Finn Friis Lauszus

Sygehus Sonderjylland · Department of Gynecology and Obstetrics

Introduction The role of complete staging surgery in women with Adult Ovarian Granulosa Cell Tumors (AOGCTs) remains uncertain. This study aimed to identify risk factors of recurrence and assess the impact of secondary staging surgery on recurrence risk among women who were incompletely staged at primary surgery. Methods Women diagnosed with AOGCT...

Glukokortikoid som kvalitetsindikator ved operationer registreret i danske databaser

Introduktion Med etableringen af hysterektomi-databasen i 2003 blev det muligt at følge kvaliteten på forskellige målepunkter og udviklingen af praksis på forskellige matrikler. Mest går kvaliteten på den operative kvalitet og komplikationer, der er relevante nok, men som ikke kan stå alene for patientens ve og vel. Mest indlysende er diskrepansen...

Introduction Ovarian adult granulosa cell tumor (aGCT) is a rare cancer usually (~90%) diagnosed at an early stage with a favorable survival rate. However, relapses occur in 20-30% and present a challenging management. The effect of adjuvant chemotherapy (AC) is debatable in primary as well as relapsing aGCT and research is limited to small and sel...

Introduction to Gynecological Endocrinology

coming out in SERGS 2024 congress paper

Background Identifying and describing molecular alterations in tumors has become common with the development of high-throughput sequencing. However, DNA sequencing in rare tumors, such as ovarian adult granulosa cell tumor (aGCT), often lacks statistical power due to the limited number of cases in each study. Questions regarding personalized treatm...

Background: Sexual activity and knowledge are frequently surveyed in risk groups or high-school adolescents. However, the link between the descriptive data and sexual performance variables are subject to recall bias and multitude of inputs with a longer time span since debut of any sexual activity. A narrower age range, population-based sampling an...

Sexual activity and knowledge are frequently surveyed in risk groups or high-school adolescents. However, the link between the descriptive data and sexual performance variables are subject to recall bias and multitude of inputs with a longer time span since debut of any sexual activity. A narrower age range, population-based sampling and short time...

Background. Leakage from gastrointestinal anastomoses (AL) is a serious complication associated with increased morbidity and mortality, prolonged hospitalization, and increased treatment costs. Moreover, AL in patients following colorectal resection is associated with an increased risk of cancer-related death and a reduced 5-year survival rate. Sev...

Comment to publication on impelmentation of method in reducing perineal tears

INTRODUCTION Early discharge holds several advantages and seems safe after planned cesarean section among low-risk women. However, breastfeeding rates are lower after cesarean section. Thus, concern has been raised that early discharge among these women may affect breastfeeding even further. Therefore, we aimed to assess the effect of early dischar...

Introduction: Sharing nude photos and exchanging intimacy favors transcends the threshold from hidden and private content into public consciousness. Ever-present is the differentiation between an image shared by consent and those not consented to and distributed as part of harassment, revenge and abuse. Similarly, the continuum of exchanging intima...

Introduction: Genitourinary syndrome of menopause (GSM) is common after natural menopause as well as in women with induced menopause due to endocrine therapy and/or oophorectomy following breast cancer. Vaginal laser therapy is a nonhormonal treatment option that appears to alleviate GSM symptoms in natural menopause; however, women with induced me...

Introduction Sertoli–Leydig cell tumors are rare tumors of the ovary. Moderate and poorly differentiated tumors can metastasize and have a poor outcome. A pathogenic variant in DICER1 is associated with an increased risk of developing these tumors along with other clinical phenotypes. We aimed to describe a national cohort of all Sertoli–Leydig cel...

Background: Robotic-assisted hysterectomy is an alternative to laparoscopic surgery as part of a minimal invasive regimen. Several treatment strategies are followed to improve the overall outcome and minimize surgical stress. Glucocorticoids provide significant analgesic and antiemetic effects but their role in reducing inflammatory stress in a fa...

