Fikrettin Sahin

Fikrettin Sahin
Yeditepe University · Department of Genetics and Bioengineering

PhD

About

619
Publications
168,793
Reads
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18,150
Citations
Citations since 2016
227 Research Items
10133 Citations
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201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500
Additional affiliations
January 1991 - September 2005
Ataturk University
Position
  • Faculty Member
March 1968 - present
Yeditepe University
Position
  • Department Chair

Publications

Publications (619)
Article
Full-text available
This is a single-center prospective, open-label, single arm interventional study to test the safety and efficacy of recently described ChipEXO™ for severe COVID-19 pneumonia. The ChipEXO™ is a natural product derived from convalescent human immune plasma of patients recovered from moderate COVID-19 infection. In September 2021, 13 patients with pen...
Article
Full-text available
Some novel triazole-bearing ketone and oxime derivatives were synthesized from Ibuprofen. In vitro cytotoxic activities of all synthesized molecules against five cancer lines (human breast cancer MCF-7, human lung cancer A549, human prostate cancer PC-3, human cervix cancer HeLa, and human chronic myelogenous leukemia K562 cell lines) were evaluate...
Article
Ex vivo dermal toxicology analyses are crucial for replacement of in vivo test methods and have been of interest in recent years for testing cosmetics, drugs, and chemicals. Development of an appropriate reconstructed epidermis model might overcome the limitations of monolayer culture systems. To that end, in the current study we used the immortali...
Article
Full-text available
Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Candida species, as the main component of human mycobiome, are the most common cause of fungal infections in intensive care units (ICU). ICU patients with COVID-19 are more prone to fungal infections, due to various causes like mechanical ventilation, use of steroids, or long-term...
Preprint
Full-text available
Background Eukaryotic elongation factor 2 kinase (eukaryotic elongation factor 2 kinase, eEF2K) is a calcium calmodulin dependent protein kinase that keeps the highest energy consuming cellular process of protein synthesis under check through negative regulation. EEF2K pauses global protein synthesis rates at the translational elongation step by ph...
Article
Human microsomal prostaglandin E synthase (mPGES)-1 is a glutathione-dependent membrane-bound enzyme which is involved in the terminal stage of prostaglandin E2 (PGE2) synthesis. It has been well reported as a key target for the discovery of new anti-inflammatory and anti-cancer drugs. Specific inhibitors of mPGES-1 are anticipated to selectively r...
Article
Nanocarriers and nanoparticles in the drug delivery systems increase the drug's effectiveness due to their permeability and retention properties to tumor tissues. Exosomes are small extracellular natural vesicles released from the plasma membrane and they are promise drug delivery vehicles to be used in anti-cancer therapy. The prominent features o...
Article
Full-text available
Bakelli et al.: Endophytic bacteria of Common tamarisk (Tamarix gallica L.) and Alkali seepweed (Suaeda fruticosa (L.) Forssk.) as potential biocontrol and plant growth-promoting agents in arid environments-3073-APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH 20(4):3073-3098. Abstract. In this study, fifty-two endophytic halotolerant bacteria from Tamar...
Article
Background Hepatocelular carcinoma is one of the leading cancer types with no effective cure as poor prognosis is still a challenging aspect. Thus, alternative therapeutics are necessary to control hepatocelular carcinoma. Boron derivatives such as boric acid (BA), sodium perborate tetrahydrate (SPT) and sodium pentaborate pentahydrate (NaB) have b...
Article
Full-text available
The transmission of the SARS-CoV-2 coronavirus has been shown through droplets generated by infected people when coughing, sneezing, or talking in close contact. These droplets either reach the next person directly or land on nearby surfaces. The objective of this study is to develop a novel, durable, and effective disinfecting antimicrobial (antiv...
Patent
Full-text available
Disclosed are naphthalimide derivatives and in particular e.g. N - aryl - substituted naphthalimidopropylamine deriva tives ( i.e. 2- [ 3- ( amino ) propyl ) -1H - benz [ de ] isoquinoline - 1,3 ( 2H ) -dione derivatives ) such as e.g. such as e.g. ( Formula I ) or ( Formula III ) as anti - parasitic agents for the treatment of Leishmaniasis . The...
