Fleming Martínez

Fleming Martínez
National University of Colombia | UNAL · Departamento de Farmacia (Bogotá)

Doctor of Science - Professor of Pharmaceutics

About

455
Publications
131,144
Reads
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7,896
Citations
Citations since 2016
208 Research Items
5574 Citations
201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000
Additional affiliations
January 2002 - December 2012
National University of Colombia
January 2002 - present
National University of Colombia
Position
  • Aspectos fisicoquímicos de la solubilidad de analgésicos en mezclas cosolventes.
Education
January 1997 - December 2001
National University of Colombia
Field of study
  • Physical Chemistry
July 1987 - June 1993
National University of Colombia
Field of study
  • Pharmacy

Publications

Publications (455)
Article
Full-text available
This work aims to improve the aqueous solubility of 4-hydroxycoumarin (4H-coumarin) as one of the lowest soluble derivatives of coumarin, by using deep eutectic solvents (DESs). The applied DESs are composed of choline chloride (ChCl) as a hydrogen bond acceptor (HBA) and ethylene glycol (EG), urea (U), or glycerol (GLY) as hydrogen bond donors (HB...
Article
Full-text available
Meloxicam is an analgesic and anti-inflammatory drug widely prescribed in current therapeutics that exhibits very low solubility in water. Thus, this physicochemical property has been studied in N-methyl-pyrrolidone (NMP)-aqueous mixtures at several temperatures to expand the solubility database about pharmaceutical compounds in aqueous-mixed solve...
Article
Full-text available
Equilibrium solubility of triclocarban (TCC) expressed in mole fraction in 1,4-dioxane and cyclohexane, as well, as in 19 {cyclohexane (1) + 1,4-dioxane (2)} mixtures, was determined at seven temperatures from T = (288.15 to 318.15) K. Logarithmic TCC solubility in these cosolvent mixtures was adequately correlated with a lineal bivariate equation...
Article
Full-text available
The solubility of drugs in cosolvent systems of pharmaceutical interest is of great importance for understanding and optimizing a large number of processes. Here, we report the solubility of isoniazid in nine (PEG 200 + water) cosolvent mixtures at nine temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, and 318.15 K) determined b...
Article
Full-text available
The solubility of allopurinol was measured at several temperatures (15–35 ºC) in ethanol–water, ethanol–ethyl acetate, and ethyl acetate–hexane mixtures. The mole fraction solubility shows two solubility maxima against the co-solvent (ethanol) ratio (70 % ethanol–water and 100 % ethyl acetate) at each of the five temperatures studied. The authors c...
Article
Thermodynamic studies of drug solubility in cosolvent mixtures at different temperatures generate information of great importance for pharmaceutical, medical, and environmental sciences. The objective of this research is to thermodynamically analyze the solubility of progesterone (PG) in cosolvent mixtures {1-octanol (1) + ethanol (2)} from 278.15...
Article
Full-text available
Meloxicam is widely prescribed as an analgesic and anti-inflammatory drug in human therapeutics. Owing the very low aqueous solubility of meloxicam, this property has been studied in dimethyl sulfoxide (DMSO)-aqueous solvent systems at several temperatures from 273.15 to 313.15 K to expand the solubility database about analgesic drugs in mixed solv...
Article
Full-text available
The equilibrium solubility of benzoic acid in water and ethanol, as well as in nine {ethanol (1) + water (2)} mixtures, was determined from T = (293.15 to 323.15) K. Benzoic acid mole fraction solubility in these aqueous-ethanolic mixtures was adequately correlated with some well-known correlation/prediction models, obtaining mean percentage deviat...
Article
Mesalazine is a low-permeable and low-soluble drug, which makes it a class IV drug in the Biopharmaceutics Classification System. Hence, its solubilization can be helpful for various stages of formulation development. The purpose of this study was to investigate the solubilization manner and thermodynamics of mesalazine in ternary solvent combinati...
Article
Full-text available
Probiotics are beneficial bacteria that have a significant effect on host health and they are widely used in preventing and treating diseases. Nowadays probiotics are present in food, drug and several commercial complement products. In recent years the use of probiotics in the nanotechnology area, especially in nanoparticle synthesis, has significa...
Article
Solubility of amlodipine besylate (AMB) in acetonitrile-water mixtures was measured by spectrophotometric technique after equilibration by a well-known shake-flask method. The solubility values were also measured at five temperatures of interests from 293.2 to 313.2 K and 11 mass fractions. The solubility of AMB enhances upon acetonitrile mass frac...
