Florence Coste

• Pharm.D., Ph.D.
• Maître de conférence en physiologie at University of Avignon

Mitochondrial fission is a key trigger of cardiac ischemia-reperfusion injuries (IR). Exercise training is an efficient cardioprotective strategy, but its impact on mitochondrial fragmentation during IR remains unknown. Using isolated rat hearts, we found that exercise training limited the activation of dynamin-like protein 1 and limited mitochondr...

Despite the end of the pandemic, coronavirus disease 2019 (COVID-19) remains a major public health concern. The first waves of the virus led to a better understanding of its pathogenesis, highlighting the fact that there is a specific pulmonary vascular disorder. Indeed, COVID-19 may predispose patients to thrombotic disease in both venous and arte...

Hyperglycemia increases the heart sensitivity to ischemia-reperfusion (IR), but the underlying cellular mechanisms remain unclear. Mitochondrial dynamics (the processes that govern mitochondrial morphology and their interactions with other organelles, such as the reticulum), has emerged as a key factor in the heart vulnerability to IR. However, it...

Expression of the nerve growth factor NGF is increased in pulmonary hypertension (PH). We have here studied whether oxidative stress and inflammation, two pathological conditions associated with transforming growth factor-β1 (TGF-β1) in PH, may trigger NGF secretion by pulmonary arterial (PA) cells. Effects of hydrogen peroxide (H2O2) and interleuk...

Introduction Mitochondrial fission is a key trigger of cardiac ischemia-reperfusion injuries (IR) injuries. Despite exercise training (ExTr) is known as an efficient strategy to protect the heart, its impact on the dynamic of the mitochondrial network remain to be investigated. Objective To evaluate the impact of ExTr on the process of mitochondri...

Endothelial nitric oxide synthase (eNOS) activation in the heart plays a key role in exercise-induced cardioprotection during ischemia–reperfusion, but the underlying mechanisms remain unknown. We hypothesized that the cardioprotective effect of exercise training could be explained by the re-localization of eNOS-dependent nitric oxide (NO)/S-nitros...

Introduction Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death worldwide caused by pollution and cigarette smoke. This leads to an airflow limitation and parenchymal destruction (emphysema). The disease is worsened by exacerbations mainly due to pulmonary infections. Cardiac dysfunction is a common feature of the disease sugg...

Introduction L’objectif de ce travail était de déterminer si les données morphologiques des voies aériennes proximales de 3e et 4e génération issues du scanner thoracique réalisé dans le cadre des soins courants permettent de prédire le phénotype « exacerbateur fréquent » chez des patients atteints de BPCO. Méthodes Les patients BPCO suivis au CHU...

Ischemic heart disease is one of the main causes of morbidity and mortality worldwide. Physical exercise is an effective lifestyle intervention to reduce the risk factors for cardiovascular disease and also to improve cardiac function and survival in patients with ischemic heart disease. Among the strategies that contribute to reduce heart damages...

Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD) and is associated with increased morbidity and mortality. Reference standard method to diagnose PH is right heart catheterization. Several non-invasive imaging techniques have been employed in the detection of PH. Among them, computed tomography (CT...

The remodelling mechanism and cellular players causing persistent airflow limitation in chronic obstructive pulmonary disease (COPD) remain largely elusive. We have recently demonstrated that circulating fibrocytes, a rare population of fibroblast-like cells produced by the bone marrow stroma, are increased in COPD patients during an exacerbation....

Background Little is known about in vivo alterations at bronchial and vascular levels in severe pulmonary hypertension (PH) of different etiologies. We aimed to compare quantitative computed tomography (CT) data from the following three groups of severe precapillary PH patients: COPD, idiopathic pulmonary arterial hypertension (iPAH), and chronic t...

The 2018 European Respiratory Society (ERS) International Congress in Paris, France, highlighted the subject of pulmonary vascular disease (PVD). 2018 was an exciting year for the PVD community as it was the first ERS International Congress since the formation of Assembly 13, which is dedicated to PVD, pulmonary embolism and the right ventricle. Th...

Background: The remodeling mechanism and cellular players causing persistent airflow limitation in chronic obstructive pulmonary disease (COPD) remain largely elusive. We have recently demonstrated that circulating fibrocytes, a rare population of fibroblast-like cells produced by the bone marrow stroma, are increased in COPD patients during an exa...

Pulmonary arterial hypertension (PAH) is a severe form of pulmonary hypertension that combines multiple alterations of pulmonary arteries, including, in particular, thrombotic and plexiform lesions. Multiple-pathological-insult animal models, developed to more closely mimic this human severe PAH form, often require complex and/or long experimental...

L’hypertension pulmonaire (HTP) est définie par une valeur de pression artérielle pulmonaire moyenne (PAPm) supérieure à 25 mmHg au repos. Il existe des formes sévères d’HTP (HTPs) avec des valeurs de PAPm encore plus élevées associées à des symptômes plus marqués et à l’apparition de lésions anatomo pathologiques spécifiques. Le diagnostic et le d...

Rationale: Severe pulmonary hypertension (PH) is very uncommon in COPD, and a distinct phenotype has been hypothesised. We aimed to evaluate whether CT can help to recognise this condition non-invasively by measuring small pulmonary vessels. Material and methods: Patients with COPD who underwent pulmonary function tests, unenhanced CT of the che...

Introduction. Pulmonary hypertension (PH) is a rare and severe disease, without any curative treatment, that ultimately leads to death. Our previous studies showed a role of the nerve growth factor NGF in severe pulmonary hypertension (SPH) by use of a rat model combining monocrotaline and chronic hypoxia. Using the same model, we have here studied...

Pulmonary hypertension (PH) is characterized by an elevation in mean pulmonary artery pressure leading to right heart failure and ultimately death. Growth factors play a role in PH development and their targeting may open novel therapeutic strategies in this disease. To evaluate the nerve growth factor NGF as a potential new target in PH. Expressio...

Thematic poster

Purpose Pulmonary hypertension (PH) is a common complication of COPD associated with increased mortality. The mechanisms coupling PH and bronchial obstruction are unknown; in particular PH appears unrelated to emphysema. We hypothesized that CT measurement of airway remodeling instead of emphysema may correlate with PH in COPD. Material and Method...

Rationale: Pulmonary hypertension (PH) is an established complication of advanced chronic obstructive pulmonary disease (COPD) associated with increased mortality. The mechanisms coupling PH and bronchial obstruction are unknown; in particular, PH appears to be unrelated to emphysema. We hypothesized that computed tomographic (CT) measurement of a...

Introduction: Severe pulmonary hypertension (PH) is an unusual complication in COPD, and a distinct phenotype has been evoked. Objectives: We evaluated whether computed tomography (CT) can support this hypothesis, by identifying airways and/or small vessels. Material and Methods: Between 2009 and 2013, 116 COPD patients underwent during a period...