Article
Background Boron (B) is an element involved in many physiological processes in humans and accelerates wound healing and increases angiogenesis. This study aimed to evaluate the possible effects of sodium pentaborate pentahydrate (NaB) on hair growth and reveal its effects on Wnt-1, β-catenin, vascular endothelial growth factor (VEGF), platelet-deri...
Article
Full-text available
Hypothalamic-pituitary-adrenal (HPA) axis regulates stress response in the body and abnormal increase in oxidative stress contributes to the various disease pathogenesis. Although hypothalamic distribution of Apelin receptor (APLNR) has been studied, the potential regulatory role in hormone releasing function of hypothalamus in response to stress i...
Article
Full-text available
Pluripotent stem cells as a promising cell source with unlimited proliferation and differentiation capacity hold great promise for cell-based therapies in regenerative medicine. Establishment of appropriate culture conditions might enable the control of cellular fate decision in cell culture. Transfer of three-dimensional (3D) embryoid bodies to tw...
Article
Full-text available
Cancer is a complex and multistage disease that causes suffering worldwide. Several mutations in tumor suppressor proteins are mostly responsible for tumorigenic development. Thus, determination of the mutations and developing a mutation targeted therapy are crucial in order to cure cancer. Moreover, since healthy cells do not have mutations in the...
Article
Full-text available
Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on macrophages plus poor aqueous solubility and poor bioavailability of the compounds limit their application in therapies. Address...
Chapter
Full-text available
Extracellular vesicles (EVs) have lately emerged as crucial mediators in parasite infections. Recent research suggests that protozoan parasites, including Leishmania, employ EVs as transport vehicles to deliver biologically active effector molecules such as parasitic virulence factors to modulate the host immune system and their microenvironment. T...
Article
Full-text available
Background Anti-cancer activity of boron has been reported. Although many boron derivatives such as boric acid (BA) have been discovered to have anticancer effects, there are many boron derivatives whose anticancer effects have not yet been discovered. Some of these include sodium pentaborate pentahydrate (NaB), which has had limited research on it...
Article
Introduction: Radiation dermatitis (RD) is a side effect of radiation therapy (RT) which is experienced by over 90% of patients being treated for breast cancer. The current clinical trial was conducted to measure the preventative effects of a boron-based gel on several different clinical outcomes (dermatitis, erythema, dry desquamation, and moist...
Article
Full-text available
Mesenchymal Stem Cells (MSCs), as an adult stem cell type, are used to treat various disorders in clinics. However, derivation of homogenous and adequate amount of MSCs limits the regenerative treatment potential. Although mesoderm is the main source of mesenchymal progenitors during embryonic development, neuromesodermal progenitors (NMPs), reside...
Article
Full-text available
Phragmites communis L. is a halophytic plant that can withstand harsh environmental conditions such as salinity. In the present study, we isolated a bacterium associated with the rhizosphere of Phragmites communis L. Based on morphological and biochemical as well as MALDI-TOF and 16S rRNA sequencing results, the strain S6 was identified as Klebsiel...
Article
Full-text available
Background Cancer cell survival depends on the cross-regulation between apoptosis and autophagy which share common signaling pathways including PI3K/Akt/mTOR and Bcl-2. The aim of this study was to elucidate the modulation patterns between apoptosis and autophagy following dual inhibition by Akt inhibitor erufosine and Bcl-2 inhibitor ABT-737 in ca...
Article
Obesity is a popular topic due to both its mortality and morbidity rates and related diseases such as cardiovascular diseases, diabetes and cancer. Cancer development and progression relate to many factors one of which is dysfunctional adipocytes found in the tumor microenvironment. However, underlying molecular mechanisms of the obesity-cancer lin...
