Fiona Streckmann

• Dr.
• PostDoc Position at University of Basel

Background Numerous studies have explored the impact of controlled exercise interventions in type 2 diabetes, as physical activity can positively influence its progression. However, our understanding of how broader lifestyle interventions can effectively promote physical activity in practical real-world scenarios remains limited. Objective This sy...

Introduction Thanks to modern therapy, the survival rate for children with cancer is constantly improving. However, the strong treatment with chemotherapy also takes its toll. It leads to delays in motor milestones (e.g. running, climbing), which limits social reintegration as well as quality of life (Bjornard et al. 2018). Peripheral neuropathy (C...

Introduction Modern therapy has improved survival for children with cancer. However, treatment has unintended consequences. More and more studies are showing that children have persisting motor and sensory dysfunctions, such as loss of sensation, numbness, pain, absent reflexes as well as loss of balance control. Developmental milestones such as wa...

Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and clinically relevant adverse effect of chemotherapy, negatively impacting patient quality of life. The lack of effective preventive or therapeutic options regarding CIPN often requires changes in cancer therapy, potentially resulting in reduced survival. Meanwhi...

Importance Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and clinically relevant adverse effect of chemotherapy, negatively impacting patient quality of life. The lack of effective preventive or therapeutic options regarding CIPN often requires changes in cancer therapy, potentially resulting in reduced survival. Objectiv...

Long COVID's (LC) emergence drives research and novel treatments for myalgic encefalitis ME/CFS. Sensomotoric-training's potential to regenerate ectodermal fibers offers hope for SFN patients. Research Focus: Long COVID's surge prompts innovative ME/CFS treatments targeting underlying causes. Sensomotoric-training's fiber regrowth potential could...

Introduction Changing lifestyle can delay the progression of type 2 diabetes (T2D). Although there are evidence-based recommendations on diet and physical activity (PA; Colberg et al., 2016; Evert et al., 2019), T2D patients have difficulties implementing them (Booth, et al., 2013). Therefore, we have developed an intervention to promote PA and a...

Introduction Neuropathies are a prevalent, heterogeneous group of diseases of the peripheral nervous system. Symptoms are often debilitating, difficult to treat, and usually become chronic. Not only do they diminish patients’ quality of life, but they can also affect medical therapy and lead to complications. To date, for most conditions there are...

Die therapieinduzierte Polyneuropathie ist eine oft unterschätzte Langzeitnebenwirkung moderner onkologischer Therapien. Die Rehabilitationsdiagnostik zielt deshalb darauf, Ausmaß und funktionelle Beeinträchtigungen im Alltag festzustellen. Eine besondere Bedeutung kommt dabei der Überprüfung des Lagesinns anhand des Vibrationsempfindens und Funkti...

Introduction The widespread prevalence of type 2 diabetes (T2D) not only influences patients’ daily lives but also has an economic impact on society. Increasing physical activity and a healthy diet can delay the progression of T2D. Although there are evidence-based recommendations on diet and physical activity, patients with T2D have difficulties i...

Whole-body vibration (WBV) is a feasible and potentially beneficial exercise strategy for managing neuromuscular impairments like decreased strength or flexibility, mobility limitations and bone health in pediatric cancer survivors. However, as starting rehabilitation as early as possible is recommended to preserve physical function, this study inv...

IntroductionPeripheral neuropathies are a prevalent, heterogeneous group of diseases of the peripheral nervous system. Symptoms are often debilitating, difficult to treat, and usually become chronic. Not only do they diminish patients’ quality of life, but they can also affect medical therapy and lead to complications. To date, for most conditions...

Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect of neurotoxic antineoplastic agents commonly used to treat cancer. Patients with CIPN experience debilitating signs and symptoms, such as combinations of tingling, numbness, pain, and cramping in the hands and feet that inhibit their daily function. Among the limited prevention...

Zusammenfassung Bei einem Sensomotoriktraining (SMT), hier konkret einem Gleichgewichtstraining als Unterform des SMT, werden Übungen auf unterschiedlich stabilen Untergründen und in verschiedenen Standpositionen durchgeführt. Es hat das Potenzial, Regenerations- und Anpassungsmechanismen anzuregen und so zur Plastizität des Nervensystems beizutrag...

Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and dose-limiting toxicity of many widely used chemotherapy regimens for the treatment of common cancers including lung, breast, prostate, gastrointestinal, and blood cancers. Symptoms include numbness, tingling, pain, and cramping in the hands and feet, as well as impaired bal...

Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent, severe, and dose-limiting toxicity of several chemotherapy regimens for the treatment of multiple cancers including lung, breast, prostate, gastrointestinal, blood, and others. Patients with CIPN may experience numbness, tingling, pain, and cramping in the hands and feet, as w...

Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically relevant side effect of chemotherapy. The symptoms diminish patients’ quality of life and represent a decisive limiting factor for medical therapy. To date, effective treatment options are lacking. Specific exercise interventions have proven promising to target relevant...

Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically meaningful side effect of cancer treatment. CIPN is induced by neurotoxic agents, causing severe sensory and/or motor deficits, resulting in disability and poor recovery, reducing patients’ quality of life and limiting medical therapy. To date, effective tr...

