Filippo Maggi

Filippo Maggi
University of Camerino | UNICAM · School of Pharmacy; Pharmaceutical Botany and Pharmacognosy Unit

Natural Sciences

About

493
Publications
135,540
Reads
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10,365
Citations
Introduction
I'm a pharmaceutical botanist working on bioactive constituents obtained from medicinal and aromatic plants
Additional affiliations
December 2015 - present
University of Camerino
Position
  • Professor (Associate)
February 2013 - March 2013
University of Dschang
Position
  • Professor
Description
  • Teacher at the Master in Pharmacy
December 2012 - December 2015
University of Camerino
Position
  • Senior Researcher

Publications

Publications (493)
Chapter
The growing popularity of nutraceuticals opens new possibilities for typical plant-based products. In particular, nutraceutical features represent the chance to rejuvenate typical food products and improve market sales. The combination of traditional knowledge and experience and the health properties of local plant-based food is the focus of this c...
Chapter
In the last decade there has been an increasing demand for hemp derivatives from legal Cannabis sativa L. (THC content < 0.3%) to be used in different industrial applications, because of the spread of its cultivation and preference in sustainable agricultural systems. In the European Union about 25,000 hectares are cultivated, and more than seventy...
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Carlina acaulis L. is a herb mainly used in central Europe as traditional medicine or food. Recently, C. acaulis essential oil (EO) and its nanoemulsion showed elevated efficacy against several insects of medical and agricultural importance. In the current study, efficacy of C. acaulis EO was estimated against several stored product pests. The EO w...
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Essential oils (EOs) represent innovative and safe botanical pesticides to be exploited in different fields, including agriculture, being often obtained by cheap and easily available plant crops. However, their use is threatened by some limits, which are mainly linked to their physico-chemical properties. In this regard, the use of nanoemulsions (N...
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The essential oils (EOs) produced by a number of Apiaceae species are well known for their insecticidal efficacy against a wide spectrum of insects, including vectors, stored product and agricultural pests. In the real world, rawly formulated EOs are scarcely effective due to their low chemical stability, limited persistence into the environment, a...
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Cannabis sativa L. is a plant that contains numerous chemically active compounds including cannabinoids such as trans-Δ-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), and flavone derivatives, such as luteolin-7-O-glucuronide and apigenin glucuronide. In particular, the polar fraction of hemp including many phenolic compounds has been overlo...
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Recently, spices have attracted the attention of scientists and agrochemical companies for their potential as insecticidal and acaricidal agents, and even as repellents to replace synthetic compounds that are labeled with detrimental impacts on environment and human and animal health. In this framework, the aim of this study was to evaluate the ins...
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Ferns can be a source of polyphenolic compounds, with the fronds being the main parts described in ethnopharmacological studies. The present study screened polyphenolic phytochemicals and evaluated in vitro activities of a methanolic extract of Asplenium adiantum-nigrum L. fronds (AAM), an Aspleniaceae fern collected from the Prades mountains (Tarr...
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Sea fennel (Crithmum maritimum L.) is an edible plant cultivated in high-salinity environments, thus representing an ideal crop in a climate change scenario. Polar extracts and essential oils obtained from this crop cultivated in central Italy were analysed. A total of 21 bioactive compounds, including hydroxycinnamic acids and flavonoids, have bee...
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The forest ecosystem is a source of material resources used since ancient times by mankind. Ferns are part of different oriental systems of traditional medicine due to the phytochemical variety of their fronds, which have allowed their traditional use to be validated through ethnopharmacological studies. In Europe, different cultures have used the...
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Atractyloside, carboxyatractyloside, their aglycon atractyligenin, and several synthetic derivatives were tested and found to be active against a panel of human tumor cell lines. Atractyligenin was subjected to oxidation, bromination, and elimination reactions, obtaining several compounds. A singular skeleton was synthesized by chemical rearrangeme...
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Patagonia is a geographical area characterized by a wide plant biodiversity. Several native plant species are traditionally used in medicine by the local population and demonstrated to be sources of biologically active compounds. Due to the massive need for green and sustainable pesticides, this study was conducted to evaluate the insecticidal acti...
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Concerning the increasing level of ultraviolet (UV) radiation in many parts of the world, researching plant establishment under UV exposure is an essential subject. This experiment was aimed at exploring the effects of UV-B on the germination rate, seedling length, radix and stem's length, seedling's fresh/dry weight, and germination indices of Scr...
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Balangu is a medicinal plant used in the Iranian traditional medicine to treat nervous, hepatic and renal diseases. To determine the effects of Myco-Root biofertilizer and chitosan nano-particles (Cs-NPs) on the physiological and biochemical properties of balangu (Lallemantia iberica (M.Bieb.) Fisch. & C.A.Mey.) under different irrigation levels, a...