Article
Full-text available
Bacteria significantly affect the plant availability of plant nutrients in the soil. This level of influence varies with the bacterial population, activity and viability time. For determination of the effects of bacteria inoculated tuff material on yield and physiological parameters of grape plant, this study conducted. In this study, ‘Sultani’ see...
Article
Full-text available
Flow cytometry analysis emerges as an alternative methodology to microscopy for determination of the Leishmania -infection rates of macrophages. Various flow cytometric approaches have been established for the quantification of Leishmania parasites within host cells, labelled either directly fluorescent dyes or indirectly with fluorescently conjuga...
Article
Full-text available
The developments of nanoparticle-based treatments that benefit from novel discoveries have an essential place in the regeneration of acute and chronic wounds. Furthermore, research about the treatment methods which attempt to swiftly and scarless wound recovery has increased over time. In recent years, it has been shown that metallic-based nanopart...
Article
Full-text available
The SARS-CoV-2 virus caused the most severe pandemic around the world, and vaccine development for urgent use became a crucial issue. Inactivated virus formulated vaccines such as Hepatitis A and smallpox proved to be reliable approaches for immunization for prolonged periods. In this study, a gamma-irradiated inactivated virus vaccine does not req...
Article
Breast cancer, a heterogeneous disease, has the highest incidence rate and is a major cause of death in females worldwide. Drug delivery by using nanotechnology has shown great promise for improving cancer treatment. Nanoliposomes are known to have enhanced accumulation ability in tumors due to prolonged systemic circulation. Peptide 18 (P18), a tu...
Article
Full-text available
As a key component of the cell-to-cell communication, small extracellular vesicles (SEVs) released from various sources are known to be affecting the physiological conditions of the target cells. Although it has been suggested that edible plant-derived nanoparticles contributes to the cross kingdom communication with the mammalian cells, the effect...
Article
To date, the role of miRNAs on pluripotency and differentiation of ESCs into specific lineages has been studied extensively. However, the specific role of miRNAs during lateral and paraxial mesoderm cell fate decision is still unclear. To address this, we firstly determined miRNA profile of mouse ESCs differentiating towards lateral and paraxial li...
Article
The reaction of 3,4-dichlorophenyl-1,3,4-oxadiazole-2( 3H )-thione with piperidine derivatives via Mannich reaction was used to generate eleven novel compounds in moderate to good yields. Synthesized molecules were characterized according to their structure with 1H NMR, 13C NMR and FT-IR spectral foundations, which were compatible with literature i...
Article
Improvements in stem cell-based research and genetic modification tools enable stem cell-based tissue regeneration applications in clinical therapies. Although inadequate cell numbers in culture, invasive isolation procedures, and poor survival rates after transplantation remain as major challenges, cell-based therapies are useful tools for tissue...
Article
Background Brucellosis is a zoonotic disease that causes serious economic losses due to factors such as miscarriages and decreased milk yield in animals. Existing live vaccines have some disadvantages, so effective vaccines need to be developed with new technological approaches. Objectives The primary objectives of this study were the expression a...
Poster
Full-text available
Resistance to dual Akt and Bcl-2 inhibition is associated with cell-type specific inhibition of apoptotic and autophagic signaling in CRPC
Article
Due to the prevalence of individuals suffering from chronic wounds, developing safe and effective wound care agents are one of the more prominent fields of research in biology. However, wound healing is a complex, multi-stage biological process, involving multiple sequences of biological responses from different types of cells, secreted mediators,...
Article
Objective To determine the antibacterial effects of different saliva-substitutes-containing-lysozyme(LYZ) or-lactoferrin(LF) on Streptococcus mutans(S. mutans) in comparison with human saliva. Design In vitro wound-healing assay was performed with L929 mouse fibroblast cell line by using various concentrations of LYZ and LF to determine optimum co...
Article
Aims The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine (P18-PEtOx-DOPE), was synthesised to construct nanoliposomes. Methods Doxorubicin (DOX) was encapsulated into the nanoliposomes b...
