Filippos TourlomousisNational Center for Scientific Research Demokritos | ncsr · Institute of Nuclear and Radiological Sciences, Energy, Technology and Safety (I.N.RA.S.T.E.S.)
Filippos Tourlomousis
PhD
founder & Chief Scientist of Superlabs | founder of Biological Lattice Industries Corp.
About
31
Publications
8,058
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240
Citations
Citations since 2017
Introduction
Additional affiliations
September 2017 - present
August 2012 - August 2017
September 2010 - June 2011
Position
- Research Assistant
Description
- Determination of critical smoke ventilation for a car-park fire using small-scale testing with helium along with PIV & Laser Scattering Techniques were employed as characterization techniques.
Publications
Publications (31)
The authors have previously reported a rigorous macroscale modeling approach for an in vitro 3D dynamic microorgan device (DMD). This paper represents the second of a two-part model-based investigation where the effect of microscale (single liver cell-level) shear-mediated mechanotransduction on drug biotransformation is deconstructed. Herein, each...
The dynamic nature of in vitro drug metabolism models demands reliable numerical tools to determine key design parameter values towards high-fidelity cell-based platforms of in vivo drug metabolism. This paper represents the first of a two-part model-based investigation of a 3D dynamic microorgan device (DMD). The prescribed tissue model in this pa...
Engineered microenvironments along with robust quantitative models of cell shape metrology that can decouple the effect of various well-defined cues on a stem cell's phenotypic response would serve as an illuminating tool for testing mechanistic hypotheses on how stem cell fate is fundamentally regulated. As an experimental testbed to probe the eff...
The direct electrostatic printing of highly viscous thermoplastic polymers onto movable collectors, a process known as melt electrospinning writing (MEW), has significant potential as an additive biomanufacturing technology. MEW has the hitherto unrealized potential of fabricating 3D porous interconnected fibrous mesh-patterned scaffolds in conjunc...
Cell morphology: Fabricating 3-D biomaterial substrates using melt electrowriting Melt electrowriting (MEW) is an advanced manufacturing process for fabricating biomaterial substrates, and in conjunction with a machine-learning algorithm to classify cell shapes, enables a cell-based model with high cell shape homogeneity. Adjusting cell shape by al...
In this study, we present a method to construct meter-scale deformable structures for underwater robotic applications by discretely assembling mechanical metamaterials. We address the challenge of scaling up nature-like deformable structures while remaining structurally efficient by combining rigid and compliant facets to form custom unit cells tha...
The present work reports a novel approach in terms of the incorporation of the self-healing agent (SHA) into quasi-isotropic carbon fiber reinforced plastics (CFRPs). More precisely, Bismaleimide-Diels-alder (BMI-DA) type resin, containing or not graphene nanoplatelets (GNPs), was integrated locally in high performance CFRPs by melt electro-writing...
Traces of heavy metals found in water resources, due to mining activities and e-waste discharge, pose a global threat. Conventional treatment processes fail to remove toxic heavy metals, such as lead, from drinking water in a resource-efficient manner when their initial concentrations are low. Here, we show that by using the yeast Saccharomyces cer...
Calibration of highly dynamic multi-physics manufacturing processes such as electro-hydrodynamics-based additive manufacturing (AM) technologies (E-jet printing) is still performed by labor-intensive trial-and-error practices. These practices have hindered the broad adoption of these technologies, demanding a new paradigm of self-calibrating E-jet...
In the current study, a novel approach in terms of the incorporation of self-healing agent (SHA) into unidirectional (UD) carbon fiber reinforced plastics (CFRPs) has been demonstrated. More precisely, Diels–Alder (DA) mechanism-based resin (Bis-maleimide type) containing or not four layered graphene nanoplatelets (GNPs) at the amount of 1 wt% was...
Traces of heavy metals found in water resources, due to mining activities and e-waste discharge, pose a global threat. Conventional treatment processes fail to remove toxic heavy metals, such as lead, from drinking water in a resource-efficient manner when their initial concentrations are low. Here, we show that by using the yeast Saccharomyces cer...
Mechanical metamaterials offer exotic properties based on local control of cell geometry and their global configuration into structures and mechanisms. Historically, these have been made as continuous, monolithic structures with additive manufacturing, which affords high resolution and throughput, but is inherently limited by process and machine co...
This paper presents the effect of transition metal dichalcogenide (TMD) surfaces and their geometric arrangements on resulting cellular morphology and adhesion. WS2 and MoS2 on SiO2 and Polydimethylsiloxane (PDMS) substrates were utilized as cell culture platforms, and cell-substrate interactions were probed via analysis of cellular morphometric fe...
This presentation showcased some of the collaborative efforts between PAXC, a NASA Pathways Intern organization, GlaxoSmithKline, the University of Minnesota, and the Massachusetts Institute of Technology to develop a sounding rocket payload consisting of various experiments for biological and pharmaceutical research. The sounding rocket payload wi...
The significant potential of engineered tissue models is bounded by the current lack of robust scalable additive biomanufacturing processes that reliably capture the cell's structural microenvironments. To address this bottleneck, a melt electrospinning writing system is designed to fabricate 3D fibrous substrates within a tight cellular dimensiona...
