Florence Coste

Florence Coste
Université d´Avignon et des Pays du Vaucluse | UAPV · Département Sciences et Techniques des Activités Physiques et Sportives

Pharm.D., Ph.D.

About

23
Publications
1,974
Reads
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189
Citations
Citations since 2017
12 Research Items
161 Citations
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Introduction
Florence Coste currently works at the "Laboratoire de Pharm-Ecologie Cardiovasculaire" EA4278
Additional affiliations
September 2018 - present
Université d´Avignon et des Pays du Vaucluse
Position
  • Maître de conférence en physiologie
Description
  • Laboratoire de Pharm-Ecologie Cardiovasculaire LaPEC EA4278
November 2016 - August 2018
French Institute of Health and Medical Research
Position
  • PostDoc Position
February 2016 - February 2016
Paul Sabatier University - Toulouse III
Position
  • Pharmaceutical Doctor

Publications

Publications (23)
Article
Full-text available
Expression of the nerve growth factor NGF is increased in pulmonary hypertension (PH). We have here studied whether oxidative stress and inflammation, two pathological conditions associated with transforming growth factor-β1 (TGF-β1) in PH, may trigger NGF secretion by pulmonary arterial (PA) cells. Effects of hydrogen peroxide (H2O2) and interleuk...
Article
Introduction Mitochondrial fission is a key trigger of cardiac ischemia-reperfusion injuries (IR) injuries. Despite exercise training (ExTr) is known as an efficient strategy to protect the heart, its impact on the dynamic of the mitochondrial network remain to be investigated. Objective To evaluate the impact of ExTr on the process of mitochondri...
Article
Full-text available
Endothelial nitric oxide synthase (eNOS) activation in the heart plays a key role in exercise-induced cardioprotection during ischemia–reperfusion, but the underlying mechanisms remain unknown. We hypothesized that the cardioprotective effect of exercise training could be explained by the re-localization of eNOS-dependent nitric oxide (NO)/S-nitros...
Article
Ischemic heart disease is one of the main causes of morbidity and mortality worldwide. Physical exercise is an effective lifestyle intervention to reduce the risk factors for cardiovascular disease and also to improve cardiac function and survival in patients with ischemic heart disease. Among the strategies that contribute to reduce heart damages...
Article
Full-text available
Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD) and is associated with increased morbidity and mortality. Reference standard method to diagnose PH is right heart catheterization. Several non-invasive imaging techniques have been employed in the detection of PH. Among them, computed tomography (CT...
Article
The remodelling mechanism and cellular players causing persistent airflow limitation in chronic obstructive pulmonary disease (COPD) remain largely elusive. We have recently demonstrated that circulating fibrocytes, a rare population of fibroblast-like cells produced by the bone marrow stroma, are increased in COPD patients during an exacerbation....
Article
Full-text available
Background: Little is known about in vivo alterations at bronchial and vascular levels in severe pulmonary hypertension (PH) of different etiologies. We aimed to compare quantitative computed tomography (CT) data from the following three groups of severe precapillary PH patients: COPD, idiopathic pulmonary arterial hypertension (iPAH), and chronic...
Article
Full-text available
The 2018 European Respiratory Society (ERS) International Congress in Paris, France, highlighted the subject of pulmonary vascular disease (PVD). 2018 was an exciting year for the PVD community as it was the first ERS International Congress since the formation of Assembly 13, which is dedicated to PVD, pulmonary embolism and the right ventricle. Th...
Preprint
Full-text available
Background: The remodeling mechanism and cellular players causing persistent airflow limitation in chronic obstructive pulmonary disease (COPD) remain largely elusive. We have recently demonstrated that circulating fibrocytes, a rare population of fibroblast-like cells produced by the bone marrow stroma, are increased in COPD patients during an exa...
Article
Full-text available
Pulmonary arterial hypertension (PAH) is a severe form of pulmonary hypertension that combines multiple alterations of pulmonary arteries, including, in particular, thrombotic and plexiform lesions. Multiple-pathological-insult animal models, developed to more closely mimic this human severe PAH form, often require complex and/or long experimental...
Thesis
L’hypertension pulmonaire (HTP) est définie par une valeur de pression artérielle pulmonaire moyenne (PAPm) supérieure à 25 mmHg au repos. Il existe des formes sévères d’HTP (HTPs) avec des valeurs de PAPm encore plus élevées associées à des symptômes plus marqués et à l’apparition de lésions anatomo pathologiques spécifiques. Le diagnostic et le d...
Article
Full-text available
Rationale: Severe pulmonary hypertension (PH) is very uncommon in COPD, and a distinct phenotype has been hypothesised. We aimed to evaluate whether CT can help to recognise this condition non-invasively by measuring small pulmonary vessels. Material and methods: Patients with COPD who underwent pulmonary function tests, unenhanced CT of the che...
Poster
Introduction. Pulmonary hypertension (PH) is a rare and severe disease, without any curative treatment, that ultimately leads to death. Our previous studies showed a role of the nerve growth factor NGF in severe pulmonary hypertension (SPH) by use of a rat model combining monocrotaline and chronic hypoxia. Using the same model, we have here studied...
Article
Full-text available
Pulmonary hypertension (PH) is characterized by an elevation in mean pulmonary artery pressure leading to right heart failure and ultimately death. Growth factors play a role in PH development and their targeting may open novel therapeutic strategies in this disease. To evaluate the nerve growth factor NGF as a potential new target in PH. Expressio...
Poster
Purpose Pulmonary hypertension (PH) is a common complication of COPD associated with increased mortality. The mechanisms coupling PH and bronchial obstruction are unknown; in particular PH appears unrelated to emphysema. We hypothesized that CT measurement of airway remodeling instead of emphysema may correlate with PH in COPD. Material and Method...
Article
Full-text available
Rationale: Pulmonary hypertension (PH) is an established complication of advanced chronic obstructive pulmonary disease (COPD) associated with increased mortality. The mechanisms coupling PH and bronchial obstruction are unknown; in particular, PH appears to be unrelated to emphysema. We hypothesized that computed tomographic (CT) measurement of a...
Conference Paper
Introduction: Severe pulmonary hypertension (PH) is an unusual complication in COPD, and a distinct phenotype has been evoked. Objectives: We evaluated whether computed tomography (CT) can support this hypothesis, by identifying airways and/or small vessels. Material and Methods: Between 2009 and 2013, 116 COPD patients underwent during a period...

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