Conference Paper
Full-text available
Extracellular vesicles (EVs) are a key element of cellular communications. They carry proteins, nucleic acids and other biomolecules from one cell to another. As natural transporters, inherent traits of extracellular vesicles makes them highly suitable as drug delivery vehicles. Extracellular vesicles are readily taken by cells, stay in circulation...
Article
Full-text available
COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, SARS-CoV-2 vaccines have become crucial for reducing morbidity and mortality. In this study, in vitro and in vivo safety and efficacy analyzes of lyophilized vaccine candidates inactivated by gamma-irradiation wer...
Article
Background Obesity is one of the most popular topic in the field of research. In order to defeat this highly widespread disease, the mechanism of fat accumulation at the molecular level and its elimination are crucial. The use of boron has been showing promising results during the recent years. Methods In this study, anti-obesity potential of Sodi...
Article
Full-text available
Background: Viral infections are among the most common problems in healthcare practice. Natural products offer great promise as potentially effective antiviral drugs. Propolis is a honeybee product with biological properties and therapeutic applications. We aimed to investigate the antiviral activity of different extracts of Standardized Propolis...
Article
The equipping of nanoparticles with the peptide moiety recognizing a particular receptor, enables cell or tissue-specific targeting, therefore the optimization of the targeted nanoparticles is a key factor in the formulation design process. In this paper, we report the optimization concept of Doxorubicin encapsulating PEtOx-b-PLA polymersome formul...
Article
Full-text available
Bacterial biofilms are related to various dental and periodontal infectious diseases, and the characterization of this biological structure with micro-computed tomography (micro-CT) may offer valuable information for clinical and research applications. In this study, we aimed to develop a model to visualize three-dimensionally the biofilm structure...
Article
Here we present self-assembled polymeric micelles as potential delivery systems for therapeutic agents with highly tunable properties. The major goal of this study is to design breast and prostate cancer...
Conference Paper
Full-text available
Breast cancer (BC) is the most common disease among women worldwide. Angiogenesis is an important factor for cancer cells and angiogenic ability of cancer also affects their metastatic capacities. In our study, we used MCF-7 and MDA-MB-231 which have different metastatic potential and aggressiveness. We aimed that the evaluation of the human umbili...
Conference Paper
Full-text available
Obesity is a common disease in worldwide and has a relation to many other diseases like cancer. Besides, advanced prostate cancer that is the second most frequent cancer in men, has been shown to be associated with obesity in overweight/obese people. Therefore, we aimed to investigate prostate cancer-obesity relation with indirect co-culture techni...
Article
Prostate cancer is the most common cancer, which is about 15–20% among male cancers worldwide. As most common strategies such as radiotherapy, chemotherapy, or surgery alone can be unsuccessful in the treatment of prostate cancer, this study aims to develop a new approach to deliver newly generated proapoptotic gene, BIKDDA, to androgen independent...
Conference Paper
Purpose: Highly aggressive and resistant to chemotherapy, pancreatic cancers are the fourth leading cause of cancer-related deaths in the western world. The absence of effective chemotherapeutics is leading researchers to develop novel drugs or repurpose existing chemicals. Alexidine dihydrochloride (AD), an orally bioavailable bis-biguanide compou...
Conference Paper
Purpose: The main purpose of this study is to demonstrate the effects of epithelial to mesenchymal transition activating transcription factor silencing (EMT-ATF silencing) on migration, invasion, drug resistance and tumor forming abilities of various pancreatic cancer cell lines. Additionally, the contribution of small molecule inhibitors of EMT (S...
Preprint
Full-text available
The SARS-CoV-2 virus caused one of the severest pandemic around the world. The vaccine development for urgent use became more of an issue during the pandemic. An inactivated virus formulated vaccines such as Hepatitis A, inactivated polio, and influenza has been proven to be a reliable approach for immunization for long years. In this pandemic, we...
Article
Neogenesis of osseous and ligamentous interfacial structures is essential for the regeneration of large oral or craniofacial defects. However, current treatment strategies are inadequate in renewing supporting tissues of teeth after trauma, chronic infections or surgical resection. Combined use of 3D scaffolds with stem cells became a promising tre...