This state-of-the-art review evaluates whether contraceptive apps could improve knowledge resulting in greater interest and use of long-acting contraception, what type of information an app should contain, and who may benefit most from apps. The studies found a high interest in easy accessibility and respect for privacy. Science- based information...

This state-of-the-art review evaluates whether contraceptive apps could improve knowledge resulting in greater interest and use of long-acting contraception, what type of information an app should contain, and who may benefit most from apps. The studies found a high interest in easy accessibility and respect for privacy. Science-based information a...

INTRODUCTION. Our aim was to conduct a follow-up of a cohort of women screened for GDM with a normal oral glucose tolerance test (OGTT) during pregnancy to investigate the incidence and time of diagnosis of manifest diabetes mellitus and identify risk factors for subsequent development of diabetes. METHODS. This was a follow-up study of a cohort wi...

In this overview of the last ten years of publications, a clear picture emerges that mothers with GDM have a significantly increased risk of their children developing ASD. Whether the timing of the diagnosis of GDM matters is uncertain, but there are many indications that the diagnosis of GDM before gestational week 30 may have an impact on the out...

( Acta Obstet Gynecol Scand . 2021;100:955–963) Enhanced recovery (ERAC) programs aim to decrease the length of hospital stay (LOS) for patients who underwent cesarean delivery (CD). While it can be positive for some parents to be discharged early, it is unclear whether others find it difficult in regard to their sense of security. The aim of this...

Objective: To reveal sexual practice with knowledge about sex education, reproductive physiology and abortion in an unselected population of adolescents. The study was performed in a non-intervention setting to minimize information bias. Design & Methods: A cross-sectional questionnaire was electronically handed out without prior notice to all nint...

INTRODUCTION. Postmenopausal bleeding is the primary reason for referral to the gynaecological fast-track suspected cancer programme due to an elevated risk of endometrial cancer. The aim of this study was to examine the diagnostic flow among women with postmenopausal bleeding. METHODS. Data were collected and analysed from 362 women at Sygehus Sø...

Thirty-four patients were enrolled in the study of vaginal laser treatment with MonaLisa Touch completing three treatments at monthly intervals. After each treatment, the effect sexual function was assessed by PISQ-12, urinary incontinence and overactive bladder symptoms was measured by using ICIQ-UI SF and ICIQ-OAB, and the improvement of incontin...

To investigate the time-course relationship between the maternalserum IGF-1 and the birthweight as an obstetrical outcome in T1DMpregnancies with various levels of background risks.

Spontaneous labor should not be included in the intervention group when discussing induction of labor vs expectant management in post‐term pregnancies.

Purpose. Our aim was a follow-up off a cohort of women screened for GDM with normal oral glucose tolerance test in pregnancy, to investigate the incidence and time of diagnosis of manifest diabetes mellitus and to identify the risk factors for later development of diabetes. Methods. A follow-up study of a cohort with normal oral glucose tolerance t...

Early discharge after caesarean section requires that major surgical complications are diagnosed before the patient leaves the hospital. The aim of this retrospective observational study was therefore to assess the time interval from surgery to diagnosis of major complications in low-risk women after planned caesarean section, where early discharge...

Background To examine which elements of an obstetric anal sphincter injury (OASI) care bundle were protective for OASI. Several interventional trials showed that application of a care bundle involving a hands-on approach to perineal protection may reduce the risk of OASI. Previously, we found that only the element “hand on the fetal head” in itself...

Artikel bragt i Ugeskrift for laeger 2021;183:V03210262 HOVEDBUDSKABER · I Danmark er der praecedens for, at kontrol af medicinsk behandlet provokeret abort i første trimester udføres med måling af humant choriongonadotropin i serum (s-hCG). · Vores erfaringer og internationale studier viser, at kontrol med måling af humant choriongonadotropin i ur...

