Florent Guerville

Florent Guerville
Centre Hospitalier Universitaire de Bordeaux | CHU Bordeaux · Pôle gérontologie clinique (Groupe hospitalier Xavier Arnozan)

Doctor of Medicine

About

23
Publications
983
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236
Citations

Publications

Publications (23)
Article
Full-text available
Aging is associated with chronic low-grade inflammation, cancer incidence and mortality. As inflammation contributes to cancer initiation and progression, one could hypothesize that age-associated chronic low-grade inflammation contributes to the increase in cancer incidence and/or mortality observed during aging. Here, we review the evidence suppo...
Chapter
This chapter offers an overview of the biological knowledge of ageing. There are two complementary approaches to the biology of ageing. In the populational approach, the focus is on the properties of ageing populations, some of which can be extrapolated to individuals. In the physiological approach, one investigates the mechanisms of ageing at the...
Article
Full-text available
Background: Frailty and cognitive impairment are common manifestations of the ageing process and are closely related. But the mechanisms linking aging, physical frailty, and cognitive disorders, are complex and remain unclear. Objectives: We aim to explore the role of cerebral amyloid pathology, but also a range of nutritional, physical, biologi...
Article
Background/objectives: Cognitive decline associated with impaired kidney function might involve neurodegeneration. Our objectives were to evaluate the longitudinal association between kidney function and cognitive decline in older adults and to assess the involvement of cortical beta-amyloid and hippocampal atrophy (features of Alzheimer's disease...
Article
Full-text available
Cytomegalovirus (CMV) infection is responsible for significant morbidity and mortality in immunocompromised patients, namely solid organ and hematopoietic cell transplant recipients, and can induce congenital infection in neonates. There is currently an unmet need for new management and treatment strategies. Establishment of an anti‐CMV immune resp...
Article
Résumé Contexte La place de l’évaluation gériatrique dans la prise en charge des patients âgés avec insuffisance rénale chronique avancée reste à définir. Dans cette population, les connaissances manquent sur les propositions de soins faites par les gériatres lors de cette évaluation, et sur le suivi de ces propositions. Objectifs Décrire une pop...
Article
Objective IgA vasculitis (IgAV) frequently occurs during or after a mucosal infection; it also rarely occurs in patients with cancer. We hypothesized that cancer could impact the baseline characteristics and/or outcome of vasculitis. We aimed to describe the presentation of IgAV in patients with cancer (IgAV ca+) compared to patients without cancer...
Article
Full-text available
Depression symptoms and lower health-related quality of life (HRQoL) are associated with inflammation. This multicenter dietary intervention was shown to reduce inflammation in older people. This was the main outcome. Here, we describe the effects on HRQoL, anxiety, and depressive symptoms according to inflammation status. Overall, 125 healthy olde...
Article
Full-text available
The Geroscience aims at a better understanding of the biological processes of aging, to prevent and/or delay the onset of chronic diseases and disability as well as to reduce the severity of these adverse clinical outcomes. Geroscience thus open up new perspectives of care to live a healthy aging, that is to say without dependency. To date, life ex...
Article
Background: Antibiotic administration by subcutaneous (SC) injection is common practice in French geriatric wards as an alternative to the intravenous (IV) route, but few pharmacokinetic/pharmacodynamic data are available. Ertapenem is useful for the treatment of infections with ESBL-producing enterobacteria. Objectives: To report and compare er...
Article
Background and objectives: Low eGFR is known to be associated with frailty, but the association between the longitudinal decline of eGFR and incident frailty in older persons remains to be determined. The objective of this study was to investigate whether a fast decline on eGFR would be associated with incident frailty. Design, setting, participa...
Article
Background: The World Health Organization (WHO) recently proposed an innovative model of care focusing on functional rather than disease-based perspectives, based on a construct of intrinsic capacity (IC). Objective: This study aimed to analyze if low-grade inflammation (LGI) (chronically raised C-reactive protein - CRP) and hyperhomocysteinemia...
Article
Résumé Contexte Les anticoagulants oraux directs (AOD) sont recommandés en première intention devant les antivitamines K (AVK) dans la prévention des évènements thromboemboliques liés à la fibrillation atriale non valvulaire (FANV). Leur risque hémorragique reste peu étudié dans la population gériatrique en « vraie vie ». Objectif Comparer la fré...
Article
Background: The absence of fever in bacteremia in patients who are older is known to delay diagnosis. Our objective was to determine whether atypical presentation was associated to mortality as a result of bacteremia in this patient cohort as well as possible factors associated with this atypical presentation. Methods: We conducted an observatio...
Article
Objectives: To assess the associations of long-term lifestyle multidomain intervention (MI) and omega-3 supplementation with frailty level evolution and frailty incidence in community-dwelling older persons. Design: Secondary analysis of the randomized controlled Multidomain Alzheimer Preventive Trial. Setting: Thirteen memory centers in Franc...
Article
Background In older patients, the agreement is low between creatinine clearance estimated with the Cockcroft-Gault equation (eCrCl) and glomerular filtration rate estimated with the Chronic Kidney Disease Epidemiology Collaboration equation (eGFRCKD-EPI). The implications of these discrepancies for drug prescription have so far been assessed only f...
Article
Introduction Les patients âgés constituent le groupe d’insuffisants rénaux chroniques stade 5 qui augmente le plus massivement. La place et les apports de l’évaluation gériatrique (EG) dans leur prise en charge ne sont pas bien définis. Aucun outil de dépistage validé prédisant une EG pathologique n’est disponible pour le néphrologue. Objectif pri...
Article
Introduction Parmi les vascularites systémiques primitives, la maladie de Horton a été largement étudiée chez les sujets âgés de plus de 75 ans mais beaucoup moins de travaux se sont intéressés aux autres vascularites dans cette population. La population gériatrique est particulière par sa polypathologie et sa polymédication. Cela peut rendre le di...
Article
C1q-binding ability may indicate the clinical relevance of de novo donor-specific anti-HLA antibodies (DSA). This study investigated the incidence and risk factors for the appearance of C1q-binding de novo DSA and their long-term impact. Using Luminex Single Antigen Flow Bead assays, 346 pretransplant nonsensitized kidney recipients were screened a...
Article
Human γδ T cells contribute to tissue homeostasis under normal conditions and participate in lymphoid stress surveillance against infection and tumors. However, the molecular mechanisms underlying the recognition of complex cell stress signatures by γδ T cells are still unclear. Tumor cells and human cytomegalovirus (HCMV)-infected cells are known...

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