Article
Full-text available
Mole fraction solubilities of tadalafil (3) in aqueous mixtures of Transcutol® and PEG 400 at temperatures from 298.15 to 333.15 K were analysed following Hildebrand solubility parameters. Cosolvency models for representing tadalafil solubility at various temperatures were also provided for correlation/prediction purposes. Apparent thermodynamic qu...
Article
Full-text available
The applications of nanoparticles in various practical fields, owing to their unique properties compared with bulk materials, have been occupying the minds of scientists for several decades. In this regard, a combination of pharmacology and nanotechnology has contributed to producing newer effective anticancer and antimicrobial agents to inactivate...
Article
The solubility of 6-methylcoumarin in water, ethanol and nine aqueous ethanol mixtures was determined from 293.15 to 323.15 K. 6-Methylcoumarin solubility expressed in mole fraction was correlated with some well-known correlation/prediction models. Gibbs energy, enthalpy and entropy, for dissolution and mixing processes, were computed using van’t H...
Article
Full-text available
Antibiotic resistance in pathogenic bacteria to various types of antibiotics has resulted in the necessity of new effective strategies to get around this problem. In recent investigations, metal or metal oxide nanoparticles specifically silver nanoparticles (AgNPs) have been employed successfully to hinder antibiotic-resistant Gram-negative and Gra...
Article
Full-text available
(Z)-N-benzyl-2-{5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl)acetamide(3) (SE11) is a newly synthesized benzylidine thiazolidinedione to inhibit aldose reductase (AR) to control Diabetes Mellitus (DM) and related complications. This reported compound exhibits poor water solubility and based on Hansen solubility parameter (HSP) considerations...
Article
Reported mole fraction solubilities of trans-resveratrol in aqueous mixtures of acetone in the temperature interval from (273.2 to 313.2) K were correlated by means of some cosolvency models, like multi-linear models of Jouyban-Acree and Jouyban-Acree-van’t Hoff and non-linear models of the modified Wilson and CNIBS/R-K model. Apparent thermodynami...
Article
Full-text available
(Z)-N-Benzyl-2-{2,4-dioxo-5-(4-prop-2-yl-1-yloxyl)benzylidene)thiazolin-3-yl)}acetamide (SE415) is a novel aldose reductase inhibitor used in the management of diabetes mellitus (DM) and associated complications. Herein, the drug was solubilized (mole fraction solubility) in a “PEG 400 (polyethylene glycol 400) + water” mixture of various ratios at...
Article
Full-text available
Solubility of sulfamethazine (SMT) in acetonitrile (MeCN) + methanol (MeOH) cosolvents was determined at nine temperatures between 278.15 and 318.15 K. From the solubility data expressed in molar fraction, the thermodynamic functions of solution, transfer and mixing were calculated using the Gibbs and van ’t Hoff equations; on the other hand, the s...
Article
The blood-brain barrier (BBB) is one of the vital and key barriers between brain tissue and the circulatory system. The BBB controls the passage of ions and molecules into brain tissue. Due to the unique features of this barrier, drug delivery for the treatment of various brain disorders is still a major challenge in the medical field. The use of n...
Article
Measuring and evaluating of the solubility of amlodipine besylate (AMB), as a low water soluble antihypertensive drug, is fundamentally important in the pharmaceutical industry. In this work, the solubility of AMB in the binary solvent system of water and polyethylene glycol 400 (PEG 400) was determined by a shake-flask method at the temperatures f...
Article
Knowledge of drug solubility is crucial and there is no available cosolvency database for baclofen, so far. In the current study, the solubility and density values of baclofen in five mono-solvents (i.e. methanol, ethanol, 1-propanol, 2-propanol and propylene glycol) and the binary mixed solvents of propylene glycol and ethanol within the temperatu...
Article
The present work is devoted to the study of the caffeine dissolution process in the non-aqueous binary mixture of N-methyl-2-pyrrolidone + ethylene glycol mixture at a temperature range of T = (293.2 – 313.2) K. The generated solubility data are mathematically represented by using some cosolvency models (i.e. Jouyban-Acree, Jouyban-Acree-van’t Hoff...
Article
At 298.15-318.15 K and 0.1 MPa, the solubility of a naturally-derived chemical sinapic acid (SA) (3) in various {ethylene glycol (EG) (1) + water (2)} mixtures has been recorded. The solubility values of SA were correlated computationally using five different models. In {EG (1) + water (2)} mixtures, the equilibrium solubility of SA was shown to ri...
Article
This paper discusses sulfamerazine (SMR) solubility in Acetonitrile (MeCN) + Methanol (MeOH) cosolvents at nine temperatures (278.15–318.15 K). Herein, the maximum SMR solubility was reached in a cosolvent mixture at the highest studied temperature, and the minimum SMR solubility was reached in neat methanol at the lowest studied temperature. Using...