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The corn silk (CS) is composed of the thread-like stigmas of female inflorescences of Zea mays L. and represents an important waste material from maize crop production that can be recycled in further applications. In this research, the CS was used for the bio-fabrication of Ag nanoparticles (AgNPs) that were evaluated against (I–V) larval instars a...
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Clinopodium candidissimum (Munby) Kuntze (Lamiaceae) is used in traditional medicine and as a food condiment in Algeria, where it is known as Zaater cheleuh and Nabta elbida. Here, we report the comprehensive characterisation of non-volatile polar constituents extracted from C. candidissimum aerial parts (a mixture of inflorescences, stems and leav...
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Drought stress is known as a major yield-limiting factor in crop production that threatens food security worldwide. Arbuscular mycorrhizal fungi (AMF) and titanium dioxide (TiO2) have shown to alleviate the effects of drought stress on plants, but information regarding their co-addition to minimize the effects of drought stress on plants is scant....
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Chemical characterization of the bulbs of Drimia pancration was conducted to isolate four steroidal saponins (1-4). Earlier, we focused on the structural elucidation of compounds 1-3. Herein, by means of 1H-NMR, 13C-NMR, Nuclear Overhauser Effects (NOE), and 2D-NMR spectra, the full stereochemical structure of 4 is reported, and all the 1H and 13C...
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The manufacturing of apple-based products leads to high volumes of apple pomace (about 25% of the fresh fruit), whose exploitation would be desirable. The aim of this study was to investigate the content of bioactive substances and elements in this waste material. Fatty acids, squalene content and mineral composition were determined in peel and see...
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Background: Stegobium paniceum (Coleoptera, Anobiidae) is an important pest of stored products causing severe damage to dried Chinese medicinal plant materials (CMPMs). Plant volatiles play an important role in host-searching of insects. The olfactory responses of S. paniceum to the most abundant volatile components of some drugstore attractant CM...
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Background: Solvent-free microwave-assisted extraction (MAE) is a green extraction capable of boosting the yield and quality profile of hemp essential oil when compared with other conventional extraction techniques. During this process, two by-products are produced, namely the aqueous residue containing bioactive phenolics, and the residual deterp...
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Mint species are one of the most traded medicinal plants with a wide array of applications in the food, pharmaceutical, and perfumery industries. Here, a field experiment based on completely randomized block design (RCBD) aimed to compare drug yield, antioxidant properties, and essen-tial oil (EO) quality of three newly introduced mints (i.e., ging...
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Hymenocardia acida (H. acida) is an African well-known shrub recognized for numerous medicinal properties, including its cancer management potential. The advent of nanotechnology in delivering bioactive medicinal plant extract with poor solubility has improved the drug delivery system, for a better therapeutic value of several drugs from natural or...
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The current study screened the oil content, fatty acids profile, and antioxidant properties of twelve Iranian sumac fruit accessions. The oil contents were variable among the investigated populations (ranging from 5.15 to 16.70%). Oleic acid (32.3- 47.41%), palmitic acid (18.90-36.29%), and linoleic acid (10.31-35.39%) were the predominant fatty ac...
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Oregano (Origanum vulgare L.) is a rich source of biologically active components such as phenolic compounds. Here, seven pot grown O. vulgare accessions belonging to three subspecies (subsp. virens, subsp. vulgare and subsp. gracile) were investigated for their content in sixteen bioactive phenolic compounds as well as their antioxidant capacities...
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Salvia majdae (Lamiaceae) is an aromatic herb of pharmaceutical interest in Iran due to its several biological properties. In the present study, we studied the chemical composition and antibacterial activity of S. majdae essential oil (EO) by comparing several extraction methods, including hydrodistillation (HD), steam distillation (SD), ultrasound...
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Horsemint, Mentha longifolia (L.) Huds. (Lamiales: Lamiaceae), is a member of the genus Mentha, widely used for the repellent and insecticidal effectiveness of its essential oil (EO). Several chemotypes have been reported for this species. Here, the efficacy of a M. longifolia EO, belonging to the piperitenone oxide-type, and a 10% (w/w) M. longifo...
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Rydingia michauxii (Briq.) Scheen and V.A.Albert (Lamiaceae) is used in Iranian traditional medicine to treat malaria, diabetes, hyperlipidemia, rheumatism and cardiovascular diseases. NMR and LC-DAD-MSn analyses were used to establish extract composition and phenylethanoid, flavonoid glycosides, lignans, labdane diterpenes and iridoids were identi...