Medical abortion with combined mifepristone and misoprostol is a highly effective, safe, and widely used method for medical termination of pregnancy. In this review, it is shown that self-testing with a urine human chorionic gonadotropin stix (detection limit > 25 IU/l) four weeks after administration of medication is a safe, practical, and cheap m...

Medical abortion with combined mifepristone and misoprostol is a highly effective, safe, and widely used method for medical termination of pregnancy. In this review, it is shown that self-testing with a urine human chorionic gonadotropin stix (detection limit greater than 25 IU/l) four weeks after administration of medication is a safe, practical,...

Background: Abnormal fetal growth can lead to adverse outcomes in pregnancy as well in later postnatal life and is more prevalent in diabetic pregnancies. These are usually associated with large for gestational age neonates, an issue that has already been broadly examined. On the other side, diabetes in pregnancy can also relate to intrauterine gro...

Abstract To evaluate the incidence and timing of the diagnosis of metabolic syndrome in a cohort of Danish women after a pregnancy with gestational diabetes (GDM) to estimate the optimum time for preventative actions in relation to metabolic syndrome (MetS). In this follow-up study, 435 women were included from a consecutive cohort with prior histo...

Objective In the last decade, there has been an increased interest in exploring the impact of the physical birth environment on midwifery practice and women’s birth experiences. This study is based on the hypothesis that the environment for birth needs greater attention to improve some of the existing challenges in modern obstetric practice, for ex...

Aims To present an overview of reviews of interventions for the prevention of diabetes in women after gestational diabetes mellitus (GDM) with the overall aim of gaining information in order to establish local interventions. Methods Six databases were searched for quantitative, qualitative or mixed‐methods systematic reviews. All types of interven...

Background: Abnormal fetal growth can lead to adverse outcomes in pregnancy as well in later postnatal life and is more prevalent in diabetic pregnancies. These are usually associated with large for gestational age neonates, an issue that has already been broadly examined. On the other side, diabetes in pregnancy can also relate to intrauterine gro...

Introduction: In some European countries, discharge the day after planned cesarean section has become an accepted procedure. However, little is known about the patients' perception of early discharge. The aim of this study was to compare early discharge to standard care in relation to parental sense of security. Further, we evaluated postoperative...

PurposeThe aim was to follow-up two cohorts of women with GDM to investigate the incidence and time of diagnosis of manifest diabetes mellitus (DM) postpartum and identify the risk factors for diabetes in our population.MethodsA follow-up study on two independent cohorts having oral glucose tolerance test (OGTT) in 1991/1992 and 2011–2016: Cohort 1...

Introduction: Length of hospital stay after birth has decreased during the last decades, but nationwide data on length of hospital stay after cesarean section are lacking. Elements of Enhanced Recovery Programs were reported to reduce the length of hospital stay. The aim of this nationwide study was to describe the length of hospital stay after ce...

Substantial evidence exists in support of postpartum lifestyle intervention to prevent diabetes in high-risk populations, among them women with prior gestational diabetes (GDM). Major randomized trials such as the Da Qing IGT and Diabetes study, the US Diabetes Prevention Program, and the Finnish Diabetes Prevention Study present data on the incide...

Introduction: Unsafe situations and unwanted pregnancies may stem from women’s lack of knowledge on Long-Acting Reversible Contraception (LARC). Furthermore, there is evidence that some physicians find it unsuitable to inform about LARCs. Using applications to inform about contraceptives could be the solution. The objectives of this study were to:...

Forsknings-og publiceringsbranchen er under forandring. Hvordan genkender man en »predatory journal«? Forfattere: inn Friis Lauszus, Ole Bredahl Rasmussen Kaere *[indsaet navn]*, som har publiceret så mange gennemgribende velskrevne artikler på et højt plan med ekstraordinaer indsigt. Vi ønsker netop dit eminente bidrag til vores kommende udgivelse...

Guideline for diagnostics, treatment, and follow-up of non-epithelial ovarian cancer

(Abstracted from Acta Obstet Gynecol Scand 2019;98:1420–1428) The minimal invasive procedure, laparoscopic hysterectomy, is safe, has low risk of complications, and requires only a short hospital stay. Within the first 4 weeks after surgery, readmission rates as low as less than 4% have been reported.