Purpose Low levels of physical activity often observed in pediatric oncology might be attributed to various functional deficits, especially those of the lower limbs as these affect gait, mobility, and, consequently, physical activity. In the past few years, whole-body vibration (WBV) has emerged as a new therapy modality for improving physical func...

Background: Although people with haematological malignancies have to endure long phases of therapy and immobility, which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocytopenia from which many patie...

Periphere Neuropathien sind eine heterogene Gruppe von Erkrankungen des peripheren Nervensystems und mit einer Prävalenz von 5–9 % der Gesamtbevölkerung ein häufiges Krankheitsbild. Kausale Therapien existieren nahezu nur für inflammatorische Neuropathien. Die Sporttherapie ist derzeit eine vielversprechende weitere Option. Neuromuskulär stimuliere...

Purpose: To assess a whole-body vibration (WBV) intervention for children after cancer treatment. Methods: Eleven children after inpatient anticancer therapy participated in a 12-week supervised WBV intervention, which consisted of one 9- to 13-minute WBV session per week, with 5 to 9 minutes' overall vibration time. Feasibility was defined as t...

Periphere Neuropathien sind eine heterogene Gruppe von Erkrankungen des peripheren Nervensystems und mit einer Prävalenz von 5–9 % der Gesamtbevölkerung ein häufiges Krankheitsbild. Kausale Therapien existieren nahezu nur für inflammatorische Neuropathien. Die Sporttherapie ist derzeit eine vielversprechende weitere Option. Neuromuskulär stimuliere...

Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and clinically relevant side-effect of cancer treatment. There are no effective treatment options to reduce the symptoms of CIPN. Promising results have so far been achieved with specific exercise interventions. We would therefore like to conduct a prospective, multicenter, ran...

Purposes: Physical activity is supposed to decrease mortality of colorectal cancer (CRC) and is suggested to reduce side-effects of the disease and its treatment. However, the knowledge about the influence of exercise interventions on patients suffering from CRC and metastasized CRC (mCRC) is still sparse. One frequently observed side effect in mC...

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected. CIPN is induced by neurotoxic chemotherapeutic agents and can manifest with sensory and/or motor deficits. It is associated...

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and relevant side effect of antineoplastic agents such as cisplatin, paclitaxel, vincristine and bortezomib. Over the last years, significant progress has been achieved in elucidating the underlying pathomechanisms of CIPN using both in vivo and in vitro models. These studies suggest tha...

Entwickeln Krebspatienten eine chemotherapieinduzierte Polyneuropathie (CIPN), verringert dies nicht nur deren Lebensqualität, sondern es kann auch die medizinische Therapie negativ beeinflussen. Bisher gibt es keine zufriedenstellende präventive oder symptomatische Behandlung. Vielversprechend erweisen sich nach neuesten wissenschaftlichen Erkennt...

Improvements in survival rates in pediatric oncology have resulted in a growing need to identify adverse effects and improve rehabilitation in this population. This cross-sectional study aimed to investigate active ankle dorsiflexion (DF) range of motion (ROM), gait, walking efficiency, and motor performance in a mixed childhood cancer survivor pop...

Exercise has been proven to reduce the risk and progression of various diseases, such as cancer, diabetes and neurodegenerative disorders. Increasing evidence suggests that exercise affects the cytokine profile and changes distribution and function of tumor-competitive immune cells. Initial studies have shown that different exercise interventions a...

Introduction: Physical exercise has increasingly been recognized as important supportive therapy for cancer patients. Scientific studies applied a variety of methods for endpoint assessment. In order to improve comparability between studies, this paper provides recommendations for outcome assessment in the oncological setting. Discussed endpoints a...

Background: Although people with haematological malignancies have to endure long phases of therapy and immobility which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocytopenia from which many patien...

Die Chemotherapie-induzierte periphere Polyneuropathie (CIPN) ist eine der relevantesten Therapie-assoziierten Nebenwirkungen. Sie führt zu motorischen und sensorischen Dysfunktionen, die zum einen die Lebensqualität der Patienten reduzieren und zum anderen die medizinische Therapie beeinträchtigen. Derzeit besteht kein effektives Behandlungskonzep...

Introduction Peripheral neuropathies (PNPs) encompass a large group of disorders of heterogeneous origin which can manifest themselves with sensory and/or motor deficits depending on the predominantly affected nerve fiber modality. It represents a highly prevalent disease group which can be associated with significant disability and poor recovery....

Lymphoma patients undergoing therapy must cope with the side-effects of the disease itself, therapy and associated immobility. Peripheral neuropathy (PNP), loss of balance control and weakness not only diminishes patients' quality of life (QOL), it can also affect planning and the dosage of therapy. Exercise may enable patients to reverse these dec...

Most scientific studies regarding physical activity in cancer patients involve breast cancer patients. It is apparent that physical activity during medical treatment and aftercare is not only feasible and safe but also effective. Current studies clearly show that regular and specific endurance and/or resistance training can reduce a number of side...

Eine Krebserkrankung selbst sowie deren intensive medizinische Behandlung haben einen enormen, häufig lang anhaltenden Einfluss auf das körperliche, funktionale, emotionale und soziale Wohlbefinden des Krebspatienten (Courneya 2003). Die meist lange Behandlung führt oft zu einer reduzierten Mobilität , die eine Minderung der körperlichen Leistungsf...