Finosh G T

Finosh G T
Western University of Health Sciences · Translational Research

PhD

About

105
Publications
32,719
Reads
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981
Citations
Citations since 2016
87 Research Items
888 Citations
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
Additional affiliations
August 2019 - present
Western University of Health Sciences
Position
  • Professor (Assistant)
August 2015 - present
Creighton University
Position
  • PostDoc Position
January 2011 - December 2014
Sree Chitra Tirunal Institute for Medical Sciences and Technology
Position
  • PhD Student

Publications

Publications (105)
Article
Myocardial regenerative strategies are promising where the choice of ideal cell population is crucial for successful translational applications. Herein, we aim to explore the regenerative/repair responses of infarct zone cardiac fibroblasts (CF) by unveiling their phenotype heterogeneity at single cell resolution. CF were isolated from the infarct...
Article
Cardiac tissue engineering is an emerging approach for cardiac regeneration utilizing the inherent healing responses elicited by the surviving heart using biomaterial templates. In this study, we aimed to develop hydrogel scaffolds for cardiac tissue regeneration following myocardial infarction (MI). Two superabsorbent hydrogels, CAHA2A and CAHA2AP...
Article
The present study hypothesizes that the ischemic insults activate epicardial adipose tissue-derived stem cells (EATDS) to secrete extracellular vesicles (EVs) packed with regenerative mediators to alter the gene expression in cardiac fibroblasts (CF). EATDS and CF were isolated from hyperlipidemic microswine and EVs were harvested from control, sim...
Article
Full-text available
Myocardial infarction (MI) causes impaired cardiac function due to the loss of cardiomyocytes following an ischemic attack. Intelligent hydrogels offer promising solutions for post-MI cardiac tissue therapy to aid in structural support, contractility, and targeted drug therapy. Hydrogels are porous hydrophilic matrices used for biological scaffoldi...
Article
Full-text available
Tendinopathy is a common tendon disorder that causes pain, loss of strength and function, and local inflammation mainly characterized by hypoxia, collagen degradation, and extracellular matrix (ECM) disorganization. Generally, ECM degradation and remodeling is tightly regulated; however, hyperactivation of matrix metalloproteases (MMPs) contributes...
Article
Arteriovenous fistula (AVF) is the preferred vascular access in hemodialysis patients; however, it is afflicted with a high failure rate. Chronic inflammation, excessive neointimal hyperplasia (NIH), vessel stenosis, early thrombosis, and failure of outward remodeling are the major causes of AVF maturation failure. Inflammatory mediator toll-like r...
Article
Background: Despite the recent advancements in the cardiac regenerative technologies, the lack of an ideal translationally relevant experimental model simulating the clinical setting of acute myocardial infarction (MI) hurdles the success of cardiac regenerative strategies. Methods: We developed a modified minimally invasive acute MI model in Yu...
Article
Lipid burden in macrophages driven by oxidized LDL (oxLDL) accelerates the foam cell formation and the activation of sterile inflammatory responses aggravating the atherosclerosis. However, there is limited information on the mediators and the pathways involved in the possible survival responses, especially at the initial phase, by lipid-burden in...
Article
Full-text available
Significant strides have been made in our understanding of the immune system and its role in cardiac transplant rejection. Despite the growing knowledge of immune responses, the mortality rate following cardiac transplantation remains grim. Related to procedural and pathological complications, toll-like receptor (TLR) and damage-associated molecula...
Article
Ischemic heart disease, a major risk factor for myocardial infarction (MI), occurs when the blood vessels supplying oxygen-rich blood to the heart become partially or fully occluded by lipid-rich plaques resulting in myocardial cell death, remodeling, and scarring. Also, MI occurs as result of lipid rich plaque rupture resulting in thrombosis and v...
Article
Full-text available
Aims Expression status of pro-resolvin lipid mediators (PLM) and receptors in the post-Coronary artery bypass grafting (CABG) coronary arteries are largely unknown. Here, we aim to investigate the expression of the enzymes involved in PLM synthesis and their receptors in the atherosclerotic post-CABG swine (AS) left anterior descending (LAD) compar...
Preprint
Full-text available
Lipid burden in macrophages driven by oxidized LDL (oxLDL) accelerates the foam cell formation and the activation of sterile inflammatory responses aggravating the atherosclerosis. However, there is limited information on the mediators and the pathways involved in the possible survival responses, especially at the initial phase, by lipid-burden in...
Article
Full-text available
Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) has been a potential target in the management of pathophysiology and clinical sequelae of atherosclerosis. LR12 peptide effectively blocks ligand–TREM-1 interaction; however, the short half-life of LR12 is a major hurdle in its translational application in atherosclerosis management warranti...
