to represent the impact of a pollution source on neighboring populations, they can result in high-exposure misclassification. Euclidean di...

Background and Aims According to the Global Burden of Disease, mortality attributed to chronic kidney disease (CKD) is steadily increasing worldwide, with an estimated increase of more than 30% since 2005. Among the candidates mentioned to explain this inflation, air pollution is attracting more and more attention. Although the link between air pol...

Ozone exacerbates allergy symptoms to certain pollens. The molecular mechanisms by which ozone affects pollen grains (PGs) and allergies are not fully understood, especially as the effects of pollutants may vary depending on the type of pollen. In this work, pollens of 22 different taxa were exposed under laboratory conditions to ozone (100 ppb) to...

Background: Cardiovascular diseases remain the leading cause of death and disabilities worldwide, with coronary heart diseases being the most frequently diagnosed. Their multifactorial etiology involves individual, behavioral and territorial determinants, and thus requires the implementation of multidimensional approaches to assess links between t...

Resolving health inequalities continues to be a priority in improving quality of life around the world. Their impact is of increasing concern to public health governance, which considers the issue of environmental health inequalities to be paramount. To meet this challenge, we have developed a methodology based on the development of spatial composi...

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4153595

Introduction (contexte de la recherche) L’asthme aigu fait partie des motifs de consultations aux urgences pédiatriques les plus fréquents, responsable de nombreuses hospitalisations. Les variations des taux de polluants atmosphériques pourraient avoir un impact sur le déclenchement de ces épisodes. Objectif Décrire l’association entre les taux de...

The integration of multidimensional data is necessary to improve the understanding of environmental and social inequalities in health. The challenge is to define a dataset that provides the most holistic description possible of the territory. This article presents a relevant dataset to characterize the territorial accumulation of health determinant...

IFEH 4TH WORLD ACADEMIC CONFERENCE ON ENVIRONMENTAL HEALTH (Tartu Health Care College, Estonia)

Background Although walkability is known to be associated with obesity and hypertension through increased physical activity; data on cardiovascular risk factors (especially in the Europe) are scarce. We assessed the relationship between neighbourhood walkability and cardiometabolic factors (including obesity, hypertension, the blood lipid profile,...

In environmental health, vulnerability reflecting the cumulative harmful constraints and nuisances to which populations are subjected and resilience defined as the capacity of a territory to cope with health inequalities have been little extensively investigated together with the same importance. Besides the diversity of factors involved, there is...

Background Strong evidence for a causal role of environmental factors in a congenital anomaly is still difficult to produce. The collection of statistical data is crucial for gaining a better understanding of the epidemiology and pathophysiology of these anomalies. We aimed to evaluate spatial variations in hypospadias within our region and it’s as...

Background Strong evidence for a causal role of environmental factors in a congenital anomaly is still difficult to produce. The collection of statistical data is crucial for gaining a better understanding of the epidemiology and pathophysiology of these anomalies. We aimed to evaluate spatial variations in hypospadias in our region, taking into ac...

Although the incidence of Crohn's disease has increased worldwide over the past 30 years, the disorder's exact causes and physiological mechanisms have yet to be determined. Given that genetic determinants alone do not explain the development of Crohn's disease, there is growing interest in “environmental” determinants. In medical science, the term...

Geographical variations in cardiovascular disease rates have been linked to individual air pollutants. Investigating the relation between cardiovascular disease and exposure to a complex mixture of air pollutants requires holistic approaches. We assessed the relationship between exposure to multiple air pollutants and the incidence of coronary hear...

Although a growing body of evidence suggests that chronic exposure to outdoor air pollution is linked to a decline in lung function, data on flow at low lung volumes that may be more specific of small airway obstruction are still scarce. We aimed to study the associations between residential exposure to air pollution and lung function, with specifi...

The wide range of factors involved in environmental health and the complexity of interactions between all environmental determinants require the validation of multidimensional approaches. While the development of composite indices is receiving growing attention by scientists and public authorities, the concept continues to lack transposability and...

Background: Geographical variations in Crohn's disease (CD) suggest that the environment has a role in the pathogenesis of this condition. Aims: To describe the spatial distribution and the clustering of CD cases in France, and to assess the relationship between the prevalence of CD and environmental risk factors. Methods: We identified all pa...

Background Somatic mutations in the KRAS gene are the most common oncogenic mutations found in human cancers. However, no clinical features have been linked to KRAS mutations in colorectal cancer [CRC]. Purpose In this study, we attempted to identify the potential geographical population clusters of KRAS mutations in CRC patients in northern Franc...

e15101 Background: Somatic mutations in the KRAS gene are present in about 40% of tumors from colorectal cancer (CRC) patients and are associated with a resistance to anti-EGFR therapies. However, no clinical features have been linked to KRAS mutations in CRC. In this study, we attempted to identify the potential geographical population clusters of...

Differential and not fair exposure to environmental risk factors across socio-demographic groups, called environmental justice (EJ), may contribute to inequalities in health and most often put disadvantaged groups at higher risk for environmental health effects. Main literature has difficulties to consider the potential exposure of populations to d...

Background A significant geographical variation in the incidence of Crohn's disease (CD) suggests the role of environmental factors in its pathogenesis. The objectives of this work were (i) to study the spatial distribution of CD cases in France from the database of the Programme de Médicalisation des Systèmes d'Information (PMSI), (ii) to study th...

This paper introduces a nonparametric scan method for multivariate data indexed in space. Contrary to many other scan methods, it does not rely on a generalized likelihood ratio but is completely distribution-free as it is based on so-called multivariate ranks. This spatial scan test seems to be more reliable for analysing data that are not Gaussia...

Introduction De fortes disparités d’incidence de l’IRCT ont récemment été observées entre les départements de France métropolitaine avec une influence notable du diabète et de la précarité sociale des populations. La littérature récente suggère également une part attribuable à l’environnement. Une analyse spatiale à fine échelle de l’incidence d’IR...

http://lodel.irevues.inist.fr/pollution-atmospherique/index.php?id=6471

Background The availability of big data in healthcare and the intensive development of data reuse and georeferencing have opened up perspectives for health spatial analysis. However, fine-scale spatial studies of ecological and medical databases are limited by the change of support problem and thus a lack of spatial unit interoperability. The use o...

Background: Strong geographic variations in the incidence of end-stage renal disease (ESRD) are observed in developed countries. The reasons for these variations are unknown. They may reflect regional inequalities in the population's sociodemographic characteristics, related diseases, or medical practice patterns. In France, at the district level,...

La question des inégalités environnementales et sociales de santé (IESS) à l’échelle des territoires est rapportée à deux dimensions cumulatives : un niveau d’exposition des populations à un environnement de vie dégradé et un niveau de vulnérabilité face à ces facteurs de risques, capables d’affecter la santé. Ces travaux de recherche concernent le...

Introduction De fortes disparités d’incidence de l’IRCT ont récemment été observées entre les départements de France métropolitaine. La région Nord–Pas de Calais (NPdC) présente les taux d’incidence les plus élevés. Compte tenu de son hétérogénéité elle semble être une aire géographique d’intérêt pour une analyse spatiale à fine échelle. Matériels...

Because of their long persistence, trace metals remain an issue in terms of contamination of the environment, health and environmental risks, including in the context of reducing emissions. Data from environmental contamination are very partial and air-monitoring network insufficiently expanded to have a clear image of the situation. In this work w...