Fleurdeliz Maglangit

Fleurdeliz Maglangit
University of the Philippines Cebu | UPCebu · College of Science

Natural Products; PhD in Chemistry

About

19
Publications
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146
Citations
Introduction

Publications

Publications (19)
Article
Covering: up to the second quarter of 2020 Threat or treat? While pathogenic bacteria pose significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat various diseases. The alarming antimicrobial resistance crisis and the dwindling clinical pipeline urgently call for the discovery and development of new antibioti...
Article
Full-text available
Background: Coral reefs offer valuable ecosystem goods and services, such as coastal protection, erosion regulation, fishery, biodiversity, habitat and nursery grounds. However, they face threats from anthropogenic activities, including poor water quality, global warming, coastal development and unsustainable fisheries. Marine Protected Areas (MPA...
Technical Report
https://encyclopedia.pub/8454?fbclid=IwAR073M_o-ZB1W6gZWg7gC1SWDJsy-XVcYq5G0BqGdxvwTZOtnfkUHifJLC4
Article
Full-text available
Continued mining of natural products from the strain Streptomyces sp. MA37 in our laboratory led to the discovery of a minor specialized metabolite (SM) called accramycin A. Owing to its low yield (0.2 mg/L) in the wild type strain, we investigated the roles of regulatory genes in the corresponding biosynthetic gene cluster (acc BGC) through gene i...
Preprint
Full-text available
Continued mining of natural products from the strain Streptomyces sp. MA37 in our laboratory led to the discovery of a minor specialised metabolite (SM) called accramycin A. Owing to its low yield (0.2mg/L) in the wild type strain, we investigated the roles of regulatory genes in the corresponding biosynthetic gene cluster (acc BGC) through gene in...
Article
Full-text available
In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated desferrioxamines, speibonoxamine 1 and desoxy-desferrioxamine D 1 2, have been isolated, together with four known hydroxamates, desfer...
Article
The introduction of fluorine atoms into organic molecules has received considerable attention as these organofluorines have often found widespread applications in bioorganic chemistry, medicinal chemistry and biomaterial science. Despite innovation of synthetic C–F forming methodologies, selective fluorination is still extremely challenging. Theref...
Article
More than 500 siderophores are known to date, but only three were identified to be aryl-containing hydroxamate siderophores, legonoxamines A and B from Streptomyces sp. MA37, and aryl ferrioxamine 2 from Micrococcus luteus KLE1011. Siderophores are produced by microorganisms to scavenge iron from the environment, thereby making this essential metal...
Article
Full-text available
Four compounds (1-4) were isolated from the extracts of Streptomyces sp. CT37 using bioassay in conjunction with mass spectrometric molecular networking (MN) driven isolation. Their complete structures were established by high-resolution electrospray ionization mass spectrometry (HR-ESIMS), and 1D and 2D nuclear magnetic resonance (NMR) data. Legon...
Article
The introduction of fluorine atoms into organic molecules has received considerable attention as these organofluorines have often found widespread applications in bioorganic chemistry, medicinal chemistry and biomaterial science. Despite innovation of synthetic C-F forming methodologies, selective fluorination is still extremely challenging. Theref...
Article
Full-text available
Streptomyces remains one of the prolific sources of structural diversity, and a reservoir to mine for novel natural products. Continued screening for new Streptomyces strains in our laboratory led to the isolation of Streptomyces sp. RK44 from the underexplored areas of Kintampo waterfalls, Ghana, Africa. Preliminary screening of the metabolites fr...
Article
Full-text available
Whole-genome sequence data of the genus Streptomyces have shown a far greater chemical diversity of metabolites than what have been discovered under typical laboratory fermentation conditions. In our previous natural product discovery efforts on Streptomyces sp. MA37, a bacterium isolated from the rhizosphere soil sample in Legon, Ghana, we discove...
Article
Full-text available
Drug-like molecules are known to contain many different building blocks with great potential as pharmacophores for drug discovery. The continued search for unique scaffolds in our laboratory led to the isolation of a novel Ghanaian soil bacterium, Streptomyces sp. MA37. This strain produces many bioactive molecules, most of which belong to carbazol...
Poster
See link of the conference and poster: https://www.embric.ugent.be/node/1760 extension://elhekieabhbkpmcefcoobjddigjcaadp/https://www.embric.ugent.be/sites/default/files/Fleurdeliz%20Maglangit%20poster.pdf
Article
The study aimed to provide baseline data by assessing the nutrient levels and sediment load in Buhisan, Bulacao and Lahug Rivers. Specifically, the study assessed the nitrates, Total Phosphorus (TP), Total Suspended Solids (TSS) and Total Dissolved Solids (TDS) concentrations of the rivers. Water samples were taken by grab sampling from three desig...
Article
Full-text available
This study was conducted to evaluate and compare the water quality of Buhisan, Bulacao and Lahug rivers in Cebu, Philippines using coliforms as indicators. Monthly sampling started from November 2011 to April 2012 in the upstream, midstream and downstream stations. The multiple tube fermentation technique was used for the analysis of coli forms. Hi...
Article
Full-text available
The use of surface waters such as rivers for domestic, agricultural andindustrial purposes have made them vulnerable to pollution leading to impairedwater quality. The water quality of Lahug River in Cebu City was evaluated usingcoliforms as indicators, in relation with physicochemical parameters such as biological oxygen demand (BOD), conductivity...
Article
The present study deals with the physico-chemical analysis of water samplescollected monthly from three established sites in Lahug River for a period ofsix months. The main purpose of the study is to provide baseline data on itsphysico-chemical characteristics as well as assess its water quality. Statistical toolswere used to analyze and interpret...

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