Article
Full-text available
Since the initial outbreak of coronavirus disease 2019 (COVID-19), extensive research has emerged from across the globe to understand the pathophysiology of this novel coronavirus. Transmission of this virus is a subject of particular interest as researchers work to understand which protective and preventative measures are most effective. Despite t...
Article
Full-text available
Replenishment of tenocytes to the injury site is an ideal strategy to improve healing response and accelerate the tendon ECM regeneration. The present study focused on the synthesis and characterization of a hybrid hydrogel scaffold system poly(propylene-fumarate)-alginate-polyvinyl alcohol-acrylic acid (PAPA) using poly(propylene-fumarate) (PPF),...
Article
Extracellular ribosomal proteins secreted in exosomes elicit biological/regenerative responses; however, ribosomal proteins contained in the exosomes of ischemia‐challenged epicardial adipose tissue‐derived stem cells (EATDS) remain unexplored. This study focuses on the identification of ribosomal proteins in the exosomes of ischemia‐challenged EAT...
Article
Full-text available
The conventional management strategies of myocardial infarction (MI) are effective to sustain life; however, myocardial regeneration has not been achieved owing to the inherently poor regenerative capacity of the native myocardium. Stem cell-based therapies are promising; however, lineage specificity and undesired differentiation profile are challe...
Chapter
Musculoskeletal tissue engineering (MSTE) is emerging as a promising strategy in the accelerated regeneration of various musculoskeletal tissues (MSTs) owing to recent advancements in basic and applied biology, medical science, and engineering technology. MSTE aims to address the MST failure/damage/injury due to degenerative and inflammatory disord...
Chapter
Tissue engineering is an emerging area in medical sciences due to its advantages over organ transplantation. A successful TE requires appropriate biomaterial scaffolds, ideal cells, and growth mediators along with advanced regenerative technologies. An array of innovative technologies is being designed and demonstrated in advanced TE applications a...
Chapter
The emerging principles of tissue engineering (TE) and regenerative medicine (RM) have already been marked as the beginning of a new epoch for next-generation therapeutics/treatment strategies. This chapter overviews the historical concepts and outstanding discoveries that geared the evolution of current TE and RM.
Chapter
Myocardial infarction is a serious cardiovascular complication causing severe health crisis and a major contributor to global death toll. The insufficiency of current management strategies and lack of donor organs for transplantation have led to the emergence of cardiac tissue engineering (CTE) as a promising therapeutic approach. Despite the prese...
Chapter
Search for an effective solution for organ failure always ends up to the organ replacement or transplantation. Especially, the damage to the most vital organs such as brain, heart, lungs, and kidney is extremely complicated to recover even with invasive surgical interventions. The field of tissue engineering and regenerative medicine (TERM) opens a...
Chapter
A comprehensive understanding regarding the structure and physiological components of the periodontium is essential to develop insights into the pathological process/responses elicited by these tissues. Such understanding is crucial for evolving tissue engineering/regenerative strategies aiming to prevent or cure the periodontal diseases. This chap...
Article
Full-text available
The global burden of cerebrovascular disease, especially cerebral infarction has been increasing at an alarming rate with the atherosclerosis in carotid arteries as the primary risk factor. Despite the active involvement of minimally oxidized LDL (oxLDL) in atherosclerosis, limited information is available regarding the role of oxLDL in the pathoge...
Chapter
Restenosis involves re-narrowing of the arterial lumen and leads to the restriction of blood flow. As a common occurrence following interventional procedures, including balloon angioplasty and intravascular stenting, to treat atherosclerotic lesions, restenosis can pose a serious problem. Animal models have significantly advanced our knowledge to b...
Preprint
Full-text available
Aims: Expression status of pro-resolving lipid mediators (PLM) and receptors in the post-CABG coronary arteries are largely unknown. Here, we aim to investigate the expression of PLMs in the atherosclerotic post-CABG swine LAD compared to without CABG (LAD-AS), and in isolated coronary artery smooth muscle cells (CASMCs) cultured under ischemia. Me...
Article
Objective Vein graft failure is a major complication following coronary artery bypass graft surgery. There is no translational model to understand the molecular mechanisms underlying vein-graft failure. We established a clinically relevant bypass graft model to investigate the underlying pathophysiological mechanisms of vein-graft failure and ident...
Article
Background Type 2 diabetes mellitus (T2DM) and periodontitis are two biologically linked diseases that often coexist in complex interaction. While periodontitis may lead to insulin receptor desensitization, diabetes may increase the expression of inflammatory cytokines, such as Tumor Necrosis Factor-α (TNF-α) and Interleukin 6 (IL-6), in the gingiv...