Article
Reported equilibrium mole fraction solubilities of sinapic acid (3) in {DMSO (1) + water (2)} and {Carbitol (1) + water (2)} mixtures at several temperatures were analyzed in terms of the Hildebrand solubility parameter of these aqueous mixtures. Moreover, the preferential solvation parameters of sinapic acid in these aqueous saturated mixtures at...
Article
Reported equilibrium mole fraction solubility values of 6-phenyl-4,5-dihydropyridazin-3(2H)-one (PDP-6) (3) in {Transcutol (1) + water (2)} and {PEG 400 (1) + water (2)} mixtures at five temperatures from T = (293.15 to 313.15) K were analyzed based on the Hildebrand solubility parameter of the respective aqueous mixtures. Cosolvency models for rep...
Article
In the current study, the sildenafil citrate solubility is investigated in (2-propanol + water) binary mixtures at five different temperatures (293.2-313.2 K). The experimental solubility data are obtained from the shake-flask method and correlated with some linear and non-linear cosolvency models (i.e. the van’t Hoff, CNIBS/Redlich-Kister, the Jou...
Article
Solubility and thermodynamic properties of lamotrigine as a practically insoluble drug in binary mixtures of choline chloride / propylene glycol deep eutectic solvent and water are determined by shake-flask method followed by a spectrophotometric method at the temperature range of 293.2-313.2 K. The acquired molar data are correlated to the linear...
Article
The solubility of ketoconazole in the mixtures of propylene glycol and ethanol is measured by a laser monitoring technique in the temperature range of 293.2–313.2 K. The generated solubility data are fitted to some linear and non-linear cosolvency models and the accuracy of each model is investigated by calculating the mean relative deviations (MRD...
Article
Equilibrium mole fraction solubility of vanillin in nine aqueous-ethanolic mixtures, as well as in neat water and neat ethanol, was determined at seven temperatures from T = 293.15 to T = 323.15 K. Vanillin solubility in these mixtures was adequately correlated with several well-known correlation models with the mean percentage deviations of 5.9 to...
Article
The thermodynamics and solubilization behavior of caffeine in non-aqueous binary mixtures of N-methyl-2-pyrrolidone (NMP) and propylene glycol (PG) at temperatures ranged from 293.2 to 313.2 K are measured using a shake-flask method and the obtained solubility data are mathematically represented by using some cosolvency models (e.g. Jouyban-Acree,...
Article
The solubility and solution thermodynamic properties of mesalazine in the binary mixtures of a deep eutectic solvent (DES) and water are determined by a shake-flask method followed by spectrophotometry method in the temperature range of 293.2–313.2 K. The obtained solubility data are correlated using some linear cosolvency models including the van’...
Article
Camelina oil, as an alternative to linseed oil, is a rich source of omega-3 fatty acids with higher oxidative stability and valuable nutritional properties. Although Iran is a suitable location for the cultivation of the Camelina sativa plant, it is not well known. Therefore, in this study, the physicochemical properties of camelina oil obtained fr...
Article
Background: Meloxicam is a powerful analgesic and anti-inflammatory drug widely prescribed by physicians in current therapeutics. Because of the very low aqueous equilibrium solubility of meloxicam, this property has been studied in {2-propanol + water} mixtures from (293.15 to 313.15) K to expand the solubility database about pharmaceutical compou...
Article
Solubility data of pharmaceutical ingredients is required for crystallization, extraction and purification processes. The solubility profile and thermodynamic modeling of caffeine in the binary non-aqueous mixed solutions of N-methyl-2-pyrrolidone (NMP) and 1-propanol at various temperatures ranging from 293.2 to 313.2 K are measured in this study...
Article
Reported equilibrium mole fraction solubility values of trans-resveratrol in some aqueous-ethanolic mixtures in the temperature interval from (273.2 to 323.2) K were correlated by means of some cosolvency models, like multi-linear models of Jouyban-Acree and Jouyban-Acree-van’t Hoff and non-linear models of the modified Wilson and Buchowski-Ksiazcz...
Article
Solubility profile for sildenafil citrate in the non-aqueous mixtures of 1-propanol and water is measured using a shake-flask method at different temperatures of 293.2 K, 298.2 K, 303.2 K, 308.2 K and 313.2 K and correlated employing some well-known cosolvency models (e.g. the CNIBS/Redlich-Kister, the Jouyban-Acree, the Jouyban-Acree-van’t Hoff, t...