Engineered microenvironments along with robust quantitative models of cell shape metrology that can decouple the effect of various well-defined cues on a stem cell's phenotypic response would serve as an illuminating tool for testing mechanistic hypotheses on how stem cell fate is fundamentally regulated. As an experimental testbed to probe the eff...
Bioprinted tissue constructs can be produced by microextrusion-based materials processing or coprinting of cells and hydrogel materials. In this paper, a gelatin-alginate hydrogel material formulation is implemented as the bio-ink toward a three-dimensional (3D) cell-laden tissue construct. However, of fundamental importance during the printing pro...
Bioprinted tissue constructs are enabled by microextrusion-based co-printing of cells and hydrogel materials. In this paper, a gelatin-alginate hydrogel material formulation is implemented as the bio-ink towards a 3D cell-laden tissue construct. However, of fundamental importance during the printing process is the interplay between the various para...
Currently, bioprinting high cellular fractions in bio-inks represents a critical step towards engineered tissue models with enhanced biological relevance. However, precise spatiotemporal mapping of high cell densities within hydrogel materials represents a significant challenge. To address these needs and challenges, this paper advances a systemati...
Transition metal dichalcogenides (TMDs) are emerging two-dimensional (2D) nanomaterials with unique material properties. While the role of TMDs in biomedical applications has been investigated, TMDs as engineered biological substrates have yet to be systematically studied. In this work, the design and fabrication of TMDs (WS2 and MoS2) yield cell c...
With recent advancements in the direct electrostatic printing of highly viscous thermoplastic polymers onto an automated collector, melt electrospinning writing technology (MEW) has shown great potential for addressing the fundamental effects of an engineered scaffold’s dimensional parameters (e.g. fiber diameter, apparent pore size, and pore shape...
Skin thermal burn wounds are classified by depth and require different levels of medical intervention. In this paper, the authors propose a novel treatment method where hyperspectral imaging (HSI) is applied to measure skin burn wound information that guide an additive biomanufacturing process to print a custom engineered skin graft in three dimens...
![Figure 5: A) Contour Map of EFC Concentration [SI: mol/m 3 ] at t = 0...](profile/Filippos-Tourlomousis/publication/278785235/figure/fig4/AS:670030500986897@1536759128778/A-Contour-Map-of-EFC-Concentration-SI-mol-m-3-at-t-0-h-B-Contour-Map-of-EFC_Q320.jpg)
The ability to incorporate three-dimensional (3D) hepatocyte-laden hydrogel constructs using layered fabrication approaches into devices that can be perfused with drugs enables the creation of dynamic microorgan devices (DMDs) that offer an optimal analog of the in vivo liver metabolism scenario. The dynamic nature of such in vitro metabolism model...
In this paper, the authors propose a novel method whereby a prescribed simulated skin graft is 3D printed, followed by the realization of a 3D model representation using an open-source software AutoDesk 123D Catch to reconstruct the entire simulated skin area. The methodology is photogrammetry, which measures the 3D model of a real-word object. Spe...
Controlling cell behavior has generated immense attention in the fields of tissue engineering and regenerative medicine. Particular emphasis has been given to the creation of 3D biomimetic cellular microenvironments that replicate the complex nature of the extracellular matrix (ECM). A key factor that has not been rigorously deconstructed using sca...
Organ printing encompasses bioadditive, digitally controlled manufacturing processes for layered, patterned deposition of complex 3D cell-bearing biological structures. This chapter discusses printing techniques that have evolved to process high-density biopolymer cell suspensions. A review of state-of-art technologies points to a need to address t...
Organ printing encompasses bioadditive, digitally controlled manufacturing processes for layered, patterned deposition of complex 3D cell-bearing biological structures. This chapter discusses printing techniques that have evolved to process high-density biopolymer cell suspensions. A review of state-of-art technologies points to a need to address t...
Physiological tissue-on-a-chip technology is enabled by adapting microfluidics to create micro scale drug screening platforms that replicate the complex drug transport and reaction processes in the human liver. The ability to incorporate three-dimensional (3d) tissue models using layered fabrication approaches into devices that can be perfused with...
Physiological tissue-on-a-chip technology is enabled by adapting microfluidics to create micro scale drug screening platforms that replicate the complex drug transport and reaction processes in the human liver. The ability to incorporate three-dimensional (3d) tissue models using layered fabrication approaches into devices that can be perfused with...
Questions
Questions (2)
Please excuse me but my background in organic chemistry is almost zero! If yes, is there a way to avoid this and still let DCM penetrate the cross linked alginate construct (small circular disk with R = 2 mm and thickness 1mm) by placing it inside a beaker filled with DCM ?
Thank you very much! Any info would be greatly appreciated!
Basically I would like to know if the FEM solution obtained by Comsol could be used as input that could guide agents to behave in a certain way in the same common mesh. For example stem cells on a scaffold with specific material properties that undergoes a certain type of deformation. What is the most appropriate ABM Software? Any guidance or tip on the procedure that must be followed in order to interface it with Comsol Multiphysics 4 would be valuable
Regards,
Filippos