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New hemp (Cannabis sativa L.) strains developed by crossbreeding selected varieties represent a novel research topic worthy of attention and investigation. This study focused on the phytochemical characterization of nine hemp commercial cultivars. Hydrodistillation was performed in order to collect the essential oils (EO), and also the residual wat...
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The antimicrobial activity of several essential oils (EOs) and their related microemulsions (MEs) was investigated. EOs were obtained from Cannabis sativa L. cv CS (C. sativa), Carum carvi L. (C. carvi), Crithmum maritimum L. (C. maritimum), Cuminum cyminum L. (C. cyminum), x Cupressocyparis leylandii A.B. Jacks & Dallim. (C. leylandii), Cupressus...
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A novel perception of botanic gardens as complex “factories of molecules” (Lombardy Region Project–Lr. 25/2016, year 2021), that mediate plant–environment interactions, and are the basis of their utility for humans, is presented. The core-topic is the medicinal plant heritage of the Ghirardi Botanic Garden (Toscolano Maderno, Brescia, Italy) of the...
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Cystic echinococcosis (CE) is one of the most important zoonotic diseases. The primary treatment is surgery and chemical sterilization of the parasitic layers by injection of a scolicidal agent. Available scolicidals possess side effects, and may cause postoperative complications. Several studies reported the scolicidal properties of monoterpene ph...
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Background: Plant essential oils (EOs) represent eco-friendly alternatives to conventional insecticides for managing pest populations. Carlina acaulis root EO showed a wide insecticidal spectrum, being highly effective against insect pests and vectors, coupled with low mammal toxicity. To boost the chemico-physical properties of this EO and its ma...
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Recently the agrochemical industry is developing eco-friendly approaches based on the fabrication of biopesticides using substances, including biomass-borne products, with limited impact on human health and environment. One of these is the use of vegetable proteins, such as the corn derived zein, as a safe nanocarrier loaded with bioactive compound...
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The incessant use of synthetic herbicides may cause several ecological problems including environmental contamination and developing herbicide-resistant species. These concerns led to exploring new eco-friendly weed control strategies. Present study is aimed to assess the phytotoxic activity of Moldavian dragonhead, Dracocephalum moldavica L., esse...
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Black mulberry, Morus nigra L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from M. nigra fruits....
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Ethnobotanical investigation was carried out using questionnaires among majority of El Kala (Algeria) inhabitants. The investigation found that lentisk (Pistacia lentiscus L.) is widely used in traditional therapy, especially in gastrointestinal and dermatological problems. Bioactive phytochemicals were determined by LC-MS/MS, and 14, 13, and 12 co...
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Coffee arabica L. is an economical crop cultivated in many countries including Yemen. The present study evaluated the phytochemical contents of the methanolic extracts, prepared by maceration, of six Yemeni green coffee beans varieties namely Esmaeli, Hamadi, Harazi, Mattari, Odaini and Yafei. Antioxidant (phosphomolybdenum, antiradical, reducing p...
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Plant essential oil-based insecticides, with special reference to those that may be obtained from largely available biomasses, represent a valuable tool for Integrated Pest Management. However, the sublethal effects and the potential effects on aggressive insect traits of these green insecticides are understudied. Herein, the lethal and sub-lethal...
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In this study the adulticidal and larvicidal effect of tansy, Tanacetum vulgare L. (Asteraceae) essential oil (EO) was estimated against four noxious stored-product insect species; Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), Tribolium confusum Jacquelin du Val (Coleoptera: Tenebrionidae), Tenebrio molitor L. (Coleoptera: Tenebrionidae...
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Isofuranodiene (IFD) is a sesquiterpene occurring in several plant species, which proved to have multiple anticancer activities. IFD has a lipophilic nature and, hence, a very low water solubility and a poor bioavailability; moreover, it is not stable, undergoing the “Cope rearrangement” to the less active curzerene. The use of appropriate delivery...
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Citation: Rosato, A.; Barbarossa, A.; Mustafa, A.M.; Bonacucina, G.; Perinelli, D.R.; Petrelli, R.; Maggi, F.; Spinozzi, E. Abstract: Plants are considered to be an excellent source of new compounds with antibiotic activity. Carlina acaulis L. is a medicinal plant whose essential oil (EO) is mainly characterized by the poly-acetylene carlina oxide,...
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This study aimed to investigate the susceptibility of Trypanosoma brucei to the Anthriscus nemorosa essential oils (EOs), isolated compounds from these oils, and artificial mixtures of the isolated compounds in their conventional and nanoencapsulated forms. The chemical composition of the essential oils from the aerial parts and roots of Anthriscus...