Article
Full-text available
Development of incisional hernia (IH) is multifactorial but inflammation and abdominal wall ECM (extracellular matrix) disorganization are key pathological events. We investigated if the differential expression of fibroblast biomarkers reflects the cellular milieu and the dysregulated ECM in IH tissues. Expression of fibroblast biomarkers, includin...
Article
Full-text available
Cardiovascular disease continues to grow as a massive global health burden, with coronary artery disease being one of its most lethal varieties. The pathogenesis of atherosclerosis induces changes in the blood vessel and its extracellular matrix (ECM) in each vascular layer. The alteration of the ECM homeostasis has significant modulatory effects o...
Chapter
The recent advancements in nanotechnology have opened immense opportunities for the management several clinical complications. The multidisciplinary approach of combining drug delivery and image-guided diagnostics led to the evolution of theranostic approaches which exhibit significant translational potential. However, these approaches are still in...
Article
Full-text available
Shoulder tendon injuries are the common musculoskeletal disorder resulting in significant pain and disability. These injuries are characterized by chronic inflammation and tissue degeneration. Tendons exhibit poor innate healing ability and enhanced inflammation, disorganization of the collagen fibers, calcification, and scar tissue formation affec...
Article
Cardiovascular disease (CVD) is a major contributor to annual deaths globally. Atherosclerosis is a prominent risk factor for CVD. Although significant developments have been recently made in the prevention and treatment, the molecular pathology of atherosclerosis remains unknown. Interestingly, the recent discovery of proprotein convertase subtili...
Article
Full-text available
Demand for donor hearts has increased globally due to cardiovascular diseases. Recently, three-dimensional (3D) bioprinting technology has been aimed at creating clinically viable cardiac constructs for the management of myocardial infarction (MI) and associated complications. Advances in 3D bioprinting show promise in aiding cardiac tissue repair...
Article
Full-text available
Atherosclerosis involves both innate and adaptive immunity. Here, we provide an overview of the role of regulatory T (Treg) cells in atherosclerotic diseases. Treg cells and their inhibitory cytokines, IL-10 and TGF-β, have been identified in atherosclerotic lesions and to inhibit progression through lipoprotein metabolism modulation. Treg cells ha...
Article
Full-text available
Atherosclerosis results in life-threatening cardiovascular pathologies, including ischemic heart disease, stroke, myocardial infarction, and peripheral arterial disease. The role of increased serum low-density lipoprotein (LDL) and resultant accumulation of oxidized-LDL (oxLDL) in atheroma formation is well established. Recent findings elucidate th...
Article
Full-text available
Chronic kidney disease is a widespread terminal illness that afflicts millions of people across the world. Hemodialysis is the predominant therapeutic management strategy for kidney failure and involves the external filtration of metabolic waste within the circulation. This process requires an arteriovenous fistula (AVF) for vascular access. Howeve...
Preprint
Full-text available
Development of incisional hernia (IH) is multifactorial but inflammation and abdominal wall ECM (extracellular matrix) disorganization are key pathological events. We investigated if the differential expression of fibroblast biomarkers reflects the cellular milieu and the dysregulated ECM in IH tissues. Expression of fibroblast biomarkers, includin...
Article
Full-text available
Atrial fibrillation (AF) is the most common cardiac arrhythmia diagnosed in clinical practice. Even though hypertension, congestive heart failure, pulmonary disease, and coronary artery disease are the potential risk factors for AF, the underlying molecular pathology is largely unknown. The reversion of the mature cardiomyocytes to fetal phenotype,...
Book
Full-text available
3D Printing / Regenerated Organs /
Chapter
The significantly increasing mortality rate due to CVDs, especially myocardial infarction (MI), has markedly increased the global agony. Heart transplantation has been the ultimate lifesaving management strategy for end stage cardiac failure; however, the lack of enough donors offers a major constrain. In addition, the multitude of complications as...
Chapter
Oro-dental diseases affect a lion’s share of global population suggesting the increasing demand for novel regenerative strategies. This chapter throws insights into the pathological implications of common oro-dental disorders and discusses the advancements in the diverse regenerative strategies. The current understanding regarding the tissue engine...
Article
Introduction: Innate and adaptive immunity play a critical role in the underlying pathological mechanisms of atherosclerosis and potential target sites of sterile inflammation open opportunities to develop novel therapeutics. In response to oxidized LDL in the intimal layer, T cell subsets are recruited and activated at the site of atheroma to upre...
Article
Performance of the biomaterials used for regenerative medicine largely depends on biocompatibility; however,, but the biological mechanisms underlying biocompatibility of a biomaterial within the host system is poorly understood. In addition to the classical immune response against non-self-entities, the sterile inflammatory response could limit th...
