Firouzeh Gholampour

Shiraz University · Department of Biology

Background Remote limb ischemic pre-conditioning (RIPreC) can invoke potent renal protection. The involvement of oxidative stress and inflammatory pathways in renal ischemia/reperfusion injury (I/RI) was also confirmed. This study was designed to investigate the RIPreC effects on IRI-induced kidney dysfunction in rats through NFĸB/TNF-α/TGF-ꞵ/apeli...

Background Hyperglycemia-induced oxidative stress is a significant contributor to diabetic complications, including hepatopathy. The current survey aimed to evaluate the ameliorative effect of quercetin (Q) on liver functional disorders and tissue damage developed by diabetes mellitus in rats. Methods Grouping of 35 male Wistar rats was performed...

Background One of the main causes of diabetic nephropathy is oxidative stress induced by hyperglycemia. Apelin inhibits insulin secretion. Besides, renal expression of TGF-β is increased in diabetes mellitus (DM). The preventive effect of quercetin (Q) against renal functional disorders and tissue damage developed by DM in rats was assessed. Metho...

Introduction: Diabetes mellitus is a chronic metabolic disease with life threatening complications such as diabetic retinopathy, renal failure and cardiovascular disease. Metformin, Glibenclamide, Acarbose, Empagliflozin, Sitagliptin and Repaglinide are the most common drugs for reducing the blood glucose. The blood glucose-lowering drugs have side...

This article discusses SARS-CoV-2 entry pathways in renal tissue and the pathophysiologicalm mechanisms of renal involvement by COVID-19.

Background This study determined the potential hepato- and renal protective role of berberine and hydroalcohol extract of Berberis integerrima (barberry) against cisplatin-induced acute liver and kidney injury. Methods Animals were dedicated into six groups (n=7 per group): control, control+Ber (berberine, 0.4 mg/kg/day during 10 days, i.p.), cont...

Background This study determined the possible anti-inflammatory and antioxidant renal protective effect of genistein, a soy isoflavone, against kidney damage and functional disorders following renal ischemia/reperfusion (I/R) in male rats. Materials and Methods The animals were dedicated to five groups (n=7 per group): Sham, Sham+Geni (genistein,...

Background: Ischemic acute kidney injury is associated with an inflammatory reaction. Objective: In the current study, berberine was assessed for its effect on the functional disorders and histological damages of testis induced by renal ischemia/reperfusion (I/R). Materials and Methods: Twenty-eight adult male Wistar rats (260-300 gr) were equally...

Background: Renal ischemia/reperfusion injury (IRI) can result in impaired ability of urine concentration and increased sodium fractional excretion. Apelin, a (neuro) vasoactive peptide, enhances diuresis by increasing the renal microcirculation and by counteracting the antidiuretic effect of arginine vasopressin on the tubules. However, changes i...

Abstract Background: Renal ischemia/reperfusion (I/R ) is considered as one of the most prevalent reasons of acute renal failure (ARF). As renal failure is progressed, renal gluconeogenesis and insulin clearance are decreased. Berberine is the most important alkaloid of Berberis vulgaris. It has anti-diabetic, anti-inflammatory, and anti-microbial...

Iron is a vitally important element for the maintenance of health in living organisms. But, iron overload can be toxic. This study investigated the protective efficacy of quercetin against ferrous sulfate-induced oxidative stress, hepato- and nephrotoxicity in rats. There were five experimental groups (n = 7): Sham (distilled water, 1 ml/day for 14...

The pathogenesis of renal ischemia–reperfusion injury (IRI) involves both inflammatory processes and oxidative stress in the kidney. This study determined whether remote ischemic per-conditioning (RIPerC) is mediated by toll-like receptor 4 (TLR4) signaling pathway in rats. Renal IR injury was induced by occluding renal arteries for 45 min followed...

Objectives: We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats. Materials and methods: I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was performed using four cycles o...

Objectives: Iron is an essential element for living organisms. Iron overload can have detrimental effects on health. This study pertains to the protective role of berberine against ferrous sulfate-induced hepatic and renal functional disorders and histological damages in rats. Materials and methods: The rats were divided into four groups (n=7):...

Objective Iron overload in the body is related with toxic effects and threatens the health. The aim of this study was to evaluate the protective role of hydroalcoholic extract of ginger (Zingiber officinale) against ferrous sulfate-induced hepatic and renal functional disorders and histological damages in rats. Materials and Methods The rats were...

Introduction:The licorice (Glycyrrhizaglabra) rhizome has been widely used in traditional medicine for treatment of gastrointestinal diseases such as gastric ulcer and relieve intestinal spasms. In the present study, the effect of hydro-alcoholic extract of licoricerhizome on mechanical activity of isolated colon of male rats has been studied. Met...