Article
The solid-liquid equilibrium of sildenafil citrate in the binary non-aqueous mixtures of propylene glycol and ethanol is investigated by a shake-flask technique at T = (293.2–313.2) K and atmospheric pressure. Some mathematical models such as the van’t Hoff, the mixture response surface, the Jouyban-Acree, the Jouyban-Acree-van’t Hoff and λh models...
Article
Equilibrium mole fraction solubility of coumarin in nine aqueous-ethanolic mixtures, as well as in neat water and neat ethanol, was determined at seven temperatures from (293.15 to 323.15) K. Coumarin solubility in was adequately correlated with several well-known correlation models with the mean percentage deviations of 5.1 to 10.8%. The respectiv...
Article
Full-text available
Solubility of meloxicam in {methanol + water} mixtures from 293.15 to 313.15 K has been determined and correlated by means of the Jouyban–Acree model. By using the van’t Hoff and Gibbs equations the respective apparent thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entropy, were calculated. A n...
Article
The solubility knowledge of pharmaceutical compounds in pure solvents and solvent mixtures has a critical role in formulation, separation and purification in the pharmaceutical and chemical industries. In the article ahead, the solid−liquid equilibria measurements for solubility of caffeine in the non-aqueous binary mixtures of N-methyl-2-pyrrolido...
Article
The equilibrium solubility of sulfamerazine (SMR) in neat ethylene glycol (EG) and nineteen {(EG) (1) + water (2)} mixtures is reported at temperatures from (278.15 to 318.15) K. Mole fraction solubility of SMR (x3) increases with temperature arising and also increases with the EG proportion increasing. It varies from 1.71 × 10–5 in neat water to 7...
Article
Extended Hildebrand Solubility Approach (EHSA) was applied in this research to analyse the equilibrium solubility of sulphadiazine in some {N-methyl-2-pyrrolidone (1) + water (2)} and {Carbitol® (1) + water (2)} mixtures at 313.15 K. Reported experimental solubilities and melting properties of this drug were used for EHSA calculations. Good predict...
Article
Solubility and density profiles for 3-aminosalicylic acid (3-ASA) in the mixed solvents of 2-propanol and water is determined by a shake-flask method at 293.2–313.2 K. The obtained numerical data is correlated by some mathematical models such as van’t Hoff, the mixture response surface, Jouyban–Acree, Jouyban–Acree–van’t Hoff and the modified Wilso...
Article
The equilibrium solubility of a weakly water-soluble drug of naproxen (NAP) in ethylene glycol (EG) + water is determined by a shake-flask method in the temperature range of 293.2–313.2 K. Five models including Jouyban-Acree, Jouyban-Acree-van't Hoff, the mixture response surface, van't Hoff and the modified Wilson models were applied to mathematic...
Article
Equilibrium mole fraction solubility of 5-fluorouracil (5-FU) in 19 aqueous-ethanolic mixtures, as well as in neat water and neat ethanol, was determined at seven temperatures from (293.15 to 323.15) K. 5-FU solubility in these mixtures was adequately correlated with several well-known correlation models. The respective apparent thermodynamic funct...
Article
In this research, the equilibrium mole fraction solubility of fluconazole (FLC) in some aqueous-ethanolic mixtures was determined at seven temperatures from (293.15 to 323.15) K. The respective apparent thermodynamic functions (Gibbs energy, enthalpy, and entropy) for the dissolution, mixing and solvation processes were computed using the van’t Hof...
Article
In this study, polymeric composite nanofiber consisting of polyvinyl alcohol (PVA)/gum tragacanth (GT)/molybdenum disulfide (MoS2) were successfully developed via electrospinning process for tetracycline (TCH) delivery. Experimental analysis including UV-vis and XRD indicated that the MoS2 nanosheets were exfoliated. Based on the SEM analysis the p...
Article
The reported solubility data of atorvastatin calcium in binary aqueous mixtures of acetone at various temperatures from 293.15 K to 328.15 K was reanalyzed based on some well-established cosolvency models and a number of points regarding the correlations were discussed.
Article
This study aimed to introduce two natural lipids including the fat tail (FT) and the local oil (Roghan Kermanshahi) in order to design lipid nanocarriers for loading of sunitinib malate as a poorly water-soluble anticancer drug. The drug-loaded solid lipid nanoparticles (SLNs) were fabricated using the modified solvent evaporation-ultrasonic combin...
Article
The aims of the current study are solubility behavior investigation of phenytoin in the mixtures of 1-propanol and water at different temperatures and correlation of the generated data to some linear and non-linear cosolvency models. As another physico-chemical property, the density of phenytoin saturated solutions is also measured and the results...