Article
Patients diagnosed with atrial fibrillation (AF) have been rising due to increased incidence, enhanced detection methods, and greater survival rates following diagnosis. Due to this increase, AF is now the most commonly diagnosed arrhythmia in clinical practice. AF is characterized by irregular, high-frequency contractions of atrial myocytes that l...
Article
Full-text available
The global incidence of coronary artery diseases (CADs), especially myocardial infarction (MI), has drastically increased in recent years. Even though the conventional therapies have improved the outcomes, the post-MI complications and the increased rate of recurrence among the survivors are still alarming. Molecular events associated with the path...
Chapter
The global incidence of coronary heartHeart diseases (CHDs) has been increasing at an alarmin rate that demands an increasing attention to develop more effective therapeutic interventions and preventive strategies. The basic and applied research have significantly advanced the understanding on the molecular pathology of CHDs and opened multiple tra...
Article
Background: Incisional hernias (IH) following a laparotomy, on average, occur in 10-20% of patients, however, little is known about its molecular basis. Thus, a better understanding of the molecular mechanisms could lead to the identification of key target(s) to intervene pre-and post-operatively. Methods: We examined the current literature desc...
Article
The major hallmark of rotator cuff tendinopathies (RCT) is the disorganization of tendon extracellular matrix (ECM) which is due to decrease in the collagen I-to-collagen III ratio. In addition, the pathology of tendon matrisome remains asymptomatic and hypoxia has been identified to be the priming signal to initiate the molecular pathology of RCT....
Article
Coronary artery bypass grafting (CABG) is the standard treatment modality in revascularization of the myocardium. However, the graft failure remains the major complication following CABG procedure. Involvement of mitochondrial damage-associated molecular patterns (mt-DAMPs) in the pathogenesis of vein-graft failure is largely unknown. Here, we inve...
Article
The growing rate of COVID-19 infection has resulted in serious health crisis and caused a huge socio-economic burden across the globe. Apart from the respiratory system, COVID-19 displayed severe pathological impact on other organs especially in the cardiovascular system as evident from the increased risk of infection and mortality among CVD patien...
Article
Full-text available
Regenerative functions of exosomes rely on their contents which are influenced by pathological stimuli, including hypoxia, in rotator cuff tendon injuries (RCTI). The hypoxic environment triggers tenocytes and adjacent adipose-derived mesenchymal stem cells (ADMSCs) to release regenerative mediators to the ECM via the exosomes which elicit autocrin...
Chapter
Organ transplantation has been considered to be a promising strategy to treat end-stage organ failure. However, the difficulty to procure healthy organs and tissues offers the major challenge for this treatment modality. Recently, tissue engineering (TE) and regenerative medicine emerged as an alternative approach, wherein the intrinsic healing cap...
Article
Rotator cuff tears are common musculoskeletal injuries that can cause significant pain and disability. While the clinical results of rotator cuff repair can be good, failure of tendon healing remains a significant problem. Molecular mechanisms underlying structural failure following surgical repair remain unclear. Histologically, enhanced inflammat...
Article
Introduction: Incisional hernias (IH) arise as a complication of patients undergoing a laparotomy. Current literature has assessed the role of extracellular matrix (ECM) disorganization, alterations in type I and type III collagen, matrix metalloproteinases, and tissue inhibitors of metalloproteases on IH. However, there is limited information on t...
Article
Full-text available
Tendonosis is characterized by an increase in collagen type III relative to collagen type I, but the precise ratio of collagen type I to collagen type III in pathologic shoulder tendons has not been reported. A tendon continuously bathed in an OA synovial environment may exhibit histomorphologic differences as compared to those from shoulders with...
Article
Full-text available
Fatty infiltration and inflammation delay the healing responses and raise major concerns in the therapeutic management of rotator cuff tendon injuries (RCTI). Our evaluations showed the upregulation of ‘metabolic check point’ AMPK and inflammatory molecule, TREM-1 from shoulder biceps tendons collected from RCTI subjects. However, the epigenetic re...
Article
The pathophysiology underlying the formation, progression, and surgical healing of incisional hernia (IH) that develops as a major complication associated with abdominal laparotomy is poorly understood. The proposed mechanisms include the switch of collagen phenotype and the proliferation of abnormal fibroblasts after surgery. The focus of this art...
Article
Full-text available
Purpose of Review Specific differences in the altered molecular mechanisms between healthy tendon tissues and tendinopathy-afflicted tendon largely correlate with increase in collagen type III and a decrease in collagen type I. The canonical IL-1R-mediated inflammation, the TGF-β/Smad signaling, and JAK/STAT pathways have been implicated as importa...