This study investigated the effect of orexin-A on the renal dysfunction and histological damage induced by ischaemia/reperfusion at an early stage. Pentobarbital anaesthetised rats were prepared for measuring renal functional variables. Ischaemia was induced by bilateral renal artery clamping for 30 min followed by a 1-h reperfusion period. In orex...

This study investigated the effect of berberine on the hepatic dysfunction and histological damage induced by renal ischaemia/ reperfusion (I/R) at an early stage. There were four groups (n=7). In Ber+I/R group, rats received berberine (Ber; 15 mg/kg/day) orally for 7 days before induction of ischemia. I/R group received distilled water orally for...

Abstract Background & aim: Glycyrrhiza glabra (Licorice is a native plant native of Iran, which is traditionally used as a medicinal plant for treatment of diseases such as gastric ulcer and arthrosclerosis. The purpose of this study was to evaluate the effect of alcoholic extract of Glycyrrhiza glabra on the electrocardiogram and interaction with...

Background & aim: Glycyrrhiza glabra (Licorice is a native plant native of Iran, which is traditionally used as a medicinal plant for treatment of diseases such as gastric ulcer and arthrosclerosis. The purpose of this study was to evaluate the effect of alcoholic extract of Glycyrrhiza glabra on the electrocardiogram and interaction with cholinerg...

Introduction: This study investigated the effect of berberine on renal dysfunction and histological damages of the lung induced by renal ischemia/ reperfusion at an early stage. Methods: There were four experimental groups of adult male rats (n=7). Seven days before induction of ischemia, the Ber+I/R group received oral (by gavage) berberine (15 mg...

Recent studies have shown remote effects of renal Ischemia/Reperfusion (I/R) injury on the liver. Furthermore, I/R injury is correlated with the generation of Reactive Oxygen Species (ROS). This study investigated the effect of Rosa canina on the hepatic dysfunction and histological damage induced by renal ischaemia/ reperfusion at an early stage....

Introduction: Orexins are novel neuropeptides that are localized in neurons in the lateral hypothalamus. They are implicated in a wide variety of physiological functions. Orexin peptides and receptors are found in many peripheral organs such as kidneys. It has been demonstrated that exogenous orexin-A can induce protective effects against ischemia-...

This research evaluated the possible therapeutic potential of Rosa canina as a preventive agent in ischmia/reperfusiom induced acute renal failure in rats. There were three groups (n = 10), in which rats received orally 7 days before induction of ischemia, hydroalcoholic extract of R. canina (500 mg/kg) in R. canina + ischmia/reperfusiom (I/R) grou...

Influence of long term exposure to electromagnetic field on serum concentration of glucose and insulin

Background: Ischemia/reperfusion induced acute renal failure causes excretory functional disorders of nephrons. Ischemia/reperfusion injury is accompanied by generation of reactive oxygen species that leads to dysfunction, injury, and death of renal cells. Antioxidants of plant origin minimize the harmful effects of reactive oxygen species. The aim...

Extremely Low Frequency Electromagnetic Fields (ELFEMFs) are produced by a variety of different sources. The aim of this study was to evaluate the influence of ELFEMF on function and structure of testis in rats. Experimental adult male Wistar rats were exposed to a 50 Hz ELFEMF, 1 MT (emitted from solenoid) for 24 h daily during 135 days. The sham...

Introduction: Nitric Oxide is an important endogenous compound that acts as bronchodilator in trachea. Electromagnetic fields (EMF) affect nitric oxide level in different tissues. The interaction of nitrergic and cholinergic systems in airways has been reported. Therefore, the present study was performed to evaluate the interaction of cholinergic a...

Extremely low frequency electromagnetic fields (EMFs) produce both positive and negative effects on biological processes and the present study was aimed to evaluate the effect of low frequency EMF on some biochemical parameters in rats. Forty five rats in 3 groups viz., control group (kept under normal conditions in animal room), group 2 (exposed f...

The kidney is a major potential route for the absorption of hazardous materials encountered in the environment. The aim of this study was to evaluate the influence of ELFEMF on function and structure of kidney in rats. Experimental adult male Wistar rats were exposed to a 50 Hz ELFEMF, 1 mT (emitted from solenoid) for 24 h daily during 135 days. Th...

There are several reports that indicate a linkage between exposure to Extremely Low Frequency Electromagnetic Fields (ELFEMF) with a variety of biological effects. The aim of this study was to evaluate the influence of ELFEMF on endocrine secretion and structure of pancreas in rats. Experimental adult male wistar rats were exposed to a 50 Hz ELFEMF...