Introduction: The objective of the study was to investigate whether outpatient total laparoscopic hysterectomy (TLH) could be performed as a routine without compromising patient satisfaction. The main outcomes were patient satisfaction with length of hospital stay, quality of life, complications and readmissions, and time to return to work. Mater...

Several experimental studies have suggested that vitamin C (vitC) deficiency during pregnancy may be detrimental to fetal development, and observational studies have shown that vitC status is lower during pregnancy and in people with diabetes. A cross-sectional study in pregnant type 1 diabetic women found that poor maternal vitC status was a signi...

Introduction: We aimed to describe sexual behaviour and knowledge about sexually transmitted infections (STI) among Danish adolescents stratified by gender and human papillomavirus (HPV) vaccination status. Methods: We conducted a questionnaire study in Viborg Municipality, Denmark. A validated questionnaire was sent to all ninth-grade pupils wi...

This case report of a 31-year-old primiparous woman discusses the importance of early diagnosis and treatment of acute fatty liver in pregnancy (AFLP) to prevent maternal or/and foetal death. AFLP is a rare disease, which is characterised by maternal liver dysfunction and/or failure. Because of similar symptoms and laboratory findings AFLP may mimi...

This case report of a 31-year-old primiparous woman discusses the importance of early diagnosis and treatment of acute fatty liver in pregnancy (AFLP) to prevent maternal or/and foetal death. AFLP is a rare disease, which is characterised by maternal liver dysfunction and/or failure. Because of similar symptoms and laboratory findings AFLP may mimi...

This case report of a 31-year-old primiparous woman discusses the importance of early diagnosis and treatment of acute fatty liver in pregnancy (AFLP) to prevent maternal or/and foetal death. AFLP is a rare disease, which is characterised by maternal liver dysfunction and/or failure. Because of similar symptoms and laboratory findings AFLP may mimi...

This review concerns the pathophysiology of diabetic pregnancy with special emphasis on macrosomia and the renovascular function in relation to the IGF system and blood pressure (BP). The reason for choosing the selective group of variables for evaluation lies back in time and place when the studies were prepared. Pregnancies complicated with nephr...

The diagnosis of an androgen-secreting tumour of the ovaries should be considered in women with hyperandrogenism. Clinical manifestations of hyperandrogenism include virilisation with hirsutism, vocal change, increased muscle mass, hypertrophy of clitoris and alopecia. Definitive diagnosis is made by histopathologic examination, and the most common...

The diagnosis of an androgen-secreting tumour of the ovaries should be considered in women with hyperandrogenism. Clinical manifestations of hyperandrogenism include virilisation with hirsutism, vocal change, increased muscle mass, hypertrophy of clitoris and alopecia. Definitive diagnosis is made by histopathologic examination, and the most common...

Introduction In the last decade, there has been an increased interest in exploring the impact of the physical birth environment on birth outcomes. The birth environment might have an important role in facilitating the production of the hormone oxytocin that causes contractions during labour. Oxytocin is released in a safe, secure and confidence-ind...

We evaluated which treatment regimens were used - and in particular hormone replacement treatment (HRT) - for bone loss prevention when women were referred to our regional Gynecology clinic Methods: Retrospective follow-up with hospital electronic chart data from all regional hospitals were collected including paraclinical data, DXA results, medica...

The purpose of the ROSE study was to investigate the effectiveness of a two-step population-based osteoporosis screening program using the Fracture Risk Assessment Tool (FRAX) derived from a self-administered questionnaire to select women for DXA scan. After the scanning, standard osteoporosis management according to Danish national guidelines was...

In this case report a 38-year-old woman presented with lower abdominal pain three weeks postpartum. She had been delivered by caesarean section after twin pregnancy and was given low-molecular heparin prophylaxis to be taken six weeks post caesarean. The initial clinical examination was normal. A CT scan revealed thrombosis in the right ovarian vei...

