Filipa Sofia Carvalho

Filipa Sofia Carvalho
University of Lisbon | UL · Faculty of Science

PhD

About

24
Publications
5,088
Reads
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920
Citations
Citations since 2016
10 Research Items
708 Citations
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2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Introduction
PhD degree in Bioscience-Toxicology at University of Coimbra. Working at the Center for Neuroscience and Cell Biology, focusing my interest in the cardiotoxicity provoked by doxorubicin, namely at the cardiac mitochondria.
Additional affiliations
January 2011 - February 2015
University of Coimbra
Position
  • PhD Student
August 2009 - June 2010
University of Coimbra
Position
  • Master's Student

Publications

Publications (24)
Preprint
Full-text available
Most cancer related deaths are due to metastases. Systemic factors, such as lipid-enriched environments (particularly LDL-cholesterol), favor breast cancer (including triple negative breast cancer, TNBC) metastasis formation. Mitochondria metabolism impacts TNBC invasive behavior but its involvement in a lipid-enriched setting is undisclosed. Here...
Article
Full-text available
Despite a multitude of methods for the sample preparation, sequencing, and data analysis of mitochondrial DNA (mtDNA), the demand for innovation remains, particularly in comparison with nuclear DNA (nDNA) research. The Applied Biosystems™ Precision ID mtDNA Whole Genome Panel (Thermo Fisher Scientific, USA) is an innovative library preparation kit...
Article
Full-text available
The microtubule-associated protein tau is implicated in the formation of oligomers and fibrillar aggregates that evade proteostasis control and spread from cell-to-cell. Tau pathology is accompanied by sustained neuroinflammation and, while the release of alarmin mediators aggravates disease at late stages, early inflammatory responses encompass pr...
Article
Full-text available
Intratumor genetic heterogeneity (ITH) is the main obstacle to effective cancer treatment and a major mechanism of drug resistance. It results from the continuous evolution of different clones of a tumor over time. However, the molecular features underlying the emergence of genetically-distinct subclonal cell populations remain elusive. Here, we co...
Article
Triterpenoids have multiple biological properties, although little information is available regarding their toxicity. The present study evaluates the toxicity of two new synthetic lupane derivatives using distinct biological models including synthetic lipids membranes, isolated liver and heart mitochondria fractions, and cell lines in culture. The...
Article
Doxorubicin (DOX), a potent and broad-spectrum antineoplastic agent, causes an irreversible, cumulative and dose-dependent cardiomyopathy that ultimately leads to congestive heart failure. The mechanisms responsible for DOX cardiotoxicity remain poorly understood, but seem to involve mitochondrial dysfunction on several levels. Epigenetics may expl...
Article
Full-text available
The use of engineered cardiac tissue for high-throughput drug screening/toxicology assessment remains largely unexplored. Here we propose a scaffold that mimics aspects of cardiac extracellular matrix while preserving the contractility of cardiomyocytes. The scaffold is based on a poly(caprolactone) (PCL) nanofilm with magnetic properties (MNF, sta...
Article
Full-text available
Aims: It is still unclear why anthracycline treatment results in a cardiac-specific myopathy. We investigated whether selective doxorubicin (DOX) cardiotoxicity involving mitochondrial degeneration is explained by different respiratory complexes reserves between tissues by comparing and contrasting treatment effects in heart vs liver and kidney. A...
Conference Paper
Full-text available
Background: Doxorubicin (DOX), a potent and broad-spectrum antineoplastic agent, causes late-onset dose-dependent cardiomyopathy that may lead to congestive heart failure. Since DOX induces a persistent depression in cardiomyocyte gene expression patterns, we hypothesize that a ‘toxic memory’ is being formed by means of epigenetic modulation. Mater...
Conference Paper
Doxorubicin (DOX), a potent and broad-spectrum antineoplastic agent, causes a cumulative dose-dependent cardiomyopathy of late-onset that may ultimately lead to congestive heart failure. The mechanisms responsible for the delayed nature of this pathology remain poorly understood. Since DOX induces a persistent depression in cardiomyocyte gene expre...
Article
Novel cationic dimethylaminopyridine derivatives of pentacyclic triterpenes were previously described to promote mitochondrial depolarization and cell death in breast and melanoma cell lines. The objective of this work was to further investigate in detail the mechanism of mitochondrial perturbations, correlating those effects with breast cancer cel...
Article
Full-text available
Doxorubicin (DOX) is an anticancer anthracycline that presents a dose-dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain DOX cardiac side effects, which culminate in the development of life-threatening cardiomyopathy. One of the most studied mechanisms involves the activ...
Article
Full-text available
a b s t r a c t The environmental dioxin 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is classified as a Group 1 human carcinogen and teratogenic agent. We hypothesize that TCDD-induced oxidative stress may also interfere with mitochondrial ATP-sensitive potassium channels (mitoKATP), which are known to regulate and to be regulated by mitochondrial r...
Article
Full-text available
Edelfosine and perifosine are alkylphospholipids that have been intensively studied as potential antitumor agents. Apoptotic cell death caused by these two compounds is mediated, at least in part, through mitochondria. Additionally, previous works demonstrated that edelfosine induces changes in mitochondrial membrane permeability that are somehow r...
Article
Full-text available
Mitochondria have long been involved in several cellular processes beyond its role in energy production. The importance of this organelle for cardiac tissue homeostasis has been greatly investigated and its impairment can lead to cell death and consequent organ failure. Several compounds have been described in the literature as having direct effect...
Article
In the present work, lipophilic caffeic and ferulic acid derivatives were synthesized, and their cytotoxicity on cultured breast cancer cells was compared. A total of six compounds were initially evaluated: caffeic acid (CA), hexyl caffeate (HC), caffeoylhexylamide (HCA), ferulic acid (FA), hexyl ferulate (HF), and feruloylhexylamide (HFA). Cell pr...
Article
Full-text available
Mitochondria are recognized as the producers of the majority of energy cells need for their normal activity. After the initial comprehension of how mitochondrial oxidative phosphorylation produces energy, mitochondrial research was not a priority for most cell biologists until novel mitochondrial functions were identified. In fact, it is now known...

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