Article
In this research, the equilibrium mole fraction solubility of 4-nitroaniline (4-NA) in some aqueous-ethanolic mixtures was determined at seven temperatures from (293.15 to 323.15) K. The respective apparent thermodynamic functions (Gibbs energy, enthalpy, and entropy) of the dissolution processes were computed using the van’t Hoff and Gibbs equatio...
Article
In this study, solubility profile of phenytoin in carbitol and water mixtures at 298.2–313.2 K is measured and some linear and non-linear cosolvency models are used to numerical representation of these data. The prediction capability of used models is investigated using training the models with minimum possible data. The accuracy of applied models...
Article
The solubilization behavior and thermodynamics of fexofenadine.HCl in the binary mixtures of ethanol and water at temperature range of T = (293.2–313.2) K are investigated and the generated solubility data are mathematically represented by using four cosolvency models (i.e. van't Hoff equation, modified Wilson, Jouyban-Acree and Jouyban-Acree-van't...
Article
Ha et al. reported the equilibrium solubility of trans-resveratrol in some {Transcutol® (1) + water (2)} mixtures at several temperatures with some numerical correlation and apparent dissolution thermodynamic analyses. Nevertheless, no attempt was made to evaluate the effect of mixtures polarity on solubility nor preferential solvation of this comp...
Article
In this research, the equilibrium mole fraction solubility of 2,4-dinitrotoluene (2,4-DNT) in some aqueous-ethanolic mixtures was determined at seven temperatures from (293.15 to 323.15) K. The respective apparent thermodynamic functions (Gibbs energy, enthalpy, and entropy of the dissolution processes) were computed using the van't Hoff and Gibbs...
Article
Solubility of sulfadiazine in {N-methyl-2-pyrrolidone (NMP) + water} mixtures from 293.15 K to 313.15 K has been determined and correlated by means of the Jouyban-Acree model. By using the van't Hoff and Gibbs equations the respective apparent thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entr...
Article
The equilibrium solubility of sulfadiazine (SD, 3) in {acetonitrile (MeCN, 1) + methanol (MeOH, 2)} mixtures at nine temperatures from 278.15 K to 318.15 K has been determined and correlated by means of some well-known thermodynamic correlation models. Five models including van't Hoff, the mixture response surface (MRS), Jouyban-Acree, Jouyban-Acre...
Article
The solubility profile of ketoconazole (KTZ) in the binary mixtures of N-methyl-2-pyrrolidone and ethanol is determined by a shake-flask method followed by a spectrophotometry method in the temperature range of 293.2–313.2 K. The obtained solubility values of KTZ are correlated using some linear and non-linear cosolvency models. Moreover, the densi...
Article
The mole fraction solubility of sulphadiazine (SD) in {Carbitol® (1) + water (2)} binary solvent mixtures at different temperatures from (278.15 to 313.15) K was determined. Solubility values were correlated with the combined nearly ideal binary solvent/Redlich-Kister, modified Wilson and Jouyban-Acree models. Preferential solvation parameters of S...
Article
In the current study, ketoconazole solubility profile is determined in the mixtures of propylene glycol and 2-propanol at temperature range of 293.2–313.2 K by employing a laser-based monitoring setup followed by a gravimetric measurement. The generated solubility data for ketoconazole are correlated with various reported mathematical solubility mo...
Article
The equilibrium solubility of sulfadiazine (SD) in {ethylene glycol (EG) Rubino (n.d.) [1] + water (Yalkowsky, 1999 [2])} mixtures at temperatures from (278.15 to 318.15) K is reported. Mole fraction solubility of SD (x3) increases with temperature arising and also increases with the EG proportion increasing. It varies from 4.81 × 10⁻⁶ in neat wate...
Article
Solubility profile for 3-aminosalicylic acid (3-ASA) in the mixtures of 1-propanol and water is measured by a shake-flask method at 293.2–313.2 K. Results indicated that the experimental mole fraction solubility of 3-ASA in the investigated mixtures firstly increase up to w1=0.6 and then decrease with the mass fraction increasing of 1-propanol at e...
Article
The solubility of triclocarban (TCC) was determined in {ethylene glycol (EG) + water} cosolvent mixtures at 7 temperatures (288.15–318.15 K). The solubility of TCC increases with increasing temperature and the polarity of the cosolvent system decreases with increasing EG concentration. In that case, TCC reaches its minimum solubility in pure water...
Article
Temperature-dependent solubility data of 3-aminosalicylic acid (3-ASA) are scarce in the literature and there is a particular need to explore cosolvency for this compound. Therefore, in the current study, the solubilization profile of 3-ASA along with density data in the mixtures of ethanol and water were measured at a temperature range of 293.2–31...