Congenital uterine anomalies (CUAs) are present in up to 10% of all women. Data suggest that women with CUAs are at higher risk of recurrent spontaneous abortions and adverse pregnancy outcomes. It is still debated whether these women have impaired fertility. The complication rate is likely to be overrepresented and assumedly many women with CUAs h...

Objective To analyze the association between each element of a hands-on intervention in childbirth and the incidence of obstetric anal sphincter injuries (OASIS). Study Design We conducted a prospective, interventional quality improvement project and implemented a care bundle with five elements at an obstetric department in Denmark with 3,000 deliv...

Adult Granulosa Cell Tumor (AGCT) is a rare neoplasm, constituting 3 % of malignant ovarian tumors. AGCT has apparently a good prognosis due to >90% in stage I. It is characterized by hormonal activity and late relapses. We used registry data from the PatoWeb on diagnosis and associated cancers. We added from hospital charts the initial staging an...

The time interval from elective cesarean section to severe postoperative complication - a registry study

Sinus tachycardia may have a definite aetiology, but in the remaining cases inappropriate sinus tachycardia (IST) may be considered. IST is primarily treated in order to improve symptoms. During pregnancy, tachycardia-induced cardiomyopathy is rare; however, it needs urgent attention and treatment due to the risk of fast progression. In Denmark, pe...

Sinus tachycardia may have a definite aetiology, but in the remaining cases inappropriate sinus tachycardia (IST) may be considered. IST is primarily treated in order to improve symptoms. During pregnancy, tachycardia-induced cardiomyopathy is rare; however, it needs urgent attention and treatment due to the risk of fast progression. In Denmark, pe...

A unicorn uterus was diagnosed at a cesarean delivery in a woman with known fetal breech presentation and suspected low fetal weight. She had had a failed attempt of cephalic version two weeks before delivery and her baby’s weight was checked regularly in third term. Unicorn uterus is associated with a higher risk of spontaneous abortions, inferti...

In this case report a unicorn uterus was diagnosed at a caesarean delivery in a 23-year-old woman with known foetal breech presentation and suspected low foetal weight. She had had a failed attempt of cephalic version two weeks before delivery, and her baby's weight was checked regularly in third term. Unicorn uterus is associated with a higher ris...

Vitamin C (vitC) is essential for normal pregnancy and fetal development and poor vitC status has been related to complications of pregnancy. We have previously shown lower vitC status in diabetic women throughout pregnancy compared to that of non-diabetic controls. Here, we evaluate the relationship between vitC status late in diabetic pregnancy i...

Adult granulosa cell tumors (AGCTs) comprise 90 % of sex cord stromal ovarian tumors. GCT is characterized by its ability to produce excessive amounts of estrogens in contrast to the more common epithelial neoplasm. Women are usually diagnosed at an early stage due to estrogen-dependent symptoms: -Abnormal vaginal bleeding, -Postmenopausal bleedin...

Adult granulosa cell tumors (AGCTs) comprise 90 % of sex cord stromal ovarian tumors. AGCT is characterized by its ability to produce excessive amounts of estrogens in contrast to the more common epithelial neoplasm. Women are usually diagnosed at an early stage due to estrogen-dependent symptoms: -Abnormal vaginal bleeding -Postmenopausal bleed...

Most studies on sexual behavior and knowledge focus on risk group identification and the conclusions are naturally biased on the primary selection. What we want to know is specific knowledge patterns, sexual attitudes and behavior but also in which way these may be influenced. The social dimension will work in concert with the contents of any quest...

Objectives: The objective of this study was to evaluate the association between the ambulatory arterial stiffness index (AASI) and markers of microvascular disease during pregnancy in women with type 1 diabetes. Study design: A total of 151 women with type 1 diabetes mellitus were recruited for repeat 24-h BP recordings thrice during pregnancy a...