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Zhumeria majdae (Rech. F. & Wendelbo) is an aromatic herb belonging to the Lamiaceae family, traditionally employed in the Persian medicine for the treatment of a wide number of diseases. In the present study, the chemical composition of Z. majdae essential oil obtained from the plant’s aerial features, and stored at various temperatures (refrigera...
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The Mela Rosa dei Monti Sibillini is an ancient apple variety cultivated by Romans in the foothills of the Sibillini Mountains, central Italy, showing potential as a source of nutraceuticals. The purpose of this study was to evaluate the protective effects of the hydroalcoholic extracts from the peel (APE) and pulp (APP) of this fruit in an animal...
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The free choice of Frankliniella occidentalis to the paper color simulative to Rosa chinensis cultivars (Ruby, Love,Parade,Mohana, Pink Peace, and Spectra) was tested in Petri dishes, and their behavioral responses to the volatiles of different these R. chinensis cultivars was tested in a Y-tube olfactometer. The results showed that F. occidentalis...
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Sweet chestnuts (Castanea sativa Mill.) are highly prized nuts, and the consumption of fresh chestnuts is usually preceded by roasting, boiling, and frying. The aim of this work was to simultaneously analyze 29 polyphenolic compounds for the first time in raw, boiled, roasted, and fried chestnut seeds and shells using HPLC-MS/MS. Principal componen...
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Hemp (Cannabis sativa L.) synthesizes and accumulates a number of secondary metabolites such as terpenes and cannabinoids. They are mostly deposited as resin into the glandular trichomes occurring on the leaves and, to a major extent, on the flower bracts. In the last few years, hemp for production of high-value chemicals became a major commodity i...
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Acmella oleracea (L.) R.K. Jansen, also named jambù, is an edible and medicinal plant native to Brazil but extensively cultivated all over the world due to its diverse utilizations in food, cosmetics, pharmaceutics, and pest management science. Most of applications are related to the presence of active ingredients, namely alkylamides, among which s...
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The family Tephritidae (Diptera) includes species that are highly invasive and harmful to crops. Due to globalization, international trade, and human displacement, their spread is continuously increasing. Unfortunately, the control of tephritid flies is still closely linked to the use of synthetic insecticides, which are responsible for detrimental...
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Among botanical insecticides based on essential oils (EOs) or their main components, Carlina acaulis EO and the aromatic polyacetylene carlina oxide, constituting more than 90% of its EO, were recently proven to be effective against the larvae and adults of some insect vectors and pests. In this study, the toxicity of C. acaulis EO and carlina oxid...
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The water deficit is one of the main limiting abiotic stress factors affecting plant physiology, growth, and productivity. The aim of the present study was to evaluate the impact of bio-fertilizer application under water stress conditions on the soybean productivity and its oil quality as a new strategy in sustainable agriculture. The experimental...
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Acinos is a small genus of economically important plants belonging to Lamiaceae family whose botanical collocation is quite problematic due to the disagreement among the botanists and the presence in literature of several names and synonyms from different sources. In the present study the chemical composition of the essential oil from aerial parts...
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Pteridophytes, represented by ferns and allies, are an important phytogenetic bridge between lower and higher plants. Ferns have evolved independently of any other species in the plant kingdom being its secondary metabolism a reservoir of phytochemicals characteristic of this taxon. The study of the potential uses of Polypodium vulgare L. ( Polypod...
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Oregano, Origanum vulgare L., is a well-reputed medicinal herb used globally in cosmetics, food and pharmaceutical industries. Essential oil (EO) composition and productivity of oregano subspecies are highly affected by water deficit stress. Here, a two-year (2018 and 2019) greenhouse study was conducted to comparatively investigate the impact of w...
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In this work, in order to explore a new Algerian medicinal plant used in traditional medicine, the essential oil of the leaves of Cachrys sicula L. (Apiaceae) collected from Algeria, obtained by hydrodistillation, was analyzed by GC/MS. Thirty-two compounds were identified accounting for 98.6% of the total oil, which is characterized by a high cont...
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Conifers are of high economic importance due to their exploitation for timber, gardening and landscaping, construction and paper, varnishes, adhesives and waterproof coatings, perfumes and pharmaceuticals, bioplastics and biodiesel. They are endowed in all parts with secretory channels producing a semi-solid resin and a liquid fraction composed of...
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The resistance of insect populations to the existing insecticides grows fast due to their continuous use. Thus, the need for new and effective formulations is increasing. Isolated compounds of botanical origin may represent a promising solution for green pest management strategies. In this study, isofuranodiene derived from Smyrnium olusatrum L. (A...